Overview
Background
Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.
She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.
Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.
Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Tumour Immunology, The University of Queensland
- Foreign Fellow, American Association of Immunologists, American Association of Immunologists
- Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
- Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
- Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
- Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
- Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
- Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
- Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
- Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
- Board Member, Neuroimmunology Australia, Neuroimmunology Australia
Research interests
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Immunology of multiple sclerosis
My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.
Works
Search Professor Judith Greer’s works on UQ eSpace
2013
Journal Article
Female reproductive issues in multiple sclerosis
McCombe, Pamela A. and Greer, Judith M. (2013). Female reproductive issues in multiple sclerosis. Multiple Sclerosis Journal, 19 (4), 392-402. doi: 10.1177/1352458512452331
2012
Journal Article
The role of epigenetic mechanisms and processes in autoimmune disorders
Greer, Judith M. and McCombe, Pamela A. (2012). The role of epigenetic mechanisms and processes in autoimmune disorders. Biologics: Targets and Therapy, 6, 307-327. doi: 10.2147/BTT.S24067
2012
Journal Article
Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis
Yan, Jun, Liu, Jia, Lin, Clement Yihao, Australia and New Zealand Multiple Sclerorsis Genetics Consortium, Csurhes, Peter A., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2012). Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis. International Journal of Molecular Sciences, 13 (10), 13667-13679. doi: 10.3390/ijms131013667
2011
Journal Article
Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms
Greer, Judith M. and McCombe, Pamela A. (2011). Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms. Journal of Neuroimmunology, 234 (1-2), 7-18. doi: 10.1016/j.jneuroim.2011.03.003
2008
Journal Article
Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis
Greer, Judith M., Csurhes, Peter A., Muller, Diane M. and Pender, Michael P. (2008). Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis. Journal of Immunology, 180 (9), 6402-6410. doi: 10.4049/jimmunol.180.9.6402
2008
Journal Article
Route of uptake of palmitoylated encephalitogenic peptides of myelin proteolipid protein by antigen-presenting cells: Importance of the type of bond between lipid chain and peptide and relevance to autoimmunity
Pfender, N., Grosch ,S., Roussell, G., Koch, M., Trifilieff, E. and Greer, Judith M. (2008). Route of uptake of palmitoylated encephalitogenic peptides of myelin proteolipid protein by antigen-presenting cells: Importance of the type of bond between lipid chain and peptide and relevance to autoimmunity. Journal of Immunology, 180 (3), 1398-1404. doi: 10.4049/jimmunol.180.3.1398
2007
Journal Article
Immunology of multiple sclerosis
Pender, Michael P. and Greer, Judith M. (2007). Immunology of multiple sclerosis. Current Allergy and Asthma Reports, 7 (4), 285-292. doi: 10.1007/s11882-007-0043-x
2005
Journal Article
The Presence of Glutamic Acid at Positions 71 or 74 in Pocket 4 of the HLA-DR beta 1 Chain is Associated with the Clinical Course of Multiple Sclerosis
Greer, J. M. and Pender, M. P. (2005). The Presence of Glutamic Acid at Positions 71 or 74 in Pocket 4 of the HLA-DR beta 1 Chain is Associated with the Clinical Course of Multiple Sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 76 (5), 656-662. doi: 10.1136/jnnp.2004.042168
2005
Journal Article
Blood-Brain Barrier Disruption And Lesion Localisation In Experimental Autoimmune Encephalomyelitis With Predominant Cerebellar And Brainstem Involvement
Muller, Diane M., Pender, Michael P. and Greer, Judith M. (2005). Blood-Brain Barrier Disruption And Lesion Localisation In Experimental Autoimmune Encephalomyelitis With Predominant Cerebellar And Brainstem Involvement. Journal of Neuroimmunology, 160 (1-2), 162-169. doi: 10.1016/j.jneuroim.2004.11.011
2005
Journal Article
Immune Dysregulation and Self-Reactivity in Schizophrenia: Do Some Cases of Schizophrenia Have an Autoimmune Basis?
Jones, Amanda L., Mowry, Bryan J., Pender, Michael P. and Greer, Judith M. (2005). Immune Dysregulation and Self-Reactivity in Schizophrenia: Do Some Cases of Schizophrenia Have an Autoimmune Basis?. Immunology and Cell Biology, 83 (1), 9-17. doi: 10.1111/j.1440-1711.2005.01305.x
2004
Journal Article
Increased circulating antibodies to an extracellular domain of myelin proteolipid protein in multiple sclerosis
Pender, MP and Greer, JM (2004). Increased circulating antibodies to an extracellular domain of myelin proteolipid protein in multiple sclerosis. Multiple Sclerosis, 10 (7032), S166-S166.
2003
Journal Article
Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis
Pender, Michael P., Csurhes, Peter A., Wolfe, Nigel P., Hooper, Kaye D., Good, Michael F., McCombe, Pamela A. and Greer, Judith M. (2003). Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis. Journal of Clinical Neuroscience, 10 (1), 63-66. doi: 10.1016/S0967-5868(02)00270-9
2002
Journal Article
Myelin proteolipid protein - the first 50 years
Greer, Judith M. and Lees, Marjorie B. (2002). Myelin proteolipid protein - the first 50 years. International Journal of Biochemistry and Cell Biology, 34 (3), 211-215. doi: 10.1016/S1357-2725(01)00136-4
2001
Journal Article
Thiopalmitoylation of myelin proteolipid protein epitopes enhances immunogenicity and encephalitogenicity
Greer, J. M., Denis, B., Sobel, R. A. and Trifilieff, E. (2001). Thiopalmitoylation of myelin proteolipid protein epitopes enhances immunogenicity and encephalitogenicity. Journal of Immunology, 166 (11), 6907-6913. doi: 10.4049/jimmunol.166.11.6907
2000
Journal Article
A Neuropathological Analysis Of Experimental Autoimmune Encephalomyelitis With Predominant Brain Stem And Cerebellar Involvement And Differences Between Active And Passive Induction
Muller, Diane M., Pender, Michael P. and Greer, Judith M. (2000). A Neuropathological Analysis Of Experimental Autoimmune Encephalomyelitis With Predominant Brain Stem And Cerebellar Involvement And Differences Between Active And Passive Induction. Acta Neuropathologica, 100 (2), 174-182. doi: 10.1007/s004019900163
2000
Journal Article
Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis than in Healthy Subjects
Pender, Michael P., Csurhes, Peter A., Greer, Judith M., Mowat, Paul D., Henderson, Robert D., Cameron, Kaye D., Purdie, David M., McCombe, Pamela A. and Good, Michael F. (2000). Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis than in Healthy Subjects. Journal of Immunology, 165 (9), 5322-5331. doi: 10.4049/jimmunol.165.9.5322
1998
Journal Article
Increased Circulating Antiganglioside Antibodies in Primary and Secondary Progressive Multiple Sclerosis
Sadatipour, B. Tayyebeh, Greer, Judith M. and Pender, Michael P. (1998). Increased Circulating Antiganglioside Antibodies in Primary and Secondary Progressive Multiple Sclerosis. Annals of Neurology, 44 (6), 980-983. doi: 10.1002/ana.410440621
1997
Journal Article
Increased Immunoreactivity to Two Overlapping Peptides of Myelin Proteolipid Protein in Multiple Sclerosis
Greer, J. M., Csurhes, P. A., Cameron, K. D., McCombe, P. A., Good, M. F. and Pender, M. P. (1997). Increased Immunoreactivity to Two Overlapping Peptides of Myelin Proteolipid Protein in Multiple Sclerosis. Brain, 120 (8), 1447-1460. doi: 10.1093/brain/120.8.1447
1997
Journal Article
Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein
Das, MP, Nicholson, LB, Greer, JM and Kuchroo, VK (1997). Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein. Journal of Experimental Medicine, 186 (6), 867-876. doi: 10.1084/jem.186.6.867
1997
Journal Article
Encephalitogenicity of murine, but not bovine, DM20 in SJL mice is due to a single amino acid difference in the immunodominant encephalitogenic epitope
Greer, JM, Klinguer, C, Trifilieff, E, Sobel, RA and Lees, MB (1997). Encephalitogenicity of murine, but not bovine, DM20 in SJL mice is due to a single amino acid difference in the immunodominant encephalitogenic epitope. Neurochemical Research, 22 (4), 541-547. doi: 10.1023/A:1027336516785
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
Other advisors: Dr Jun Yan, Dr Aakanksha Dixit
-
Doctor Philosophy
The role of Epstein-Barr virus infection in multiple sclerosis
Principal Advisor
Other advisors: Professor Pamela McCombe
-
Doctor Philosophy
Investigation of the role of BTK and NF-kB signalling in CNS cells
Principal Advisor
Other advisors: Dr Jun Yan
Completed supervision
-
2022
Doctor Philosophy
Anti-Muscarinic Acetylcholine Receptor Antibodies in First Episode Psychosis
Principal Advisor
Other advisors: Professor James Scott
-
2022
Doctor Philosophy
Investigating the mechanism of action of a novel therapeutic derived from parasitic worms in animal models of multiple sclerosis
Principal Advisor
-
2015
Doctor Philosophy
Amino acid variants of myelin proteolipid protein: potential inducers of multiple sclerosis or potential means to a cure?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2013
Doctor Philosophy
Altered peptide ligands as therapeutic agents for a model of multiple sclerosis: Determining the signature of clinical efficacy
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Immune dysregulation in schizophrenia: Do some cases of schizophrenia have an autoimmune basis?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender, Professor Bryan Mowry
-
2012
Doctor Philosophy
Neuropathological and Neuroimmunological Studies of the Central Nervous System of Mice With Axial-Rotatory Experimental Autoimmune Encephalomyelitis
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2007
Doctor Philosophy
Development of immunomodulatory peptides for the treatment of the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
Principal Advisor
-
2014
Doctor Philosophy
Pathogenesis of Guillain-Barre syndrome and chronic inflammatory polyradiculoneuropathy
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2007
Doctor Philosophy
EXAMINATION OF SURFACE-RECORDED MOTOR UNITS AND A NEW APPROACH TO MOTOR UNIT NUMBER ESTIMATES
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2003
Doctor Philosophy
MITOCHONDRIAL IRON METABOLISM AND THE ROLE OF FRATAXIN IN IRON AND HAEM METABOLISM
Associate Advisor
Media
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