
Overview
Background
Professor Geoff Hill MBChB MD BHB FRCPA FRACP geoffH@qimr.edu.au
NHMRC Australia and QLD Health Senior Clinical Research Fellow
Coordinator, Cancer Programme, QIMR Berghofer
Head, Bone Marrow Transplantation Laboratory, QIMR Berghofer
Director of Research, Cancer Care Services, Royal Brisbane & Womens’ Hospital
Bone Marrow Transplant Physician and Haematologist, Royal Brisbane & Womens’ Hospital
Geoff Hill is a medical graduate of the University of Auckland and Haematologist, training in New Zealand, The Dana Farber Cancer Institute in Boston. He is a NHMRC Australia Fellow and his immunology laboratory focuses on the interactions between cytokines, antigen presenting cells and regulatory T cells during transplantation.
Professor Hill was the 2005 Queenslander of the Year and recipient of the Transplantation Society of Australia and New Zealand 2009 Ian McKenzie Award and the 2014 Translational Research Institute National Prize for excellence within basic and clinical research in the transplant field. He was also awarded a Queensland Health Senior Clinical Research Fellowship in 2010 to translate new cytokine and cell based therapies into clinic practice.
Availability
- Honorary Professor Geoffrey Hill is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, The University of Auckland
- Masters (Coursework) of Medicine Surgery, The University of Auckland
- Doctoral Diploma of Medicine, The University of Auckland
- Royal Australasian College of Physicians, Royal Australasian College of Physicians
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
Works
Search Professor Geoffrey Hill’s works on UQ eSpace
2017
Journal Article
Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome
Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A ., Hugenholtz, Philip and Hill, Geoffrey R. (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Blood, 129 (15), 2172-2185. doi: 10.1182/blood-2016-08-732628
2017
Journal Article
Chronic graft-versus-host disease: biological insights from preclinical and clinical studies
MacDonald, Kelli P. A., Hill, Geoffrey R. and Blazar, Bruce R. (2017). Chronic graft-versus-host disease: biological insights from preclinical and clinical studies. Blood, 129 (1), 13-21. doi: 10.1182/blood-2016-06-686618
2016
Journal Article
Novel platform technology for modular mucosal vaccine that protects against streptococcus
Zaman, Mehfuz, Ozberk, Victoria, Langshaw, Emma L., McPhun, Virginia, Powell, Jessica L., Phillips, Zachary N., Ho, Mei Fong, Calcutt, Ainslie, Batzloff, Michael R., Toth, Istvan, Hill, Geoffrey R., Pandey, Manisha and Good, Michael F. (2016). Novel platform technology for modular mucosal vaccine that protects against streptococcus. Scientific Reports, 6 (1) 39274, 1-11. doi: 10.1038/srep39274
2016
Journal Article
IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection
Sebina, Ismail, James, Kylie R., Soon, Megan S. F., Fogg, Lily G., Best, Shannon E., Labastida Rivera, Fabian de, Montes de Oca, Marcela, Amante, Fiona H., Thomas, Bryce S., Beattie, Lynette, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J., Hertzog, Paul J., Hill, Geoffrey R., Hutloff, Andreas, Engwerda, Christian R. and Haque, Ashraful (2016). IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection. PLoS Pathogens, 12 (11) e1005999, e1005999. doi: 10.1371/journal.ppat.1005999
2016
Journal Article
Agonistic CD40 mAb-driven IL12 reverses resistance to anti-PD1 in a T-cell-rich tumor
Ngiow, Shin Foong, Young, Arabella, Blake, Stephen J., Hill, Geoffrey R., Yagita, Hideo, Teng, Michele W. L., Korman, Alan J. and Smyth, Mark J. (2016). Agonistic CD40 mAb-driven IL12 reverses resistance to anti-PD1 in a T-cell-rich tumor. Cancer Research, 76 (21), 6266-6277. doi: 10.1158/0008-5472.CAN-16-2141
2016
Journal Article
Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease
Le Texier, Laetitia, Lineburg, Katie E., Cao, Benjamin, McDonald-Hyman, Cameron, Leveque-El Mouttie, Lucie, Nicholls, Jemma, Melino, Michelle, Nalkurthi, Blessy C., Alexander, Kylie A., Teal, Bianca, Blake, Stephen J., Souza-Fonseca-Guimaraes, Fernando, Engwerda, Christian R., Kuns, Rachel D., Lane, Steven W., Teng, Michele, Teh, Charis, Gray, Daniel, Clouston, Andrew D., Nilsson, Susan K., Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2016). Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease. JCI Insight, 1 (15) e86850, e86850. doi: 10.1172/jci.insight.86850
2016
Journal Article
Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD
Leveque-El Mouttie, Lucie, Koyama, Motoko, Le Texier, Laetitia, Markey, Kate A., Cheong, Melody, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Alexander, Kylie A., Clouston, Andrew D., Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2016). Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD. Blood, 128 (6), 794-804. doi: 10.1182/blood-2015-11-680876
2016
Journal Article
Coinfection with human cytomegalovirus genetic variants in transplant recipients and its impact on antiviral T cell immune reconstitution
Smith, Corey, Brennan, Rebekah M., Tey, Siok-Keen, Smyth, Mark J., Burrows, Scott R., Miles, John J., Hill, Geoffrey R. and Khanna, Rajiv (2016). Coinfection with human cytomegalovirus genetic variants in transplant recipients and its impact on antiviral T cell immune reconstitution. Journal of Virology, 90 (16), 7497-7507. doi: 10.1128/JVI.00297-16
2016
Journal Article
Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner
McDonald-Hyman, Cameron, Flynn, Ryan, Panoskaltsis-Mortari, Angela, Peterson, Nicholas, MacDonald, Kelli P. A., Hill, Geoffrey R., Luznik, Leo, Serody, Jonathan S., Murphy, William J., Maillard, Ivan, Munn, David H., Turka, Laurence A., Koreth, John, Cutler, Corey S., Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome and Blazar, Bruce R. (2016). Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner. Blood, 128 (7), 1013-1017. doi: 10.1182/blood-2016-05-715896
2016
Journal Article
Pharmacokinetics and immunological outcomes of alemtuzumab-based treatment for steroid-refractory acute GvHD
Tey, S-K., Vuckovic, S., Varelias, A., Martins, J. P., Olver, S., Samson, L., Sturgeon, E., Leach, J., Avery, J., Nakagaki, M., Butler, J. P., Curley, C., Morton, A. J., Durrant, S. T., Kennedy, G. A. and Hill, G. R. (2016). Pharmacokinetics and immunological outcomes of alemtuzumab-based treatment for steroid-refractory acute GvHD. Bone Marrow Transplantation, 51 (8), 1153-1155. doi: 10.1038/bmt.2016.83
2016
Journal Article
Alloantigen presentation and graft-versus-host disease: fuel for the fire
Koyama, Motoko and Hill, Geoffrey R. (2016). Alloantigen presentation and graft-versus-host disease: fuel for the fire. Blood, 127 (24), 2963-2970. doi: 10.1182/blood-2016-02-697250
2016
Conference Publication
Autophagy-dependent TIGIT+ Treg are critical for the maintenance of tolerance
MacDonald, Kelli P. A., Le Texier, Laetitia, Leveque-ElMouttie, Lucie, Lineburg, Katie, Nicholls, Jemma, Guimaraes, Fernando Souza-Fonseca, Alexander, Kylie, Clouston, Andrew, Blazar, Bruce R. and Hill, Geoff R. (2016). Autophagy-dependent TIGIT+ Treg are critical for the maintenance of tolerance. Immunology 2016 Meeting, Seattle, WA United States, 13-17 May 2016. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.196.supp.125.14
2016
Journal Article
Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism
Flynn, Ryan, Paz, Katelyn, Du, Jing, Reichenbach, Dawn K., Taylor, Patricia A., Panoskaltsis-Mortari, Angela, Vulic, Ante, Luznik, Leo, MacDonald, Kelli K. P., Hill, Geoffrey R., Nyuydzefe, Melanie S., Weiss, Jonathan M., Chen, Wei, Trzeciak, Alissa, Serody, Jon S., Aguilar, Ethan G., Murphy, William J., Maillard, Ivan, Munn, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, Waksal, Samuel D., Zanin-Zhorov, Alexandra and Blazar, Bruce R. (2016). Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism. Blood, 127 (17), 2144-2154. doi: 10.1182/blood-2015-10-678706
2016
Journal Article
Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation
Ullah, Md Ashik, Hill, Geoffrey R. and Tey, Siok-Keen (2016). Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation. Frontiers in Immunology, 7 (APR) 144, 144. doi: 10.3389/fimmu.2016.00144
2016
Journal Article
Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies
Guillerey, Camille, Nakamura, Kyohei, Vuckovic, Slavica, Hill, Geoffrey R. and Smyth, Mark J. (2016). Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies. Cellular and Molecular Life Sciences, 73 (8), 1569-1589. doi: 10.1007/s00018-016-2135-z
2016
Journal Article
Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling
Vu, Therese, Austin, Rebecca, Kuhn, Catherine Paine, Bruedigam, Claudia, Song, Axia, Guignes, Solene, Jacquelin, Sebastien, Ramshaw, Hayley S., Hill, Geoffrey R., Lopez, Angel F. and Lane, Steven W. (2016). Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling. Haematologica, 101 (3), E77-E80. doi: 10.3324/haematol.2015.136705
2016
Journal Article
Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model
Melino, Michelle, Gadd, Victoria L., Alexander, Kylie A., Beattie, Lynette, Lineburg, Katie E., Martinez, Michelle, Teal, Bianca, Le Texier, Laetitia, Irvine, Katharine M., Miller, Gregory C., Boyle, Glen M., Hill, Geoffrey R., Clouston, Andrew D., Powel, Elizabeth E. and MacDonald, Kelli P. A. (2016). Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model. American Journal of Pathology, 186 (3), 524-538. doi: 10.1016/j.ajpath.2015.10.029
2016
Journal Article
Erratum: Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated Tissue pathology (PLoS Pathogens (2016) 12:1 (e1005398) DOI: 10.1371/journal.ppat.1005398)
De Oca, Marcela Montes, Kumar, Rajiv, De Labastida Rivera, Fabian, Amante, Fiona H., Sheel, Meru, Faleiro, Rebecca J., Bunn, Patrick T., Best, Shannon E., Beattie, Lynette, Ng, Susanna S., Edwards, Chelsea L., Muller, Werner, Cretney, Erika, Nutt, Stephen L., Smyth, Mark J., Haque, Ashraful, Hill, Geoffrey R., Sundar, Shyam, Kallies, Axel and Engwerda, Christian R. (2016). Erratum: Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated Tissue pathology (PLoS Pathogens (2016) 12:1 (e1005398) DOI: 10.1371/journal.ppat.1005398). PLoS Pathogens, 12 (2) e1005460. doi: 10.1371/journal.ppat.1005460
2016
Journal Article
Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated tissue pathology
Montes de Oca, Marcela, Kumar, Rajiv, de Labastida Rivera, Fabian, Amante, Fiona H., Sheel, Meru, Faleiro, Rebecca J., Bunn, Patrick T., Best, S.E., Beattie, Lynette, Ng, Susanna S., Edwards, Chelsea L., Muller, Werner, Cretney, Erika, Nutt, Stephen L., Smyth, Mark J., Haque, Ashraful, Hill, Geoffrey R., Sundar, Shyam, Kallies, Axel and Engwerda, Christian R. (2016). Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated tissue pathology. PLoS Pathogens, 12 (1) e1005398, 1-21. doi: 10.1371/journal.ppat.1005398
2015
Journal Article
IL-17A-Producing gamma delta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver
Sheel, Meru, Beattie, Lynette, Frame, Teija C. M., Rivera, Fabian de Labastida, Faleiro, Rebecca J., Bunn, Patrick T., de Oca, Marcela Montes, Edwards, Chelsea L., Ng, Susanna S., Kumar, Rajiv, Amante, Fiona H., Best, Shannon E., McColl, Shaun R., Varelias, Antiopi, Kuns, Rachel D., MacDonald, Kelli P. A., Smyth, Mark J., Haque, Ashraful, Hill, Geoff R. and Engwerda, Christian R. (2015). IL-17A-Producing gamma delta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver. Journal of Immunology, 195 (12), 5707-5717. doi: 10.4049/jimmunol.1501046
Supervision
Availability
- Honorary Professor Geoffrey Hill is:
- Available for supervision
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Supervision history
Completed supervision
-
2019
Doctor Philosophy
Understanding the role of IL-6 signalling in Graft-Versus-Host Disease (GVHD)
Principal Advisor
Other advisors: Associate Professor Kate Gartlan
-
2019
Doctor Philosophy
Restoring myeloma-immune equilibrium by stem cell transplantation
Principal Advisor
-
2019
Doctor Philosophy
Anti-leukaemia effect of Interferons
Principal Advisor
Other advisors: Professor Steven Lane, Associate Professor Kate Gartlan
-
2012
Doctor Philosophy
Mechanisms of Immune Modulation after Stem Cell Transplantation
Principal Advisor
-
2021
Doctor Philosophy
Interplay between cytomegalovirus infection and graft-versus-leukaemia effect
Associate Advisor
-
2019
Doctor Philosophy
The Psychosocial Impact of Haematopoietic Stem Cell Donation on Adult Related Donors
Associate Advisor
-
2019
Doctor Philosophy
The contribution of cytokine signals, autophagy and antigen presentation to complications associated with allogeneic stem cell transplantation
Associate Advisor
-
2017
Doctor Philosophy
Maintenance of blood stem cells and the development of haematological malignancies
Associate Advisor
Other advisors: Professor Steven Lane
-
2016
Doctor Philosophy
Stem Cell Therapies and Radiological Imaging in Ataxia Telangiectasia
Associate Advisor
Other advisors: Professor Ernst Wolvetang
-
2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
-
2012
Doctor Philosophy
T cell immune response to human cytomegalovirus in latency and reactivation
Associate Advisor
-
2012
Doctor Philosophy
Self-renewal pathways in leukaemia stem cells and haematopoietic stem cells
Associate Advisor
-
2011
Doctor Philosophy
Antigen Presentation and Inflammation in Allogeneic Bone Marrow Transplantation
Associate Advisor
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Associate Advisor
Other advisors: Professor Ian Frazer
Media
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