![Professor Bryan Fry](/sites/default/files/profiles/540.jpeg)
Overview
Background
Venoms play a range of adaptive roles in the animal kingdom from predation to defense to competitor deterrence. Remarkably, despite their biological importance and uniqueness, the evolution of venom systems is poorly understood. New insights into the evolution of venom systems and the importance of the associated toxins cannot be advanced without recognition of the true biochemical, ecological, morphological and pharmacological diversity of venoms and associated venom systems. A major limitation has been the very narrow taxonomical range studied. Entire groups of venomous animals remain virtually unstudied. My research is inherently interdisciplinary, integrating ecological, evolutionary, and functional genomics approaches in order to understand the evolution of venom systems. Studies range from discovering the shock-inducing hypotensive and anticoagulant venom of the iconic Komodo Dragon through to exploring the unique temperature specific adaptations of Antarctic octopus venoms.
Availability
- Professor Bryan Fry is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Bryan Fry’s works on UQ eSpace
2020
Journal Article
The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein
Scheib, Holger, Nekaris, K. Anne-Isola, Rode-Margono, Johanna, Ragnarsson, Lotten, Baumann, Kate, Dobson, James S., Wirdateti, Wirdateti, Nouwens, Amanda, Nijman, Vincent, Martelli, Paolo, Ma, Rui, Lewis, Richard J., Kwok, Hang Fai and Fry, Bryan Grieg (2020). The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein. Toxins, 12 (2) toxins12020086, 86. doi: 10.3390/toxins12020086
2020
Journal Article
A web of coagulotoxicity: failure of antivenom to neutralize the destructive (non-clotting) fibrinogenolytic activity of Loxosceles and Sicarius spider venoms
Grashof, Dwin, Zdenek, Christina N., Dobson, James S., Youngman, Nicholas J., Coimbra, Francisco, Benard-Valle, Melisa, Alagon, Alejandro and Fry, Bryan G. (2020). A web of coagulotoxicity: failure of antivenom to neutralize the destructive (non-clotting) fibrinogenolytic activity of Loxosceles and Sicarius spider venoms. Toxins, 12 (2) toxins12020091, 91. doi: 10.3390/toxins12020091
2020
Journal Article
The sweet side of venom: glycosylated prothrombin activating metalloproteases from Dispholidus typus (boomslang) and Thelotornis mossambicanus (twig snake)
Debono, Jordan, Dashevsky, Daniel, Nouwens, Amanda and Fry, Bryan G. (2020). The sweet side of venom: glycosylated prothrombin activating metalloproteases from Dispholidus typus (boomslang) and Thelotornis mossambicanus (twig snake). Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 227 108625, 108625. doi: 10.1016/j.cbpc.2019.108625
2020
Conference Publication
The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation
Fernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014
2019
Journal Article
Audio Technology
Sohn, Emily and Fry, Bryan (2019). Audio Technology. Nature, 576 (7787), S75-S75.
2019
Journal Article
Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals
Casewell, Nicholas R., Petras, Daniel, Card, Daren C., Suranse, Vivek, Mychajliw, Alexis M., Richards, David, Koludarov, Ivan, Albulescu, Laura-Oana, Slagboom, Julien, Hempel, Benjamin-Florian, Ngum, Neville M., Kennerley, Rosalind J., Brocca, Jorge L., Whiteley, Gareth, Harrison, Robert A., Bolton, Fiona M. S., Debono, Jordan, Vonk, Freek J., Alföldi, Jessica, Johnson, Jeremy, Karlsson, Elinor K., Lindblad-Toh, Kerstin, Mellor, Ian R., Süssmuth, Roderich D., Fry, Bryan G., Kuruppu, Sanjaya, Hodgson, Wayne C., Kool, Jeroen, Castoe, Todd A. ... Turvey, Samuel T. (2019). Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals. Proceedings of the National Academy of Sciences, 116 (51), 25745-25755. doi: 10.1073/pnas.1906117116
2019
Journal Article
Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus
Walker, Andrew A., Robinson, Samuel D., Undheim, Eivind A. B., Jin, Jiayi, Han, Xiao, Fry, Bryan G., Vetter, Irina and King, Glenn F. (2019). Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus. Toxins, 11 (11) 673, 673. doi: 10.3390/toxins11110673
2019
Journal Article
Clinical implications of coagulotoxic variations in Mamushi (Viperidae: Gloydius) snake venoms
Debono, Jordan, Bos, Mettine H.A., Do, Min Seock and Fry, Bryan G. (2019). Clinical implications of coagulotoxic variations in Mamushi (Viperidae: Gloydius) snake venoms. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 225 108567, 108567. doi: 10.1016/j.cbpc.2019.108567
2019
Journal Article
Clinical implications of convergent procoagulant toxicity and differential antivenom efficacy in Australian elapid snake venoms
Zdenek, Christina N., den Brouw, Bianca op, Dashevsky, Daniel, Gloria, Alexandra, Youngman, Nicholas, Watson, Ebony, Green, Patrick, Hay, Chris, Dunstan, Nathan, Allen, Luke and Fry, Bryan G. (2019). Clinical implications of convergent procoagulant toxicity and differential antivenom efficacy in Australian elapid snake venoms. Toxicology Letters, 316, 171-182. doi: 10.1016/j.toxlet.2019.08.014
2019
Journal Article
Clinical implications of differential antivenom efficacy in neutralising coagulotoxicity produced by venoms from species within the arboreal viperid snake genus Trimeresurus
Debono, Jordan, Bos, Mettine H.A., Frank, Nathaniel and Fry, Bryan (2019). Clinical implications of differential antivenom efficacy in neutralising coagulotoxicity produced by venoms from species within the arboreal viperid snake genus Trimeresurus. Toxicology Letters, 316, 35-48. doi: 10.1016/j.toxlet.2019.09.003
2019
Journal Article
A taxon-specific and high-throughput method for measuring ligand binding to nicotinic acetylcholine receptors
Zdenek, Christina N., Harris, Richard J., Kuruppu, Sanjaya, Youngman, Nicholas J., Dobson, James S., Debono, Jordan, Khan, Muzaffar, Smith, Ian, Yarski, Mike, Harrich, David, Sweeney, Charlotte, Dunstan, Nathan, Allen, Luke and Fry, Bryan G. (2019). A taxon-specific and high-throughput method for measuring ligand binding to nicotinic acetylcholine receptors. Toxins, 11 (10) 600, 600. doi: 10.3390/toxins11100600
2019
Journal Article
Differential destructive (non-clotting) fibrinogenolytic activity in Afro-Asian elapid snake venoms and the links to defensive hooding behavior
Bittenbinder, Mátyás A., Dobson, James S., Zdenek, Christina N., op den Brouw, Bianca, Naude, Arno, Vonk, Freek J. and Fry, Bryan G. (2019). Differential destructive (non-clotting) fibrinogenolytic activity in Afro-Asian elapid snake venoms and the links to defensive hooding behavior. Toxicology in Vitro, 60, 330-335. doi: 10.1016/j.tiv.2019.05.026
2019
Journal Article
Basal but divergent: clinical implications of differential coagulotoxicity in a clade of Asian vipers
Debono, Jordan, Bos, Mettine H.A., Coimbra, Francisco, Ge, Lilin, Frank, Nathaniel, Kwok, Hang Fai and Fry, Bryan G. (2019). Basal but divergent: clinical implications of differential coagulotoxicity in a clade of Asian vipers. Toxicology in Vitro, 58, 195-206. doi: 10.1016/j.tiv.2019.03.038
2019
Journal Article
Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom
Zdenek, Christina N., Hay, Chris, Arbuckle, Kevin, Jackson, Timothy N.W., Bos, Mettine H.A., op den Brouw, Bianca, Debono, Jordan, Allen, Luke, Dunstan, Nathan, Morley, Terry, Herrera, María, Gutiérrez, José M., Williams, David J. and Fry, Bryan G. (2019). Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom. Toxicology in Vitro, 58, 97-109. doi: 10.1016/j.tiv.2019.03.031
2019
Journal Article
Venomous landmines: Clinical implications of extreme coagulotoxic diversification and differential neutralization by antivenom of venoms within the viperid snake genus Bitis
Youngman, Nicholas J., Debono, Jordan, Dobson, James S., Zdenek, Christina N., Harris, Richard J., op den Brouw, Bianca, Coimbra, Francisco C. P., Naude, Arno, Coster, Kristian, Sundman, Eric, Braun, Ralph, Hendrikx, Iwan and Fry, Bryan G. (2019). Venomous landmines: Clinical implications of extreme coagulotoxic diversification and differential neutralization by antivenom of venoms within the viperid snake genus Bitis. Toxins, 11 (7) 422, 422. doi: 10.3390/toxins11070422
2019
Journal Article
Varanid lizard venoms disrupt the clotting ability of human fibrinogen through destructive cleavage
Dobson, James S., Zdenek, Christina N., Hay, Chris, Violette, Aude, Fourmy, Rudy, Cochran, Chip and Fry, Bryan G. (2019). Varanid lizard venoms disrupt the clotting ability of human fibrinogen through destructive cleavage. Toxins, 11 (5) 255, 255. doi: 10.3390/toxins11050255
2019
Journal Article
Habu coagulotoxicity: clinical implications of the functional diversification of Protobothrops snake venoms upon blood clotting factors
Debono, Jordan, Bos, Mettine H.A., Nouwens, Amanda, Ge, Lilin, Frank, Nathaniel, Kwok, Hang Fai and Fry, Bryan (2019). Habu coagulotoxicity: clinical implications of the functional diversification of Protobothrops snake venoms upon blood clotting factors. Toxicology in Vitro, 55, 62-74. doi: 10.1016/j.tiv.2018.11.008
2019
Conference Publication
Coagulating colubrids: evolutionary, pathophysiological and biodiscovery implications of venom variations between Dispholidus typus and Thelotornis mossambicanus
Debono, Jordan, Dobson, James, Casewell, Nicholas R., Romilio, Anthony, Li, Bin, Kurniawan, Nyoman, Mardon, Karine, Weisbecker, Vera, Nouwens, Amanda, Kwok, Hang Fai and Fry, Bryan G. (2019). Coagulating colubrids: evolutionary, pathophysiological and biodiscovery implications of venom variations between Dispholidus typus and Thelotornis mossambicanus. 19th World Congress of the International-Society-on-Toxinology (IST) / 11th Asia Pacific Congress of the International-Society-on-Toxinology (IST) / 13th Chinese Conference on Toxins and Medical Applications, Haikou, Peoples Republic of China, 24-31 October 2017. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2018.10.144
2019
Journal Article
Vampire venom: vasodilatory mechanisms of vampire bat (Desmodus rotundus) blood feeding
Kakumanu, Rahini, Hodgson, Wayne, Ravi, Ravina, Alagon, Alejandro, Harris, Richard, Brust, Andreas, Alewood, Paul, Kemp-Harper, Barbara and Fry, Bryan (2019). Vampire venom: vasodilatory mechanisms of vampire bat (Desmodus rotundus) blood feeding. Toxins, 11 (1) 26, 26. doi: 10.3390/toxins11010026
2019
Journal Article
Mud in the blood: Novel potent anticoagulant coagulotoxicity in the venoms of the Australian elapid snake genus Denisonia (mud adders) and relative antivenom efficacy
Youngman, Nicholas J., Zdenek, Christina N., Dobson, James S., Bittenbinder, Matyas A., Gillett, Amber, Hamilton, Brett, Dunstan, Nathan, Allen, Luke, Veary, Andrew, Veary, Elle and Fry, Bryan G. (2019). Mud in the blood: Novel potent anticoagulant coagulotoxicity in the venoms of the Australian elapid snake genus Denisonia (mud adders) and relative antivenom efficacy. Toxicology Letters, 302, 1-6. doi: 10.1016/j.toxlet.2018.11.015
Funding
Supervision
Availability
- Professor Bryan Fry is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Venom variation in American pit vipers
Principal Advisor
Other advisors: Dr Andrew Walker
-
Doctor Philosophy
Evolutionary and clinical implications of differential pathophysiological effects of rattlesnake venoms upon blood coagulation, cell function, and nerve transmission.
Principal Advisor
Other advisors: Dr Andrew Walker
-
Doctor Philosophy
Evaluation of Phylogenetic Patterns of Scorpion Pathophysiological Effects and Effectiveness of Next-Generation Antivenoms
Principal Advisor
Other advisors: Professor Glenn King, Dr Sam Robinson
-
Doctor Philosophy
The evolution of prey-selectivity for snake venom neurotoxins, and the parallel evolution of neurotoxin resistance in prey
Principal Advisor
-
Doctor Philosophy
Venom variation in New World pit vipers
Principal Advisor
Other advisors: Dr Fernanda Cardoso, Dr Andrew Walker
-
Doctor Philosophy
Utilising invertebrates to identify novel coagulotoxins
Associate Advisor
Other advisors: Professor Glenn King, Dr Andrew Walker
Completed supervision
-
2023
Doctor Philosophy
Therapeutic options for divergent snake venom.
Principal Advisor
Other advisors: Dr Mary-Louise Roy Manchadi
-
2023
Doctor Philosophy
Coagulotoxicity and neurotoxicity variation in Bitis venoms: Evolutionary, pathophysiological and biodiscovery implications
Principal Advisor
Other advisors: Dr Andrew Walker
-
2022
Doctor Philosophy
The Co-Evolutionary Dynamics of alpha-Neurotoxic Snake Venoms and their Nicotinic Acetylcholine Receptor Targets
Principal Advisor
Other advisors: Dr Andrew Walker
-
2022
Doctor Philosophy
Evolution and Diversification of the Anguimorphan Lizard Venom System
Principal Advisor
Other advisors: Professor Irina Vetter
-
2020
Doctor Philosophy
Characterising venom variation and antivenom effectiveness within the "True" vipers (Viperinae: Viperidae)
Principal Advisor
Other advisors: Professor Irina Vetter
-
2020
Doctor Philosophy
Novelty in three-finger toxin evolution
Principal Advisor
Other advisors: Professor Irina Vetter
-
2020
Doctor Philosophy
Effects of Australian snake venoms on coagulation: Differential potency, biochemistry, and antivenom efficacy
Principal Advisor
Other advisors: Professor Irina Vetter
-
2019
Doctor Philosophy
A Blood Bond: Evolutionary, Pathophysiological and Biodiscovery implications of coagulotoxic snake venoms
Principal Advisor
Other advisors: Professor Irina Vetter
-
2019
Doctor Philosophy
Tarantulas of Australia: phylogenetics and venomics
Principal Advisor
Other advisors: Professor Glenn King, Associate Professor Lyn Cook
-
2018
Doctor Philosophy
Evolution of the venom system in aculeate hymenoptera
Principal Advisor
Other advisors: Professor Irina Vetter
-
2017
Doctor Philosophy
An investigation of the evolution of the Anguimorph lizard venom system
Principal Advisor
-
2016
Doctor Philosophy
Evolution and diversification of the cnidarian venom system
Principal Advisor
-
2016
Doctor Philosophy
A philosophical and empirical investigation of the evolution of the toxicoferan reptile venom system
Principal Advisor
Other advisors: Professor Irina Vetter, Professor Glenn King
-
2014
Doctor Philosophy
Centipede Venom Evolution: Casting light on a neglected group of venomous animals
Associate Advisor
Other advisors: Professor Glenn King
Media
Enquiries
Contact Professor Bryan Fry directly for media enquiries about:
- Animal venoms
- Antivenoms
- Biodiscovery
- Drug design
- Venom
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