Professor Linda Lua
Professor

Linda Lua

Email: 

Availability

Professor Linda Lua is:
Not available for supervision

Fields of research

Biological control Bioprocessing, bioproduction and bioproducts Environmental biotechnology Industrial biotechnology

Qualifications

  • Bachelor (Honours) of Applied Science, The University of Queensland
  • Doctor of Philosophy of Bioengineering, The University of Queensland

Research interests

  • Protein Technologies

  • Bioengineering virus-like particle as vaccines

Search Professor Linda Lua’s works on UQ eSpace

85 works between 1999 and 2024
All (85) Journal Article (70) Book Chapter (3) Conference Publication (9) Other Outputs (3)

41 - 60 of 85 works

2014

Journal Article

Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation

Wibowo, Nani, Chuan, Yap P., Seth, Arjun, Cordoba, Yoann, Lua, Linda H. L. and Middelberg, Anton P. J. (2014). Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation. Vaccine, 32 (29), 3664-3669. doi: 10.1016/j.vaccine.2014.04.043

Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation

2014

Journal Article

Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopes

Wibowo, Nani, Hughes, Fiona K., Fairmaid, Emily J., Lua, Linda H. L., Brown, Lorena E. and Middelberg, Anton P. J. (2014). Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopes. Vaccine, 32 (29), 3651-3655. doi: 10.1016/j.vaccine.2014.04.062

Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopes

2014

Journal Article

Bioengineering virus-like particles as vaccines

Lua, Linda H. L., Connors, Natalie K., Sainsbury, Frank, Chuan, Yap P., Wibowo, Nani and Middelberg, Anton P. J. (2014). Bioengineering virus-like particles as vaccines. Biotechnology and Bioengineering, 111 (3), 425-440. doi: 10.1002/bit.25159

Bioengineering virus-like particles as vaccines

2013

Journal Article

Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants

Chuan, Yap P., Wibowo, Nani, Connors, Natalie K., Wu, Yang, Hughes, Fiona K., Batzloff, Michael R., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants. Biotechnology and Bioengineering, Early View (6), 1-9. doi: 10.1002/bit.25172

Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants

2013

Journal Article

Virus-like particle bioprocessing: challenges and opportunities

Middelberg, Anton P. J. and Lua, Linda H. L. (2013). Virus-like particle bioprocessing: challenges and opportunities. Pharmaceutical Bioprocessing, 1 (5), 407-409. doi: 10.4155/pbp.13.49

Virus-like particle bioprocessing: challenges and opportunities

2013

Journal Article

Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle

Anggraeni, Melisa R., Connors, Natalie K., Wu, Yang, Chuan, Yap P., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle. Vaccine, 31 (40), 4428-4435. doi: 10.1016/j.vaccine.2013.06.087

Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle

2013

Journal Article

Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines

Connors, Natalie K., Wu, Yang, Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines. Food and Bioproducts Processing, 92 (2), 143-151. doi: 10.1016/j.fbp.2013.08.012

Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines

2013

Journal Article

Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine

Chuan, Yap P., Rivera-Hernandez, Tania, Wibowo, Nani, Connors, Natalie K., Wu, Yang, Hughes, Fiona K., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine. Biotechnology and Bioengineering, 110 (9), 2343-2351. doi: 10.1002/bit.24907

Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine

2013

Journal Article

Virus-like particle formulation optimization by miniaturized high-throughput screening

Mohr, Johannes, Chuan, Yap P., Wu, Yang, Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Virus-like particle formulation optimization by miniaturized high-throughput screening. Methods, 60 (3), 248-256. doi: 10.1016/j.ymeth.2013.04.019

Virus-like particle formulation optimization by miniaturized high-throughput screening

2013

Journal Article

Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations

Zhang, Lin, Tang, Ronghong, Bai, Shu, Connors, Natalie K., Lua, Linda H. L., Chuan, Yap P., Middelberg, Anton P. J. and Sun, Yan (2013). Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations. Journal of Physical Chemistry B, 117 (18), 5411-5421. doi: 10.1021/jp311170w

Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations

2013

Journal Article

Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS)

Rivera-Hernandez, Tania, Hartas, Jon, Wu, Yang, Chuan, Yap P., Lua, Linda H. L., Good, Michael, Batzloff, Michael R. and Middelberg, Anton P. J. (2013). Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS). Vaccine, 31 (15), 1950-1955. doi: 10.1016/j.vaccine.2013.02.013

Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS)

2013

Other Outputs

Immunogenic compositions and methods therefor

Middelberg, Anton P. J. and Lua, Linda H. L (2013). Immunogenic compositions and methods therefor. WO2013020183 A1.

Immunogenic compositions and methods therefor

2013

Journal Article

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

Chen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

2012

Journal Article

Modular engineering of a microbially-produced viral capsomere vaccine for influenza

Wibowo, Nani, Chuan, Yap P., Lua, Linda H. L. and Middelberg, Anton P. J. (2012). Modular engineering of a microbially-produced viral capsomere vaccine for influenza. Chemical Engineering Science, 103, 12-20. doi: 10.1016/j.ces.2012.04.001

Modular engineering of a microbially-produced viral capsomere vaccine for influenza

2012

Book Chapter

Advances in protein production technologies

Lua, Linda H. L. and Chuan, Yap Pang (2012). Advances in protein production technologies. Biopharmaceutical production technology. (pp. 43-77) edited by Ganapathy Subramanian. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527653096.ch2

Advances in protein production technologies

2012

Book Chapter

Virus-like particle bioprocessing

Chuan, Yap Pang, Lua, Linda H. L. and Middelberg, Anton P. J. (2012). Virus-like particle bioprocessing. Biopharmaceutical production technology. (pp. 139-163) edited by Ganapathy Subramanian. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527653096.ch5

Virus-like particle bioprocessing

2011

Journal Article

A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines

Middelberg, Anton P.J., Rivera-Hernandez, Tania, Wibowo, Nani, Lua, Linda H.L., Fan, Yuanyuan, Magor, Graham, Chang, Cindy, Chuan, Yap P., Good, Michael F. and Batzloff, Michael R. (2011). A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine, 29 (41), 7154-7162. doi: 10.1016/j.vaccine.2011.05.075

A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines

2011

Journal Article

A new bioproduction route for a novel antimicrobial peptide

Tay, Derrick Kok Sing, Rajagopalan, Gobinath, Li, Xiang, Chen, Yu, Linda H.L. Lua and Leong, Susanna Su Jan (2011). A new bioproduction route for a novel antimicrobial peptide. Biotechnology and Bioengineering, 108 (3), 572-581. doi: 10.1002/bit.22970

A new bioproduction route for a novel antimicrobial peptide

2011

Journal Article

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

Hu, Shu-Hong, Christie, Michelle P., Saez, Natalie J., Latham, Catherine F., Jarrott, Russell, Lua, Linda H. L., Collins, Brett M. and Martin, Jennifer L. (2011). Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America, 108 (3), 1040-1045. doi: 10.1073/pnas.0914906108

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

2010

Journal Article

Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres

Chuan, Yap P., Fan, Yuan Y., Lua, Linda H.L. and Middelberg, Anton P.J. (2010). Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres. Journal of The Royal Society Interface, 7 (44), 409-421. doi: 10.1098/rsif.2009.0175

Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres

Past funding

  • 2021 - 2022
    Scale-down biomanufacturing capabilities to translate health discoveries into clinical applications
    IPF Healthy - Medical Research
    Open grant
  • 2020 - 2023
    Enhancing biopharmaceuticals: a disruptive bioseparation resin technology (ARC Discovery Project administered by Griffith University)
    Griffith University
    Open grant
  • 2019
    Advanced biomanufacturing with versatile yeast expression platform
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2019
    Cyto-Mine to accelerate Cell Line Development for Vaccines and Biopharmaceuticals
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Continuous chromatography system for advanced bioprocessing
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Enabling research and development of next generation mammalian cell-based products
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2019
    Engineering a nanovaccine for cost-effective influenza poultry vaccination
    ARC Discovery Projects
    Open grant
  • 2016
    Rapid analysis of protein stability and aggregation
    UQ Major Research Facility Fund
    Open grant
  • 2014 - 2016
    Human enterovirus-like particle vaccine development
    Sentinext Therapeutics
    Open grant
  • 2014
    Coxsackievirus-A16 VLP Vaccine Development
    UniQuest Pty Ltd
    Open grant
  • 2012 - 2014
    Expression of EV71 VLPs in insect cells
    UniQuest Pty Ltd
    Open grant
  • 2010 - 2013
    Vaccine Now - Beating Infectious Disease with Rapid Response Technology
    Queensland Government Smart State National and International Research Alliances Program
    Open grant
  • 2007 - 2009
    Terahertz Spectroscopy of Mass-Manufactured Viral Vaccines
    ARC Discovery Projects
    Open grant
  • 2006 - 2007
    Simplified Process Methods for Mass Vaccine Manufacture
    NHMRC Potential Avian Influenza - induced pandemic
    Open grant
  • 2005 - 2008
    Bio-based Functional Materials from Engineered Self-Assembling Peptides (BASE)
    Department of Innovation, Industry, Science and Research - ISL French-Australian Science and Technology Program
    Open grant

Availability

Professor Linda Lua is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Broad Spectrum Medical Countermeasure development for Organophosphate Compounds

    Principal Advisor

    Other advisors: Professor David Owen

  • Doctor Philosophy

    Development of commercially viable cyclic peptide production for the protection of the Great Barrier Reef

    Principal Advisor

    Other advisors: Dr Conan Wang, Professor David Craik, Dr Thomas Durek

  • Doctor Philosophy

    Development of continuous downstream processing platform tools for implementation at a biologics contract development and manufacturing organization

    Principal Advisor

Completed supervision

Enquiries

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