Overview
Background
Associate Professor West is a molecular microbiologist, expert in bacterial pathogenesis. He is Head of “Tuberculosis Research” in the School of Chemistry and Molecular Biosciences, University of Queensland. Nick has a particular interest in drug development for TB. His research utilises modern molecular technologies to identify the genetic requirements for Mycobacterium tuberculosis to cause Tuberculosis (TB) with these genetic discoveries translated into novel antibiotic therapies. Research within his group falls largely into one of the following four themes: Essential Gene Identification in M. tuberculosis, Understanding TB Latency, Targeted TB Drug Development and Improving TB Vaccination.
Nick conducted postdoctoral research at the University of Oxford and Imperial College London. Returning to Australia in 2004, he spent several years at Sydney’s Centenary Institute as an Associate Faculty member before relocating to University of Queensland in 2012. In addition to drug development, Nick’s research portfolio includes programmes of vaccine and diagnostic development and testing.
Availability
- Associate Professor Nick West is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Wollongong
Works
Search Professor Nick West’s works on UQ eSpace
2016
Journal Article
Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985
2016
Journal Article
Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985
2015
Journal Article
Naked-eye colorimetric and electrochemical detection of Mycobacterium tuberculosis—toward rapid screening for active case finding
Ng, Benjamin Y. C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015). Naked-eye colorimetric and electrochemical detection of Mycobacterium tuberculosis—toward rapid screening for active case finding. ACS Sensors, 1 (2), 173-178. doi: 10.1021/acssensors.5b00171
2015
Journal Article
Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold Nanoparticles
Ng, Benjamin Y. C., Xiao, Wei, West, Nicholas P., Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2015). Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold Nanoparticles. Analytical Chemistry, 87 (20), 10613-10618. doi: 10.1021/acs.analchem.5b03121
2015
Journal Article
Rapid DNA detection of Mycobacterium tuberculosis-towards single cell sensitivity in point-of-care diagnosis
Ng, Benjamin Y.C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015). Rapid DNA detection of Mycobacterium tuberculosis-towards single cell sensitivity in point-of-care diagnosis. Scientific Reports, 5 (1) 15027, 15027.1-15027.7. doi: 10.1038/srep15027
2015
Journal Article
Host-pathogen interaction during bacterial vaccination
Barnett, Timothy C., Lim, Jin Yan, Soderholm, Amelia T., Rivera-Hernandez, Tania, West, Nicholas P. and Walker, Mark J. (2015). Host-pathogen interaction during bacterial vaccination. Current Opinion in Immunology, 36, 1-7. doi: 10.1016/j.coi.2015.04.002
2015
Journal Article
First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity
Eng, Wai Soon, Hockova, Dana, Spacek, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T. and Guddat, Luke W. (2015). First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity. Journal of Medicinal Chemistry, 58 (11), 4822-4838. doi: 10.1021/acs.jmedchem.5b00611
2015
Journal Article
Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence
Turner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15
2014
Journal Article
The contribution of non-human primate models to the development of human vaccines
Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.
2014
Journal Article
ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics
Marteyn, Benoit S., Karimova, Gouzel, Fenton, Andrew K., Gazi, Anastasia D., West, Nicholas, Touqui, Lhousseine, Prevost, Marie-Christine, Betton, Jean-Michel, Poyraz, Oemer, Ladant, Daniel, Gerdes, Kenn, Sansonetti, Philippe J. and Tang, Christoph M. (2014). ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics. mBio, 5 (2) e00022-14. doi: 10.1128/mBio.00022-14
2014
Journal Article
Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing
Ly, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754
2013
Journal Article
Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1- phosphate uridyltransferase (GlmU)
Tran, A. T., Wen, D., West, N. P., Baker, E. N., Britton, W. J. and Payne, R. J. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1- phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11 (46), 8113-8126. doi: 10.1039/c3ob41896k
2013
Journal Article
TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines
Tyne, Anneliese S., Chan, John Gar Yan, Shanahan, Erin R., Atmosukarto, Ines, Chan, Hak-Kim, Britton, Warwick J. and West, Nicholas P. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31 (40), 4322-4329. doi: 10.1016/j.vaccine.2013.07.022
2013
Journal Article
Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents
Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Spaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John and Guddat, Luke W. (2013). Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry, 56 (17), 6967-6984. doi: 10.1021/jm400779n
2013
Journal Article
Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis
Pinto, Rachel, Leotta, Lisa, Shanahan, Erin R., West, Nicholas P., Leyh, Thomas S., Britton, Warwick and Triccas, James A. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. Journal of Infectious Diseases, 207 (5), 778-785. doi: 10.1093/infdis/jis751
2012
Journal Article
Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy
Anh Thu Tran, West, Nicholas P., Britton, Warwick J. and Payne, Richard J. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. Chemmedchem, 7 (6), 1031-1043. doi: 10.1002/cmdc.201100606
2012
Journal Article
The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice
Kao, Fan F., Mahmuda, Sultana, Pinto, Rachel, Triccas, James A., West, Nicholas P. and Britton, Warwick J. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PLoS One, 7 (5) e34991, e34991. doi: 10.1371/journal.pone.0034991
2012
Journal Article
Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site
Manos-Turvey, Alexandra, Cergol, Katie M., Salam, Noeris K., Bulloch, Esther M. M., Chi, Gamma, Pang, Angel, Britton, Warwick J., West, Nicholas P., Baker, Edward N., Lott, J. Shaun and Payne, Richard J. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10 (46), 9223-9236. doi: 10.1039/c2ob26736e
2011
Journal Article
Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis
West, Nicholas P., Thomson, Scott A., Triccas, James A., Medveczky, C. Jill, Ramshaw, Ian A. and Britton, Warwick J. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29 (44), 7759-7765. doi: 10.1016/j.vaccine.2011.07.109
2011
Journal Article
Synthesis and Evaluation of Potent Ene-yne Inhibitors of Type II Dehydroquinases as Tuberculosis Drug Leads
Anh Thu Tran, Cergol, Katie M., West, Nicholas P., Randall, Elizabeth J., Britton, Warwick J., Bokhari, Syed Ali Imran, Ibrahim, Musadiq, Lapthorn, Adrian J. and Payne, Richard J. (2011). Synthesis and Evaluation of Potent Ene-yne Inhibitors of Type II Dehydroquinases as Tuberculosis Drug Leads. Chemmedchem, 6 (2), 262-265. doi: 10.1002/cmdc.201000399
Funding
Current funding
Supervision
Availability
- Associate Professor Nick West is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Boosting BCG: The use of Potent Immunostimulatory Secreted Antigens of Mycobacterium tuberculosis.
Principal Advisor
Other advisors: Dr Emily Strong
-
Doctor Philosophy
A Multidisciplinary Approach to Identifying Novel Vaccine and Drug Targets of Non-Tuberculous Mycobacteria
Principal Advisor
Other advisors: Dr Brian Forde
-
Doctor Philosophy
Advanced Genetic Toolkit for Cryptococcus neoformans: Iterating Upon Currently Used Techniques in the WHO¿s Top-Ranked Fungal Pathogen
Associate Advisor
Other advisors: Professor James Fraser
Completed supervision
-
2023
Doctor Philosophy
Host-pathogen interactions in tuberculosis: Functional insights into a novel mycobacterial two-component system TcrXY
Principal Advisor
-
2022
Doctor Philosophy
Disseminated Tuberculosis; Defining Pathogen Encoded Mechanisms
Principal Advisor
Other advisors: Professor Mark Walker
-
2017
Doctor Philosophy
A Functional Genomics Approach to Vaccine Development Against Mycobacterium tuberculosis and the Role MmpL13 Plays in Tuberculosis Infection
Principal Advisor
-
2023
Doctor Philosophy
New Antimicrobial Drug Targets
Associate Advisor
Other advisors: Professor Luke Guddat
-
2019
Doctor Philosophy
Point-of-care tuberculosis diagnostics: Meeting global needs through innovative nanotechnologies
Associate Advisor
Other advisors: Professor Matt Trau
-
2016
Doctor Philosophy
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
Associate Advisor
Other advisors: Professor Luke Guddat
Media
Enquiries
Contact Associate Professor Nick West directly for media enquiries about:
- TB Drug Development
- TB Vaccine Development
- Tuberculosis (TB)
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