
Overview
Background
Prof Lipman is Executive Director of the Burns Trauma & Critical Care Research Centre; Professor of Anesthesiology & Critical Care, The University of Queensland and until recently (for 23 years) was Director of Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital; He holds Honorary Professorial appointments at Chinese University of Hong Kong, Unversity of Witwatersrand (South Africa) and Qeensland University of Technology.
He has qualifications in anesthesia and intensive care and has set up and been in charge of a number of Intensive Care and Trauma Units in South Africa before coming to Australia in 1997. he currently manages a large multidisciplinary research team with an output of over 120 peer-reviewed articles per annum. He has supervised dozens of PhD students to completion and is currently supervising 6 PhD, 1 MPhil and 1 MBBS/Hons students. Prof Lipman has been instrumental in developing the anaesthesiology and critical care component of a graduate medical program for Queensland and continues to lecture to medical and postgraduate students.
Prof Lipman is the author of over 550 peer reviewed publications, 30 book chapters and has been invited to deliver over 120 lectures at national and international conferences in many countries across the world. His research interests include all aspects of infection management in intensive care and he has a special interest in the pharmacokinetics of antibiotic dosage, an area in which he received his MD in 2006. His research into antibiotic usage in acute situations has received international recognition and he is regarded as an expert in the field. As such, he and his research team have conducted and presently conduct a number of clinical trials in Australia, New Zealand, Hong Kong, Europe and the UK.
Prof Lipman is an Editorial Board member for 10 International Journals, is Section Editor on four Antibiotic related Journals, reviews for 23 journals and is an external reviewer for NHMRC project grants (Local) as well as equivalent for a number overseas countries.
He is Chief Investigator on a 7000 patient International Randomised Controlled Trial comparing bolus dosing versus continuous infusions of meropenem and piperacillin-tazobactam
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
- Media expert
Fields of research
Research interests
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Antibiotic dosing in critically ill patients
Severe sepsis is defined as failure of one or more organ systems, most commonly cardiovascular (including shock), respiratory and renal failure, caused by infection. Bacteria, either alone or in combination with other pathogens, are the most common cause of severe sepsis, and Gram-positive and Gram-negative organism account for up to 87% of culture positive episodes. Severe sepsis is a major cause of mortality worldwide. The ANZICS CTG reported that the Australian and New Zealand adult annual incidence of severe sepsis is 77 cases per 100,000,4 which is equivalent to over 17,000 patient episodes per year at an estimated cost per episode of AUD 42,300. Similar population incidence rates have been reported elsewhere. Importantly, 11.8% of all admissions to Australian and New Zealand ICUs are associated with severe sepsis and in-hospital mortality is 37.5%. In patients with septic shock, mortality approaches 60%. The burden of death is almost four times the annual national road toll. The death rate also exceeds other diseases that impact significantly on the Australian community, such as breast and colorectal cancer. In short, severe sepsis is a major public health concern in Australia and improved therapies are needed urgently. My research group is conducting national and international clinical trials investigating the effect of various dosing regimes on health outcomes in critically ill patients.
Research impacts
My research has been instrumental in changing antibiotic prescribing habits worldwide for critically ill patients, first with aminoglycosides (I did the first and still largest clinical trial to show single daily dosing to be effective) and more recently with beta-lactam antibiotics. Due to critically ill patients having altered pharmacokinetics, using standard antibiotic dosing for these patients is fraught with problems. This has led to the use of Therapeutic Drug Monitoring (TDM) for beta-lactams.
TDM of aminoglycosides and glycopeptides is performed to decrease side-effects of these drugs. Beta-lactams have a large therapeutic ratio and hence measurement of them is infrequent. I helped set up routine TDM of beta-lactam antibiotics at RBWH. I have changed how we dose patients particularly in ICU but also within the wards of RBWH. By means of TDM we have shown we need dose adjustments in 74% of patients to which we administer β-lactam antibiotics in the ICU (Roberts JA et al. Int J Antimicrob Agents 2010;36:332-39). Although scarcely performed world-wide, TDM of beta-lactams is now becoming more commonly performed. We are currently collating data from 5 International centres that also use TDM in an attempt to show outcome benefits of TDM and are starting to publish accordingly (Wong G et al. An international, multi-centre survey of beta-lactam antibiotics TDM practice in intensive care units. J Antimicrob Chemother 2014;69: 1416–1423).
Works
Search Professor Jeffrey Lipman’s works on UQ eSpace
2014
Journal Article
Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy
Sime, Fekade Bruck, Roberts, Michael S., Warner, Morgyn S., Hahn, Uwe, Robertson, Thomas A., Yeend, Sue, Phay, Andy, Lehman, Sheila, Lipman, Jeffrey, Peake, Sandra L. and Roberts, Jason A. (2014). Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy. Antimicrobial Agents and Chemotherapy, 58 (6), 3533-3537. doi: 10.1128/AAC.02340-14
2014
Journal Article
Long-Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomized Controlled Trial
Gallagher M., Cass A., Bellomo R., Finfer S., Gattas D., Lee J., Lo S., McGuinness S., Myburgh J., Parke R., Rajbhandari D., Mitchell I., Taylor E., Whyte R., Raza A., Nand K., Sara T., Millis D., Wong H., Harrigan P., Hardie M., Whitaker D., Bhonagiri D., Micallef S., Ellem K., Lintott M., Cole L., Cuzner C., Weisbrodt L. ... D'Haeseleer S. (2014). Long-Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomized Controlled Trial. PLoS Medicine, 11 (2) e1001601, 1-13. doi: 10.1371/journal.pmed.1001601
2014
Journal Article
A new marker of sepsis post burn injury?
Paratz, Jennifer D., Lipman, Jeffrey, Boots, Robert J., Muller, Michael J. and Paterson, David L. (2014). A new marker of sepsis post burn injury?. Critical Care Medicine, 42 (9), 2029-2036. doi: 10.1097/CCM.0000000000000400
2014
Journal Article
Antimicrobial stewardship of β-lactams in intensive care units
Cotta, Menino Osbert, Roberts, Jason A., Tabah, Alexis, Lipman, Jeffrey, Vogelaers, Dirk and Blot, Stijn (2014). Antimicrobial stewardship of β-lactams in intensive care units. Expert Review of Anti-Infective Therapy, 12 (5), 581-595. doi: 10.1586/14787210.2014.902308
2014
Journal Article
Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration
Roberts, Jason A., Udy, Andrew A., Bulitta, Juergen B., Stuart, Janin, Jarrett, Paul, Starr, Therese, Lassig-Smith, Melissa, Roberts, Natasha A., Dunlop, Rachel, Hayashi, Yoshiro, Wallis, Steven C. and Lipman, Jeffrey (2014). Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration. Journal of Antimicrobial Chemotherapy, 69 (9) dku177, 2508-2516. doi: 10.1093/jac/dku177
2014
Journal Article
Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration
Varghese, Julie M., Jarrett, Paul, Boots, Robert J., Kirkpatrick, Carl M. J., Lipman, Jeffrey and Roberts, Jason A. (2014). Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration. International Journal of Antimicrobial Agents, 43 (4), 343-348. doi: 10.1016/j.ijantimicag.2014.01.009
2014
Journal Article
A national survey of renal replacement therapy prescribing practice for acute kidney injury in Malaysian intensive care units
Jamal, Janattul-Ain, Mat-Nor, Mohd-Basri, Mohamad-Nor, Fariz-Safhan, Udy, Andrew A., Lipman, Jeffrey and Roberts, Jason A. (2014). A national survey of renal replacement therapy prescribing practice for acute kidney injury in Malaysian intensive care units. Nephrology, 19 (8), 507-512. doi: 10.1111/nep.12276
2014
Journal Article
Preface
Zoltan, Horvoelgyi, Eva, Kiss and Etelka, Tombacz (2014). Preface. Periodica Polytechnica-Chemical Engineering, 58, 1-1. doi: 10.1007/978-981-10-5336-8
2014
Journal Article
Individualised antibiotic dosing for patients who are critically ill: Challenges and potential solutions
Roberts, Jason A., Abdul-Aziz, Mohd H., Lipman, Jeffrey, Mouton, Johan W., Vinks, Alexander ., Felton, Timothy W., Hope, William W., Farkas, Andras, Neely, Michael N., Schentag, Jerome J., Drusano, George, Frey, Otto R., Theuretzbacher, Ursula and Kuti, Joseph L. (2014). Individualised antibiotic dosing for patients who are critically ill: Challenges and potential solutions. The Lancet Infectious Diseases, 14 (6), 498-509. doi: 10.1016/S1473-3099(14)70036-2
2014
Journal Article
Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients
De Waele, Jan J., Lipman, J., Akova, M., Bassetti, M., Dimopoulos, G., Kaukonen, M., Koulenti, D., Martin, C., Montravers, P., Rello, J., Rhodes, A., Udy, A. A., Starr, T., Wallis, S. C. and Roberts, J. A. (2014). Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients. Intensive Care Medicine, 40 (9), 1340-1351. doi: 10.1007/s00134-014-3403-8
2014
Journal Article
The authors reply
Udy, Andrew A., Joynt, Gavin M. and Lipman, Jeffrey (2014). The authors reply. Critical Care Medicine, 42 (10), e675-e676. doi: 10.1097/CCM.0000000000000532
2013
Journal Article
Clinical implications of antibiotic pharmacokinetic principles in the critically ill
Udy, Andrew A., Roberts, Jason A. and Lipman, Jeffrey (2013). Clinical implications of antibiotic pharmacokinetic principles in the critically ill. Intensive Care Medicine, 39 (12), 2070-2082. doi: 10.1007/s00134-013-3088-4
2013
Journal Article
B-type natriuretic peptide: not just a heart throb
Paratz, Jennifer and Lipman, Jeffrey (2013). B-type natriuretic peptide: not just a heart throb. A & A Case Reports, 1 (4), 59-61. doi: 10.1097/ACC.0b013e31829737ab
2013
Journal Article
A comparison of CKD-EPI estimated glomerular filtration rate and measured creatinine clearance in recently admitted critically ill patients with normal plasma creatinine concentrations
Udy, Andrew A., Morton, Fraser J. A., Nguyen-Pham, Sallyanne, Jarrett, Paul, Lassig-Smith, Melissa, Stuart, Janine, Dunlop, Rachel, Starr, Therese, Boots, Robert J. and Lipman, Jeffrey (2013). A comparison of CKD-EPI estimated glomerular filtration rate and measured creatinine clearance in recently admitted critically ill patients with normal plasma creatinine concentrations. BMC Nephrology, 14 (1) 250, 250. doi: 10.1186/1471-2369-14-250
2013
Journal Article
Ampicillin/sulbactam: Its potential use in treating infections in critically ill patients
Adnan, Syamhanin, Paterson, David L., Lipman, Jeffrey and Roberts, Jason A. (2013). Ampicillin/sulbactam: Its potential use in treating infections in critically ill patients. International Journal of Antimicrobial Agents, 42 (5), 384-389. doi: 10.1016/j.ijantimicag.2013.07.012
2013
Journal Article
Molecular analysis of the Acinetobacter baumannii biofilm-associated protein
Goh, H. M. Sharon, Beatson, Scott A., Totsika, Makrina, Moriel, Danilo G., Phan, Minh-Duy, Szubert, Jan, Runnegar, Naomi, Sidjabat, Hanna E., Paterson, David L., Nimmo, Graeme R., Lipman, Jeffrey and Schembri, Mark A. (2013). Molecular analysis of the Acinetobacter baumannii biofilm-associated protein. Applied and Environmental Microbiology, 79 (21), 6535-6543. doi: 10.1128/AEM.01402-13
2013
Journal Article
Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii
Moriel, Danilo G., Beatson, Scott A., Wurpel, Daniël J., Lipman, Jeffrey, Nimmo, Graeme R., Paterson, David L. and Schembri, Mark A. (2013). Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii. PLoS ONE, 8 (10) e77631, e77631.1-e77631.9. doi: 10.1371/journal.pone.0077631
2013
Journal Article
What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review
Parker, Suzanne, Lipman, Jeffrey, Koulenti, Despoina, Dimopoulos, George and Roberts, Jason A. (2013). What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review. International Journal of Antimicrobial Agents, 42 (4), 289-293. doi: 10.1016/j.ijantimicag.2013.05.018
2013
Journal Article
Antibiotic prescription for respiratory tract infections in ventilated patients: where are we heading?
Rello, Jordi and Lipman, Jeffrey (2013). Antibiotic prescription for respiratory tract infections in ventilated patients: where are we heading?. Intensive Care Medicine, 39 (9), 1644-1646. doi: 10.1007/s00134-013-2983-z
2013
Journal Article
Phenytoin loading doses in adult critical care patients: does current practice achieve adequate drug levels?
Putt, M. T., Udy, A. A., Jarrett, P., Martin, J., Hennig, S., Salmon, N., Lipman, J. and Roberts, J. A. (2013). Phenytoin loading doses in adult critical care patients: does current practice achieve adequate drug levels?. Anaesthesia and Intensive Care, 41 (5), 602-609. doi: 10.1177/0310057x1304100505
Funding
Current funding
Past funding
Supervision
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
Supervision history
Current supervision
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Doctor Philosophy
Local and International epidemiology of Hospital Acquired Blood Stream Infections in the Critically Ill
Principal Advisor
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Principal Advisor
Other advisors: Professor Kiran Shekar
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Doctor Philosophy
Critical care management of burns patients
Associate Advisor
Other advisors: Associate Professor Jeremy Cohen, Professor Michael Reade
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Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
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Doctor Philosophy
How to use antibiotics better in Paediatric Intensive Care using pharmacokinetic principles
Associate Advisor
Other advisors: Dr Mark Coulthard, Dr Xin Liu, Dr Patty Mitre, Professor Jason Roberts
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Doctor Philosophy
Studies of Microcirculatory Responses to Traumatic Haemorrhagic Shock
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
Completed supervision
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2024
Doctor Philosophy
Optimising Antibiotic Dosing for Treatment of Nosocomial Central Nervous System Infections in Neurocritical Care Patients
Principal Advisor
Other advisors: Professor Jason Roberts
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2020
Doctor Philosophy
Early predictors of Health-Related Quality of Life outcomes post-burns for hospitalised adults in Australia.
Principal Advisor
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2019
Doctor Philosophy
Emergency department patients with sepsis: risk stratification and clinical prediction rules
Principal Advisor
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2014
Doctor Philosophy
Augmented Renal Clearance in the Critically Ill: Prevalence, Risk Factors, and Implications for Beta-lactam Therapy
Principal Advisor
Other advisors: Associate Professor Robert Boots
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2014
Doctor Philosophy
Dose optimisation of antibiotics during different forms of renal replacement therapy: focus on tissue and target site antibiotic concentrations
Principal Advisor
Other advisors: Professor Jason Roberts, Associate Professor Robert Boots
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2009
Doctor Philosophy
Beta-lactam antibiotic dosing in critical care units: Bolus vs continuous dosing
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts
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2024
Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
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2023
Doctor Philosophy
Strategies to improve the use of antimicrobials in hospitalised Indonesian patients
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2023
Doctor Philosophy
Translating Microsampling Techniques into Improved Antimicrobial Dosing for Critically Ill Children
Associate Advisor
Other advisors: Professor Jason Roberts
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Associate Advisor
Other advisors: Professor Dan Chambers
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2019
Doctor Philosophy
A pharmacokinetic/pharmacodynamic and clinical outcome evaluation of beta-lactam antibiotic therapeutic drug monitoring in critically ill patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2017
Doctor Philosophy
Improving antibiotic dosing in critically ill Australian Indigenous patients with severe sepsis
Associate Advisor
Other advisors: Professor Jason Roberts
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2017
Doctor Philosophy
Clinical Guidelines relating to the Anaesthetic Management of Obese Parturients: An Evaluation of the Evidence Supporting the Recommendations and their Utility in Clinical Practice
Associate Advisor
Other advisors: Professor Leonie Callaway, Professor Andre Van Zundert
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2016
Doctor Philosophy
Translating Innovative Pharmacokinetic Sampling Techniques into Improved Antibiotic Dosing Regimens in Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2016
Doctor Philosophy
Optimizing beta-lactam antibiotic dosing in critically ill patients: Prolonged infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Dr Christine Staatz, Professor Jason Roberts
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2016
Doctor Philosophy
An Investigation of the Pharmacokinetics of Piperacillin, Meropenem and Fluconazole in Critically Ill Obese Patients
Associate Advisor
Other advisors: Professor Jason Roberts, Emeritus Professor Michael Roberts
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2015
Master Philosophy
Vancomycin-associated nephrotoxicity in the Critically-Ill
Associate Advisor
Other advisors: Professor Jason Roberts
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2015
Doctor Philosophy
ß-lactam antibiotic pharmacokinetics during continuous venovenous haemofiltration in critically ill patients: Continuous infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Professor Jason Roberts
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2014
Doctor Philosophy
Improving Antimicrobial Use In Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2012
Master Philosophy
Challenges in management of infections on a burn injury unit.
Associate Advisor
Other advisors: Professor Jason Roberts
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2012
Doctor Philosophy
"Phantom Skin Pain" - Neuropathic Pain Following Burn Injury: An Examination of Incidence and Treatment
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2007
Doctor Philosophy
EXAMINATION OF THE ROLE OF POSTURAL CHANGE IN VENTILATED INTENSIVE CARE PATIENTS. CURRENT PRACTICE, INVESTIGATION AND GUIDELINES
Associate Advisor
Media
Enquiries
Contact Professor Jeffrey Lipman directly for media enquiries about:
- Antibiotics
- Intensive care
- pharmacokinetics
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