
Overview
Background
Prof Lipman is Executive Director of the Burns Trauma & Critical Care Research Centre; Professor of Anesthesiology & Critical Care, The University of Queensland and until recently (for 23 years) was Director of Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital; He holds Honorary Professorial appointments at Chinese University of Hong Kong, Unversity of Witwatersrand (South Africa) and Qeensland University of Technology.
He has qualifications in anesthesia and intensive care and has set up and been in charge of a number of Intensive Care and Trauma Units in South Africa before coming to Australia in 1997. he currently manages a large multidisciplinary research team with an output of over 120 peer-reviewed articles per annum. He has supervised dozens of PhD students to completion and is currently supervising 6 PhD, 1 MPhil and 1 MBBS/Hons students. Prof Lipman has been instrumental in developing the anaesthesiology and critical care component of a graduate medical program for Queensland and continues to lecture to medical and postgraduate students.
Prof Lipman is the author of over 550 peer reviewed publications, 30 book chapters and has been invited to deliver over 120 lectures at national and international conferences in many countries across the world. His research interests include all aspects of infection management in intensive care and he has a special interest in the pharmacokinetics of antibiotic dosage, an area in which he received his MD in 2006. His research into antibiotic usage in acute situations has received international recognition and he is regarded as an expert in the field. As such, he and his research team have conducted and presently conduct a number of clinical trials in Australia, New Zealand, Hong Kong, Europe and the UK.
Prof Lipman is an Editorial Board member for 10 International Journals, is Section Editor on four Antibiotic related Journals, reviews for 23 journals and is an external reviewer for NHMRC project grants (Local) as well as equivalent for a number overseas countries.
He is Chief Investigator on a 7000 patient International Randomised Controlled Trial comparing bolus dosing versus continuous infusions of meropenem and piperacillin-tazobactam
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
- Media expert
Fields of research
Research interests
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Antibiotic dosing in critically ill patients
Severe sepsis is defined as failure of one or more organ systems, most commonly cardiovascular (including shock), respiratory and renal failure, caused by infection. Bacteria, either alone or in combination with other pathogens, are the most common cause of severe sepsis, and Gram-positive and Gram-negative organism account for up to 87% of culture positive episodes. Severe sepsis is a major cause of mortality worldwide. The ANZICS CTG reported that the Australian and New Zealand adult annual incidence of severe sepsis is 77 cases per 100,000,4 which is equivalent to over 17,000 patient episodes per year at an estimated cost per episode of AUD 42,300. Similar population incidence rates have been reported elsewhere. Importantly, 11.8% of all admissions to Australian and New Zealand ICUs are associated with severe sepsis and in-hospital mortality is 37.5%. In patients with septic shock, mortality approaches 60%. The burden of death is almost four times the annual national road toll. The death rate also exceeds other diseases that impact significantly on the Australian community, such as breast and colorectal cancer. In short, severe sepsis is a major public health concern in Australia and improved therapies are needed urgently. My research group is conducting national and international clinical trials investigating the effect of various dosing regimes on health outcomes in critically ill patients.
Research impacts
My research has been instrumental in changing antibiotic prescribing habits worldwide for critically ill patients, first with aminoglycosides (I did the first and still largest clinical trial to show single daily dosing to be effective) and more recently with beta-lactam antibiotics. Due to critically ill patients having altered pharmacokinetics, using standard antibiotic dosing for these patients is fraught with problems. This has led to the use of Therapeutic Drug Monitoring (TDM) for beta-lactams.
TDM of aminoglycosides and glycopeptides is performed to decrease side-effects of these drugs. Beta-lactams have a large therapeutic ratio and hence measurement of them is infrequent. I helped set up routine TDM of beta-lactam antibiotics at RBWH. I have changed how we dose patients particularly in ICU but also within the wards of RBWH. By means of TDM we have shown we need dose adjustments in 74% of patients to which we administer β-lactam antibiotics in the ICU (Roberts JA et al. Int J Antimicrob Agents 2010;36:332-39). Although scarcely performed world-wide, TDM of beta-lactams is now becoming more commonly performed. We are currently collating data from 5 International centres that also use TDM in an attempt to show outcome benefits of TDM and are starting to publish accordingly (Wong G et al. An international, multi-centre survey of beta-lactam antibiotics TDM practice in intensive care units. J Antimicrob Chemother 2014;69: 1416–1423).
Works
Search Professor Jeffrey Lipman’s works on UQ eSpace
2014
Journal Article
Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures
Carlier, Mieke, Noe, Michael, Roberts, Jason A., Stove, Veronique, Verstraete, Alain G., Lipman, Jeffrey and De Waele, Jan J. (2014). Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures. Journal of Antimicrobial Chemotherapy, 69 (10), 2797-2803. doi: 10.1093/jac/dku195
2014
Journal Article
Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels
Hanberger, Hakan, Antonelli, Massimo, Holmbom, Martin, Lipman, Jeffrey, Pickkers, Peter, Leone, Marc, Rello, Jordi, Sakr, Yasser, Walther, Sten M., Vanhems, Philippe, Vincent, Jean-Louis, for the EPIC II Group of Investigators and Koulenti, D. (2014). Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels. BMC Infectious Diseases, 14 (513) 513. doi: 10.1186/1471-2334-14-513
2014
Journal Article
Impact of loading doses on the time to adequate predicted beta-lactam concentrations in prolonged and continuous infusion dosing schemes: reply to Rhodes et al
Roberts, Jason A., Paul, Sanjoy K., Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Kaukonen, Kirsi-Maija, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C. and Lipman, Jeffrey (2014). Impact of loading doses on the time to adequate predicted beta-lactam concentrations in prolonged and continuous infusion dosing schemes: reply to Rhodes et al. Clinical Infectious Diseases, 59 (6), 907-908. doi: 10.1093/cid/ciu403
2014
Journal Article
Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections
Luque, S., Grau, S., Alvarez-Lerma, F., Ferrandez, O., Campillo, N., Horcajada, J.P., Basas, M., Lipman, J. and Roberts, J.A. (2014). Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections. International Journal of Antimicrobial Agents, 44 (5), 409-415. doi: 10.1016/j.ijantimicag.2014.07.001
2014
Journal Article
Infections and use of antibiotics in patients admitted for severe acute pancreatitis: Data from the epic II study
De Waele, Jan J., Rello, Jordi, Anzueto, Antonio, Moreno, Rui, Lipman, Jeffrey, Sakr, Yasser, Pickkers, Peter, Leone, Marc, Ferguson, Andrew, Oud, Lavi and Vincent, Jean-Louis (2014). Infections and use of antibiotics in patients admitted for severe acute pancreatitis: Data from the epic II study. Surgical Infections, 15 (4), 394-398. doi: 10.1089/sur.2012.228
2014
Journal Article
The authors reply
Udy, Andrew A., Baptista, João P., Lim, Noelle L., Joynt, Gavin M., Jarrett, Paul, Boots, Robert J. and Lipman, Jeffrey (2014). The authors reply. Critical Care Medicine, 42 (8), e602-e603. doi: 10.1097/CCM.0000000000000465
2014
Journal Article
Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome
De Waele, Jan, Lipman, Jeffrey, Sakr, Yasser, Marshall, John C., Vanhems, Philippe, Barrera Groba, Casiano, Leone, Marc and Vincent, Jean-Louis (2014). Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome. BMC Infectious Diseases, 14 (420) 420, 1-17. doi: 10.1186/1471-2334-14-420
2014
Journal Article
The impact of variation in renal replacement therapy settings on piperacillin, meropenem, and vancomycin drug clearance in the critically ill: an analysis of published literature and dosing regimens
Jamal, Janattul-Ain, Udy, Andrew A., Lipman, Jeffrey and Roberts, Jason A. (2014). The impact of variation in renal replacement therapy settings on piperacillin, meropenem, and vancomycin drug clearance in the critically ill: an analysis of published literature and dosing regimens. Critical Care Medicine, 42 (7), 1640-1650. doi: 10.1097/CCM.0000000000000317
2014
Journal Article
Burn resuscitation - hourly urine output vs alternative endpoints: a systematic review
Paratz, Jennifer D., Stockton, Kellie, Paratz, Elizabeth D., Blot, Stijn, Muller, Michael, Lipman, Jeffrey and Boots, Robert J. (2014). Burn resuscitation - hourly urine output vs alternative endpoints: a systematic review. Shock, 42 (4), 295-306. doi: 10.1097/SHK.0000000000000204
2014
Journal Article
Variable ganciclovir concentrations in a critically ill patient receiving continuous renal replacement therapy and plasma exchange?
Nunez-Nunez, Maria, Bellapart, Judith, O’Donoghue, Steven, McWhinney, Brett, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2014). Variable ganciclovir concentrations in a critically ill patient receiving continuous renal replacement therapy and plasma exchange?. International journal of antimicrobial agents, 43 (6), 572-573. doi: 10.1016/j.ijantimicag.2014.03.001
2014
Journal Article
Randomised controlled trials: the long hard climb to the summit - is there another way in the 21st century?
Dulhunty, Joel M., Starr, Therese, Bellomo, Rinaldo and Lipman, Jeffrey (2014). Randomised controlled trials: the long hard climb to the summit - is there another way in the 21st century?. Critical Care and Resuscitation, 16 (2), 87-89.
2014
Journal Article
Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study
Blot, Stijn, Koulenti, Despoina, Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Kaukonen, Kirsi-Maija, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2014). Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study. Critical Care, 18 (3) R99, 1-11. doi: 10.1186/cc13874
2014
Journal Article
Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients
Roberts, Jason A., Udy, Andrew A., Jarrett, Paul, Wallis, Steven C., Hope, William W., Sharma, Raman, Kirkpatrick, Carl M. J., Kruger, Peter S., Roberts, Michael S. and Lipman, Jeffrey (2014). Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients. Journal of Antimicrobial Chemotherapy, 70 (5) dku564, 1495-1502. doi: 10.1093/jac/dku564
2014
Journal Article
An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units
Wong, Gloria, Brinkman, Alexander, Benefield, Russell J., Carlier, Mieke, De Waele, Jan J., Helali, Najoua, Frey, Otto, Harbarth, Stephan, Huttner, Angela, McWhinney, Brett, Misset, Benoit, Pea, Federico, Preisenberger, Judit, Roberts, Michael S., Robertson, Thomas A., Roehr, Anka, Sime, Fekade Bruck, Taccone, Fabio Silvio, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2014). An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units. Journal of Antimicrobial Chemotherapy, 69 (5) dkt523, 1416-1423. doi: 10.1093/jac/dkt523
2014
Journal Article
The influence of acute kidney injury on antimicrobial dosing in critically ill patients: Are dose reductions always necessary?
Blot,Stijn, Lipman, Jeffrey, Roberts, Darren M. and Roberts, Jason A (2014). The influence of acute kidney injury on antimicrobial dosing in critically ill patients: Are dose reductions always necessary?. Diagnostic Microbiology and Infectious Disease, 79 (1), 77-84. doi: 10.1016/j.diagmicrobio.2014.01.015
2014
Journal Article
Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit
Vincent, Jean-Louis, Marshall, John C., Namendys-Silva, Silvo A., Francois, Bruno, Martin-Loeches, Ignacio, Lipman, Jeffrey, Reinhart, Konrad, Antonelli, Massimo, Pickkers, Peter, Njimi, Hassane, Jimenez, Edgar and Sakr, Yasser (2014). Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit. The Lancet Respiratory Medicine, 2 (5), 380-386. doi: 10.1016/S2213-2600(14)70061-X
2014
Journal Article
DALI: defining antibiotic levels in intensive care unit patients. Are current beta-lactam antibiotic doses sufficient for critically ill patients?
Roberts, Jason A., Paul, Sanjoy K., Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Kaukonen, Kirsi-Maija, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C. and Lipman, Jeffrey (2014). DALI: defining antibiotic levels in intensive care unit patients. Are current beta-lactam antibiotic doses sufficient for critically ill patients?. Clinical Infectious Diseases, 58 (8), 1072-1083. doi: 10.1093/cid/ciu027
2014
Journal Article
Calorie intake and patient outcomes in severe acute kidney injury: Findings from The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study trial
Bellomo, Rinaldo, Cass, Alan, Cole, Louise, Finfer, Simon, Gallagher, Martin, Lee, Janne, Lo, Serigne, McArthur, Colin, McGuinness, Shay, Myburgh, John, Norton, Robyn, Scheinkestel, Carlos, The RENAL Study Investigators, Lipman, Jeffrey and Boots, Robert (2014). Calorie intake and patient outcomes in severe acute kidney injury: Findings from The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study trial. Critical Care, 18 (2) R45, 1-11. doi: 10.1186/cc13767
2014
Journal Article
Seated and semi-recumbent positioning of the ventilated intensive care patient - effect on gas exchange, respiratory mechanics and hemodynamics
Thomas, Peter, Paratz, Jennifer and Lipman, Jeffrey (2014). Seated and semi-recumbent positioning of the ventilated intensive care patient - effect on gas exchange, respiratory mechanics and hemodynamics. Heart and Lung: Journal of Acute and Critical Care, 43 (2), 105-111. doi: 10.1016/j.hrtlng.2013.11.011
2014
Journal Article
Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DALI Study
Roberts, J. A., Stove, V., De Waele, J. J., Sipinkoski, B., McWhinney, B., Ungerer, J. P. J., Akova, M., Bassetti, M., Dimopoulos, G., Kaukonen, K.-M., Koulenti, D., Martin, C., Montravers, P., Rello, J., Rhodes, A., Starr, T., Wallis, S. C. and Lipman, J. (2014). Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DALI Study. International Journal of Antimicrobial Agents, 43 (5), 423-430. doi: 10.1016/j.ijantimicag.2014.01.023
Funding
Current funding
Past funding
Supervision
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
Supervision history
Current supervision
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Doctor Philosophy
Optimising antibiotic dosing for the treatment and prevention of central nervous system infections
Principal Advisor
Other advisors: Professor Jason Roberts
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Doctor Philosophy
Local and International epidemiology of Hospital Acquired Blood Stream Infections in the Critically Ill
Principal Advisor
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Principal Advisor
Other advisors: Professor Kiran Shekar
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Doctor Philosophy
How to use antibiotics better in Paediatric Intensive Care using pharmacokinetic principles
Associate Advisor
Other advisors: Dr Mark Coulthard, Dr Xin Liu, Dr Patty Mitre, Professor Jason Roberts
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Doctor Philosophy
Critical care management of burns patients
Associate Advisor
Other advisors: Associate Professor Jeremy Cohen, Professor Michael Reade
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Doctor Philosophy
Studies of the Microcirculatory Responses to Hemorrhagic Shock and Resuscitation
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
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Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
-
Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
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Doctor Philosophy
Studies of the Microcirculatory Responses to Hemorrhagic Shock and Resuscitation
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
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Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
Completed supervision
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2024
Doctor Philosophy
Optimising Antibiotic Dosing for Treatment of Nosocomial Central Nervous System Infections in Neurocritical Care Patients
Principal Advisor
Other advisors: Professor Jason Roberts
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2020
Doctor Philosophy
Early predictors of Health-Related Quality of Life outcomes post-burns for hospitalised adults in Australia.
Principal Advisor
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2019
Doctor Philosophy
Emergency department patients with sepsis: risk stratification and clinical prediction rules
Principal Advisor
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2014
Doctor Philosophy
Augmented Renal Clearance in the Critically Ill: Prevalence, Risk Factors, and Implications for Beta-lactam Therapy
Principal Advisor
Other advisors: Associate Professor Robert Boots
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2014
Doctor Philosophy
Dose optimisation of antibiotics during different forms of renal replacement therapy: focus on tissue and target site antibiotic concentrations
Principal Advisor
Other advisors: Professor Jason Roberts, Associate Professor Robert Boots
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2009
Doctor Philosophy
Beta-lactam antibiotic dosing in critical care units: Bolus vs continuous dosing
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts
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2024
Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
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2023
Doctor Philosophy
Strategies to improve the use of antimicrobials in hospitalised Indonesian patients
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2023
Doctor Philosophy
Translating Microsampling Techniques into Improved Antimicrobial Dosing for Critically Ill Children
Associate Advisor
Other advisors: Professor Jason Roberts
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Associate Advisor
Other advisors: Professor Dan Chambers
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2019
Doctor Philosophy
A pharmacokinetic/pharmacodynamic and clinical outcome evaluation of beta-lactam antibiotic therapeutic drug monitoring in critically ill patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2017
Doctor Philosophy
Improving antibiotic dosing in critically ill Australian Indigenous patients with severe sepsis
Associate Advisor
Other advisors: Professor Jason Roberts
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2017
Doctor Philosophy
Clinical Guidelines relating to the Anaesthetic Management of Obese Parturients: An Evaluation of the Evidence Supporting the Recommendations and their Utility in Clinical Practice
Associate Advisor
Other advisors: Professor Leonie Callaway, Professor Andre Van Zundert
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2016
Doctor Philosophy
Translating Innovative Pharmacokinetic Sampling Techniques into Improved Antibiotic Dosing Regimens in Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2016
Doctor Philosophy
Optimizing beta-lactam antibiotic dosing in critically ill patients: Prolonged infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Dr Christine Staatz, Professor Jason Roberts
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2016
Doctor Philosophy
An Investigation of the Pharmacokinetics of Piperacillin, Meropenem and Fluconazole in Critically Ill Obese Patients
Associate Advisor
Other advisors: Professor Jason Roberts, Emeritus Professor Michael Roberts
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2015
Doctor Philosophy
ß-lactam antibiotic pharmacokinetics during continuous venovenous haemofiltration in critically ill patients: Continuous infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Professor Jason Roberts
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2015
Master Philosophy
Vancomycin-associated nephrotoxicity in the Critically-Ill
Associate Advisor
Other advisors: Professor Jason Roberts
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2014
Doctor Philosophy
Improving Antimicrobial Use In Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2012
Master Philosophy
Challenges in management of infections on a burn injury unit.
Associate Advisor
Other advisors: Professor Jason Roberts
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2012
Doctor Philosophy
"Phantom Skin Pain" - Neuropathic Pain Following Burn Injury: An Examination of Incidence and Treatment
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2007
Doctor Philosophy
EXAMINATION OF THE ROLE OF POSTURAL CHANGE IN VENTILATED INTENSIVE CARE PATIENTS. CURRENT PRACTICE, INVESTIGATION AND GUIDELINES
Associate Advisor
Media
Enquiries
Contact Professor Jeffrey Lipman directly for media enquiries about:
- Antibiotics
- Intensive care
- pharmacokinetics
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