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2026 Journal Article Body mass index and mortality: The “Obesity Paradox” in critically ill patients with intra-abdominal infection or sepsis – An international cohort studyDonckels, Fien, Antonelli, Massimo, Arvaniti, Kostoula, Creagh‑Brown, Ben, Conoscenti, Elena, de Lange, Dylan W., Pascale, Gennaro De, Waele, Jan De, Deschepper, Mieke, Dikmen, Yalim, Dimopoulos, George, Eckmann, Christian, Francois, Guy, Girardis, Massimo, Koulenti, Despoina, Labeau, Sonia, Lipman, Jeffrey, Maseda, Emilio, Montravers, Philippe, Mikstacki, Adam, Paiva, Jose‑Artur, Papathanakos, Georgios, Rello, Jordi, Timsit, Jean‑Francois, Vogelaers, Dirk and Blot, Stijn (2026). Body mass index and mortality: The “Obesity Paradox” in critically ill patients with intra-abdominal infection or sepsis – An international cohort study. Intensive and Critical Care Nursing, 93 104281, 104281. doi: 10.1016/j.iccn.2025.104281 |
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2026 Journal Article Continuous infusion of Beta-Lactams in the critically ill: Considerations for global implementationDenny, Kerina J., Best-Lane, Janis, Brett, Stephen J., Dulhunty, Joel, Gous, Andries G.S., Machado, Flavia R., Mangalore, Rekha Pai, Mehta, Reena, Rajbhandari, Dorrilyn, Scribante, Juan and Lipman, Jeffery (2026). Continuous infusion of Beta-Lactams in the critically ill: Considerations for global implementation. Journal of Critical Care, 91 155254, 155254. doi: 10.1016/j.jcrc.2025.155254 |
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2025 Journal Article In vitro dexamethasone suppression of cytokine production assay and plasma total and free cortisol responses to ACTH in healthy volunteersNethathe, Gladness Dakalo, Cohen, Jeremy, Lipman, Jeffrey, Anderson, Ronald, Hay, Karen Elizabeth, Pretorius, Carel J. and Feldman, Charles (2025). In vitro dexamethasone suppression of cytokine production assay and plasma total and free cortisol responses to ACTH in healthy volunteers. Scientific Reports, 15 (1) 43127, 43127. doi: 10.1038/s41598-025-26260-1 |
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2025 Journal Article Beyond the numbers: do nomograms capture the complexity of RRT dosing? Author’s replyColmenero, Manuel, Roberts, Jason A., Lipman, Jeffrey and Ulldemolins, Marta (2025). Beyond the numbers: do nomograms capture the complexity of RRT dosing? Author’s reply. Intensive Care Medicine, 51 (11), 2170-2171. doi: 10.1007/s00134-025-08160-0 |
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2025 Journal Article The long walk to a short half-life: the discovery of augmented renal clearance and its impact on antibiotic dosingLipman, Jeffrey and Lewis, Russell E (2025). The long walk to a short half-life: the discovery of augmented renal clearance and its impact on antibiotic dosing. Journal of Antimicrobial Chemotherapy, 80 (12) dkaf378, 3367-3374. doi: 10.1093/jac/dkaf378 |
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2025 Journal Article Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)-2 Score: A Consensus StatementMoreno, Rui, Rhodes, Andrew, Ranzani, Otavio, Salluh, Jorge I F, Berger-Estilita, Joana, Coopersmith, Craig M., Juffermans, Nicole P., Laffey, John, Reinikainen, Matti, Neto, Ary Serpa, Tavares, Miguel, Timsit, Jean-François, Arias Lopez, Maria Del Pilar, Arulkumaran, Nish, Azoulay, Elie, Chaudhuri, Dipayan, De Lange, Dylan, De Waele, Jan, Dos Santos, Claudia C., Du, Bin, Einav, Sharon, Ferrer, Ricard, Fujii, Tomoko, Gershengorn, Hayley B., Haniffa, Rashan, Hasan, Mohd Shahnaz, Hollenberg, Steve, Ippolito, Mariachiara, Jung, Christian ... Singer, Mervyn (2025). Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)-2 Score: A Consensus Statement. JAMA network open, 8 (10) e2545040, e2545040. doi: 10.1001/jamanetworkopen.2025.45040 |
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2025 Journal Article Antibiotic therapy for severe bacterial infectionsTimsit, Jean-Francois, Ling, Lowell, de Montmollin, Etienne, Bracht, Hendrik, Conway-Morris, Andrew, De Bus, Liesbet, Falcone, Marco, Harris, Patrick N. A., Machado, Flavia R., Paiva, Jose-Artur, Paterson, David L., Poulakou, Garyphallia, Roberts, Jason A., Roger, Claire, Shorr, Andrew F., Tabah, Alexis and Lipman, Jeffrey (2025). Antibiotic therapy for severe bacterial infections. Intensive Care Medicine, 51 (10), 1867-1885. doi: 10.1007/s00134-025-08063-0 |
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2025 Journal Article Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapyRoberts, Jason A., Ulldemolins, Marta, Liu, Xin, Baptista, João P., Bilgrami, Irma, Boidin, Clement, Brinkmann, Alexander, Castro, Pedro, Choi, Gordon, Cole, Louise, De Waele, Jan J., Deans, Renae, Donnellan, Sine, Eastwood, Glenn M., Frey, Otto R., Goutelle, Sylvain, Gresham, Rebecca, Jamal, Janattul Ain, Joynt, Gavin M., Kanji, Salmaan, Kluge, Stefan, König, Christina, Koulouras, Vasilios P., Lassig-Smith, Melissa, Laterre, Pierre-Francois, Lee, Anna, Lefrant, Jean-Yves, Lei, Katie, Leung, Patricia ... Young, Helen (2025). Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy. Intensive Care Medicine, 51 (9), 1628-1640. doi: 10.1007/s00134-025-08067-w |
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2025 Journal Article Source control in bloodstream infections in patients with sepsis, septic shock, or requiring ICU admission: a scoping review with recommendations for standardizing researchTabah, Alexis, De Waele, Jan, Ssi Yan Kai, Nathalie, Aslan, Abdullah Tarik, Buetti, Niccolò, Timsit, Jean-François, Ballard, Emma, Eriksson, Lars, Laupland, Kevin B. and Lipman, Jeffrey (2025). Source control in bloodstream infections in patients with sepsis, septic shock, or requiring ICU admission: a scoping review with recommendations for standardizing research. Intensive Care Medicine, 51 (8), 1462-1475. doi: 10.1007/s00134-025-08026-5 |
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2025 Journal Article Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patientsKumta, Nilesh, Heffernan, Aaron J., Liu, Xin, Parker, Suzanne L., Cotta, Menino Osbert, Wallis, Steven C., Livermore, Amelia, Starr, Therese, Wai, Wong Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2025). Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients. International Journal of Antimicrobial Agents, 65 (5) 107461, 107461. doi: 10.1016/j.ijantimicag.2025.107461 |
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2025 Journal Article Transfusion strategy in the most critically patients with trauma brain injury: Differences to other populations?Coisy, Fabien, Ajavon, Florian, Lipman, Jeffrey, Lefrant, Jean-Yves and Bobbia, Xavier (2025). Transfusion strategy in the most critically patients with trauma brain injury: Differences to other populations?. Anaesthesia Critical Care and Pain Medicine, 44 (2) 101490, 101490-2. doi: 10.1016/j.accpm.2025.101490 |
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2025 Journal Article Continuous versus intermittent bolus dosing of beta-lactam antibiotics in a South African multi-disciplinary intensive care unit: a randomized controlled trialKhan, Ayesha Bibi, Abdul-Aziz, Mohd Hafiz, Hindle, Lucy, Lipman, Jeffrey, Simelela, Fetolang and Omar, Shahed (2025). Continuous versus intermittent bolus dosing of beta-lactam antibiotics in a South African multi-disciplinary intensive care unit: a randomized controlled trial. Journal of Infection, 90 (5) 106487, 1-6. doi: 10.1016/j.jinf.2025.106487 |
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2025 Journal Article Cefazolin versus placebo for surgical antibiotic prophylaxis in low-risk cesarean delivery: a feasibility blinded randomized controlled trialEley, Victoria A., Navarro, Severine, Martin, Elizabeth, Amoako, Akwasi, Hartel, Gunter, Woods, Christine, Lu, Yan, Lipman, Jeffrey, Roberts, Jason, Tang, Mimi and Callaway, Leonie (2025). Cefazolin versus placebo for surgical antibiotic prophylaxis in low-risk cesarean delivery: a feasibility blinded randomized controlled trial. BMC Pregnancy and Childbirth, 25 (1) 353, 353. doi: 10.1186/s12884-025-07484-5 |
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2025 Journal Article Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot studyRoberts, J. A., Heffernan, A. J., Chai, M. G., Harris, P. N. A., Legg, A., Farkas, A., Laupland, K., Dhanani, J., Fourie, C., Murray, L., Abdul-Aziz, H., Ungerer, J., McWhinney, B., Lipman, J. and Cotta, M. O. (2025). Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study. CMI Communications, 2 (1) 105051, 105051. doi: 10.1016/j.cmicom.2024.105051 |
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2025 Journal Article Antibiotic dosing optimization in critically ill patientsKoulenti, Despoina, Roger, Claire and Lipman, Jeffrey (2025). Antibiotic dosing optimization in critically ill patients. Intensive Care Medicine, 51 (3), 603-606. doi: 10.1007/s00134-025-07822-3 |
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2025 Journal Article Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU studyRoberts, Jason A., Sime, Fekade B., Lipman, Jeffrey, Hernández-Mitre, María Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Ceccarelli, Giancarlo, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2025). Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study. Intensive Care Medicine, 51 (2), 1-16. doi: 10.1007/s00134-025-07793-5 |
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2025 Journal Article Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 ScoreRanzani, Otavio T., Singer, Mervyn, Salluh, Jorge I. F., Shankar-Hari, Manu, Pilcher, David, Berger-Estilita, Joana, Coopersmith, Craig M., Juffermans, Nicole P., Laffey, John, Reinikainen, Matti, Neto, Ary Serpa, Tavares, Miguel, Timsit, Jean-François, Arias Lopez, Maria Del Pilar, Arulkumaran, Nish, Aryal, Diptesh, Azoulay, Elie, Celi, Leo Anthony, Chaudhuri, Dipayan, De Lange, Dylan, De Waele, Jan, Dos Santos, Claudia C., Du, Bin, Einav, Sharon, Engelbrecht, Teresa, Fazla, Fathima, Ferrer, Ricard, Finazzi, Stefano, Fujii, Tomoko ... Moreno, Rui (2025). Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score. JAMA, 334 (23), 2090. doi: 10.1001/jama.2025.20516 |
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2024 Journal Article A pooled pharmacokinetic analysis for piperacillin/tazobactam across different patient populations: From premature infants to the elderlyKong, Daming, Roberts, Jason A., Lipman, Jeffrey, Taccone, Fabio Silvio, Cohen-Wolkowiez, Michael, Sime, Fekade B., Tsai, Danny, De Cock, Pieter A. J. G., Jaruratanasirikul, Sutep, Dhaese, Sofie A. M., Udy, Andrew A., Felton, Timothy W., Michelet, Robin, Thibault, Celine, Koomen, Jeroen V., Eleveld, Douglas J., Struys, Michel M. R. F., De Waele, Jan J., Colin, Pieter J., Damen, Caroline and PIP/TAZ Consortium (2024). A pooled pharmacokinetic analysis for piperacillin/tazobactam across different patient populations: From premature infants to the elderly. Clinical Pharmacokinetics, 64 (1) 769329, 107-126. doi: 10.1007/s40262-024-01460-6 |
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2024 Journal Article Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patientsKumta, Nilesh, Heffernan, Aaron J., Cotta, Menino Osbert, Liu, Xin, Parker, Suzanne, Wallis, Steven, Livermore, Amelia, Starr, Therese, Wong, Wai Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2024). Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patients. Antimicrobial Agents and Chemotherapy, 69 (2), e0060124. doi: 10.1128/aac.00601-24 |
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2024 Journal Article Continuous vs intermittent β-lactam antibiotic infusions for sepsis-ReplyDulhunty, Joel M., Roberts, Jason A. and Lipman, Jeffrey (2024). Continuous vs intermittent β-lactam antibiotic infusions for sepsis-Reply. JAMA: The Journal of the American Medical Association, 333 (2), 174-175. doi: 10.1001/jama.2024.23275 |
