Overview
Availability
- Professor Jean-Pierre Levesque is:
- Available for supervision
Works
Search Professor Jean-Pierre Levesque’s works on UQ eSpace
2021
Journal Article
In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early
Lévesque, Jean-Pierre, Purton, Louise E., Hidalgo, Andrés, Zon, Leonard, Katayama, Yoshio, Scadden, David, Bowman, Teresa V., Stanley, E. Richard, Lucas, Daniel and Pinho, Sandra (2021). In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early. Experimental Hematology, 101-102, 1-6. doi: 10.1016/j.exphem.2021.08.002
2021
Journal Article
Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches
Lévesque, Jean-Pierre, Summers, Kim M., Millard, Susan, Bisht, Kavita, Winkler, Ingrid G. and Pettit, Allison R. (2021). Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches. Experimental Hematology, 100, 12-31. doi: 10.1016/j.exphem.2021.07.001
2021
Journal Article
Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress
Tay, Joshua, Barbier, Valerie, Helwani, Falak M, Price, Gareth R, Levesque, Jean-Pierre and Winkler, Ingrid G (2021). Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress. Stem Cells, 39 (11), 1532-1545. doi: 10.1002/stem.3438
2021
Journal Article
Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal cord-injured mice in a lesion level-dependent manner
Debaud, Charlotte, Tseng, Hsu-Wen, Chedik, Malha, Kulina, Irina, Genêt, François, Ruitenberg, Marc J. and Levesque, Jean-Pierre (2021). Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal cord-injured mice in a lesion level-dependent manner. Journal of Neurotrauma, 38 (15) neu.2021.0058, 2162-2175. doi: 10.1089/neu.2021.0058
2021
Journal Article
Adhesion to E-selectin primes macrophages for activation through AKT and mTOR
Davies, Julie M., Radford, Kristen J., Begun, Jakob, Levesque, Jean-Pierre and Winkler, Ingrid G. (2021). Adhesion to E-selectin primes macrophages for activation through AKT and mTOR. Immunology and Cell Biology, 99 (6) imcb.12447, 622-639. doi: 10.1111/imcb.12447
2021
Journal Article
Neurogenic heterotopic ossifications recapitulate hematopoietic stem cell niche development within an adult osteogenic muscle environment
Girard, Dorothée, Torossian, Frédéric, Oberlin, Estelle, Alexander, Kylie A., Gueguen, Jules, Tseng, Hsu-Wen, Genêt, François, Lataillade, Jean-Jacques, Salga, Marjorie, Levesque, Jean-Pierre, Le Bousse-Kerdilès, Marie-Caroline and Banzet, Sébastien (2021). Neurogenic heterotopic ossifications recapitulate hematopoietic stem cell niche development within an adult osteogenic muscle environment. Frontiers in Cell and Developmental Biology, 9 611842, 611842. doi: 10.3389/fcell.2021.611842
2021
Journal Article
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release
Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452
2021
Journal Article
Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice
Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy C., Millard, Susan M., Batoon, Lena, Sandrock, Cheyenne J., Ferrari-Cestari, Michelle, Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology and Oncology, 14 (1) 3, 1-19. doi: 10.1186/s13045-020-00997-w
2020
Journal Article
Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophils
Tseng, Hsu‐Wen, Kulina, Irina, Salga, Marjorie, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Levesque, Jean‐Pierre and Alexander, Kylie A (2020). Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophils. Journal of Bone and Mineral Research, 35 (11) jbmr.4118, 2242-2251. doi: 10.1002/jbmr.4118
2020
Journal Article
When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification
Alexander, Kylie A., Tseng, Hsu-Wen, Salga, Marjorie, Genêt, François and Levesque, Jean-Pierre (2020). When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification. Current Osteoporosis Reports, 18 (6), 666-676. doi: 10.1007/s11914-020-00636-w
2020
Journal Article
Bacterial lipopolysaccharides suppress erythroblastic islands and erythropoiesis in the bone marrow in an extrinsic and G- CSF-, IL-1-, and TNF-independent manner
Bisht, Kavita, Tay, Joshua, Wellburn, Rebecca N., McGirr, Crystal, Fleming, Whitney, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Pierre (2020). Bacterial lipopolysaccharides suppress erythroblastic islands and erythropoiesis in the bone marrow in an extrinsic and G- CSF-, IL-1-, and TNF-independent manner. Frontiers in Immunology, 11 583550, 1-16. doi: 10.3389/fimmu.2020.583550
2020
Conference Publication
3092 – Stable colony stimulating factor 1 fusion protein treatment increases the hematopoietic stem cell pool and enhances their mobilization in mice
Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy, Millard, Susan, Batoon, Lena, Sandrock, Cheyenne, Levesque, Jean-Pierre, Hume, David, Raggatt, Liza and Pettit, Allison (2020). 3092 – Stable colony stimulating factor 1 fusion protein treatment increases the hematopoietic stem cell pool and enhances their mobilization in mice. 49th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, New York, NY USA, 20-23 August 2020. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.exphem.2020.09.105
2020
Journal Article
Acute myeloid leukemia chemo-resistance is mediated by E-selectin receptor CD162 in bone marrow niches
Erbani, Johanna, Tay, Joshua, Barbier, Valerie, Levesque, Jean-Pierre and Winkler, Ingrid G. (2020). Acute myeloid leukemia chemo-resistance is mediated by E-selectin receptor CD162 in bone marrow niches. Frontiers in Cell and Developmental Biology, 8 668, 668. doi: 10.3389/fcell.2020.00668
2020
Journal Article
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
Barbier, Valerie, Erbani, Johanna, Fiveash, Corrine, Davies, Julie M., Tay, Joshua, Tallack, Michael R., Lowe, Jessica, Magnani, John L., Pattabiraman, Diwakar R., Perkins, Andrew C., Lisle, Jessica, Rasko, John E. J., Levesque, Jean-Pierre and Winkler, Ingrid G. (2020). Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance. Nature Communications, 11 (1) 2042, 2042. doi: 10.1038/s41467-020-15817-5
2020
Journal Article
Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrow
Tay, Joshua, Bisht, Kavita, McGirr, Crystal, Millard, Susan M., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2020). Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrow. Experimental Hematology, 82, 33-42. doi: 10.1016/j.exphem.2020.02.003
2020
Journal Article
CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient derived strains
Nowlan, Bianca, Williams, Elizabeth D., Doran, Michael R. and Levesque, Jean-Pierre (2020). CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient derived strains. Haematologica, 105 (1), 71-82. doi: 10.3324/haematol.2018.212910
2019
Conference Publication
Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways
Winkler, Ingrid G., Barbier, Valerie, Tay, Joshua, Levesque, Jean-Pierre, Magnani, John L., Fiveash, Corrine E. and Erbani, Johanna D. (2019). Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways. 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Orlando, FL, United States, 7-10 December 2019. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2019-132212
2019
Journal Article
Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor
Bisht, Kavita, McGirr, Crystal, Alexander, Kylie A, Fleming, Whitney, Sims, Natalie, Newen, Gerhard Müller-, Winkler, Ingrid G and Levesque, Jean-Pierre (2019). Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor. Blood, 134 (Supplement_1), 4469-4469. doi: 10.1182/blood-2019-127431
2019
Conference Publication
CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche
Erbani, Johanna D., Tay, Joshua, Barbier, Valerie, Levesque, Jean-Pierre, Magnani, John L. and Winkler, Ingrid G. (2019). CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche. 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Orlando, FL, United States, 7-10 December 2019. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2019-132233
2019
Journal Article
Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2
Brennan, Faith H., Jogia, Trisha, Gillespie, Ellen R., Blomster, Linda V., Li, Xaria X., Nowlan, Bianca, Williams, Gail M., Jacobson, Esther, Osborne, Geoff W., Meunier, Frederic A., Taylor, Stephen M., Campbell, Kate E., MacDonald, Kelli P.A., Levesque, Jean-Pierre, Woodruff, Trent M. and Ruitenberg, Marc J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight, 4 (9) e98254. doi: 10.1172/jci.insight.98254
Funding
Supervision
Availability
- Professor Jean-Pierre Levesque is:
- Available for supervision
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Supervision history
Completed supervision
-
2023
Doctor Philosophy
Role of infections and gut microflora in the development of neurogenic heterotopic ossifications following spinal cord injury in a mouse model
Principal Advisor
Other advisors: Dr Kylie Alexander
-
2021
Doctor Philosophy
The Role of Macrophages in Acute Myeloid Leukaemia Progression and Sensitivity to Chemotherapy
Principal Advisor
Other advisors: Dr Ingrid Winkler
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2015
Doctor Philosophy
Role of Bone Marrow Macrophages in Regulating Haematopoiesis
Principal Advisor
Other advisors: Dr Ingrid Winkler
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2011
Doctor Philosophy
The Role of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in Haematopoiesis
Principal Advisor
Other advisors: Dr Ingrid Winkler
-
2019
Doctor Philosophy
Understanding the splenic regulation of the monocyte trafficking during spinal cord injury
Associate Advisor
Other advisors: Professor Marc Ruitenberg
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2019
Doctor Philosophy
The role of bone marrow niches in the regulation of normal and malignant haematopoietic stem cells
Associate Advisor
Other advisors: Dr Ingrid Winkler
-
2018
Doctor Philosophy
The role of macrophages in facilitating haematopoietic stem cell engraftment and reconstitution
Associate Advisor
Other advisors: Dr Liza Raggatt, Professor Allison Pettit
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2017
Doctor Philosophy
The role of prostaglandin I2 in haematopoietic stem cell in the bone marrow niche
Associate Advisor
Other advisors: Dr Ingrid Winkler
-
2015
Doctor Philosophy
Understanding heterotopic ossification after spinal cord injury
Associate Advisor
Other advisors: Dr Ingrid Winkler
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