Overview
Availability
- Dr Kylie Alexander is:
- Available for supervision
Qualifications
- Bachelor, Griffith University
- Doctor of Philosophy, The University of Queensland
Research interests
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Neurogenic heterotopic ossification
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Macrophage biology and inflammation
Works
Search Professor Kylie Alexander’s works on UQ eSpace
2024
Journal Article
A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury
Alexander, Kylie A., Tseng, Hsu-Wen, Lao, Hong Wa, Girard, Dorothée, Barbier, Valérie, Ungerer, Jacobus P. J., McWhinney, Brett C., Samuel, Selwin G., Fleming, Whitney, Winkler, Ingrid G., Salga, Marjorie, Genêt, François, Banzet, Sébastien, Ruitenberg, Marc J. and Lévesque, Jean-Pierre (2024). A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury. Cell Reports Medicine, 5 (12) 101849, 101849. doi: 10.1016/j.xcrm.2024.101849
2024
Conference Publication
Endotoxemia As Possible Cause of Inflammatory Bowel Diseases-Associated Anemia
Bisht, Kavita, An, Yoon-Kyo, Shatunova, Svetlana, Wang, Ran, Barbier, Valerie, Giri, Rabina, Amiss, Anna, Tang, Yifu, Alexander, Kylie, Millard, Susan, Winkler, Ingrid G., Pettit, Allison, Begun, Jakob and Levesque, Jean-Pierre (2024). Endotoxemia As Possible Cause of Inflammatory Bowel Diseases-Associated Anemia. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-193349
2024
Journal Article
Interleukin-6 does not contribute to neurogenic heterotopic ossification pathogenesis
Girard, Dorothee, Tseng, Hsu-Wen, Rival, Bastien, Barbier, Valerie, Shatunova, Svetlana, Goriot, Marie-Emmanuelle, Samuel, Selwin Gabriel, Genet, Francois, Salga, Marjorie, Banzet, Sebastien, Alexander, Kylie A. and Levesque, Jean-Pierre (2024). Interleukin-6 does not contribute to neurogenic heterotopic ossification pathogenesis. Neurotrauma Reports, 5 (1), 1101-1112. doi: 10.1089/neur.2024.0106
2024
Conference Publication
Endogenous glucocorticoids promote neurogenic heterotopic ossification after spinal cord injury and glucocorticoid receptor antagonist treatment prevents their development
Alexander, Kylie, Tseng, Hsu-Wen, Girard, Dorothee, Barbier, Valerie, Lao, Hong Wa, Samuel, Selwin G., Ungerer, Jacobus P. J., McWhinney, Brett C., Fleming, Whitney, Salga, Marjorie, Genet, Francois, Ruitenberg, Mark J., Banzet, Sebastien and Levesque, Jean-Pierre (2024). Endogenous glucocorticoids promote neurogenic heterotopic ossification after spinal cord injury and glucocorticoid receptor antagonist treatment prevents their development. 2024 Annual Meeting of the American Society for Bone and Mineral Research (ASBMR), Toronto, ON, Canada, 27-30 September 2024. Cary, NC, United States: Oxford University Press. doi: 10.1093/jbmr/zjae183
2023
Journal Article
Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development
Salga, Marjorie, Samuel, Selwin G., Tseng, Hsu‐Wen, Gatin, Laure, Girard, Dorothée, Rival, Bastien, Barbier, Valerie, Bisht, Kavita, Shatunova, Svetlana, Debaud, Charlotte, Winkler, Ingrid G., Paquereau, Julie, Dinh, Aurélien, Genêt, Guillaume, Kerever, Sébastien, Abback, Paer‐Sélim, Banzet, Sébastien, Genêt, François, Lévesque, Jean‐Pierre and Alexander, Kylie A. (2023). Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development. Journal of Bone and Mineral Research, 38 (11), 1-18. doi: 10.1002/jbmr.4905
2022
Journal Article
Preclinical activity and pharmacokinetic/pharmacodynamic relationship for a series of novel benzenesulfonamide perforin inhibitors
Gartlan, Kate H., Jaiswal, Jagdish K., Bull, Matthew R., Akhlaghi, Hedieh, Sutton, Vivien R., Alexander, Kylie A., Chang, Karshing, Hill, Geoffrey R., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Trapani, Joseph A., Charman, Susan A., Spicer, Julie A. and Jamieson, Stephen M. F. (2022). Preclinical activity and pharmacokinetic/pharmacodynamic relationship for a series of novel benzenesulfonamide perforin inhibitors. ACS Pharmacology and Translational Science, 5 (6), 429-439. doi: 10.1021/acsptsci.2c00009
2022
Journal Article
Inflammasomes and the IL-1 family in bone homeostasis and disease
Tseng, Hsu-Wen, Samuel, Selwin Gabriel, Schroder, Kate, Lévesque, Jean-Pierre and Alexander, Kylie A (2022). Inflammasomes and the IL-1 family in bone homeostasis and disease. Current Osteoporosis Reports, 20 (3), 170-185. doi: 10.1007/s11914-022-00729-8
2022
Journal Article
Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification
Tseng, Hsu‐Wen, Kulina, Irina, Girard, Dorothée, Gueguen, Jules, Vaquette, Cedryck, Salga, Marjorie, Fleming, Whitney, Jose, Beulah, Millard, Susan M., Pettit, Allison R., Schroder, Kate, Thomas, Gethin, Wheeler, Lawrie, Genêt, François, Banzet, Sébastien, Alexander, Kylie A. and Levesque, Jean‐Pierre (2022). Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification. Journal of Bone and Mineral Research, 37 (3), 531-546. doi: 10.1002/jbmr.4482
2022
Journal Article
Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles
Tseng, Hsu-Wen, Girard, Dorothée, Alexander, Kylie A., Millard, Susan M., Torossian, Frédéric, Anginot, Adrienne, Fleming, Whitney, Gueguen, Jules, Goriot, Marie-Emmanuelle, Clay, Denis, Jose, Beulah, Nowlan, Bianca, Pettit, Allison R., Salga, Marjorie, Genêt, François, Bousse-Kerdilès, Marie-Caroline Le, Banzet, Sébastien and Lévesque, Jean-Pierre (2022). Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles. Bone Research, 10 (1) 22, 22. doi: 10.1038/s41413-022-00188-y
2022
Journal Article
Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injury
Alexander, Kylie A., Tseng, Hsu-Wen, Kulina, Irina, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Ruitenberg, Marc J. and Lévesque, Jean-Pierre (2022). Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injury. Neurotrauma Reports, 3 (1), 87-96. doi: 10.1089/neur.2021.0072
2021
Journal Article
Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization
Bisht, Kavita, McGirr, Crystal, Lee, Seo-Youn, Tseng, Hsu-Wen, Fleming, Whitney, Alexander, Kylie A., Matsumoto, Taichi, Barbier, Valérie, Sims, Natalie A., Müller-Newen, Gerhard, Winkler, Ingrid G., Bonig, Halvard and Lévesque, Jean-Pierre (2021). Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization. Leukemia, 36 (2), 333-347. doi: 10.1038/s41375-021-01413-z
2021
Journal Article
Neurogenic heterotopic ossifications recapitulate hematopoietic stem cell niche development within an adult osteogenic muscle environment
Girard, Dorothée, Torossian, Frédéric, Oberlin, Estelle, Alexander, Kylie A., Gueguen, Jules, Tseng, Hsu-Wen, Genêt, François, Lataillade, Jean-Jacques, Salga, Marjorie, Levesque, Jean-Pierre, Le Bousse-Kerdilès, Marie-Caroline and Banzet, Sébastien (2021). Neurogenic heterotopic ossifications recapitulate hematopoietic stem cell niche development within an adult osteogenic muscle environment. Frontiers in Cell and Developmental Biology, 9 611842, 611842. doi: 10.3389/fcell.2021.611842
2020
Journal Article
Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophils
Tseng, Hsu‐Wen, Kulina, Irina, Salga, Marjorie, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Levesque, Jean‐Pierre and Alexander, Kylie A (2020). Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophils. Journal of Bone and Mineral Research, 35 (11) jbmr.4118, 2242-2251. doi: 10.1002/jbmr.4118
2020
Journal Article
When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification
Alexander, Kylie A., Tseng, Hsu-Wen, Salga, Marjorie, Genêt, François and Levesque, Jean-Pierre (2020). When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification. Current Osteoporosis Reports, 18 (6), 666-676. doi: 10.1007/s11914-020-00636-w
2019
Journal Article
Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor
Bisht, Kavita, McGirr, Crystal, Alexander, Kylie A, Fleming, Whitney, Sims, Natalie, Newen, Gerhard Müller-, Winkler, Ingrid G and Levesque, Jean-Pierre (2019). Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor. Blood, 134 (Supplement_1), 4469-4469. doi: 10.1182/blood-2019-127431
2019
Journal Article
Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury
Alexander, Kylie A., Tseng, Hsu-Wen, Fleming, Whitney, Jose, Beulah, Salga, Marjorie, Kulina, Irina, Millard, Susan M., Pettit, Allison R., Genet, Francois and Levesque, Jean-Pierre (2019). Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury. Frontiers in Immunology, 10 (MAR) 377. doi: 10.3389/fimmu.2019.00377
2019
Journal Article
Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice
Salga, Marjorie, Tseng, Hsu-Wen, Alexander, Kylie A., Jose, Beulah, Vaquette, Cedryck, Debaud, Charlotte, Gatin, Laure, Genêt, François and Levesque, Jean-Pierre (2019). Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice. Annals of Physical and Rehabilitation Medicine, 62 (3), 189-192. doi: 10.1016/j.rehab.2019.01.005
2018
Conference Publication
Oncostatin M is a key effector of heterotopic ossification following spinal cord injuries
Tseng, Hsu-Wen, Alexander, Kylie, Kulina, Irina, Salga, Marjorie, Jose, Beulah, Genet, Francois, Torossian, Frederic, Guerton, Bernadette, Anginot, Adrienne, Fleming, Whitney, Millard, Susan, Pettit, Allison, Sims, Natalie, Lataillade, Jean-Jacques, Le Bousse-Kerdiles, Marie-Caroline and Levesque, Jean Pierre (2018). Oncostatin M is a key effector of heterotopic ossification following spinal cord injuries. Annual Meeting of the American Society for Bone and Mineral Research, Montreal Canada, September 28 - October 1 2018. Hoboken, NJ United States: Wiley.
2017
Journal Article
Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms
Levesque, Jean-Pierre, Sims, Natalie A., Pettit, Allison R., Alexander, Kylie A., Tseng, Hsu-Wen, Torossian, Frédéric, Genêt, François, Lataillade, Jean-Jacques and Le Bousse-Kerdilès, Marie-Caroline (2017). Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms. Journal of Bone and Mineral Research, 33 (2), 365-366. doi: 10.1002/jbmr.3346
2017
Journal Article
Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications
Torossian, Frédéric, Guerton, Bernadette, Anginot, Adrienne, Alexander, Kylie A., Desterke, Christophe , Soave, Sabrina, Tseng, Hsu-Wen, Arouche, Nassim, Boutin, Laetitia, Kulina, Irina, Salga, Marjorie, Jose, Beulah, Pettit, Allison R., Clay, Denis, Rochet, Nathalie, Vlachos, Erica, Genet, Guillaume, Debaud, Charlotte, Denormandie, Philippe, Genet, François, Sims, Natalie A., Banzet, Sébastien, Levesque, Jean-Pierre, Lataillade, Jean-Jacques and Le Bousse-Kerdilès, Marie-Caroline (2017). Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight, 2 (21) e96034. doi: 10.1172/jci.insight.96034
Funding
Past funding
Supervision
Availability
- Dr Kylie Alexander is:
- Available for supervision
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Supervision history
Completed supervision
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2023
Doctor Philosophy
Role of infections and gut microflora in the development of neurogenic heterotopic ossifications following spinal cord injury in a mouse model
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
Media
Enquiries
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