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2025 Journal Article Role of endocrinal dysregulations in traumatic heterotopic ossification pathogenesisLévesque, Jean-Pierre and Alexander, Kylie A. (2025). Role of endocrinal dysregulations in traumatic heterotopic ossification pathogenesis. Current Opinion in Endocrinology, Diabetes and Obesity 0913. doi: 10.1097/MED.0000000000000913 |
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2024 Journal Article A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injuryAlexander, Kylie A., Tseng, Hsu-Wen, Lao, Hong Wa, Girard, Dorothée, Barbier, Valérie, Ungerer, Jacobus P. J., McWhinney, Brett C., Samuel, Selwin G., Fleming, Whitney, Winkler, Ingrid G., Salga, Marjorie, Genêt, François, Banzet, Sébastien, Ruitenberg, Marc J. and Lévesque, Jean-Pierre (2024). A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury. Cell Reports Medicine, 5 (12) 101849, 101849. doi: 10.1016/j.xcrm.2024.101849 |
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2024 Conference Publication Endotoxemia As Possible Cause of Inflammatory Bowel Diseases-Associated AnemiaBisht, Kavita, An, Yoon-Kyo, Shatunova, Svetlana, Wang, Ran, Barbier, Valerie, Giri, Rabina, Amiss, Anna, Tang, Yifu, Alexander, Kylie, Millard, Susan, Winkler, Ingrid G., Pettit, Allison, Begun, Jakob and Levesque, Jean-Pierre (2024). Endotoxemia As Possible Cause of Inflammatory Bowel Diseases-Associated Anemia. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-193349 |
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2024 Journal Article Interleukin-6 does not contribute to neurogenic heterotopic ossification pathogenesisGirard, Dorothee, Tseng, Hsu-Wen, Rival, Bastien, Barbier, Valerie, Shatunova, Svetlana, Goriot, Marie-Emmanuelle, Samuel, Selwin Gabriel, Genet, Francois, Salga, Marjorie, Banzet, Sebastien, Alexander, Kylie A. and Levesque, Jean-Pierre (2024). Interleukin-6 does not contribute to neurogenic heterotopic ossification pathogenesis. Neurotrauma Reports, 5 (1), 1101-1112. doi: 10.1089/neur.2024.0106 |
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2024 Conference Publication Endogenous glucocorticoids promote neurogenic heterotopic ossification after spinal cord injury and glucocorticoid receptor antagonist treatment prevents their developmentAlexander, Kylie, Tseng, Hsu-Wen, Girard, Dorothee, Barbier, Valerie, Lao, Hong Wa, Samuel, Selwin G., Ungerer, Jacobus P. J., McWhinney, Brett C., Fleming, Whitney, Salga, Marjorie, Genet, Francois, Ruitenberg, Mark J., Banzet, Sebastien and Levesque, Jean-Pierre (2024). Endogenous glucocorticoids promote neurogenic heterotopic ossification after spinal cord injury and glucocorticoid receptor antagonist treatment prevents their development. 2024 Annual Meeting of the American Society for Bone and Mineral Research (ASBMR), Toronto, ON, Canada, 27-30 September 2024. Cary, NC, United States: Oxford University Press. doi: 10.1093/jbmr/zjae183 |
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2023 Journal Article Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification DevelopmentSalga, Marjorie, Samuel, Selwin G., Tseng, Hsu‐Wen, Gatin, Laure, Girard, Dorothée, Rival, Bastien, Barbier, Valerie, Bisht, Kavita, Shatunova, Svetlana, Debaud, Charlotte, Winkler, Ingrid G., Paquereau, Julie, Dinh, Aurélien, Genêt, Guillaume, Kerever, Sébastien, Abback, Paer‐Sélim, Banzet, Sébastien, Genêt, François, Lévesque, Jean‐Pierre and Alexander, Kylie A. (2023). Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development. Journal of Bone and Mineral Research, 38 (11), 1-18. doi: 10.1002/jbmr.4905 |
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2022 Journal Article Preclinical activity and pharmacokinetic/pharmacodynamic relationship for a series of novel benzenesulfonamide perforin inhibitorsGartlan, Kate H., Jaiswal, Jagdish K., Bull, Matthew R., Akhlaghi, Hedieh, Sutton, Vivien R., Alexander, Kylie A., Chang, Karshing, Hill, Geoffrey R., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Trapani, Joseph A., Charman, Susan A., Spicer, Julie A. and Jamieson, Stephen M. F. (2022). Preclinical activity and pharmacokinetic/pharmacodynamic relationship for a series of novel benzenesulfonamide perforin inhibitors. ACS Pharmacology and Translational Science, 5 (6), 429-439. doi: 10.1021/acsptsci.2c00009 |
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2022 Journal Article Inflammasomes and the IL-1 family in bone homeostasis and diseaseTseng, Hsu-Wen, Samuel, Selwin Gabriel, Schroder, Kate, Lévesque, Jean-Pierre and Alexander, Kylie A (2022). Inflammasomes and the IL-1 family in bone homeostasis and disease. Current Osteoporosis Reports, 20 (3), 170-185. doi: 10.1007/s11914-022-00729-8 |
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2022 Journal Article Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossificationTseng, Hsu‐Wen, Kulina, Irina, Girard, Dorothée, Gueguen, Jules, Vaquette, Cedryck, Salga, Marjorie, Fleming, Whitney, Jose, Beulah, Millard, Susan M., Pettit, Allison R., Schroder, Kate, Thomas, Gethin, Wheeler, Lawrie, Genêt, François, Banzet, Sébastien, Alexander, Kylie A. and Levesque, Jean‐Pierre (2022). Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification. Journal of Bone and Mineral Research, 37 (3), 531-546. doi: 10.1002/jbmr.4482 |
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2022 Journal Article Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within musclesTseng, Hsu-Wen, Girard, Dorothée, Alexander, Kylie A., Millard, Susan M., Torossian, Frédéric, Anginot, Adrienne, Fleming, Whitney, Gueguen, Jules, Goriot, Marie-Emmanuelle, Clay, Denis, Jose, Beulah, Nowlan, Bianca, Pettit, Allison R., Salga, Marjorie, Genêt, François, Bousse-Kerdilès, Marie-Caroline Le, Banzet, Sébastien and Lévesque, Jean-Pierre (2022). Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles. Bone Research, 10 (1) 22, 22. doi: 10.1038/s41413-022-00188-y |
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2022 Journal Article Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injuryAlexander, Kylie A., Tseng, Hsu-Wen, Kulina, Irina, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Ruitenberg, Marc J. and Lévesque, Jean-Pierre (2022). Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injury. Neurotrauma Reports, 3 (1), 87-96. doi: 10.1089/neur.2021.0072 |
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2021 Journal Article Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilizationBisht, Kavita, McGirr, Crystal, Lee, Seo-Youn, Tseng, Hsu-Wen, Fleming, Whitney, Alexander, Kylie A., Matsumoto, Taichi, Barbier, Valérie, Sims, Natalie A., Müller-Newen, Gerhard, Winkler, Ingrid G., Bonig, Halvard and Lévesque, Jean-Pierre (2021). Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization. Leukemia, 36 (2), 333-347. doi: 10.1038/s41375-021-01413-z |
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2021 Journal Article Neurogenic heterotopic ossifications recapitulate hematopoietic stem cell niche development within an adult osteogenic muscle environmentGirard, Dorothée, Torossian, Frédéric, Oberlin, Estelle, Alexander, Kylie A., Gueguen, Jules, Tseng, Hsu-Wen, Genêt, François, Lataillade, Jean-Jacques, Salga, Marjorie, Levesque, Jean-Pierre, Le Bousse-Kerdilès, Marie-Caroline and Banzet, Sébastien (2021). Neurogenic heterotopic ossifications recapitulate hematopoietic stem cell niche development within an adult osteogenic muscle environment. Frontiers in Cell and Developmental Biology, 9 611842, 611842. doi: 10.3389/fcell.2021.611842 |
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2020 Journal Article Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophilsTseng, Hsu‐Wen, Kulina, Irina, Salga, Marjorie, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Levesque, Jean‐Pierre and Alexander, Kylie A (2020). Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophils. Journal of Bone and Mineral Research, 35 (11) jbmr.4118, 2242-2251. doi: 10.1002/jbmr.4118 |
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2020 Journal Article When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossificationAlexander, Kylie A., Tseng, Hsu-Wen, Salga, Marjorie, Genêt, François and Levesque, Jean-Pierre (2020). When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification. Current Osteoporosis Reports, 18 (6), 666-676. doi: 10.1007/s11914-020-00636-w |
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2019 Journal Article Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixaforBisht, Kavita, McGirr, Crystal, Alexander, Kylie A, Fleming, Whitney, Sims, Natalie, Newen, Gerhard Müller-, Winkler, Ingrid G and Levesque, Jean-Pierre (2019). Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor. Blood, 134 (Supplement_1), 4469-4469. doi: 10.1182/blood-2019-127431 |
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2019 Journal Article Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord InjuryAlexander, Kylie A., Tseng, Hsu-Wen, Fleming, Whitney, Jose, Beulah, Salga, Marjorie, Kulina, Irina, Millard, Susan M., Pettit, Allison R., Genet, Francois and Levesque, Jean-Pierre (2019). Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury. Frontiers in Immunology, 10 (MAR) 377. doi: 10.3389/fimmu.2019.00377 |
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2019 Journal Article Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in miceSalga, Marjorie, Tseng, Hsu-Wen, Alexander, Kylie A., Jose, Beulah, Vaquette, Cedryck, Debaud, Charlotte, Gatin, Laure, Genêt, François and Levesque, Jean-Pierre (2019). Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice. Annals of Physical and Rehabilitation Medicine, 62 (3), 189-192. doi: 10.1016/j.rehab.2019.01.005 |
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2018 Conference Publication Oncostatin M is a key effector of heterotopic ossification following spinal cord injuriesTseng, Hsu-Wen, Alexander, Kylie, Kulina, Irina, Salga, Marjorie, Jose, Beulah, Genet, Francois, Torossian, Frederic, Guerton, Bernadette, Anginot, Adrienne, Fleming, Whitney, Millard, Susan, Pettit, Allison, Sims, Natalie, Lataillade, Jean-Jacques, Le Bousse-Kerdiles, Marie-Caroline and Levesque, Jean Pierre (2018). Oncostatin M is a key effector of heterotopic ossification following spinal cord injuries. Annual Meeting of the American Society for Bone and Mineral Research, Montreal Canada, September 28 - October 1 2018. Hoboken, NJ United States: Wiley. |
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2017 Journal Article Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven MechanismsLevesque, Jean-Pierre, Sims, Natalie A., Pettit, Allison R., Alexander, Kylie A., Tseng, Hsu-Wen, Torossian, Frédéric, Genêt, François, Lataillade, Jean-Jacques and Le Bousse-Kerdilès, Marie-Caroline (2017). Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms. Journal of Bone and Mineral Research, 33 (2), 365-366. doi: 10.1002/jbmr.3346 |
