Overview
Availability
- Dr Kylie Alexander is:
- Available for supervision
Qualifications
- Bachelor, Griffith University
- Doctor of Philosophy, The University of Queensland
Research interests
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Neurogenic heterotopic ossification
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Macrophage biology and inflammation
Works
Search Professor Kylie Alexander’s works on UQ eSpace
2017
Journal Article
Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-beta production
Du, Jing, Paz, Katelyn, Flynn, Ryan, Vulic, Ante, Robinson, Tara M., Lineburg, Katie E., Alexander, Kylie A., Meng, Jingjing, Roy, Sabita, Panoskaltsis-Mortari, Angela, Loschi, Michael, Hill, Geoffrey R., Serody, Jonathan S., Maillard, Ivan, Miklos, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, MacDonald, Kelli P., Schacker, Timothy W., Luznik, Leo and Blazar, Bruce R. (2017). Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-beta production. Blood, 129 (18), 2570-2580. doi: 10.1182/blood-2017-01-758854
2016
Journal Article
Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease
Le Texier, Laetitia, Lineburg, Katie E., Cao, Benjamin, McDonald-Hyman, Cameron, Leveque-El Mouttie, Lucie, Nicholls, Jemma, Melino, Michelle, Nalkurthi, Blessy C., Alexander, Kylie A., Teal, Bianca, Blake, Stephen J., Souza-Fonseca-Guimaraes, Fernando, Engwerda, Christian R., Kuns, Rachel D., Lane, Steven W., Teng, Michele, Teh, Charis, Gray, Daniel, Clouston, Andrew D., Nilsson, Susan K., Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2016). Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease. JCI Insight, 1 (15) e86850, e86850. doi: 10.1172/jci.insight.86850
2016
Journal Article
Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration
Alexander, Kylie Anne, Raggatt, Liza-Jane, Millard, Susan, Batoon, Lena, Wu, Andy Chiu-Ku, Chang, Ming-Kang, Hume, David Arthur and Pettit, Allison Robyn (2016). Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration. Immunology and Cell Biology, 95 (1), 7-16. doi: 10.1038/icb.2016.74
2016
Journal Article
Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD
Leveque-El Mouttie, Lucie, Koyama, Motoko, Le Texier, Laetitia, Markey, Kate A., Cheong, Melody, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Alexander, Kylie A., Clouston, Andrew D., Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2016). Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD. Blood, 128 (6), 794-804. doi: 10.1182/blood-2015-11-680876
2016
Conference Publication
Autophagy-dependent TIGIT+ Treg are critical for the maintenance of tolerance
MacDonald, Kelli P. A., Le Texier, Laetitia, Leveque-ElMouttie, Lucie, Lineburg, Katie, Nicholls, Jemma, Guimaraes, Fernando Souza-Fonseca, Alexander, Kylie, Clouston, Andrew, Blazar, Bruce R. and Hill, Geoff R. (2016). Autophagy-dependent TIGIT+ Treg are critical for the maintenance of tolerance. Immunology 2016 Meeting, Seattle, WA United States, 13-17 May 2016. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.196.supp.125.14
2016
Journal Article
Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model
Melino, Michelle, Gadd, Victoria L., Alexander, Kylie A., Beattie, Lynette, Lineburg, Katie E., Martinez, Michelle, Teal, Bianca, Le Texier, Laetitia, Irvine, Katharine M., Miller, Gregory C., Boyle, Glen M., Hill, Geoffrey R., Clouston, Andrew D., Powel, Elizabeth E. and MacDonald, Kelli P. A. (2016). Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model. American Journal of Pathology, 186 (3), 524-538. doi: 10.1016/j.ajpath.2015.10.029
2015
Journal Article
Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease
Flynn, Ryan, Allen, Jessica L., Luznik, Leo, MacDonald, Kelli P., Paz, Katelyn, Alexander, Kylie A., Vulic, Ante, Du, Jing, Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Poe, Jonathan C., Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Maillard, Ivan, Koreth, John, Cutler, Corey S., Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Chao, Nelson J., Clynes, Raphael A., Sarantopoulos, Stefanie and Blazar, Bruce R. (2015). Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease. Blood, 125 (26), 4085-4094. doi: 10.1182/blood-2014-08-595470
2015
Journal Article
Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation
Varelias, Antiopi, Gartlan, Kate H., Kreijveld, Ellen, Olver, Stuart D., Lor, Mary, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Raffelt, Neil C., Cheong, Melody, Alexander, Kylie A., Koyama, Motoko, Markey, Kate A., Sturgeon, Elise, Leach, Justine, Reddy, Pavan, Kennedy, Glen A., Yanik, Gregory A., Blazar, Bruce R., Tey, Siok-Keen, Clouston, Andrew D., MacDonald, Kelli P. A., Cooke, Kenneth R. and Hill, Geoffrey R. (2015). Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation. Blood, 125 (15), 2435-2444. doi: 10.1182/blood-2014-07-590232
2015
Conference Publication
Autophagy-Dependent Tigit Positive Helios Positive Regulatory T Cells Are Critical for Controlling Gvhd After Allogeneic Stem Cell Transplantation
Le Texier, Laetitia, Leveque-ElMouttie, Lucie, Lineburg, Katie E., Alexander, Kylie A., Melino, Michelle, Teal, Bianca, Martinez, Michelle, Kuns, Rachel D., Lane, Steven W., Engwerda, Christian, Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2015). Autophagy-Dependent Tigit Positive Helios Positive Regulatory T Cells Are Critical for Controlling Gvhd After Allogeneic Stem Cell Transplantation. 14th Transplantation Science Symposium of the Transplantation-Society (TSS), Lorne, VIC, Australia, 11-13 November 2015. Philadelphia, PA, United States: Lippincott Williams & Wilkins.
2014
Journal Article
Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification
Raggatt, Liza J., Wullschleger, Martin E., Alexander, Kylie A., Wu, Andy C. K., Millard, Susan M., Kaur, Simranpreet, Maugham, Michelle L., Gregory, Laura S., Steck, Roland and Pettit, Allison R. (2014). Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification. American Journal of Pathology, 184 (12), 3192-3204. doi: 10.1016/j.ajpath.2014.08.017
2014
Conference Publication
Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation
Varelias, Antiopi, Gartlan, Kate H., Kreijveld, Ellen, Olver, Stuart D., Lor, Mary, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Raffelt, Neil C., Cheong, Melody, Alexander, Kylie A., Koyama, Motoko, Markey, Kate A., Sturgeon, Elise, Leach, Justine, Reddy, Pavan, Kennedy, Glen, Yanik, Gregory, Blazar, Bruce R., Tey, Siok K., Clouston, Andrew, MacDonald, Kelli P. A., Cooke, Kenneth R. and Hill, Geoffrey R. (2014). Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, Australia, 26-29 October 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.195
2014
Journal Article
CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease
Alexander K.A., Flynn R., Lineburg K.E., Kuns R.D., Teal B.E., Olver S.D., Lor M., Raffelt N.C., Koyama M., Leveque L., Le Texier L., Melino M., Markey K.A., Varelias A., Engwerda C., Serody J.S., Janela B., Ginhoux F., Clouston A.D., Blazar B.R., Hill G.R. and MacDonald K.P.A. (2014). CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease. Journal of Clinical Investigation, 124 (10), 4266-4280. doi: 10.1172/JCI75935
2014
Conference Publication
CSF-1-dependant M2 macrophages mediate chronic graft-versus-host disease
Alexander, K., Flynn, R., Lineburg, K., Kuns, R., Janela, B., Teal, B., Olver, S., Lor, M., Raffelt, N., Koyama, M., Leveque, L., Le Texier, L., Melino, M., Markey, K., Varelias, A., Ginhoux, F., Engwerda, C., Clouston, A., Blazer, B., Hill, G. and MacDonald, K. (2014). CSF-1-dependant M2 macrophages mediate chronic graft-versus-host disease. World Transplant Congress, San Francisco, CA, United States, 26-31 July 2014. Hoboken, NJ, United States: Wiley-Blackwell.
2014
Conference Publication
CSF-1-Dependant M2 Macrophages Mediate Chronic Graft-Versus-Host Disease
Alexander, K., Flynn, R., Lineburg, K., Kuns, R., Janela, B., Teal, B., Olver, S., Lor, M., Raffelt, N., Koyama, M., Leveque, L., Le Texier, L., Melino, M., Markey, K., Varelias, A., Ginhoux, F., Engwerda, C., Clouston, A., Blazer, B., Hill, G. and MacDonald, K. (2014). CSF-1-Dependant M2 Macrophages Mediate Chronic Graft-Versus-Host Disease. World Transplant Congress, San Francisco United States, Jul 26-31, 2014. Philadelphia United States: Lippincott Williams & Wilkins. doi: 10.1097/01.tp.0000452130.27963.71
2013
Journal Article
Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL
Walsh, N. C., Alexander, K. A., Manning, C. A., Karmakar, S. K., Wang, J. F., Weyand, C. M., Pettit, A. R. and Gravallese, E. M. (2013). Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL. Genes and Immunity, 14 (5), 336-345. doi: 10.1038/gene.2013.29
2013
Journal Article
Unraveling macrophage contributions to bone repair
Wu, Andy C., Raggatt, Liza J., Alexander, Kylie A. and Pettit, Allison R. (2013). Unraveling macrophage contributions to bone repair. BoneKEy Reports, 2 (373), 1-1. doi: 10.1038/bonekey.2013.107
2013
Journal Article
Absence of B cells does Not compromise intramembranous bone formation during healing in a tibial injury model
Raggatt, Liza J., Alexander, Kylie A., Kaur, Simranpreet, Wu, Andy C., MacDonald, Kelli P. A. and Pettit, Allison R. (2013). Absence of B cells does Not compromise intramembranous bone formation during healing in a tibial injury model. American Journal of Pathology, 182 (5), 1501-1508. doi: 10.1016/j.ajpath.2013.01.046
2013
Journal Article
Promoting regulation via the inhibition of DNAM-1 after transplantation
Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Leveque, Lucie, Chan, Christopher J., Robb, Renee J., Markey, Kate A., Alexander, Kylie A., Varelias, Antiopi, Clouston, Andrew D., Smyth, Mark J., MacDonald, Kelli P.A. and Hill, Geoffrey R. (2013). Promoting regulation via the inhibition of DNAM-1 after transplantation. Blood, 121 (17), 3511-3520. doi: 10.1182/blood-2012-07-444026
2013
Conference Publication
Fracture Healing Via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Endochondral Ossification
Pettit, A., Raggatt, L., Wullschleger, M., Alexander, K., Steck, R., Kaur, S. and Wu, A. (2013). Fracture Healing Via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Endochondral Ossification. Annual Meeting of the American Society for Bone and Mineral Research, Baltimore MD United States, 4-7 October 2013. Hoboken, NJ United States: Wiley-Blackwell.
2013
Conference Publication
Lung Parenchyma-Derived IL-6 Induces Alloantigen Specific Th17 Differentiation Within The Lung and Idiopathic Pneumonia Syndrome After Allogeneic Stem Cell Transplantation
Varelias, Antiopi, Gartlan, Kate H., Olver, Stuart D., Lineburg, Katie E., Kuns, Rachel D., Lor, Mary, Teal, Bianca E., Cheong, Melody, Koyama, Motoko, Markey, Kate A., Alexander, Kylie, Budelsky, Alison, Sturgeon, Elise, Leach, Justine, Avery, Judy, Kennedy, Glen A., Siok-Tey, Clouston, Andrew D., MacDonald, Kelli P. A. and Hill, Geoff R. (2013). Lung Parenchyma-Derived IL-6 Induces Alloantigen Specific Th17 Differentiation Within The Lung and Idiopathic Pneumonia Syndrome After Allogeneic Stem Cell Transplantation. 55th Annual Meeting of the American Society of Hematology, New Orleans, LA United States, 7-10 December 2013. Washington, DC United States: American Society of Hematology.
Funding
Past funding
Supervision
Availability
- Dr Kylie Alexander is:
- Available for supervision
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Supervision history
Completed supervision
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2023
Doctor Philosophy
Role of infections and gut microflora in the development of neurogenic heterotopic ossifications following spinal cord injury in a mouse model
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
Media
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