Overview
Background
Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research Institute - the University of Queensland, Brisbane, Australia.
A/Prof Winkler’s research focuse is understanding how micro-environments in the body protect and control normal and/or malignant stem Cells. Her innovative stem cell niche research has been recognised as among ten of the best research projects in Australia (by National Health and Medical Research Council) with patents and clinical translation.
A/Prof Winker's current research explores how stem cell niches change with ageing, inflammation, cancer therapy or radiation damage, with view to identify key detrimental niche components involved. This knowledge may be used to develop novel treatment strategies to improve cancer therapy outcomes, alleviate adverse cancer therapy side-effects that currently affect up tp 80% of Australian cancer therapy patientts plus facilitate healthier old age.
Availability
- Dr Ingrid Winkler is:
- Available for supervision
Research impacts
A/Prof's research on how normal and malignant cells alter their local environment (niches) was at the forefront of this new field. The identification of mechanisms by which normal and malignant cells change their niche, enabled these components to be therapeutically targeted leading to high impact manuscripts, industry partnerships and clinical translation with large Phase 2/3 clinical trials ongoing.
Works
Search Professor Ingrid Winkler’s works on UQ eSpace
2024
Journal Article
Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?
Uy, Geoffrey L., DeAngelo, Daniel J., Lozier, Jay N., Fisher, Dennis M., Jonas, Brian A., Magnani, John L., Becker, Pamela S., Lazarus, Hillard M. and Winkler, Ingrid G. (2024). Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?. Blood Reviews, 65 101184, 101184. doi: 10.1016/j.blre.2024.101184
2023
Journal Article
Characterization of human engraftment and hemophagocytic lymphohistiocytosis in NSG-SGM3 neonate mice engrafted with purified CD34+ hematopoietic stem cells
Liam, O'Brien, Carina, Walpole, Ingrid, Leal-Rojas, Svetlana, Shatunova, Andrew, Moore, Winkler, Ingrid G, Camille, Guillerey and Radford, Kristen J (2023). Characterization of human engraftment and hemophagocytic lymphohistiocytosis in NSG-SGM3 neonate mice engrafted with purified CD34+ hematopoietic stem cells. Experimental Hematology, 130 104134, 104134. doi: 10.1016/j.exphem.2023.11.008
2023
Journal Article
Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development
Salga, Marjorie, Samuel, Selwin G., Tseng, Hsu‐Wen, Gatin, Laure, Girard, Dorothée, Rival, Bastien, Barbier, Valerie, Bisht, Kavita, Shatunova, Svetlana, Debaud, Charlotte, Winkler, Ingrid G., Paquereau, Julie, Dinh, Aurélien, Genêt, Guillaume, Kerever, Sébastien, Abback, Paer‐Sélim, Banzet, Sébastien, Genêt, François, Lévesque, Jean‐Pierre and Alexander, Kylie A. (2023). Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development. Journal of Bone and Mineral Research, 38 (11), 1-18. doi: 10.1002/jbmr.4905
2023
Book Chapter
Imaging flow cytometric analysis of primary bone marrow erythroblastic islands
Tay, Joshua, Bisht, Kavita, Winkler, Ingrid G. and Levesque, Jean-Pierre (2023). Imaging flow cytometric analysis of primary bone marrow erythroblastic islands. Spectral and imaging cytometry methods and protocols. (pp. 43-61) edited by Natasha S. Barteneva and Ivan A. Vorobjev. New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-3020-4_3
2022
Journal Article
The role of the neuronal microenvironment in sensory function and pain pathophysiology
Starobova, Hana, Alshammari, Ammar, Winkler, Ingrid G. and Vetter, Irina (2022). The role of the neuronal microenvironment in sensory function and pain pathophysiology. Journal of Neurochemistry. doi: 10.1111/jnc.15724
2021
Journal Article
Macrophages form erythropoietic niches and regulate iron homeostasis to adapt erythropoiesis in response to infections and inflammation
Lévesque, Jean-Pierre, Summers, Kim M., Bisht, Kavita, Millard, Susan M., Winkler, Ingrid G. and Pettit, Allison R. (2021). Macrophages form erythropoietic niches and regulate iron homeostasis to adapt erythropoiesis in response to infections and inflammation. Experimental Hematology, 103, 1-14. doi: 10.1016/j.exphem.2021.08.011
2021
Journal Article
Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization
Bisht, Kavita, McGirr, Crystal, Lee, Seo-Youn, Tseng, Hsu-Wen, Fleming, Whitney, Alexander, Kylie A., Matsumoto, Taichi, Barbier, Valérie, Sims, Natalie A., Müller-Newen, Gerhard, Winkler, Ingrid G., Bonig, Halvard and Lévesque, Jean-Pierre (2021). Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization. Leukemia, 36 (2), 333-347. doi: 10.1038/s41375-021-01413-z
2021
Journal Article
Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress
Tay, Joshua, Barbier, Valerie, Helwani, Falak M, Price, Gareth R, Levesque, Jean-Pierre and Winkler, Ingrid G (2021). Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress. Stem Cells, 39 (11), 1532-1545. doi: 10.1002/stem.3438
2021
Journal Article
Adhesion to E-selectin primes macrophages for activation through AKT and mTOR
Davies, Julie M., Radford, Kristen J., Begun, Jakob, Levesque, Jean-Pierre and Winkler, Ingrid G. (2021). Adhesion to E-selectin primes macrophages for activation through AKT and mTOR. Immunology and Cell Biology, 99 (6) imcb.12447, 622-639. doi: 10.1111/imcb.12447
2021
Journal Article
Inteligência artificial e virtualização em ambientes virtuais de ensino e aprendizagem: desafios e perspectivas tecnológicas
Santos, Sanval Ebert de Freitas, Jorge, Eduardo Manuel de Freitas and Winkler, Ingrid (2021). Inteligência artificial e virtualização em ambientes virtuais de ensino e aprendizagem: desafios e perspectivas tecnológicas. ETD - Educação Temática Digital, 23 (1), 2-19. doi: 10.20396/etd.v23i1.8656150
2020
Journal Article
Acute myeloid leukemia chemo-resistance is mediated by E-selectin receptor CD162 in bone marrow niches
Erbani, Johanna, Tay, Joshua, Barbier, Valerie, Levesque, Jean-Pierre and Winkler, Ingrid G. (2020). Acute myeloid leukemia chemo-resistance is mediated by E-selectin receptor CD162 in bone marrow niches. Frontiers in Cell and Developmental Biology, 8 668, 668. doi: 10.3389/fcell.2020.00668
2020
Journal Article
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
Barbier, Valerie, Erbani, Johanna, Fiveash, Corrine, Davies, Julie M., Tay, Joshua, Tallack, Michael R., Lowe, Jessica, Magnani, John L., Pattabiraman, Diwakar R., Perkins, Andrew C., Lisle, Jessica, Rasko, John E. J., Levesque, Jean-Pierre and Winkler, Ingrid G. (2020). Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance. Nature Communications, 11 (1) 2042, 2042. doi: 10.1038/s41467-020-15817-5
2020
Journal Article
Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrow
Tay, Joshua, Bisht, Kavita, McGirr, Crystal, Millard, Susan M., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2020). Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrow. Experimental Hematology, 82, 33-42. doi: 10.1016/j.exphem.2020.02.003
2019
Conference Publication
CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche
Erbani, Johanna D., Tay, Joshua, Barbier, Valerie, Levesque, Jean-Pierre, Magnani, John L. and Winkler, Ingrid G. (2019). CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche. 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Orlando, FL, United States, 7-10 December 2019. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2019-132233
2019
Conference Publication
Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways
Winkler, Ingrid G., Barbier, Valerie, Tay, Joshua, Levesque, Jean-Pierre, Magnani, John L., Fiveash, Corrine E. and Erbani, Johanna D. (2019). Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways. 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Orlando, FL, United States, 7-10 December 2019. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2019-132212
2019
Journal Article
Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor
Bisht, Kavita, McGirr, Crystal, Alexander, Kylie A, Fleming, Whitney, Sims, Natalie, Newen, Gerhard Müller-, Winkler, Ingrid G and Levesque, Jean-Pierre (2019). Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor. Blood, 134 (Supplement_1), 4469-4469. doi: 10.1182/blood-2019-127431
Featured
2019
Journal Article
Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells
Lukowski, Samuel W., Patel, Jatin, Andersen, Stacey B., Sim, Seen-Ling, Wong, Ho Yi, Tay, Joshua, Winkler, Ingrid, Powell, Joseph E. and Khosrotehrani, Kiarash (2019). Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells. Cell Reports, 27 (9), 2748-2758. doi: 10.1016/j.celrep.2019.04.102
2019
Conference Publication
Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells
Patel, Jatin, Lukowski, Samuel L., Winkler, Ingrid, Tay, Joshua and Khosrotehrani, Kiarash (2019). Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells. Annual Scientific Meeting and Scientific Sessions of the American-Heart-Association on Vascular Discovery - From Genes to Medicine, Boston, MA United States, 14-16 May 2019. Philadelphia, PA United States: Lippincott Williams & Wilkins.
2019
Journal Article
HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR
Bisht, Kavita, Brunck, Marion E., Matsumoto, Taichi, McGirr, Crystal, Nowlan, Bianca, Fleming, Whitney, Keech, Thomas, Magor, Graham, Perkins, Andrew C., Davies, Julie, Walkinshaw, Gail, Flippin, Lee, Winkler, Ingrid G. and Levesque, Jean-Pierre (2019). HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR. Blood Advances, 3 (3), 406-418. doi: 10.1182/bloodadvances.2018017566
2018
Journal Article
Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment
Kaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663
Funding
Current funding
Supervision
Availability
- Dr Ingrid Winkler is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Reducing long-term side-effects of chemotherapy in cancer survivors
Associate Advisor
Other advisors: Dr Hana Starobova, Professor Irina Vetter
-
Doctor Philosophy
Understanding pain mechanisms in the path towards target-specific analgesic agent design
Associate Advisor
Other advisors: Dr Hana Starobova, Professor Irina Vetter
Completed supervision
-
2024
Doctor Philosophy
Immune cell regulation by the microenvironment
Principal Advisor
Other advisors: Honorary Professor Kristen Radford, Dr Hana Starobova
-
-
2019
Doctor Philosophy
The role of bone marrow niches in the regulation of normal and malignant haematopoietic stem cells
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
-
2017
Doctor Philosophy
The role of prostaglandin I2 in haematopoietic stem cell in the bone marrow niche
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
-
2015
Doctor Philosophy
Understanding heterotopic ossification after spinal cord injury
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
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2023
Doctor Philosophy
Unravelling the response and functional role of microglia in different inflammatory conditions
Associate Advisor
Other advisors: Professor Marc Ruitenberg, Associate Professor Jana Vukovic
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2022
Doctor Philosophy
Establishing Humanized Mouse Models to Evaluate Immunotherapy
Associate Advisor
Other advisors: Dr Camille Guillerey, Honorary Professor Kristen Radford
-
2021
Doctor Philosophy
The Role of Macrophages in Acute Myeloid Leukaemia Progression and Sensitivity to Chemotherapy
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
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2015
Doctor Philosophy
Role of Bone Marrow Macrophages in Regulating Haematopoiesis
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
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2011
Doctor Philosophy
The Role of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in Haematopoiesis
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
Media
Enquiries
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