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2019 Journal Article Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4Landsem, A., Fure, H., Krey Ludviksen, J., Christiansen, D., Lau, C., Mathisen, M., Bergseth, G., Nymo, S., Lappegård, K. T., Woodruff, T. M., Espevik, T., Mollnes, T. E. and Brekke, O. L. (2019). Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4. Clinical and Experimental Immunology, 196 (1), 97-110. doi: 10.1111/cei.13240 |
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2019 Journal Article Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Liu, Ning, Levin, Samantha C., Ottosson, Lars, Andersson, Ulf, Harris, Helena E. and Woodruff, Trent M. (2019). Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 16 (1) 45, 45. doi: 10.1186/s12974-019-1435-2 |
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2018 Journal Article C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliteransVerghese, Divya A., Chun, Nicholas, Paz, Katelyn, Fribourg, Miguel, Woodruff, Trent M., Flynn, Ryan, Hu, Yuan, Xiong, Huabao, Zhang, Weijia, Yi, Zhengzi, Du, Jing, Blazar, Bruce R. and Heeger, Peter S. (2018). C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans. JCI Insight, 3 (24). doi: 10.1172/jci.insight.124646 |
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2018 Journal Article Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signallingSchofield, Zoe V., Croker, Daniel, Robertson, Avril A. B., Massey, Nicholas L., Donovan, Chantal, Tee, Ernest, Edwards, David, Woodruff, Trent M., Halai, Reena, Hansbro, Philip M. and Cooper, Matthew A. (2018). Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling. Scientific Reports, 8 (1) 17819, 17819. doi: 10.1038/s41598-018-36242-1 |
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2018 Journal Article Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performanceCoulthard, Liam G., Hawksworth, Owen A., Conroy, Jacinta, Lee, John D. and Woodruff, Trent M. (2018). Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance. Molecular Immunology, 101, 176-181. doi: 10.1016/j.molimm.2018.06.271 |
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2018 Journal Article New tricks for an ancient system: physiological and pathological roles of complement in the CNSTenner, Andrea J., Stevens, Beth and Woodruff, Trent M. (2018). New tricks for an ancient system: physiological and pathological roles of complement in the CNS. Molecular Immunology, 102, 3-13. doi: 10.1016/j.molimm.2018.06.264 |
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2018 Journal Article Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosisLee, John D., Levin, Samantha C., Willis, Emily F., Li, Rui, Woodruff, Trent M. and Noakes, Peter G. (2018). Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 15 (1) 171, 171. doi: 10.1186/s12974-018-1217-2 |
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2018 Journal Article Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in miceKumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4 |
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2018 Journal Article Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitisMichailidou, Iliana, Jongejan, Aldo, Vreijling, Jeroen P., Georgakopoulou, Theodosia, de Wissel, Marit B., Wolterman, Ruud A., Ruizendaal, Patrick, Klar-Mohamad, Ngaisah, Grootemaat, Anita E., Picavet, Daisy I., Kumar, Vinod, van Kooten, Cees, Woodruff, Trent M., Morgan, B. Paul, van der Wel, Nicole N., Ramaglia, Valeria, Fluiter, Kees and Baas, Frank (2018). Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis. Acta Neuropathologica Communications, 6 (1) 36, 36. doi: 10.1186/s40478-018-0536-y |
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2018 Journal Article T cell expression of C5a receptor 2 augments murine regulatory T cell (T) generation and T-dependent cardiac allograft survivalA. Verghese, Divya, Demir, Markus, Chun, Nicholas, Fribourg, Miguel, Cravedi, Paolo, Llaudo, Ines, Woodruff, Trent M., Yadav, Pragya, Lira, Sergio A., Medof, M. Edward and Heeger, Peter S. (2018). T cell expression of C5a receptor 2 augments murine regulatory T cell (T) generation and T-dependent cardiac allograft survival. Journal of Immunology, 200 (6), 2186-2198. doi: 10.4049/jimmunol.1701638 |
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2018 Journal Article Complement in stem cells and developmentHawksworth, Owen A., Coulthard, Liam G., Mantovani, Susanna and Woodruff, Trent M (2018). Complement in stem cells and development. Seminars in Immunology, 37 (C), 74-84. doi: 10.1016/j.smim.2018.02.009 |
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2018 Journal Article Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviourGiacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018). Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour. The Journal of Infectious Diseases, 218 (9), 1511-1516. doi: 10.1093/infdis/jiy092 |
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2018 Journal Article Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulationSkjeflo, E. W., Christiansen, D., Fure, H., Ludviksen, J. K., Woodruff, T. M., Espevik, Terje, Nielsen, E. W., Brekke, O. L. and Mollnes, T. E. (2018). Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation. Journal of Thrombosis and Haemostasis, 16 (5), 905-918. doi: 10.1111/jth.13979 |
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2018 Journal Article Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced painMorgan, Michael, Deuis, Jennifer R., Woodruff, Trent M., Lewis, Richard J. and Vetter, Irina (2018). Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology, 94, 68-74. doi: 10.1016/j.molimm.2017.12.016 |
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2018 Journal Article Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease TreatmentHerrmann, Johannes B., Muenstermann, Marcel, Strobel, Lea, Schubert-Unkmeir, Alexandra, Woodruff, Trent M., Gray-Owen, Scott D., Klos, Andreas and Johswich, Kay O. (2018). Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment. mBio, 9 (1) e01755-17, 1-17. doi: 10.1128/mBio.01755-17 |
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2017 Journal Article C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritisDick, Jonathan, Gan, Poh-Yi, Ford, Sharon L., Odobasic, Dragana, Alikhan, Maliha A., Loosen, Sven H., Hall, Pam, Westhorpe, Clare L., Li, Anqi, Ooi, Joshua D., Woodruff, Trent M., Mackay, Charles R., Kitching, A Richard, Hickey, Michael J. and Holdsworth, Stephen R. (2017). C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis. Kidney International, 93 (3), 615-625. doi: 10.1016/j.kint.2017.09.018 |
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2017 Journal Article The concise guide to pharmacology 2017/18: OverviewAlexander, Stephen P. H., Kelly, Eamonn, Marrion, Neil V., Peters, John A., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Buneman, O. Peter, Cidlowski, John A., Christopoulos, Arthur, Davenport, Anthony P., Fabbro, Doriano, Spedding, Michael, Striessnig, Jorg, Davies, Jamie A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K., Arumugam, T., V, Attali, B., Back, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M. ... Woodruff, Trent (2017). The concise guide to pharmacology 2017/18: Overview. British Journal of Pharmacology, 174, S1-S16. doi: 10.1111/bph.13882/full |
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2017 Journal Article Monitoring C5AR2 expression using a floxed tdtomato-C5AR2 knock-in mouseKarsten, Christian M., Wiese, Anna V., Mey, Fabian, Figge, Julia, Woodruff, Trent M., Reuter, Tom, Scurtu, Olga, Kordowski, Anna, Almeida, Larissa N., Briukhovetska, Daria, Quell, Katharina M., Sun, Jing, Ender, Fanny, Schmudde, Inken, Vollbrandt, Tillman, Laumonnier, Yves and Köhl, Jörg (2017). Monitoring C5AR2 expression using a floxed tdtomato-C5AR2 knock-in mouse. Journal of Immunology, 199 (9), 3234-3248. doi: 10.4049/jimmunol.1700710 |
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2017 Journal Article New concepts on the therapeutic control of complement anaphylatoxin receptorsHawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J. and Woodruff, Trent M. (2017). New concepts on the therapeutic control of complement anaphylatoxin receptors. Molecular Immunology, 89, 36-43. doi: 10.1016/j.molimm.2017.05.015 |
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2017 Journal Article Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammationChen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4 |
