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2023 Journal Article Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infectionSikder, Md. Al Amin, Rashid, Ridwan B., Ahmed, Tufael, Sebina, Ismail, Howard, Daniel R., Ullah, Md. Ashik, Rahman, Muhammed Mahfuzur, Lynch, Jason P., Curren, Bodie, Werder, Rhiannon B., Simpson, Jennifer, Bissell, Alec, Morrison, Mark, Walpole, Carina, Radford, Kristen J., Kumar, Vinod, Woodruff, Trent M., Ying, Tan Hui, Ali, Ayesha, Kaiko, Gerard E., Upham, John W., Hoelzle, Robert D., Cuív, Páraic Ó., Holt, Patrick G., Dennis, Paul G. and Phipps, Simon (2023). Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity, 56 (5), 1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002 |
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2023 Journal Article TLQP-21 is a low potency partial C3aR activator on human primary macrophagesLi, Xaria X., Lee, John D., Lee, Han S., Clark, Richard J. and Woodruff, Trent M. (2023). TLQP-21 is a low potency partial C3aR activator on human primary macrophages. Frontiers in Immunology, 14 1086673, 1-10. doi: 10.3389/fimmu.2023.1086673 |
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2022 Journal Article Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022)Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y. (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022). Advanced Therapeutics, 5 (12) 2270030, 1-1. doi: 10.1002/adtp.202270030 |
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2022 Journal Article Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptorsCoughlan, Melinda T., Ziemann, Mark, Laskowski, Adrienne, Woodruff, Trent M. and Tan, Sih Min (2022). Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors. Scientific Reports, 12 (1) 20278, 1-10. doi: 10.1038/s41598-022-24851-w |
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2022 Journal Article Synthetic oligodeoxynucleotide CpG motifs activate human complement through their backbone structure and induce complement-dependent cytokine releasede Boer, Eline, Sokolova, Marina, Quach, Huy Q., McAdam, Karin E., Götz, Maximilian P., Chaban, Viktoriia, Vaage, Jarle, Fageräng, Beatrice, Woodruff, Trent M., Garred, Peter, Nilsson, Per H., Mollnes, Tom E. and Pischke, Søren E. (2022). Synthetic oligodeoxynucleotide CpG motifs activate human complement through their backbone structure and induce complement-dependent cytokine release. The Journal of Immunology, 209 (9), 1760-1767. doi: 10.4049/jimmunol.2101191 |
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2022 Journal Article Complement system inhibition modulates the inflammation induced by the venom of Premolis semirufa, an Amazon rainforest moth caterpillarGabrili, Joel J. M., Villas-Boas, Isadora Maria, Pidde, Giselle, Squaiella-Baptistão, Carla Cristina, Woodruff, Trent M. and Tambourgi, Denise V. (2022). Complement system inhibition modulates the inflammation induced by the venom of Premolis semirufa, an Amazon rainforest moth caterpillar. International Journal of Molecular Sciences, 23 (21) 13333, 1-20. doi: 10.3390/ijms232113333 |
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2022 Journal Article Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disordersMcDonald, Tanya S., Lerskiatiphanich, Titaya, Woodruff, Trent M., McCombe, Pamela A. and Lee, John D. (2022). Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders. Journal of Cerebral Blood Flow and Metabolism, 43 (1), 26-43. doi: 10.1177/0271678x221135061 |
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2022 Journal Article Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacyXu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics, 5 (12) 2200109, 2200109. doi: 10.1002/adtp.202200109 |
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2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
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2022 Journal Article Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variantsIsaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262 |
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2022 Journal Article Thrombin differentially modulates the acute inflammatory response to Escherichia coli and Staphylococcus aureus in human whole bloodJohnson, Christina, Quach, Huy Quang, Lau, Corinna, Ekholt, Karin, Espevik, Terje, Woodruff, Trent M., Pischke, Søren Erik, Mollnes, Tom Eirik and Nilsson, Per H. (2022). Thrombin differentially modulates the acute inflammatory response to Escherichia coli and Staphylococcus aureus in human whole blood. The Journal of Immunology, 208 (12), 2771-2778. doi: 10.4049/jimmunol.2101033 |
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2022 Journal Article Bothrops jararaca snake venom inflammation induced in human whole blood: role of the complement systemLeonel, Thyago Bispo, Gabrili, Joel José Megale, Squaiella-Baptistão, Carla Cristina, Woodruff, Trent M., Lambris, John D. and Tambourgi, Denise V. (2022). Bothrops jararaca snake venom inflammation induced in human whole blood: role of the complement system. Frontiers in Immunology, 13 885223, 1-16. doi: 10.3389/fimmu.2022.885223 |
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2022 Journal Article Complement drives circuit modulation in the adult brainParker, Sandra E., Bellingham, Mark C. and Woodruff, Trent M. (2022). Complement drives circuit modulation in the adult brain. Progress in Neurobiology, 214 102282, 102282. doi: 10.1016/j.pneurobio.2022.102282 |
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2022 Journal Article Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasisOrtiz-Espinosa, Sergio, Morales, Xabier, Senent, Yaiza, Alignani, Diego, Tavira, Beatriz, Macaya, Irati, Ruiz, Borja, Moreno, Haritz, Remírez, Ana, Sainz, Cristina, Rodriguez-Pena, Alejandro, Oyarbide, Alvaro, Ariz, Mikel, Andueza, Maria P., Valencia, Karmele, Teijeira, Alvaro, Hoehlig, Kai, Vater, Axel, Rolfe, Barbara, Woodruff, Trent M., Lopez-Picazo, Jose Maria, Vicent, Silvestre, Kochan, Grazyna, Escors, David, Gil-Bazo, Ignacio, Perez-Gracia, Jose Luis, Montuenga, Luis M., Lambris, John D., Ortiz de Solorzano, Carlos ... Pio, Ruben (2022). Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. Cancer Letters, 529, 70-84. doi: 10.1016/j.canlet.2021.12.027 |
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2022 Journal Article Reduced Growth, Altered Gut Microbiome and Metabolite Profile, and Increased Chronic Kidney Disease Risk in Young Pigs Consuming a Diet Containing Highly Resistant ProteinMurray, Margaret, Coughlan, Melinda T., Gibbon, Anne, Kumar, Vinod, Marques, Francine Z., Selby-Pham, Sophie, Snelson, Matthew, Tsyganov, Kirill, Williamson, Gary, Woodruff, Trent M., Wu, Tong and Bennett, Louise E. (2022). Reduced Growth, Altered Gut Microbiome and Metabolite Profile, and Increased Chronic Kidney Disease Risk in Young Pigs Consuming a Diet Containing Highly Resistant Protein. Frontiers in Nutrition, 9 816749, 816749. doi: 10.3389/fnut.2022.816749 |
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2021 Journal Article In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacyCui, Cedric S., Kumar, Vinod, Gorman, Declan M., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacy. ACS Pharmacology and Translational Science, 5 (1) acsptsci.1c00227, 41-51. doi: 10.1021/acsptsci.1c00227 |
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2021 Journal Article Unexpected off-target activities for recombinant C5a in human macrophagesLi, Xaria X., Gorman, Declan M., Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2021). Unexpected off-target activities for recombinant C5a in human macrophages. Journal of Immunology, 208 (1), 133-142. doi: 10.4049/jimmunol.2100444 |
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2021 Journal Article Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in miceXu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3 |
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2021 Journal Article Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivoGorman, Declan M., Li, Xaria X., Payne, Colton D., Cui, Cedric S., Lee, John D., Rosengren, K. Johan, Woodruff, Trent M. and Clark, Richard J. (2021). Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivo. ACS Pharmacology and Translational Science, 4 (6) acsptsci.1c00199, 1808-1817. doi: 10.1021/acsptsci.1c00199 |
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2021 Journal Article Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo ActivityGorman, Declan M., Li, Xaria X., Lee, John D., Fung, Jenny N., Cui, Cedric S., Lee, Han Siean, Rolfe, Barbara E., Woodruff, Trent M. and Clark, Richard J. (2021). Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. Journal of Medicinal Chemistry, 64 (22) acs.jmedchem.1c01174, 16598-16608. doi: 10.1021/acs.jmedchem.1c01174 |
