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2017 Journal Article The concise guide to pharmacology 2017/18: OverviewAlexander, Stephen P. H., Kelly, Eamonn, Marrion, Neil V., Peters, John A., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Buneman, O. Peter, Cidlowski, John A., Christopoulos, Arthur, Davenport, Anthony P., Fabbro, Doriano, Spedding, Michael, Striessnig, Jorg, Davies, Jamie A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K., Arumugam, T., V, Attali, B., Back, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M. ... Woodruff, Trent (2017). The concise guide to pharmacology 2017/18: Overview. British Journal of Pharmacology, 174, S1-S16. doi: 10.1111/bph.13882/full |
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2017 Journal Article Monitoring C5AR2 expression using a floxed tdtomato-C5AR2 knock-in mouseKarsten, Christian M., Wiese, Anna V., Mey, Fabian, Figge, Julia, Woodruff, Trent M., Reuter, Tom, Scurtu, Olga, Kordowski, Anna, Almeida, Larissa N., Briukhovetska, Daria, Quell, Katharina M., Sun, Jing, Ender, Fanny, Schmudde, Inken, Vollbrandt, Tillman, Laumonnier, Yves and Köhl, Jörg (2017). Monitoring C5AR2 expression using a floxed tdtomato-C5AR2 knock-in mouse. Journal of Immunology, 199 (9), 3234-3248. doi: 10.4049/jimmunol.1700710 |
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2017 Journal Article New concepts on the therapeutic control of complement anaphylatoxin receptorsHawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J. and Woodruff, Trent M. (2017). New concepts on the therapeutic control of complement anaphylatoxin receptors. Molecular Immunology, 89, 36-43. doi: 10.1016/j.molimm.2017.05.015 |
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2017 Journal Article Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammationChen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4 |
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2017 Journal Article The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microgliaDeora, Vandana, Albornoz, Eduardo A., Zhu, Kevin, Woodruff, Trent M. and Gordon, Richard (2017). The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microglia. Journal of Neuroimmune Pharmacology, 12 (4), 1-7. doi: 10.1007/s11481-017-9754-5 |
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2017 Journal Article Serping1/C1 inhibitor affects cortical development in a cell autonomous and non-cell autonomous mannerGorelik, Anna, Sapir, Tamar, Woodruff, Trent M. and Reiner, Orly (2017). Serping1/C1 inhibitor affects cortical development in a cell autonomous and non-cell autonomous manner. Frontiers in Cellular Neuroscience, 11 169. doi: 10.3389/fncel.2017.00169 |
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2017 Journal Article Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosisWang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M. and Noakes, Peter G. (2017). Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Skeletal Muscle, 7 (1) 10, 10. doi: 10.1186/s13395-017-0128-8 |
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2017 Journal Article Developmental activities of the complement pathway in migrating neuronsGorelik, Anna , Sapir, Tamar , Haffner-Krausz, Rebecca , Olender, Tsviya , Woodruff, Trent M. and Reiner, Orly (2017). Developmental activities of the complement pathway in migrating neurons. Nature Communications, 8 (1) 15096, 15096 .1-15096 .12. doi: 10.1038/ncomms15096 |
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2017 Journal Article The alternative receptor for complement component 5a, C5aR2, conveys neuroprotection in traumatic spinal cord injuryBiggins, Patrick, Brennan, Faith, Taylor, Stephen, Woodruff, Trent and Ruitenberg, Marc (2017). The alternative receptor for complement component 5a, C5aR2, conveys neuroprotection in traumatic spinal cord injury. Journal of Neurotrauma, 34 (12), 2075-2085. doi: 10.1089/neu.2016.4701 |
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2017 Journal Article Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanismJain, U., Midgen, C. A., Woodruff, T. M., Schwaeble, W. J., Stover, C. M. and Stadnyk, A. W. (2017). Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanism. Clinical and Experimental Immunology, 188 (1), 36-44. doi: 10.1111/cei.12922 |
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2017 Journal Article Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring systemSpiers, Jereme G., Chen, Hsiao-Jou Cortina, Steyn, Frederik J., Lavidis, Nickolas A., Woodruff, Trent M. and Lee, John D. (2017). Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system. Stress, 20 (1), 59-67. doi: 10.1080/10253890.2016.1276898 |
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2016 Journal Article Complement in the fundamental processes of the cellHawksworth, Owen A., Coulthard, Liam G. and Woodruff, Trent M. (2016). Complement in the fundamental processes of the cell. Molecular Immunology, 84, 17-25. doi: 10.1016/j.molimm.2016.11.010 |
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2016 Journal Article Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degenerationGordon, Richard, Neal, Matthew L., Luo, Jie, Langley, Monica R., Harischandra, Dilshan S., Panicker, Nikhil, Charli, Adhithiya, Jin, Huajun, Anantharam, Vellareddy, Woodruff, Trent M., Zhou, Qun-Yong, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications, 7 (1) 12932, 12932.1-12932.18. doi: 10.1038/ncomms12932 |
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2016 Journal Article Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signallingCroker, Daniel E., Monk, Peter N., Halai, Reena, Kaeslin, Geraldine, Schofield, Zoe, Wu, Mike C. L., Clark, Richard J., Blaskovich, Mark A. T., Morikis, Dimitrios, Floudas, Christodoulos A., Cooper, Matthew and Woodruff, Trent M. (2016). Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. Immunology and Cell Biology, 94 (8), 787-795. doi: 10.1038/icb.2016.43 |
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2016 Journal Article Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer compositionZhang, Jing, Woodruff, Trent M., Clark, Richard J., Martin, Darren J. and Minchin, Rodney F. (2016). Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition. Acta Biomaterialia, 41, 264-272. doi: 10.1016/j.actbio.2016.05.034 |
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2016 Journal Article C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupusMahajan, Supriya D., Tutino, Vincent M., Redae, Yonas, Meng, Hui, Siddiqui, Adnan, Woodruff, Trent M., Jarvis, James N., Hennon, Teresa, Schwartz, Stanley, Quigg, Richard J. and Alexander, Jessy J. (2016). C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology, 148 (4), 407-419. doi: 10.1111/imm.12619 |
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2016 Journal Article Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosisGu, Hongmei, Fisher, Amanda J., Mickler, Elizabeth A., Duerson, Frank, III, Cummings, Oscar W., Peters-Golden, Marc, Twigg, Homer L., III, Woodruff, Trent M., Wilkes, David S. and Vittal, Ragini (2016). Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis. FASEB Journal, 30 (6), 2336-2350. doi: 10.1096/fj.201500044 |
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2016 Journal Article The complement system component C5a produces thermal hyperalgesia via macrophage-to-nociceptor signaling that requires NGF and TRPV1Shutov, Leonid P., Warwick, Charles A., Shi, Xiaoyu, Gnanasekaran, Aswini, Shepherd, Andrew J., Mohapatra, Durga P., Woodruff, Trent M., David Clark, J. and Usachev, Yuriy M. (2016). The complement system component C5a produces thermal hyperalgesia via macrophage-to-nociceptor signaling that requires NGF and TRPV1. Journal of Neuroscience, 36 (18), 5055-5070. doi: 10.1523/JNEUROSCI.3249-15.2016 |
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2016 Journal Article The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responsesNabizadeh, Jamileh A., Manthey, Helga D., Steyn, Frederik J., Chen, Weiyu, Widiapradja, Alexander, Akhir, Fazrena N. Md, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2016). The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses. Journal of Immunology, 196 (11), 4783-4792. doi: 10.4049/jimmunol.1600210 |
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2016 Journal Article Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defectsDenny, Kerina J., Kelly, Christina F., Kumar, Vinod, Witham, Katey L., Cabrera, Robert M., Fennell, Richard H., Taylor, Stephen M., Jeanes, Angela and Woodruff, Trent M. (2016). Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology, 106 (3), 201-207. doi: 10.1002/bdra.23483 |
