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2012 Journal Article De novo peptide design with C3a receptor agonist and antagonist activities: Theoretical predictions and experimental validationBellows-Peterson, Meghan L., Fung, Ho Ki, Floudas, Christodoulos A., Kieslich, Chris A., Zhang, Li, Morikis, Dimitrios, Wareham, Kathryn J., Monk, Peter N., Hawksworth, Owen A. and Woodruff, Trent M. (2012). De novo peptide design with C3a receptor agonist and antagonist activities: Theoretical predictions and experimental validation. Journal of Medicinal Chemistry, 55 (9), 4159-4168. doi: 10.1021/jm201609k |
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2011 Journal Article Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive ratsIyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay (2011). Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 58 (5), 479-486. doi: 10.1097/FJC.0b013e31822a7a09 |
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2011 Journal Article Inhibiting the C5-C5a receptor axisWoodruff, Trent M., Nandakumar, Kutty S. and Tedesco, Francesco (2011). Inhibiting the C5-C5a receptor axis. Molecular Immunology, 48 (14), 1631-1642. doi: 10.1016/j.molimm.2011.04.014 |
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2011 Journal Article Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) miceManthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara and Taylor, Stephen M. (2011). Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice. FASEB Journal, 25 (7), 2447-2455. doi: 10.1096/fj.10-174284 |
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2011 Journal Article Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in ratsBreivik, T., Gundersen, Y., Gjermo, P., Taylor, S. M., Woodruff, T. M. and Opstad, P. K. (2011). Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats. Journal of Periodontal Research, 46 (6), 643-647. doi: 10.1111/j.1600-0765.2011.01383.x |
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2011 Journal Article Pathophysiology, treatment, and animal and cellular models of human ischemic strokeWoodruff, Trent M., Thundyil, John, Tang, Sung Chun, Sobey, Christopher G., Taylor, Stephen M. and Arumugam, Thiruma V. (2011). Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Molecular Neurodegeneration, 6 (1) 11, 1-19. doi: 10.1186/1750-1326-6-11 |
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2011 Journal Article Increased expression of C5a receptor (CD88) mRNA in canine mammary tumorsHezmee, Mohd Noor Mohd, Kyaw-Tanner, Myat, Lee, Jia Yu Peppermint, Shiels, Ian A., Rolfe, Barbara, Woodruff, Trent and Mills, Paul C. (2011). Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors. Veterinary Immunology and Immunopathology, 139 (1), 50-56. doi: 10.1016/j.vetimm.2010.08.005 |
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2011 Journal Article Comparative efficacy of a secretory phospholipase A(2) inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritisCoulthard, Liam G., Costello, Jaclyn, Robinson, Brent, Shiels, Ian A., Taylor, Stephen M. and Woodruff, Ttrent M. (2011). Comparative efficacy of a secretory phospholipase A(2) inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis. Arthritis Research & Therapy, 13 (2) R42, R42-1-R42-10. doi: 10.1186/ar3278 |
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2010 Journal Article Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal deathThundyil, John, Tang, Sung-Chun, Okun, Eitan, Shah, Kausik, Karamyan, Vardan T., Li , Yu-I, Woodruff, Trent M., Taylor, Stephen M., Jo, Dong-Gyu, Mattson, Mark P and Arumugam, Thiruma V. (2010). Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death. Experimental and Translational Stroke Medicine, 2 (1) 15, 15-1-15-8. doi: 10.1186/2040-7378-2-15 |
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2010 Journal Article The role of the ribosomal protein S19 C-terminus in Gi protein-dependent alternative activation of p38 MAP kinase via the C5a receptor in HMC-1 cellsNishiura, Hiroshi, Tokita, Kazutaka, Li, Ying, Harada, Koichi, Woodruff, Trent W., Taylor, Stephen M., Nsiama, Tienabe K., Nishino, Norikazu and Yamamoto, Tetsuro (2010). The role of the ribosomal protein S19 C-terminus in Gi protein-dependent alternative activation of p38 MAP kinase via the C5a receptor in HMC-1 cells. Apoptosis, 15 (8), 966-981. doi: 10.1007/s10495-010-0511-y |
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2010 Journal Article The role of the complement system and the activation fragment C5a in the central nervous systemWoodruff, T. M., Ager, R. R., Tenner, A. J., Noakes, P. G. and Taylor, S. M. (2010). The role of the complement system and the activation fragment C5a in the central nervous system. Neuromolecular Medecine, 12 (2), 179-192. doi: 10.1007/s12017-009-8085-y |
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2010 Journal Article Microglial C5aR (CD88) expression correlates with amyloid-β deposition in murine models of Alzheimer's diseaseAger, Rahasson R., Fonseca, Maira I., Chu, Shu-Hui, Sanderson, Sam D., Taylor, Stephen M., Woodruff, Trent M. and Tenner, Andrea J. (2010). Microglial C5aR (CD88) expression correlates with amyloid-β deposition in murine models of Alzheimer's disease. Journal of Neurochemistry, 113 (2), 389-401. doi: 10.1111/j.1471-4159.2010.06595.x |
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2010 Journal Article Quantitative analysis of cellular inflammation after traumatic spinal cord injury: Evidence for a multiphasic inflammatory response in the acute to chronic environmentBeck, Kevin D., Nguyen, Hal X., Galvan, Manuel D., Salazar, Desireé L., Woodruff, Trent M. and Anderson, Aileen J. (2010). Quantitative analysis of cellular inflammation after traumatic spinal cord injury: Evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain, 133 (2), 433-447. doi: 10.1093/brain/awp322 |
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2009 Journal Article Dendritic cell function in allostimulation is modulated by C5aR signalingPeng, Qi, Li, Ke, Wang, Naiyin, Li, Qijun, Asgari, Elham, Lu, Bao, Woodruff, Trent M., Sacks, Steven H. and Zhou, Wuding (2009). Dendritic cell function in allostimulation is modulated by C5aR signaling. Journal of Immunology, 183 (10), 6058-6068. doi: 10.4049/jimmunol.0804186 |
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2009 Journal Article Complement component 5a (C5a)Manthey, Helga D., Woodruff, Trent M., Taylor, Stephen M. and Monk, Peter N. (2009). Complement component 5a (C5a). International Journal of Biochemistry and Cell Biology, 41 (11), 2114-2117. doi: 10.1016/j.biocel.2009.04.005 |
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2009 Journal Article Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic strokeLathia, Justin D., Chigurupati, Srinivasulu, Thundyil, John, Selvaraj, Pradeep K., Mughal, Mohamed R., Woodruff, Trent M., Chan, Sic L., Karamyan, Vardan T., Mattson, Mark P. and Arumugam, Thiruma V. (2009). Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke. Experimental Neurology, 221 (1), 107-114. doi: 10.1016/j.expneurol.2009.10.007 |
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2009 Journal Article Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's diseaseFonseca, Maria I., Ager, Rahasson R., Chu, Shu-Hui, Yazan, Ozkan, Sanderson, Sam D., LaFerla, Frank M., Taylor, Stephen M., Woodruff, Trent M. and Tenner, Andrea J. (2009). Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. Journal of Immunology, 183 (2), 1375-1383. doi: 10.4049/jimmunol.0901005 |
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2009 Journal Article Toll-like receptors in ischemia-reperfusion injuryArumugam, Thiruma V., Okun, Eitan, Tang, Sung-Chun, Thundyil, John, Taylor, Stephen M. and Woodruff, Trent M. (2009). Toll-like receptors in ischemia-reperfusion injury. Shock, 32 (1), 4-16. doi: 10.1097/SHK.0b013e318193e333 |
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2009 Journal Article Complement factors C3a and C5a have distinct hemodynamic effects in the ratProctor, Lavinia M., Moore, Tyson A., Monk, Peter N., Sanderson, Sam D., Taylor, Stephen M. and Woodruff, Trent M. (2009). Complement factors C3a and C5a have distinct hemodynamic effects in the rat. International Immunopharmacology, 9 (6), 800-806. doi: 10.1016/j.intimp.2009.03.002 |
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2009 Journal Article Neuroprotection in stroke by complement inhibition and immunoglobulin therapyArumugam, T V, Woodruff, T M, Lathia, J D, Selvaraj, P K, Mattson, M P and Taylor, S M (2009). Neuroprotection in stroke by complement inhibition and immunoglobulin therapy. Neuroscience, 158 (3), 1074-1089. doi: 10.1016/j.neuroscience.2008.07.015 |
