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2009 Journal Article The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibresCrane, James W., Baiquni, Gilang P., Sullivan, Robert K. P., Lee, John D, Sah, Pankaj, Taylor, Stephen M, Noakes, Peter G. and Woodruff, Trent (2009). The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres. Journal of Neuroinflammation, 6 (34) 34, 34.1-34.10. doi: 10.1186/1742-2094-6-34 |
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2008 Journal Article The Complement Factor C5a Contributes to Pathology in a Rat Model of Amyotrophic Lateral SclerosisWoodruff, Trent M., Costantini, Kerina J., Crane, James W., Atkin, Julie D., Monk, Peter N., Taylor, Stephen M. and Noakes, Peter G. (2008). The Complement Factor C5a Contributes to Pathology in a Rat Model of Amyotrophic Lateral Sclerosis. Journal of Immunology, 181 (12), 8727-8734. doi: 10.4049/jimmunol.181.12.8727 |
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2008 Journal Article Role of complement in motor neuron disease: animal models and therapeutic potential of complement inhibitorsWoodruff, Trent M., Costantini, Kerina J., Taylor, Steve M. and Noakes, Peter G. (2008). Role of complement in motor neuron disease: animal models and therapeutic potential of complement inhibitors. Advances in Experimental Medicine and Biology, 632, 143-158. |
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2008 Journal Article Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administrationMorgan, Michael, Bulmer, Andrew C., Woodruff, Trent M., Proctor, Lavinia M., Williams, Hua M., Stocks, Shelli Z., Pollitt, Sandra, Taylor, Stephen M. and Shiels, Ian A (2008). Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration. European Journal of Pharmaceutical Sciences, 33 (4-5), 390-398. doi: 10.1016/j.ejps.2008.01.009 |
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2008 Journal Article Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory painTing, E., Guerrero, A. T. G., Cunha, T. M., Verri, W. A., Taylor, S. M., Woodruff, T. M., Cunha, F. Q. and Ferreira, S. H. (2008). Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain. British Journal of Pharmacology, 153 (5), 1043-1053. doi: 10.1038/sj.bjp.0707640 |
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2008 Journal Article Targeting ischemic brain injury with intravenous immunoglobulinArumugam, Thiruma V., Selvaraj, Pradeep K., Woodruff, Trent M. and Mattson, Mark P. (2008). Targeting ischemic brain injury with intravenous immunoglobulin. Expert Opinion on Therapeutic Targets, 12 (1), 19-29. doi: 10.1517/14728222.12.1.19 |
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2007 Journal Article The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand bindingScola, A. M., Higginbottom, A., Partridge, L, J., Reid, R. C., Woodruff, T., Taylor, S. M., Fairlie, D. P. and Monk, P. N. (2007). The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. Journal of Biological Chemistry, 282 (6), 3664-3671. doi: 10.1074/jbc.M609178200 |
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2006 Journal Article Complement mediators in ischemia-reperfusion injuryArumugam, Thiruma V., Magnus, Tim, Woodruff, Trent M., Proctor, Lavinia M., Shiels, Ian A., Taylor, Stephen M., A. H. Wu and J. Delanghe (2006). Complement mediators in ischemia-reperfusion injury. Clinica Chimica Acta, 374 (1-2), 33-45. doi: 10.1016/j.cca.2006.06.010 |
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2006 Journal Article Transdermal pharmacology of small molecule cyclic C5a antagonistsProctor, Lavinia M, Woodruff, Trent M, Sharma, Prakirti, Shiels, Ian A and Taylor, Stephen M (2006). Transdermal pharmacology of small molecule cyclic C5a antagonists. Advances in experimental medicine and biology, 586, 329-345. |
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2006 Journal Article Complement inhibitors selectively attenuate injury following administration of cobra venom factor to ratsProctor, Lavinia M., Strachan, Anna J., Woodruff, Trent M., Mahadevan, Indumathy B., Williams, H. Ming, Shiels, Ian A. and Taylor, Stephen M. (2006). Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. International Immunopharmacology, 6 (8), 1224-1232. doi: 10.1016/j.intimp.2006.03.002 |
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2006 Journal Article Therapeutic activity of C5a receptor antagonists in a rat model of neurodegenerationWoodruff, Trent M., Crane, James W., Proctor, Lavinia. M., Buller, Kathryn M., Shek, Annie B., De Vos, Kurt, Pollitt, Sandra, Williams, Hua M., Shiels, Ian A., Monk, Peter N. and Taylor, Stephen M. (2006). Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration. FASEB Journal, 20 (9), 1407-1417. doi: 10.1096/fj.05-5814com |
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2006 Journal Article Recent developments in C5/C5a inhibitorsProctor, Lavinia M., Woodruff, Trent M. and Taylor, Stephen M. (2006). Recent developments in C5/C5a inhibitors. Expert Opinion On Therapeutic Patents, 16 (4), 445-458. doi: 10.1517/13543776.16.4.445 |
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2006 Journal Article Complement factor 5a as a therapeutic targetWoodruff, T.M., Proctor, L.M., Strachan, A.J. and Taylor, S.M. (2006). Complement factor 5a as a therapeutic target. Drugs of The Future, 31 (4), 325-334. doi: 10.1358/dof.2006.031.04.980656 |
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2005 Journal Article Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding siteHigginbottom, Adrian, Cain, Stuart A., Woodruff, Trent M., Proctor, Lavinia M., Madala, Praveen K., Tyndall, Joel D. A., Taylor, Stephen M., Fairlie, David P. and Monk, Peter N. (2005). Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280 (18), 17831-17840. doi: 10.1074/jbc.M410797200 |
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2005 Journal Article A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitisWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005). A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 (5), 883-892. doi: 10.1016/j.intimp.2005.01.003 |
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2005 Journal Article Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel diseaseWoodruff, T. M., Pollitt, S., Proctor, L. M., Stocks, S. Z., Manthey, H. D., Williams, H. M., Mahadevan, I. B., Shiels, I. A. and Taylor, S. M. (2005). Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease. Journal of Pharmacology And Experimental Therapeutics, 314 (2), 811-817. doi: 10.1124/jpet.105.086835 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/S0168-8278(04)00066-2 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/j.jhep.2004.02.017 |
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2004 Journal Article The role of the complement system in ischemia-reperfusion injuryArumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Granger, D. Neil and Taylor, Stephen M. (2004). The role of the complement system in ischemia-reperfusion injury. Shock, 21 (5), 401-409. doi: 10.1097/01.shk.0000121227.73012.86 |
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2004 Journal Article Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in ratsWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 (1), 81-90. doi: 10.1016/j.jss.2003.04.001 |
