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2016 Journal Article Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defectsDenny, Kerina J., Kelly, Christina F., Kumar, Vinod, Witham, Katey L., Cabrera, Robert M., Fennell, Richard H., Taylor, Stephen M., Jeanes, Angela and Woodruff, Trent M. (2016). Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology, 106 (3), 201-207. doi: 10.1002/bdra.23483 |
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2016 Journal Article EPHA4-FC treatment reduces ischemia/reperfusion-induced intestinal injury by inhibiting vascular permeabilityWoodruff, Trent M., Wu, Mike C.-L., Morgan, Michael, Bain, Nathan T., Jeanes, Angela, Lipman, Jeffrey, Ting, Michael J., Boyd, Andrew W., Taylor, Stephen M. and Coulthard, Mark G. (2016). EPHA4-FC treatment reduces ischemia/reperfusion-induced intestinal injury by inhibiting vascular permeability. Shock, 45 (2), 184-191. doi: 10.1097/SHK.0000000000000494 |
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2016 Journal Article Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic miceMantovani, Susanna, Gordon, Richard, Li, Rui, Christie, Daniel C., Kumar, Vinod and Woodruff, Trent M. (2016). Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice. Human Molecular Genetics, 25 (9) ddw050, 1780-1791. doi: 10.1093/hmg/ddw050 |
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2016 Journal Article Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditionsBrennan, Faith H., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2016). Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions. Seminars in Immunology, 28 (3), 292-308. doi: 10.1016/j.smim.2016.03.015 |
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2015 Journal Article The receptor for advanced glycation endproducts does not contribute to pathology in a mouse mesenteric ischemia/reperfusion-induced injury modelWu, Mike C. L., Gilmour, Timothy D., Mantovani, Susanna and Woodruff, Trent M. (2015). The receptor for advanced glycation endproducts does not contribute to pathology in a mouse mesenteric ischemia/reperfusion-induced injury model. Frontiers in Immunology, 6 (DEC) 614, 1-7. doi: 10.3389/fimmu.2015.00614 |
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2015 Journal Article Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosisNgo, S. T., Steyn, F. J., Huang, L., Mantovani, S., Pfluger, C. M. M., Woodruff, T. M., O'Sullivan, J. D., Henderson, R. D. and McCombe, P. A. (2015). Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 357 (1-2), 22-27. doi: 10.1016/j.jns.2015.06.053 |
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2015 Journal Article Co-ordinated expression of innate immune molecules during mouse neurulationJeanes, Angela, Coulthard, Liam G., Mantovani, Susanna, Markham, Kathryn and Woodruff, Trent M. (2015). Co-ordinated expression of innate immune molecules during mouse neurulation. Molecular Immunology, 68 (2), 253-260. doi: 10.1016/j.molimm.2015.09.004 |
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2015 Journal Article Placental lipase expression in pregnancies complicated by preeclampsia: A case-control studyBarrett, Helen L., Kubala, Marta H., Scholz Romero, Katherin., Denny, Kerina J., Woodruff, Trent M., McIntyre, H.David., Callaway, Leonie K. and Dekker Nitert, Marloes. (2015). Placental lipase expression in pregnancies complicated by preeclampsia: A case-control study. Reproductive Biology and Endocrinology, 13 (1) 100, 100. doi: 10.1186/s12958-015-0098-9 |
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2015 Journal Article C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosusMahajan, Supriya D., Parikh, Neil U., Woodruff, Trent M., Jarvis, James N., Lopez, Molly, Hennon, Teresa, Cunningham, Patrick, Quigg, Richard J., Schwartz, Stanley A. and Alexander, Jessy J. (2015). C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus. Immunology, 146 (1), 130-143. doi: 10.1111/imm.12489 |
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2015 Journal Article The role of C5a receptor signaling in endotoxin-induced miscarriage and preterm birthDenny, Kerina J., Coulthard, Liam G., Mantovani, Susanna, Simmons, David, Taylor, Stephen M. and Woodruff, Trent M. (2015). The role of C5a receptor signaling in endotoxin-induced miscarriage and preterm birth. American Journal of Reproductive Immunology, 74 (2), 148-155. doi: 10.1111/aji.12386 |
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2015 Journal Article Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cordKhan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015). Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord. Pharmacology Research and Perspectives, 3 (3) e00137, 1-16. doi: 10.1002/prp2.137 |
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2015 Journal Article Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1<sup>G93A</sup> mouse model of amyotrophic lateral sclerosisLee, Jia Y., Lee, John D., Phipps, Simon, Noakes, Peter G. and Woodruff, Trent M. (2015). Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 12 (1) 90, 90. doi: 10.1186/s12974-015-0310-z |
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2015 Journal Article A commentary on: "NF kappa B-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease". A cautionary note regarding C3aRWoodruff, Trent M. and Tenner, Andrea J. (2015). A commentary on: "NF kappa B-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease". A cautionary note regarding C3aR. Frontiers in Immunology, 6 (MAY) 220, 220. doi: 10.3389/fimmu.2015.00220 |
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2015 Journal Article The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injuryBrennan, Faith H., Gordon, Richard, Lao, Hong W., Biggins, Patrick J., Taylor, Stephen M., Franklin, Robin J. M., Woodruff, Trent M. and Ruitenberg, Marc J. (2015). The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury. Journal of Neuroscience, 35 (16), 6517-6531. doi: 10.1523/JNEUROSCI.5218-14.2015 |
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2015 Journal Article Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the mythCoulthard, Liam G. and Woodruff, Trent M. (2015). Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth. Journal of Immunology, 194 (8), 3542-3548. doi: 10.4049/jimmunol.1403068 |
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2015 Journal Article Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent mannerJain, Umang, Cao, Qi, Thomas, Nikhil A, Woodruff, Trent M, Schwaeble, Wilhelm J, Stover, Cordula M and Stadnyk, Andrew W (2015). Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent manner. Journal of Immunology, 194 (7), 3414-3421. doi: 10.4049/jimmunol.1401814 |
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2015 Journal Article A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy modelsBenson, Melissa J, Thomas, Nicola K, Talwar, Sahil, Hodson, Mark P, Lynch, Joseph W, Woodruff, Trent M and Borges, Karin (2015). A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models. Neurobiology of Disease, 76, 87-97. doi: 10.1016/j.nbd.2015.02.004 |
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2014 Journal Article Derivation of ligands for the complement C3a receptor from the C-terminus of C5aHalai, Reena, Bellows-Peterson, Meghan L., Branchett, Will, Smadbeck, James, Kieslich, Chris A., Croker, Daniel E., Cooper, Matthew A., Morikis, Dimitrios, Woodruff, Trent M., Floudas, Christodoulos A. and Monk, Peter N. (2014). Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. European Journal of Pharmacology, 745, 176-181. doi: 10.1016/j.ejphar.2014.10.041 |
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2014 Journal Article Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014). Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 (12), 3278-3284. doi: 10.1002/stem.1801 |
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2014 Journal Article Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methodsKhan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014). Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126, 13-27. doi: 10.1016/j.pbb.2014.09.003 |
