
Overview
Background
Professor Brandon Wainwright AM is Co-Director of the Children’s Brain Cancer Centre and leads a laboratory within the UQ Diamantina Institute focused on understanding the genetic pathways behind medulloblastoma, a type of brain tumour that occurs predominantly in children. He is Chair of the European Molecular Biology Laboratory (EMBL) Australia, Chair of the Advisory Board of the Robinson Research Institute and Chair of the Board of the South Australian Immunogenomics Cancer Institute (SAIGENCI), and serves on the boards the Australian Genome Research Facility as well as several national and international scientific review committees, including the MRFF Brain Tumour Roadmap Committee.
Professor Wainwright completed his undergraduate and postgraduate studies at The University of Adelaide, after which he secured a postdoctoral fellowship with St Mary's Hospital at Imperial College London. During his six years at Imperial he worked on the first human genome project and also became a Medical Research Council Senior Research Fellow. He returned to Australia in 1990 to join UQ's Centre for Molecular and Cellular Biology (now IMB) and led the Institute for Molecular Biology until 2019.
Professor Wainwright is a geneticist, renowned for discovering the genetic pathway that causes most human cancer. He is skilled in molecular genetics, where he is using genetic approaches to dig through DNA and find the genes that cause disease. He commenced using these skills to locate the cystic fibrosis gene, but it was when isolating a gene responsible for a rare form of brain cancer called Medulloblastoma, that he discovered the role of the ‘Hedgehog Pathway' in common human cancer.
Availability
- Professor Brandon Wainwright is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Cancer and cell signalling
Skin cancer is a major public health issue in Australia, with the treatment of non-melanoma skin cancer costing our community more than $264 million each year. Moreover, brain tumours remain the most common cause of cancer-related death in children and of these, medulloblastoma is the most commonly diagnosed. Our laboratory has made great progress in understanding the genetic pathways behind the most common form of skin cancer in Australia, Basal Cell Carcinoma (BCC), and medulloblastoma, a type of brain tumour that occurs predominantly in children. Having mapped and isolated the Naevoid Basel Cell Carcinoma Syndrome (NBCCS) gene called Patched, which is the driver for a medical condition where affected individuals have a predisposition for developing BCC and medulloblastoma, we were able to identify the Patched gene as a controller of a molecular signalling pathway called the Hedgehog pathway. The Hedgehog pathway is a set of genetic mutations that contribute to the development of a wide range of tumour types, including lung, pancreatic and ovarian cancer. By examining this pathway and how it interacts with other genetic pathways, our scientists have gained a better understanding of the normal development of the skin and cerebellum, a part of the brain that controls motor functions. By manipulating the strength of the Hedgehog pathway we believe stem cell populations can be expanded or can be induced to become cancerous. Our lab has identified the core genetic components that lead to the development of medulloblastoma. This work will enable the therapeutic targeting of every medulloblastoma, not just a subset, leading to more powerful clinical trials and ultimately more effective treatment options.
Works
Search Professor Brandon Wainwright’s works on UQ eSpace
1998
Journal Article
No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types
Wicking, C, Evans, T, Henk, B, Hayward, N, Simms, LA, Chenevix-Trench, G, Pietsch, T and Wainwright, B (1998). No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types. Oncogene, 16 (8), 1091-1093. doi: 10.1038/sj.onc.1201644
1998
Journal Article
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice
Smith, Stephen N., Delaney, Stephen J., Dorin, Julia R., Farley, Raymond, Geddes, Duncan M., Porteous, David J., Wainwright, Brandon J. and Alton, Eric W. F. W. (1998). Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice. American Journal of Physiology - Cell Physiology, 274 (2 43-2), C492-C499. doi: 10.1152/ajpcell.1998.274.2.c492
1998
Conference Publication
Novel susceptibility gene for NIDDM is localised to human chromosome 12q
Shaw, JTE, Lovelock, PK, Duffy, D, Cardinal, J, Berkholz, JR, Kesting, JB and Wainwright, B (1998). Novel susceptibility gene for NIDDM is localised to human chromosome 12q. NEW YORK: SPRINGER VERLAG.
1997
Journal Article
Mapping the multiple self-healing squamous epithelioma (MSSE) gene and investigation of xeroderma pigmentosum group A (XPA) and PATCHED (PTCH) as candidate genes
Richards, Frances M., Goudie, David R., Cooper, Wendy N., Jene, Quitz, Barroso, Inês , Wicking, Carol, Wainwright, Brandon J. and Ferguson-Smith, Malcolm A. (1997). Mapping the multiple self-healing squamous epithelioma (MSSE) gene and investigation of xeroderma pigmentosum group A (XPA) and PATCHED (PTCH) as candidate genes. Human Genetics, 101 (3), 317-322. doi: 10.1007/s004390050635
1997
Journal Article
Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome
Lench, NJ, Telford, EAR, High, AS, Markham, AF, Wicking, C and Wainwright, BJ (1997). Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome. Human Genetics, 100 (5-6), 497-502. doi: 10.1007/s004390050541
1997
Journal Article
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
Pietsch, T, Waha, A, Koch, A, Kraus, J, Albrecht, S, Tonn, J, Sorensen, N, Berthold, F, Henk, B, Schmandt, N, Wolf, HK, vonDeimling, A, Wainwright, B, ChenevixTrench, G, Wiestler, OD and Wicking, C (1997). Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Research, 57 (11), 2085-2088.
1997
Journal Article
Rare mutations and no hypermethylation at the CDKN2A locus in epithelial ovarian tumours
Shih, Yang-Chia, Kerr, Judith, Liu, Jim, Hurst, Terry, Khoo, Soo-Keat, Ward, Bruce, Wainwright, Brandon and Chenevix-Trench, Georgia (1997). Rare mutations and no hypermethylation at the CDKN2A locus in epithelial ovarian tumours. International Journal of Cancer, 70 (5), 508-511. doi: 10.1002/(SICI)1097-0215(19970304)70:53.0.CO;2-1
1997
Journal Article
Two N-terminal self-association domains are required for the dominant negative transcriptional activity of WT1 Denys-Drash mutant proteins
Holmes, G, Boterashvili, S, English, M, Wainwright, B, Licht, J and Little, M (1997). Two N-terminal self-association domains are required for the dominant negative transcriptional activity of WT1 Denys-Drash mutant proteins. Biochemical and Biophysical Research Communications, 233 (3), 723-728. doi: 10.1006/bbrc.1997.6545
1997
Journal Article
No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung
Suzuki, K, Daigo, Y, Fukuda, S, Tokino, T, Isomura, M, Isono, K, Wainwright, B and Nakamura, Y (1997). No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung. Japanese journal of cancer research : Gann, 88 (3), 225-8. doi: 10.1111/j.1349-7006.1997.tb00370.x
1997
Journal Article
Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident
Wicking, Carol, Shanley, Susan, Smyth, Ian, Gillies, Susan, Negus, Kylie, Graham, Scott, Suthers, Graeme, Haites, Neva, Edwards, Matt, Wainwright, Brandon and Chenevix-Trench, Georgia (1997). Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. American Journal of Human Genetics, 60 (1), 21-26.
1997
Journal Article
Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: Placement of a novel zinc finger gene within the NBCCS and ESS1 region
Levanat, S, Chidambaram, A, Wicking, C, BrayWard, P, Pressman, C, Toftgard, R, Gailani, MR, Myers, JC, Wainwright, B, Dean, M and Bale, AE (1997). Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: Placement of a novel zinc finger gene within the NBCCS and ESS1 region. Cytogenetics and Cell Genetics, 76 (3-4), 208-213. doi: 10.1159/000134551
1997
Journal Article
De novo mutations of the patched gene in nevoid basal cell carcinoma syndrome help to define the clinical phenotype
Wicking, C., Gillies, S., Smyth, I., Shanley, S., Fowles, L., Ratcliffe, J., Wainwright, B. and Chenevix-Trench, G. (1997). De novo mutations of the patched gene in nevoid basal cell carcinoma syndrome help to define the clinical phenotype. American Journal of Medical Genetics Part A, 73 (3), 304-307. doi: 10.1002/(SICI)1096-8628(19971219)73:33.0.CO;2-N
1996
Journal Article
Targeted disruption of the Wnt2 gene results in placentation defects
Monkley, Susan J., Delaney, Stephen J., Pennisi, David J., Christiansen, Jeffrey H. and Wainwright, Brandon J. (1996). Targeted disruption of the Wnt2 gene results in placentation defects. Development, 122 (11), 3343-3353. doi: 10.1242/dev.122.11.3343
1996
Journal Article
A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction
Dorin, J. R., Farley, R., Webb, S., Smith, S. N., Farini, E., Delaney, S. J., Wainwright, B. J., Alton, E. W.F.W. and Porteous, D. J. (1996). A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. Gene Therapy, 3 (9), 797-801.
1996
Journal Article
A novel target for the Wilms' tumour suppressor protein (WT1) is bound by a unique combination of zinc fingers
Little, MH, Holmes, G, Pell, L, Caricasole, A, Duarte, A, Law, M, Ward, A and Wainwright, B (1996). A novel target for the Wilms' tumour suppressor protein (WT1) is bound by a unique combination of zinc fingers. Oncogene, 13 (7), 1461-1469.
1996
Journal Article
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
Hahn, H, Wicking, C, Zaphiropoulos, PG, Gailani, MR, Shanley, S, Chidambaram, A, Vorechovsky, , Holmberg, E, Unden, AB, Gillies, S, Negus, K, Smyth, , Pressman, C, Leffell, DJ, Gerrard, B, Goldstein, AM, Dean, M, Toftgard, R, ChenevixTrench, G, Wainwright, B and Bale, AE (1996). Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell, 85 (6), 841-851. doi: 10.1016/S0092-8674(00)81268-4
1996
Journal Article
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
Hahn, Heidi, Christiansen, Jeffrey, Wicking, Carol, Zaphiropoulos, Peter G., Chidambaram, Abirami, Gerrard, Bernard, Vorechovsky, Igor, Bale, Allen E., Toftgard, Rune, Dean, Michael and Wainwright, Brandon (1996). A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. Journal of Biological Chemistry, 271 (21), 12125-12128. doi: 10.1074/jbc.271.21.12125
1996
Journal Article
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations
Delaney, Stephen J., Alton, Eric W.F.W., Smith, Stephen N., Lunn, Dominic P., Farley, Ray, Lovelock, Paul K., Thomson, Scott A., Hume, David A., Lamb, David, Porteous, David J., Dorin, Julia R. and Wainwright, Brandon J. (1996). Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO Journal, 15 (5), 955-963. doi: 10.1002/j.1460-2075.1996.tb00432.x
1996
Journal Article
New pharmaceutical approaches to the treatment of cystic fibrosis. Gene therapy for cystic fibrosis is advancing rapidly but drug therapy is quickly catching up (pages 467-469)
Delaney, Stephen J. and Wainwright, Brandon J. (1996). New pharmaceutical approaches to the treatment of cystic fibrosis. Gene therapy for cystic fibrosis is advancing rapidly but drug therapy is quickly catching up (pages 467-469). Nature Medicine, 2 (4), 392-393. doi: 10.1038/nm0496-392
1996
Journal Article
+P5(D1S3309E), a novel target binding site for the Wilms' tumour suppressor 1 (WT1) gene, maps to human chromosome 1q21->q22
Negus, K, Holmes, GH, Wicking, C, Wainwright, BJ and Little, MH (1996). +P5(D1S3309E), a novel target binding site for the Wilms' tumour suppressor 1 (WT1) gene, maps to human chromosome 1q21->q22. Cytogenetics and Cell Genetics, 72 (4), 306-309. doi: 10.1159/000134210
Funding
Current funding
Past funding
Supervision
Availability
- Professor Brandon Wainwright is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
New treatments for children with medulloblastoma.
Principal Advisor
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Doctor Philosophy
New treatments for children with medulloblastoma.
Principal Advisor
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Doctor Philosophy
The role of the blood brain barrier in the successful treatment of brain tumours in children
Principal Advisor
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Doctor Philosophy
A new therapy for paediatric brain tumours.
Principal Advisor
Other advisors: Dr Joseph Yunis
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Doctor Philosophy
Complex neoantigen prediction in cancers
Associate Advisor
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Doctor Philosophy
Investigation into network-defined novel targeted therapies for medulloblastoma
Associate Advisor
Other advisors: Dr Laura Genovesi
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Doctor Philosophy
Investigation into network-defined novel targeted therapies for medulloblastoma
Associate Advisor
Other advisors: Dr Laura Genovesi
Completed supervision
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2018
Doctor Philosophy
Targeting Apoptosis as A Novel Therapy for Medulloblastoma
Principal Advisor
Other advisors: Dr Laura Genovesi
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2017
Doctor Philosophy
The Relationship between Patched and Sox9 in Regulating Skin Stem Cells, Wound Response and Skin Tumorigenesis
Principal Advisor
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2016
Doctor Philosophy
Genetic Regulation of Development and Disorders of the Cerebellum
Principal Advisor
Other advisors: Dr Laura Genovesi
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2012
Doctor Philosophy
The Role of Dicer in Cerebellar Development and Hedgehog-Mediated Medulloblastoma
Principal Advisor
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2012
Doctor Philosophy
The Role of N-myc and C-myc in Skin Development and in Hedgehog Pathway-Induced Tumorigenesis
Principal Advisor
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2011
Doctor Philosophy
The role of Patched1 during development of the mouse cerebellum and regulation of neural stem cells in medulloblastoma
Principal Advisor
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2010
Doctor Philosophy
The molecular basis of medulloblastoma: interaction of hedgehog and Notch signalling in brain development and cancer
Principal Advisor
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2010
Doctor Philosophy
Hedgehog signalling in lung development and airway regeneration
Principal Advisor
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2007
Doctor Philosophy
Characterisation of the Host Immune Response in Cystic Fibrosis Mice.
Principal Advisor
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2006
Doctor Philosophy
IDENTIFICATION OF NOVEL DOWNSTREAM TARGETS OF SONIC, INDIAN AND DESERT HEDGEHOG
Principal Advisor
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2005
Doctor Philosophy
THE STRUCTURE-FUNCTION ANALYSIS OF THE PATCHED PROTEIN
Principal Advisor
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2003
Doctor Philosophy
EFFECTS OF SONIC, DESERT AND INDIAN HEDGEHOG SIGNALLING IN SKIN
Principal Advisor
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2003
Doctor Philosophy
DOWNSTREAM TARGETS OF PATCHED, THE GENE RESPONSIBLE FOR NEVOID BASAL CELL CARCINOMA SYNDROME
Principal Advisor
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2024
Doctor Philosophy
Investigation into network-defined novel targeted therapies for medulloblastoma
Associate Advisor
Other advisors: Dr Laura Genovesi
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2021
Doctor Philosophy
An exploration of unsolved central nervous system white matter disorders with next-generation sequencing
Associate Advisor
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2020
Doctor Philosophy
The role of Nuclear Factor One transcription factors in cerebellar development
Associate Advisor
Other advisors: Professor Michael Piper
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2020
Doctor Philosophy
A computational analysis of transcription factor interactions and binding guided by epigenetics
Associate Advisor
Other advisors: Professor Michael Piper, Professor Mikael Boden
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2009
Doctor Philosophy
Novel genes regulated by the hedgehog pathway, and their contribution to limb and craniofacial development
Associate Advisor
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2006
Doctor Philosophy
THE GENETICS OF TYPE 2 DIABETES
Associate Advisor
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2005
Doctor Philosophy
MOLECULAR EVENTS IN HEDGEHOG SIGNALLING: REGULATION BY VESICULAR TRAFFICKING AND STEROLS
Associate Advisor
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2004
Doctor Philosophy
TRANSCRIPTIONAL ANALYSIS OF MACROPHAGE SIGNALLING IN RESPONSE TO LIPOPOLYSACCHARIDE
Associate Advisor
Other advisors: Professor David Hume
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2004
Doctor Philosophy
IDENTIFICATION OF NOVEL GLI3 DEPENDENT TRANSCRIPTS IN THE DEVELOPING VERTEBATE LIMB
Associate Advisor
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2004
Doctor Philosophy
THE MOLECULAR GENETICS OF MAMMALIAN SEX DETERMINATION
Associate Advisor
Media
Enquiries
Contact Professor Brandon Wainwright directly for media enquiries about:
- brain cancer
- brain tumour
- genetics
- genomics
- health research
- medical research
- medulloblastoma
- science policy
- scientific leadership
- skin cancer
- tumours
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