Dr Nicole Lawrence
Dr

Nicole Lawrence

Email: 
Phone: 
+61 7 344 36298

Background

My research focuses on using host defence molecules as the basis for designing peptide-based drugs with improved safety and reduced likelihood of drug resistance to combat infectious disease caused by pathogenic bacteria and malaria parasites. Zooming in to investigate molecular interactions at the cell surface and inside infected cells allows me to describe and refine how drug candidates overcome disease organisms to produce the next generation of antimicrobial drugs.

Availability

Dr Nicole Lawrence is:
Available for supervision
Media expert

Fields of research

Biological Sciences Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Developing next generation medicines from antimicrobial peptides

    Developing new drugs from natures host defence molecules - with improved safety and less likely to induce drug resistance.

Search Professor Nicole Lawrence’s works on UQ eSpace

54 works between 1994 and 2025
All (54) Journal Article (48) Other Outputs (1) Conference Publication (4) Book Chapter (1)

41 - 54 of 54 works

2017

Journal Article

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7

Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I. and Henriques, Sónia T. (2017). Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7. Biochimica et Biophysica Acta. Biomembranes, 1859 (5), 835-844. doi: 10.1016/j.bbamem.2017.01.020

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7

2016

Journal Article

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7

Troeira Henriques, Sonia, Deplazes, Evelyne, Lawrence, Nicole, Cheneval, Olivier, Chaousis, Stephanie, Inserra, Marco, Thongyoo, Panumart, King, Glenn F., Mark, Alan E., Vetter, Irina, Craik, David J. and Schroeder, Christina Ingrid (2016). Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7. The Journal of Biological Chemistry, 291 (33), 17049-17065. doi: 10.1074/jbc.M116.729095

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7

2016

Journal Article

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

Philippe, Gregoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P., Craik, David J., Dantas De Araujo, Aline and Troeira Henriques, Sonia (2016). Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers - Peptide Science, 106 (6), 853-863. doi: 10.1002/bip.22893

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

2012

Journal Article

Biophysical properties of Naᵥ 1.8/Naᵥ 1.2 chimeras and inhibition by µO-conotoxin MrVIB

Knapp, O., Nevin, S. T., Yasuda, T., Lawrence, N., Lewis, R. J. and Adams, D. J. (2012). Biophysical properties of Naᵥ 1.8/Naᵥ 1.2 chimeras and inhibition by µO-conotoxin MrVIB. British Journal of Pharmacology, 166 (7), 2148-2160. doi: 10.1111/j.1476-5381.2012.01955.x

Biophysical properties of Naᵥ 1.8/Naᵥ 1.2 chimeras and inhibition by µO-conotoxin MrVIB

2009

Journal Article

Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily

Loughnan, Marion L., Nicke, Annette, Lawrence, Nicole and Lewis, Richard J. (2009). Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry, 48 (17), 3717-3729. doi: 10.1021/bi9000326

Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily

2006

Journal Article

Population dynamics and gene flow of Helicoverpa armigera (Lepidoptera : Noctuidae) on cotton and grain crops in the Murrumbidgee Valley, Australia

Scott, Leon J., Lawrence, Nicole, Lange, Corinna L., Graham, Glenn C., Hardwick, Scott, Rossiter, Louise, Dillon, Martin L. and Scott, Kirsten D. (2006). Population dynamics and gene flow of Helicoverpa armigera (Lepidoptera : Noctuidae) on cotton and grain crops in the Murrumbidgee Valley, Australia. Journal of Economic Entomology, 99 (1), 155-163. doi: 10.1603/0022-0493(2006)099[0155:PDAGFO]2.0.CO;2

Population dynamics and gene flow of Helicoverpa armigera (Lepidoptera : Noctuidae) on cotton and grain crops in the Murrumbidgee Valley, Australia

2005

Journal Article

Assessing moth migration and population structuring in Helicoverpa annigera (Lepidoptera : Noctuidae) at the regional scale: Example from the Darling Downs, Australia

Scott, Kirsten D., Lawrence, Nicole, Lange, Corinna L., Scott, Leon J., Wilkinson, Kendle S., Merritt, Melissa A., Miles, Melina, Murray, David and Graham, Glenn C. (2005). Assessing moth migration and population structuring in Helicoverpa annigera (Lepidoptera : Noctuidae) at the regional scale: Example from the Darling Downs, Australia. Journal of Economic Entomology, 98 (6), 2210-2219. doi: 10.1093/jee/98.6.2210

Assessing moth migration and population structuring in Helicoverpa annigera (Lepidoptera : Noctuidae) at the regional scale: Example from the Darling Downs, Australia

2005

Journal Article

Gene-flow between populations of cotton bollworm Helicoverpa armigera (Lepidoptera: Noctuidae) is highly variable between years

Scott, K. D., Wilkinson, K. S., Lawrence, N., Lange, C. L., Scott, L. J., Merritt, M. A., Lowe, A. J. and Graham, G. C. (2005). Gene-flow between populations of cotton bollworm Helicoverpa armigera (Lepidoptera: Noctuidae) is highly variable between years. Bulletin of Entomological Research, 95 (4), 381-392. doi: 10.1079/BER2005369

Gene-flow between populations of cotton bollworm Helicoverpa armigera (Lepidoptera: Noctuidae) is highly variable between years

2000

Journal Article

Recombinant chimeric proteins generated from conserved regions of Plasmodium falciparum merozoite surface protein 2 generate antiparasite humoral responses in mice

Lawrence, N, Stowers, A, Mann, V, Taylor, D and Saul, A (2000). Recombinant chimeric proteins generated from conserved regions of Plasmodium falciparum merozoite surface protein 2 generate antiparasite humoral responses in mice. Parasite Immunology, 22 (5), 211-221. doi: 10.1046/j.1365-3024.2000.00293.x

Recombinant chimeric proteins generated from conserved regions of Plasmodium falciparum merozoite surface protein 2 generate antiparasite humoral responses in mice

1997

Journal Article

Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2

Stowers, Anthony, Taylor, Darrin, Prescott, Nicole, Cheng, Qin, Cooper, Juan and Saul, Allan (1997). Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2. Infection and Immunity, 65 (6), 2329-2338. doi: 10.1128/IAI.65.6.2329-2338.1997

Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2

1997

Journal Article

Evidence of cross-contamination among laboratory lines of Plasmodium berghei

Saul, A, Prescott, N, Smith, F, Cheng, Q and Walliker, D (1997). Evidence of cross-contamination among laboratory lines of Plasmodium berghei. Molecular and Biochemical Parasitology, 84 (1), 143-147. doi: 10.1016/S0166-6851(96)02779-X

Evidence of cross-contamination among laboratory lines of Plasmodium berghei

1997

Other Outputs

The production of immunogenic recombinant proteins and protein chimeras from plasmodial merozoite surface proteins

Prescott, Nicole (1997). The production of immunogenic recombinant proteins and protein chimeras from plasmodial merozoite surface proteins. PhD Thesis, Tropical Health Program, The University of Queensland. doi: 10.14264/27cf1ff

The production of immunogenic recombinant proteins and protein chimeras from plasmodial merozoite surface proteins

1995

Journal Article

Immunogenicity of recombinant Plasmodium falciparum rhoptry associated proteins 1 and 2

Stowers, A, Prescott, N, Cooper, J, Takacs, B, Stueber, D, Kennedy, P and Saul, A (1995). Immunogenicity of recombinant Plasmodium falciparum rhoptry associated proteins 1 and 2. Parasite Immunology, 17 (12), 631-642. doi: 10.1111/j.1365-3024.1995.tb01009.x

Immunogenicity of recombinant Plasmodium falciparum rhoptry associated proteins 1 and 2

1994

Journal Article

Plasmodium falciparum genetic diversity can be characterised using the polymorphic merozoite surface antigen 2 (MSA-2) gene as a single locus marker

Prescott, N, Stowers, AW, Cheng, Q, Bobogare, A, Rzepczyk, CM and Saul, A (1994). Plasmodium falciparum genetic diversity can be characterised using the polymorphic merozoite surface antigen 2 (MSA-2) gene as a single locus marker. Molecular and Biochemical Parasitology, 63 (2), 203-212. doi: 10.1016/0166-6851(94)90056-6

Plasmodium falciparum genetic diversity can be characterised using the polymorphic merozoite surface antigen 2 (MSA-2) gene as a single locus marker

Current funding

  • 2022 - 2026
    Next-generation peptide-based medicines for malaria
    United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
    Open grant

Past funding

  • 2022 - 2024
    Developing FXIIa inhibitors as next-generation anticoagulants
    NHMRC Development Grant
    Open grant
  • 2020 - 2023
    Developing targeted antimalarial drug leads from host defence peptide-drug conjugates (NHMRC Ideas Grant led by ANU)
    Australian National University
    Open grant

Availability

Dr Nicole Lawrence is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Dr Nicole Lawrence directly for media enquiries about:

  • drug design
  • drug-resistant bacteria
  • malaria
  • peptides
  • tropical health

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