
Overview
Background
Professor Khosrotehrani is a clinical scientist, dircetor of the Frazer institute, the university of Queensalnd, sharing his passion for academic medicine and translation of science discorveries into real world solutions for patients. Prof Khosrotehrani is a dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Frazer Institute within the Translational Research Institute in Brisbane, Australia. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
As the inaugural St Baker-Soyer chair of Dermatology at the University of Queensland, Professor Khosrotehrani is a national leader in the discipline of Dermatology. He is a board director at the Australasian College of Dermatologists and the Queensland Skin and Cancer Foundation and the director of the Dermatology Department at the Princess Alexandra Hospital. He has held multiple leadership roles as past-President of the Australasian Society for Dermatology Research, Editor in chief of the Australasian Journal of Dermatology and board member of the International Society of investigative Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2019
Journal Article
Abstract 576: Immunosuppression Agent Cyclosporine Reduces Self-Renewal and Vessel Regeneration Potentiation of Human Endothelial Colony Forming Cells
Sim, Seen-Ling, Alexis, Josue, Shafiee, Abbas, Khosrotehrani, Kiarash and Patel, Jatin (2019). Abstract 576: Immunosuppression Agent Cyclosporine Reduces Self-Renewal and Vessel Regeneration Potentiation of Human Endothelial Colony Forming Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 39 (Suppl_1). doi: 10.1161/atvb.39.suppl_1.576
2019
Journal Article
Risk of melanoma recurrence after diagnosis of a high-risk primary tumor
Von Schuckmann, Lena A., Hughes, Maria Celia B., Ghiasvand, Reza, Malt, Maryrose, Van Der Pols, Jolieke C., Beesley, Vanessa L., Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adele C. (2019). Risk of melanoma recurrence after diagnosis of a high-risk primary tumor. JAMA Dermatology, 155 (6), 688-693. doi: 10.1001/jamadermatol.2019.0440
2019
Conference Publication
Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells
Patel, Jatin, Lukowski, Samuel L., Winkler, Ingrid, Tay, Joshua and Khosrotehrani, Kiarash (2019). Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells. Annual Scientific Meeting and Scientific Sessions of the American-Heart-Association on Vascular Discovery - From Genes to Medicine, Boston, MA United States, 14-16 May 2019. Philadelphia, PA United States: Lippincott Williams & Wilkins.
2019
Journal Article
Abstract 393: Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells
PATEL, Jatin, Lukowski, Samuel L, Winkler, Ingrid, Tay, Joshua and Khosrotehrani, Kiarash (2019). Abstract 393: Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 39 (Suppl_1). doi: 10.1161/atvb.39.suppl_1.393
2019
Journal Article
Management of organ transplant recipients attending a high-throughput skin cancer surgery and surveillance clinic in Queensland
Papier, K., Gordon, L. G., Khosrotehrani, K., Isbel, N., Campbell, S., Griffin, A. and Green, A. C. (2019). Management of organ transplant recipients attending a high-throughput skin cancer surgery and surveillance clinic in Queensland. British Journal of Dermatology, 180 (3), 631-636. doi: 10.1111/bjd.17001
2019
Conference Publication
Laser dermabrasion: a potential treatment for non-melanoma skin cancers
Wong, H., Roy, E., Kapadia, S., Murigneux, V., Chong, S. and Khosrotehrani, K. (2019). Laser dermabrasion: a potential treatment for non-melanoma skin cancers. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.567
2019
Conference Publication
Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell Carcinoma
Villani, R., Roy, E., Murigneux, V., Sim, S., Malapitan, C., Galbraith, J., Kapadia, S., Fink, L. and Khosrotehrani, K. (2019). Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell Carcinoma. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September 2019. New York, NY United States: Elsevier. doi: 10.1016/j.jid.2019.07.507
2019
Journal Article
Sun protection behaviour after diagnosis of high-risk primary melanoma and risk of a subsequent primary
von Schuckmann, Lena A., Wilson, Louise F., Hughes, Maria Celia B., Beesley, Vanessa L., Janda, Monika, van der Pols, Jolieke C., Smithers, B. Mark, Khosrotehrani, Kiarash and Green, Adele C. (2019). Sun protection behaviour after diagnosis of high-risk primary melanoma and risk of a subsequent primary. Journal of the American Academy of Dermatology, 80 (1), 139-148.e4. doi: 10.1016/j.jaad.2018.06.068
2019
Conference Publication
Skin bacterial composition is driven largely by host genetic background and polymorphisms regulating innate immunity
Legrand, J., Muller, N., Baz, B., Morahan, G., Walker, G., Morrison, M. and Khosrotehrani, K. (2019). Skin bacterial composition is driven largely by host genetic background and polymorphisms regulating innate immunity. 49th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Bordeaux, France, 18-21 September 2019. New York, NY United States: Elsevier. doi: 10.1016/j.jid.2019.07.631
2019
Journal Article
Survival of patients with early invasive melanoma down-staged under the new 8 AJCC edition
von Schuckmann, Lena A., Hughes, Maria Celia B., Lee, Rebecca, Lorigan, Paul, Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adele C. (2019). Survival of patients with early invasive melanoma down-staged under the new 8 AJCC edition. Journal of the American Academy of Dermatology, 80 (1), 272-274. doi: 10.1016/j.jaad.2018.04.017
2019
Conference Publication
Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring
Patel, J., Hamilton, H., Kahler, S., Sim, S., Wong, H. and Khosrotehrani, K. (2019). Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.628
2019
Conference Publication
Melanoma patient survival: Prognostic value of pSTAT5 as a biomarker
Chong, S., Rowe, C., Malt, M., Brown, S., Smithers, M. and Khosrotehrani, K. (2019). Melanoma patient survival: Prognostic value of pSTAT5 as a biomarker. Australasian College of Dermatologists, 52nd Annual Scientific Meeting, Melbourne, VIC Australia, 18–21 May 2019. Richmond, VIC Australia: Wiley-Blackwell.
2019
Conference Publication
Epidermal clonal expansion upon UV irradiation: consequences of the epidermal duality of proliferative behaviour on the skin carcinogenesis
Roy, E., Wong, H. and Khosrotehrani, K. (2019). Epidermal clonal expansion upon UV irradiation: consequences of the epidermal duality of proliferative behaviour on the skin carcinogenesis. 49th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.570
2019
Conference Publication
SOX18 activation in primary melanoma tumours
Chong, S., Rowe, C., Malt, M., Smithers, M., Green, A. and Khosrotehrani, K. (2019). SOX18 activation in primary melanoma tumours. Australasian College of Dermatologists, 52nd Annual Scientific Meeting, Melbourne, VIC Australia, 18–21 May 2019. Richmond, VIC Australia: Wiley-Blackwell.
2019
Conference Publication
Clinicopathological factors associated with death from thin (<= 1 mm) melanoma
Claeson, M., Baade, P., Brown, S., Soyer, P., Smithers, M., Green, A., Whiteman, D. and Khosrotehrani, K. (2019). Clinicopathological factors associated with death from thin (
2019
Conference Publication
Modulating NFkB signaling in skin wounds through pharmacological or probiotic intervention using Faecalibacterium prausnitzii extracts
Stefia, L., Lee, J., Legrand, J., Rodero, M., Patel, J., Linedale, R., Burman, S., Morrison, M. and Khosrotehrani, K. (2019). Modulating NFkB signaling in skin wounds through pharmacological or probiotic intervention using Faecalibacterium prausnitzii extracts. 49th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Bordeaux, France, 18-21 September 2019. New York, NY, United States: Elsevier. doi: 10.1016/j.jid.2019.07.663
2018
Journal Article
The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice
Lee, James S., Robertson, Avril A. B., Cooper, Matthew A. and Khosrotehrani, Kiarash (2018). The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice. International Journal of Molecular Sciences, 19 (11) 3289, 3289. doi: 10.3390/ijms19113289
2018
Journal Article
Increase in preventive behaviour by organ transplant recipients after sun protection information in a skin cancer surveillance clinic
Papier, K., Gordon, L.G., Khosrotehrani, K., Isbel, N., Campbell, S., Griffin, A. and Green, A.C. (2018). Increase in preventive behaviour by organ transplant recipients after sun protection information in a skin cancer surveillance clinic. British Journal of Dermatology, 179 (5), 1195-1196. doi: 10.1111/bjd.16836
2018
Journal Article
Immunosuppression agent cyclosporine reduces self-renewal and vessel regeneration potentiation of human endothelial colony forming cells: deleterious effect of cyclosporine on ECFC
Sim, Seen-Ling, Alexis, Josue, Roy, Edwige, Shafiee, Abbas, Khosrotehrani, Kiarash and Patel, Jatin (2018). Immunosuppression agent cyclosporine reduces self-renewal and vessel regeneration potentiation of human endothelial colony forming cells: deleterious effect of cyclosporine on ECFC. STEM CELLS Translational Medicine, 8 (2), 162-168. doi: 10.1002/sctm.18-0103
2018
Journal Article
Genetic variation in the MAPK/ERK pathway affects contact hypersensitivity responses
Legrand, Julien M. D., Roy, Edwige, Baz, Batoul, Mukhopadhyay, Pamela, Wong, Ho Yi, Ram, Ramesh, Morahan, Grant, Walker, Graeme and Khosrotehrani, Kiarash (2018). Genetic variation in the MAPK/ERK pathway affects contact hypersensitivity responses. Journal of Allergy and Clinical Immunology, 142 (3), 981-984.e7. doi: 10.1016/j.jaci.2018.04.028
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Master Philosophy
Skin micro-bio-tox: understanding the skin toxicity associated with immune checkpoint inhibitors
Principal Advisor
Other advisors: Dr Janin Chandra
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Quan Nguyen, Dr Lena Von Schuckmann
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Defining the role of non-immune MHCII expression in the development of squamous cell cancers.
Associate Advisor
Other advisors: Dr Debottam Sinha, Dr Janin Chandra
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
Completed supervision
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2025
Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Imaging.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2025
Master Philosophy
Antibody-mediated exacerbation of chronic wounds colonised with Pseudomonas aeruginosa
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Mark Smithers
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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