
Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2019
Conference Publication
Skin bacterial composition is driven largely by host genetic background and polymorphisms regulating innate immunity
Legrand, J., Muller, N., Baz, B., Morahan, G., Walker, G., Morrison, M. and Khosrotehrani, K. (2019). Skin bacterial composition is driven largely by host genetic background and polymorphisms regulating innate immunity. 49th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Bordeaux, France, 18-21 September 2019. New York, NY United States: Elsevier. doi: 10.1016/j.jid.2019.07.631
2019
Journal Article
Survival of patients with early invasive melanoma down-staged under the new 8 AJCC edition
von Schuckmann, Lena A., Hughes, Maria Celia B., Lee, Rebecca, Lorigan, Paul, Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adele C. (2019). Survival of patients with early invasive melanoma down-staged under the new 8 AJCC edition. Journal of the American Academy of Dermatology, 80 (1), 272-274. doi: 10.1016/j.jaad.2018.04.017
2018
Journal Article
The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice
Lee, James S., Robertson, Avril A. B., Cooper, Matthew A. and Khosrotehrani, Kiarash (2018). The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice. International Journal of Molecular Sciences, 19 (11) 3289, 3289. doi: 10.3390/ijms19113289
2018
Journal Article
Increase in preventive behaviour by organ transplant recipients after sun protection information in a skin cancer surveillance clinic
Papier, K., Gordon, L.G., Khosrotehrani, K., Isbel, N., Campbell, S., Griffin, A. and Green, A.C. (2018). Increase in preventive behaviour by organ transplant recipients after sun protection information in a skin cancer surveillance clinic. British Journal of Dermatology, 179 (5), 1195-1196. doi: 10.1111/bjd.16836
2018
Journal Article
Immunosuppression agent cyclosporine reduces self-renewal and vessel regeneration potentiation of human endothelial colony forming cells: deleterious effect of cyclosporine on ECFC
Sim, Seen-Ling, Alexis, Josue, Roy, Edwige, Shafiee, Abbas, Khosrotehrani, Kiarash and Patel, Jatin (2018). Immunosuppression agent cyclosporine reduces self-renewal and vessel regeneration potentiation of human endothelial colony forming cells: deleterious effect of cyclosporine on ECFC. STEM CELLS Translational Medicine, 8 (2), 162-168. doi: 10.1002/sctm.18-0103
2018
Journal Article
Past stem cells and finally in transit: SLC1A3 instructs skin niche coupling
Roy, Edwige and Khosrotehrani, Kiarash (2018). Past stem cells and finally in transit: SLC1A3 instructs skin niche coupling. The EMBO Journal, 37 (9) e99393, e99393. doi: 10.15252/embj.201899393
2018
Journal Article
Clustering of prevention behaviours in patients with high-risk primary melanoma
Green, Adèle C., Hughes, Maria Celia B., von Schuckmann, Lena A., Khosrotehrani, Kiarash and Mark Smithers, B. (2018). Clustering of prevention behaviours in patients with high-risk primary melanoma. Psycho-Oncology, 27 (5), 1442-1449. doi: 10.1002/pon.4565
2018
Conference Publication
Natural history of bacterial composition in skin wounds and its relationship to healing
Khosrotehrani, K., Matigian, N., Baz, B., Legrand, J., Muller, N., Morrison, M. and Walker, G. (2018). Natural history of bacterial composition in skin wounds and its relationship to healing. International Investigative Dermatology (IID) Meeting, Orlando, FL United States, 16-19 May 2018. New York, NY United States: Elsevier.
2018
Journal Article
Temporal regulation of natural Killer T cell interferon gamma responses by beta-catenin-dependent and -independent Wnt signaling
Kling, Jessica C., Jordan, Margaret A., Pitt, Lauren A., Meiners, Jana, Thanh-Tran, Thao , Tran, Le Son , Nguyen, Tam T. K., Mittal, Deepak, Villani, Rehan, Steptoe, Raymond J., Khosrotehrani, Kiarash, Berzins, Stuart P., Baxter, Alan G., Godfrey, Dale I. and Blumenthal, Antje (2018). Temporal regulation of natural Killer T cell interferon gamma responses by beta-catenin-dependent and -independent Wnt signaling. Frontiers in Immunology, 9 (MAR) 483, 483. doi: 10.3389/fimmu.2018.00483
2018
Journal Article
Meso-Endothelial Bipotent Progenitors from Human Placenta Display Distinct Molecular and Cellular Identity
Shafiee, Abbas, Patel, Jatin, Hutmacher, Dietmar W., Fisk, Nicholas M. and Khosrotehrani, Kiarash (2018). Meso-Endothelial Bipotent Progenitors from Human Placenta Display Distinct Molecular and Cellular Identity. Stem Cell Reports, 10 (3), 890-904. doi: 10.1016/j.stemcr.2018.01.011
2018
Journal Article
Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization
Lee, James, Rodero, Mathieu Paul, Patel, Jatin, Moi, Davide, Mazzieri, Roberta and Khosrotehrani, Kiarash (2018). Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 32 (4), fj201700773R-2094. doi: 10.1096/fj.201700773R
2018
Book Chapter
Whole-mount immunofluorescent staining coupled to multicolor lineage tracing model for analyzing the spatiotemporal organization of epidermal stem cells
Roy, Edwige and Khosrotehrani, Kiarash (2018). Whole-mount immunofluorescent staining coupled to multicolor lineage tracing model for analyzing the spatiotemporal organization of epidermal stem cells. Skin stem cells: methods protocols. (pp. 111-118) edited by Kursad Turksen. New York, NY, United States: Humana Press. doi: 10.1007/7651_2018_165
2018
Conference Publication
Endovascular progenitors initiate and drive de novo vascularisation in melanoma
Patel, J., Dight, J., Donovan, P., Wong, H. and Khosrotehrani, K. (2018). Endovascular progenitors initiate and drive de novo vascularisation in melanoma. International Investigative Dermatology (IID) Meeting, Orlando, FL United States, 16-19 May 2018. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2018.03.1255
2018
Book Chapter
Fetal endothelial progenitors and mesenchymal stem cells from the human term placenta
Patel, Jatin and Khosrotehrani, Kiarash (2018). Fetal endothelial progenitors and mesenchymal stem cells from the human term placenta. Perinatal stem cells: research and therapy. (pp. 131-140) edited by Anthony Atala, Kyle J. Cetrulo, Rouzbeh R. Raghizadeh, Sean V. Murphy and Curtis L. Cetrulo, Jr.. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-812015-6.00009-1
2018
Conference Publication
Effect of a previous diagnosis of primary invasive melanoma on the progression of subsequent primary invasive melanoma
Chong, S., Green, A., Rowe, C., Malt, M., Brown, S., Smithers, M. and Khosrotehrani, K. (2018). Effect of a previous diagnosis of primary invasive melanoma on the progression of subsequent primary invasive melanoma. Australasian College of Dermatologists, 51st Annual Scientific Meeting, Gold Coast, QLD, Australia, 19-22 May 2018. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/ajd.17_12815
2018
Conference Publication
Genome wide mapping identifies regulation of MAPKinase pathway as key genetic determinant of allergic contact dermatitis
Roy, E., Legrand, J., Baz, B., Wong, H., Morahan, G., Walker, G. and Khosrotehrani, K. (2018). Genome wide mapping identifies regulation of MAPKinase pathway as key genetic determinant of allergic contact dermatitis. International Investigative Dermatology (IID) Meeting, Orlando, FL, United States, 16 - 19 May 2018. London, United Kingdom: Nature Publishing Group.
2018
Conference Publication
Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling
Edwige, Roy, Zoltan, Neufeld, Luca, Cerone, Yi, Wong Ho, Samantha, Hodgson, Jean, Livet and Kiarash, Khosrotehrani (2018). Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling. Joint 10th Annual Scientific Meeting of the Australian Gene and Cell Therapy Society (AGCTS) and Australasian Society for Stem Cell Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/jgm.3003
2017
Journal Article
Accelerated Endothelial to Mesenchymal Transition increased fibrosis via deleting Notch signalling in wound vasculature
Patel, Jatin, Baz, Betoul, Wong, Ho Yi, Lee, James S. and Khosrotehrani, Kiarash (2017). Accelerated Endothelial to Mesenchymal Transition increased fibrosis via deleting Notch signalling in wound vasculature. The Journal of Investigative Dermatology, 138 (5), 1166-1175. doi: 10.1016/j.jid.2017.12.004
2017
Journal Article
Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma
Villani, R and Khosrotehrani, K (2017). Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma. The British Journal of Dermatology, 177 (6), 1472-1473. doi: 10.1111/bjd.15988
2017
Journal Article
New insights into naevoid melanomas: a clinicopathological reassessment
Cook, Martin G., Massi, Daniela, Blokx, Willeke A. M., Van den Oord, Joost, Koljenović, Senada, De Giorgi, Vincenzo, Kissin, Eleanor, Grant, Megan, Mandal, Amit, Gremel, Gabriela, Gaudy, Caroline, Viros, Amaya, Dhomen, Nathalie, Khosrotehrani, Kiarash, Marais, Richard, Green, Adele C. and Mihm, Martin C. (2017). New insights into naevoid melanomas: a clinicopathological reassessment. Histopathology, 71 (6), 943-950. doi: 10.1111/his.13317
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Principal Advisor
-
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
-
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Master Philosophy
Antibody-mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
Completed supervision
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
-
2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
-
2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
-
2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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