Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2017
Journal Article
Accelerated Endothelial to Mesenchymal Transition increased fibrosis via deleting Notch signalling in wound vasculature
Patel, Jatin, Baz, Betoul, Wong, Ho Yi, Lee, James S. and Khosrotehrani, Kiarash (2017). Accelerated Endothelial to Mesenchymal Transition increased fibrosis via deleting Notch signalling in wound vasculature. The Journal of Investigative Dermatology, 138 (5), 1166-1175. doi: 10.1016/j.jid.2017.12.004
2017
Journal Article
Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma
Villani, R and Khosrotehrani, K (2017). Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma. The British Journal of Dermatology, 177 (6), 1472-1473. doi: 10.1111/bjd.15988
2017
Journal Article
New insights into naevoid melanomas: a clinicopathological reassessment
Cook, Martin G., Massi, Daniela, Blokx, Willeke A. M., Van den Oord, Joost, Koljenović, Senada, De Giorgi, Vincenzo, Kissin, Eleanor, Grant, Megan, Mandal, Amit, Gremel, Gabriela, Gaudy, Caroline, Viros, Amaya, Dhomen, Nathalie, Khosrotehrani, Kiarash, Marais, Richard, Green, Adele C. and Mihm, Martin C. (2017). New insights into naevoid melanomas: a clinicopathological reassessment. Histopathology, 71 (6), 943-950. doi: 10.1111/his.13317
2017
Journal Article
Keratinocyte sonic hedgehog up-regulation drives the development of giant congenital nevi via paracrine endothelin-1 secretion
Chitsazan, Arash, Ferguson, Blake, Villani, Rehan, Handoko, Herlina Y, Mukhopadhyay, Pamela, Gabrielli, Brian, Mooi, Wolter J, Soyer, H Peter, Lambie, Duncan, Khosrotehrani, Kiarash, Morahan, Grant and Walker, Graeme J (2017). Keratinocyte sonic hedgehog up-regulation drives the development of giant congenital nevi via paracrine endothelin-1 secretion. The Journal of investigative dermatology, 138 (4), 893-902. doi: 10.1016/j.jid.2017.10.032
2017
Journal Article
In vitro co-culture of mesenchymal stem cells and endothelial colony forming cells
Shafiee, Abbas and Khosrotehrani, Kiarash (2017). In vitro co-culture of mesenchymal stem cells and endothelial colony forming cells. Bio-Protocol, 7 (20) ARTN e2587, e2587. doi: 10.21769/bioprotoc.2587
2017
Journal Article
Mesenchymal stem/stromal cells enhance engraftment, vasculogenic and pro-angiogenic activities of endothelial colony forming cells in immunocompetent hosts
Shafiee, Abbas, Patel, Jatin, Lee, James S, Hutmacher, Dietmar W, Fisk, Nicholas M and Khosrotehrani, Kiarash (2017). Mesenchymal stem/stromal cells enhance engraftment, vasculogenic and pro-angiogenic activities of endothelial colony forming cells in immunocompetent hosts. Scientific reports, 7 (1) 13558, 1-10. doi: 10.1038/s41598-017-13971-3
2017
Journal Article
Defining tissue resident vascular stem cells
Patel, Jatin, Donovan, Prudence and Khosrotehrani, Kiarash (2017). Defining tissue resident vascular stem cells. Oncotarget, 8 (49), 84618-84619. doi: 10.18632/oncotarget.21389
2017
Journal Article
Fetal Bone Marrow-Derived Mesenchymal Stem/Stromal Cells Enhance Humanization and Bone Formation of BMP7 Loaded Scaffolds
Shafiee, Abbas, Baldwin, Jeremy G., Patel, Jatin, Holzapfel, Boris M., Fisk, Nicholas M., Khosrotehrani, Kiarash and Hutmacher, Dietmar W. (2017). Fetal Bone Marrow-Derived Mesenchymal Stem/Stromal Cells Enhance Humanization and Bone Formation of BMP7 Loaded Scaffolds. Biotechnology Journal, 12 (12) 1700414, 1700414. doi: 10.1002/biot.201700414
2017
Journal Article
Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle
Castela, Mathieu, Linay, Fabien, Roy, Edwige, Moguelet, Philippe, Xu, Jie, Holzenberger, Martin, Khosrotehrani, Kiarash and Aractingi, Selim (2017). Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle. Experimental Dermatology, 26 (9), 785-791. doi: 10.1111/exd.13287
2017
Journal Article
Associations of statins and diabetes with diagnosis of ulcerated cutaneous melanoma
von Schuckmann, Lena A., Smith, David, Hughes, Maria Celia B., Malt, Maryrose, van der Pols, Jolieke C., Khosrotehrani, Kiarash, Smithers, Bernard M. and Green, Adele C. (2017). Associations of statins and diabetes with diagnosis of ulcerated cutaneous melanoma. Journal of Investigative Dermatology, 137 (12), 2599-2605. doi: 10.1016/j.jid.2017.07.836
2017
Journal Article
Prognostic importance of a second invasive primary melanoma according to tumour stage
Youlden, D R, Baade, P D, Aitken, J F, Green, A C and Khosrotehrani, K (2017). Prognostic importance of a second invasive primary melanoma according to tumour stage. British Journal of Dermatology, 177 (6), e336-e337. doi: 10.1111/bjd.15863
2017
Journal Article
A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning
Wang, Qixuan, Oh, Ji Won, Lee, Hye-Lim, Dhar, Anukriti, Peng, Tao, Ramos, Raul, Guerrero-Juarez, Christian Fernando, Wang, Xiaojie, Zhao, Ran, Cao, Xiaoling, Le, Jonathan, Fuentes, Melisa A., Jocoy, Shelby C, Rossi, Antoni R, Vu, Brian, Pham, Kim, Wang, Xiaoyang, Mali, Nanda Maya, Park, Jung Min, Choi, June-Hyug, Lee, Hyunsu, Legrand, Julien M. D., Kandyba, Eve, Kim, Jung Chul, Kim, Moonkyu, Foley, John, Yu, Zhengquan, Kobielak, Krzysztof, Andersen, Bogi ... Plikus, Maksim V. (2017). A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning. Elife, 6 e22772. doi: 10.7554/eLife.22772
2017
Journal Article
Endothelial progenitors: a consensus statement on nomenclature
Medina, Reinhold J., Barber, Chad L., Sabatier, Florence, Dignat-George, Francoise, Melero-Martin, Juan M., Khosrotehrani, Kiarash, Ohneda, Osamu, Randi, Anna M., Chan, Jerry K. Y., Yamaguchi, Teruhide, Van Hinsbergh, Victor W. M., Yoder, Mervin C. and Stitt, Alan W. (2017). Endothelial progenitors: a consensus statement on nomenclature. Stem Cells Translational Medicine, 6 (5), 1316-1320. doi: 10.1002/sctm.16-0360
2017
Journal Article
Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types
Villani, Rehan, Hodgson, Samantha, Legrand, Julien, Greaney, Jessica, Wong, Ho Yi, Pichol-Thievend, Cathy, Adolphe, Christelle, Wainwight, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2017). Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development, 144 (10), 1887-1895. doi: 10.1242/dev.143917
2017
Journal Article
Use of support services in a sample of patients with high-risk primary melanomas in urban, regional and rural Queensland
von Schuckmann, Lena A., Smithers, Bernhard M., Khosrotehrani, Kiarash, Beesley, Vanessa L., van der Pols, Jolieke C., Hughes, Maria B. and Green, Adele C. (2017). Use of support services in a sample of patients with high-risk primary melanomas in urban, regional and rural Queensland. Australian and New Zealand Journal of Public Health, 41 (3), 315-319. doi: 10.1111/1753-6405.12662
2017
Journal Article
Epidermal YAP2-5SA-ΔC drives β-catenin activation to promote keratinocyte proliferation in mouse skin in vivo
Akladios, Bassem, Mendoza-Reinoso, Veronica, Samuel, Michael S., Hardeman, Edna C., Khosrotehrani, Kiarash, Key, Brian and Beverdam, Annemiek (2017). Epidermal YAP2-5SA-ΔC drives β-catenin activation to promote keratinocyte proliferation in mouse skin in vivo. Journal of Investigative Dermatology, 137 (3), 716-726. doi: 10.1016/j.jid.2016.10.029
2017
Journal Article
Functional definition of progenitors versus mature endothelial cells reveals key SoxF-dependent differentiation process
Patel, Jatin, Seppanen, Elke J., Rodero, Mathieu, Wong, Ho Yi, Donovan, Prudence, Neufeld, Zoltan, Fisk, Nicholas, Francois, Mathias and Khosrotehrani, Kiarash (2017). Functional definition of progenitors versus mature endothelial cells reveals key SoxF-dependent differentiation process. Circulation, 135 (8), 786-805. doi: 10.1161/CIRCULATIONAHA.116.024754
2017
Journal Article
Priming of endothelial colony-forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling
Shafiee, Abbas, Patel, Jatin, Wong, Ho Yi, Donovan, Prudence, Hutmacher, Dietmar W., Fisk, Nicholas M. and Khosrotehrani, Kiarash (2017). Priming of endothelial colony-forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling. The FASEB Journal, 31 (2), 610-624. doi: 10.1096/fj.201600937
2017
Journal Article
Tell me about your stemness. I’ll give your cancer risk!
Khosrotehrani, Kiarash and Roy, Edwige (2017). Tell me about your stemness. I’ll give your cancer risk!. Cell Death and Differentiation, 24 (1), 6-7. doi: 10.1038/cdd.2016.144
2017
Conference Publication
A novel in vivo endothelial hierarchy from progenitor to mature endothelial cells reveals key SoxF-dependent differentiation process
Patel, Jatin, Seppanen, Elke J., Rodero, Mathieu, Wong, Ho Yi, Donovan, Prudence, Fisk, Nicholas M., Francois, Mathias and Khosrotehrani, Kiarash (2017). A novel in vivo endothelial hierarchy from progenitor to mature endothelial cells reveals key SoxF-dependent differentiation process. American-Heart-Association's Arteriosclerosis, Thrombosis and Vascular Biology/Peripheral Vascular Disease Scientific Sessions, Minneapolis MN, United States, 4-6 May 2017. Philadelphia, PA United States: Lippincott Williams & Wilkins.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Dr Brigid Betz-Stablein, Ms Laura Sormani Le Bourhis
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Dr Timothy Wells
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Associate Advisor
Other advisors: Professor Annette Dobson, Dr Lena Von Schuckmann
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Dr Mitchell Stark
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Elucidate the role of interferon signalling pathways in skin diseases
Associate Advisor
Other advisors: Associate Professor Fiona Simpson, Dr Snehlata Kumari
Completed supervision
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
Other advisors: Associate Professor Andrew Brooks
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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