
Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2023
Journal Article
Anti‐IL17A , Ixekizumab, for treatment‐resistant chronic venous leg ulcers: a phase II randomized, double‐blind, placebo‐controlled pilot trial
Cox, C., Fry, K., Sivakumaran, Y., Spelman, L. and Khosrotehrani, K. (2023). Anti‐IL17A , Ixekizumab, for treatment‐resistant chronic venous leg ulcers: a phase II randomized, double‐blind, placebo‐controlled pilot trial. Journal of the European Academy of Dermatology and Venereology, 143 (5), S259-e975. doi: 10.1111/jdv.19041
2023
Journal Article
Targeting Staphylococcus aureus dominated skin dysbiosis in actinic keratosis to prevent the onset of cutaneous squamous cell carcinoma: Outlook for future therapies?
Bromfield, Jacoba Isobella, Hugenholtz, Philip, Frazer, Ian Hector, Khosrotehrani, Kiarash and Chandra, Janin (2023). Targeting Staphylococcus aureus dominated skin dysbiosis in actinic keratosis to prevent the onset of cutaneous squamous cell carcinoma: Outlook for future therapies?. Frontiers in Oncology, 13 1091379, 1091379. doi: 10.3389/fonc.2023.1091379
2023
Journal Article
Conditional survival in patients with stage IB‐IIIA melanoma undergoing sentinel node biopsy in Queensland: a longitudinal study
Tedman, Alexander James, Liyanage, Upekha E., Chong, Sharene, Rowe, Casey, von Schuckmann, Lena A., Malt, Maryrose, Green, Adele C., Smithers, B. Mark and Khosrotehrani, Kiarash (2023). Conditional survival in patients with stage IB‐IIIA melanoma undergoing sentinel node biopsy in Queensland: a longitudinal study. Australasian Journal of Dermatology, 64 (1), e34-e40. doi: 10.1111/ajd.13974
2023
Journal Article
Tribute to reviewers
Khosrotehrani, Kiarash and Schaider, Helmut (2023). Tribute to reviewers. Australasian Journal of Dermatology, 64 (1), 162-166. doi: 10.1111/ajd.13990
2023
Journal Article
Risk factors associated with first and second primary melanomas in a high-incidence population
Olsen, Catherine M., Pandeya, Nirmala, Dusingize, Jean Claude, Neale, Rachel E., MacGregor, Stuart, Law, Matthew H., Whiteman, David C., for the QSkin Study, Hayward, Nicholas K., Khosrotehrani, Kiarash and Gordon, Louisa G. (2023). Risk factors associated with first and second primary melanomas in a high-incidence population. JAMA Dermatology, 159 (1), 37-46. doi: 10.1001/jamadermatol.2022.4975
2022
Conference Publication
Epidermal ablation reduces keratinocyte cancer burden by lowering skin mutation load
Wong, H., Lee, R., Roy, E., Kapadia, S., Murigneux, V., Chong, S., Freeman, M. and Khosrotehrani, K. (2022). Epidermal ablation reduces keratinocyte cancer burden by lowering skin mutation load. 51st Annual ESDR Meeting, Amsterdam, Netherlands, 28 September-1 October 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2022.09.449
2022
Conference Publication
Variation in epidermal mutation burden after field treatment with topical 5-fluorouracil
Lee, R., Wong, H., Brown, S., Roy, E. and Khosrotehrani, K. (2022). Variation in epidermal mutation burden after field treatment with topical 5-fluorouracil. 51st Annual ESDR Meeting, Amsterdam, Netherlands, 28 September-1 October 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2022.09.504
2022
Journal Article
Macrophages in skin wounds: functions and therapeutic potential
Sim, Seen Ling, Kumari, Snehlata, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Macrophages in skin wounds: functions and therapeutic potential. Biomolecules, 12 (11) 1659, 1-31. doi: 10.3390/biom12111659
2022
Journal Article
Melanoma tumour vascularization and tissue-resident endothelial progenitor cells
Hashemi, Ghazaleh, Dight, James, Khosrotehrani, Kiarash and Sormani, Laura (2022). Melanoma tumour vascularization and tissue-resident endothelial progenitor cells. Cancers, 14 (17) 4216, 1-23. doi: 10.3390/cancers14174216
2022
Journal Article
Skin biomechanics: a potential therapeutic intervention target to reduce scarring
Hosseini, Motaharesadat, Brown, Jason, Khosrotehrani, Kiarash, Bayat, Ardeshir and Shafiee, Abbas (2022). Skin biomechanics: a potential therapeutic intervention target to reduce scarring. Burns and Trauma, 10 tkac036, tkac036. doi: 10.1093/burnst/tkac036
2022
Journal Article
Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration
Sim, Seen Ling, Blumenthal, Antje, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration. Frontiers in Endocrinology, 13 957833, 957833. doi: 10.3389/fendo.2022.957833
2022
Journal Article
Objective assessment of tumor infiltrating lymphocytes as a prognostic marker in melanoma using machine learning algorithms
Aung, Thazin Nwe, Shafi, Saba, Wilmott, James S., Nourmohammadi, Saeed, Vathiotis, Ioannis, Gavrielatou, Niki, Fernandez, Aileen, Yaghoobi, Vesal, Sinnberg, Tobias, Amaral, Teresa, Ikenberg, Kristian, Khosrotehrani, Kiarash, Osman, Iman, Acs, Balazs, Bai, Yalai, Martinez-Morilla, Sandra, Moutafi, Myrto, Thompson, John F., Scolyer, Richard A. and Rimm, David L. (2022). Objective assessment of tumor infiltrating lymphocytes as a prognostic marker in melanoma using machine learning algorithms. eBioMedicine, 82 104143, 1-14. doi: 10.1016/j.ebiom.2022.104143
2022
Journal Article
High-yield isolation of pure fetal endothelial colony forming cells and mesenchymal stem cells from the human full-term placenta
Nano, Rachel, Sim, Seen Ling, Shafiee, Abbas, Khosrotehrani, Kiarash and Patel, Jatin (2022). High-yield isolation of pure fetal endothelial colony forming cells and mesenchymal stem cells from the human full-term placenta. STAR Protocols, 3 (2) 101354, 101354. doi: 10.1016/j.xpro.2022.101354
2022
Journal Article
Keratinocyte Cancer Mortality in Kidney Transplant Recipients
Shao, Emily Ximin, Betz-Stablein, Brigid, Khosrotehrani, Kiarash, Campbell, Scott, Isbel, Nicole and Green, Adele C. (2022). Keratinocyte Cancer Mortality in Kidney Transplant Recipients. Transplantation, 106 (5), 1078-1083. doi: 10.1097/tp.0000000000003827
2022
Journal Article
Diet quality is associated with primary melanoma thickness
Hughes, M. C. B., Malt, M., Khosrotehrani, K., Smithers, B. M. and Green, A. C. (2022). Diet quality is associated with primary melanoma thickness. Journal of the European Academy of Dermatology and Venereology, 36 (10), 1745-1750. doi: 10.1111/jdv.18174
2022
Journal Article
Pathways from diagnosis to death from keratinocyte cancer in kidney transplant recipients
Shao, Emily Ximin, Khosrotehrani, Kiarash, Campbell, Scott, Isbel, Nicole and Green, Adele (2022). Pathways from diagnosis to death from keratinocyte cancer in kidney transplant recipients. Dermatology, 238 (6), 1-8. doi: 10.1159/000524120
2022
Journal Article
Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study
Clayton, Bethan, Muneeb, Ferhan, Hughes, Maria Celia B., Grant, Megan E., Khosrotehrani, Kiarash, Smithers, B. Mark, Spina, Romina, Campana, Luca G., Oudit, Deemesh and Green, Adele C. (2022). Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study. International Journal of Cancer, 151 (3), 396-401. doi: 10.1002/ijc.34020
2022
Journal Article
Chemoprevention of cutaneous squamous cell carcinoma and its precursors in solid organ transplant recipients using topical sirolimus: a randomized, double-blind, placebo-controlled pilot trial
Chong, Sharene, Wong, Ho Yi, Althabteh, Ahmad, Cox, Charlotte, Stevenson, Paul H., Brown, Susan, Griffin, Anthony, Isbel, Nicole, Siller, Gregory, Soyer, H. Peter, Schaider, Helmut, Roy, Edwige, Campbell, Scott, Green, Adele C. and Khosrotehrani, Kiarash (2022). Chemoprevention of cutaneous squamous cell carcinoma and its precursors in solid organ transplant recipients using topical sirolimus: a randomized, double-blind, placebo-controlled pilot trial. Journal of the American Academy of Dermatology, 87 (5), 1163-1166. doi: 10.1016/j.jaad.2022.02.039
2022
Journal Article
A murine Kitl allele regulates skin mast cell density across 58 collaborative mouse cross strains
Walker, Graeme J., Galbraith, Jack A., Baz, Betoul, Ferguson, Blake, Handoko, Herlina Y. and Khosrotehrani, Kiarash (2022). A murine Kitl allele regulates skin mast cell density across 58 collaborative mouse cross strains. Journal of Investigative Dermatology, 142 (8), 2275-2280.e4. doi: 10.1016/j.jid.2021.12.032
2022
Journal Article
Training and retaining physician‒scientists in dermatology: Australia
Khosrotehrani, Kiarash, Murrell, Dedee, Veysey, Emma, Tong, Philipp, Bennett, Haley, Mar, Victoria and Soyer, H. Peter (2022). Training and retaining physician‒scientists in dermatology: Australia. JID Innovations, 2 (1) 100074, 100074. doi: 10.1016/j.xjidi.2021.100074
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Principal Advisor
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Master Philosophy
Antibody-mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
Completed supervision
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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