
Overview
Background
Professor Khosrotehrani is a clinical scientist, dircetor of the Frazer institute, the university of Queensalnd, sharing his passion for academic medicine and translation of science discorveries into real world solutions for patients. Prof Khosrotehrani is a dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Frazer Institute within the Translational Research Institute in Brisbane, Australia. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
As the inaugural St Baker-Soyer chair of Dermatology at the University of Queensland, Professor Khosrotehrani is a national leader in the discipline of Dermatology. He is a board director at the Australasian College of Dermatologists and the Queensland Skin and Cancer Foundation and the director of the Dermatology Department at the Princess Alexandra Hospital. He has held multiple leadership roles as past-President of the Australasian Society for Dermatology Research, Editor in chief of the Australasian Journal of Dermatology and board member of the International Society of investigative Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2023
Journal Article
Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns
Chand, Kirat, Patel, Jatin, Matthews, Kate, Nano, Rachel, Musco, Hannah, Khosrotehrani, Kiarash, Colditz, Paul and Wixey, Julie (2023). Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns. IBRO Neuroscience Reports, 15, S171-S171. doi: 10.1016/j.ibneur.2023.08.249
2023
Conference Publication
Dermocosmetics in management of cancer-related skin toxicities: International expert consensus highlighting the key role of oncology nurses
Dielenseger, P., Lacouture, M., Khosrotehrani, K., De Barros Silva, G., Wolf, J. Ryan, Kerob, D., Trombetta, M., Atenguena, E.O., Pan, M., Scotte, F., Krakowski, I. and Dreno, B. (2023). Dermocosmetics in management of cancer-related skin toxicities: International expert consensus highlighting the key role of oncology nurses. ESMO Congress 2023, Madrid, Spain, 20-24 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2023.09.873
2023
Journal Article
Patterns and cost of care according to keratinocyte cancer risk stratification in a volunteer population screening clinic: real‐world data from the TRoPICS study
Lee, Ruby Chia‐Lin, Liyanage, Upekha, Fry, Kirsty, Brown, Susan, von Schuckmann, Lena, Spelman, Lynda, Soyer, H. Peter, Neale, Rachel E., Gordon, Louisa G., Whiteman, David C., Olsen, Catherine M., Janda, Monika and Khosrotehrani, Kiarash (2023). Patterns and cost of care according to keratinocyte cancer risk stratification in a volunteer population screening clinic: real‐world data from the TRoPICS study. Australasian Journal of Dermatology, 64 (3), 389-396. doi: 10.1111/ajd.14054
2023
Journal Article
Metamorphosis of topical semisolid products—understanding the role of rheological properties in drug permeation under the “in use” condition
Jin, Xuping, Alavi, Seyed Ebrahim, Shafiee, Abbas, Leite-Silva, Vania Rodrigues, Khosrotehrani, Kiarash and Mohammed, Yousuf (2023). Metamorphosis of topical semisolid products—understanding the role of rheological properties in drug permeation under the “in use” condition. Pharmaceutics, 15 (6) 1707, 1707. doi: 10.3390/pharmaceutics15061707
2023
Conference Publication
Dermocosmetics in management of cancer-related skin toxicities: International expert consensus
Dreno, Brigitte, Khosrotehrani, Kiarash, De Barros Silva, Giselle, Ryan-Wolf, Julie, Kerob, Delphine, Trombetta, Mark G., Atenguena Okobalemba, Etienne, Dielenseger, Pascale, Pan, Meng and Lacouture, Mario E. (2023). Dermocosmetics in management of cancer-related skin toxicities: International expert consensus. 2023 ASCO Annual Meeting, Chicago, IL United States, 2-6 June 2023. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2023.41.16_suppl.e24115
2023
Conference Publication
Dermocosmetics in management of cancer-related skin toxicities: International expert consensus
Dreno, Brigitte, Khosrotehrani, Kiarash, Silva, Giselle De Barros, Ryan-Wolf, Julie, Kerob, Delphine, Trombetta, Mark G., Okobalemba, Etienne Atenguena, Dielenseger, Pascale, Pan, Meng and Lacouture, Mario E. (2023). Dermocosmetics in management of cancer-related skin toxicities: International expert consensus. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago Il, Jun 02-06, 2023. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
2023
Journal Article
The association between <scp>BRAF‐V600E</scp> mutations and death from thin (≤1.00 mm) melanomas: a nested case‐case study from Queensland, Australia
Claeson, M., Tan, S. X., Lambie, D., Brown, S., Walsh, M. D., Baade, P. D., Pandeya, N., Whitehead, K. J., Soyer, H. P., Smithers, B. M., Whiteman, D. C. and Khosrotehrani, K. (2023). The association between BRAF‐V600E mutations and death from thin (≤1.00 mm) melanomas: a nested case‐case study from Queensland, Australia. Journal of the European Academy of Dermatology and Venereology, 37 (9), e1168-e1172. doi: 10.1111/jdv.19173
2023
Conference Publication
275 Spatial transcriptomics of early invasive melanomas reveals molecular determinants of patient survival
Zhou, C., Tan, S. X., Kao, Y., Claeson, M., Brown, S., Lambie, D., Whiteman, D., Soyer, H., Stark, M., Nguyen, Q. and Khosrotehrani, K. (2023). 275 Spatial transcriptomics of early invasive melanomas reveals molecular determinants of patient survival. 1st International Societies for Investigative Dermatology Meeting (ISID 2023), Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.279
2023
Conference Publication
Anatomical distribution of severe keratinocyte carcinomas in solid organ transplant recipients
Cox, Charlotte, Lee, Ruby, Liyanage, Upekha, Brown, Susan, Isbel, Nicole, Chambers, Daniel, Griffin, Anthony, Campbell, Scott, Hopkins, Peter, Schaider, Helmut, Soyer, Peter and Khosrotehrani, Kiarash (2023). Anatomical distribution of severe keratinocyte carcinomas in solid organ transplant recipients. HOBOKEN: WILEY.
2023
Conference Publication
Anti-IL17A, Ixekizumab, for treatment-resistant chronic venous leg ulcers: a phase II randomized, double-blind, placebo-controlled pilot trial
Cox, C., Fry, K., Sivakumaran, Y., Spelman, L. and Khosrotehrani, K. (2023). Anti-IL17A, Ixekizumab, for treatment-resistant chronic venous leg ulcers: a phase II randomized, double-blind, placebo-controlled pilot trial. 1st International Societies for Investigative Dermatology Meeting Abstract Supplement, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1530
2023
Conference Publication
A pilot study using total body photography to monitor the change in size and colour of naevi during pregnancy
Mahon, Clare and Khosrotehrani, Kiarash (2023). A pilot study using total body photography to monitor the change in size and colour of naevi during pregnancy. HOBOKEN: WILEY.
2023
Conference Publication
Targeting tumour vascularisation through endothelial-specific Sox9 deletion reduces melanoma metastasis
Hashemi, G., Sormani Le Bourhis, L., Dight, J., Zhou, C., Roy, E. and Khosrotehrani, K. (2023). Targeting tumour vascularisation through endothelial-specific Sox9 deletion reduces melanoma metastasis. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, May 12-13 2023. Oxford, United Kingdom: Elsevier.
2023
Conference Publication
1439 Development of a complex skin organ in human induced pluripotent stem cell-derived organoids
Shafiee, A., Sun, J., Ahmed, I., Brown, J. and Khosrotehrani, K. (2023). 1439 Development of a complex skin organ in human induced pluripotent stem cell-derived organoids. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1455
2023
Conference Publication
PDGFRA-expressing endovascular progenitors contribute to differentiated endothelium of aorta and wounds
Styke, C., Kaur, S., Sim, S., Zhao, J., Shafiee, A., Zhou, C., Wong, H. and Khosrotehrani, K. (2023). PDGFRA-expressing endovascular progenitors contribute to differentiated endothelium of aorta and wounds. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1476
2023
Conference Publication
The impact of immune checkpoint inhibitors on actinic keratosis
Cox, Charlotte, Brown, Susan, Ladwa, Rahul and Khosrotehrani, Kiarash (2023). The impact of immune checkpoint inhibitors on actinic keratosis. HOBOKEN: WILEY.
2023
Conference Publication
Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma
Tan, S. X., Aung, T. Nwe, Claeson, M., Zhou, C., Brown, S., Acs, B., Lambie, D., Baade, P., Pandeya, N., Soyer, H., Smithers, B., Whiteman, D., Rimm, D. and Khosrotehrani, K. (2023). Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 12 - 13 May 2023. Oxford, United Kingdom: Elsevier.
2023
Conference Publication
Targeting tumour vascularisation through endothelial-specific Sox9 deletion reduces melanoma metastasis
Hashemi, G., Le Bourhis, L. Sormani, Dight, J., Zhou, C., Roy, E. and Khosrotehrani, K. (2023). Targeting tumour vascularisation through endothelial-specific Sox9 deletion reduces melanoma metastasis. 1st International Societies for Investigative Dermatology Meeting (ISID 2023), Tokyo, Japan, 10-13 May 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.jid.2023.03.1288
2023
Conference Publication
Epidermal somatic mutation is correlated with keratinocyte cancer burden
Lee, Ruby, Wong, Ho Yi, Brown, Susan, Roy, Edwige, Soyer, Peter and Khosrotehrani, Kiarash (2023). Epidermal somatic mutation is correlated with keratinocyte cancer burden. HOBOKEN: WILEY.
2023
Conference Publication
1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling
Sim, S., Kaur, S., Styke, C., Millard, S., Blumenthal, A., Pettit, A. and Khosrotehrani, K. (2023). 1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1528
2023
Conference Publication
Anti-IL17A, Ixekizumab, for treatment-resistant chronic venous leg ulcers: A phase II randomised, double-blind, placebo-controlled pilot trial
Cox, Charlotte, Fry, Kirsty, Sivakumaran, Yogeesan, Spelman, Lynda and Khosrotehrani, Kiarash (2023). Anti-IL17A, Ixekizumab, for treatment-resistant chronic venous leg ulcers: A phase II randomised, double-blind, placebo-controlled pilot trial. HOBOKEN: WILEY.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
Other advisors: Dr Lea Dousset
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Master Philosophy
Antibody-mediated exacerbation of chronic wounds colonised with Pseudomonas aeruginosa
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
Completed supervision
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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