
Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2020
Journal Article
Statins may reduce disease recurrence in patients with ulcerated primary melanoma
von Schuckmann, L. A., Khosrotehrani, K., Ghiasvand, R., Hughes, M. C.B., van der Pols, J. C., Malt, M., Smithers, B. M. and Green, A. C. (2020). Statins may reduce disease recurrence in patients with ulcerated primary melanoma. British Journal of Dermatology, 183 (6), 1049-1055. doi: 10.1111/bjd.19012
2020
Journal Article
Long‐term deaths from melanoma according to tumour thickness at diagnosis
Baade, Peter D., Whiteman, David C., Janda, Monika, Cust, Anne E., Neale, Rachel E., Smithers, B. Mark, Green, Adele C., Khosrotehrani, Kiarash, Mar, Victoria, Soyer, H. Peter and Aitken, Joanne F. (2020). Long‐term deaths from melanoma according to tumour thickness at diagnosis. International Journal of Cancer, 147 (5) ijc.32930, 1391-1396. doi: 10.1002/ijc.32930
2020
Journal Article
Secretome components from Faecalibacterium prausnitzii strains A2-165 and AHMP21 modulate cutaneous wound inflammation
Stefia, Laurancia Vina, Lee, James, Patel, Jatin, de Sousa, Silmara Rodrigues, Legrand, Julien, Rodero, Mathieu, Burman, Sriti, Linedale, Richard, Morrison, Mark and Khosrotehrani, Kiarash (2020). Secretome components from Faecalibacterium prausnitzii strains A2-165 and AHMP21 modulate cutaneous wound inflammation. Journal of Investigative Dermatology, 140 (11), 2312-2315.e6. doi: 10.1016/j.jid.2020.02.027
2020
Journal Article
Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression
Villani, Rehan, Sim, Seen Ling, Roy, Edwige, Wainwright, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2020). Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression. Journal of Dermatological Science, 98 (3), 179-185. doi: 10.1016/j.jdermsci.2020.04.006
2019
Journal Article
Level of contact hypersensitivity response to diphencyprone and keratinocyte cancer
Bullen, A., Polcz, M., Rowe, C. J., Byrom, L., Soyer, H. P. and Khosrotehrani, K. (2019). Level of contact hypersensitivity response to diphencyprone and keratinocyte cancer. Journal of the European Academy of Dermatology and Venereology, 33 (11) jdv.15766, 2101-2105. doi: 10.1111/jdv.15766
2019
Journal Article
Clinicopathological factors associated with death from thin (≤ 1·00 mm) melanoma
Claeson, M., Baade, P., Brown, S., Soyer, H. P., Smithers, B. M., Green, A. C., Whiteman, D. C. and Khosrotehrani, K. (2019). Clinicopathological factors associated with death from thin (≤ 1·00 mm) melanoma. British Journal of Dermatology, 182 (4) bjd.18560, 927-931. doi: 10.1111/bjd.18560
2019
Journal Article
R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma
Overman, Jeroen, Fontaine, Frank, Wylie-Sears, Jill, Moustaqil, Mehdi, Huang, Lan, Meurer, Marie, Chiang, Ivy Kim, Lesieur, Emmanuelle, Patel, Jatin, Zuegg, Johannes, Pasquier, Eddy, Sierecki, Emma, Gambin, Yann, Hamdan, Mohamed, Khosrotehrani, Kiarash, Andelfinger, Gregor, Bischoff, Joyce and Francois, Mathias (2019). R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. eLife, 8 e43026. doi: 10.7554/elife.43026
2019
Journal Article
The effects of a multidisciplinary high-throughput skin clinic on healthcare costs of organ transplant recipients
Gordon, L. G., Rodriguez-Acevedo, A. J., Papier, K., Khosrotehrani, K., Isbel, N., Campbell, S., Griffin, A. and Green, A. C. (2019). The effects of a multidisciplinary high-throughput skin clinic on healthcare costs of organ transplant recipients. Journal of the European Academy of Dermatology and Venereology, 33 (7) jdv.15458, 1290-1296. doi: 10.1111/jdv.15458
2019
Conference Publication
Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells
Patel, Jatin, Lukowski, Samuel L., Winkler, Ingrid, Tay, Joshua and Khosrotehrani, Kiarash (2019). Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells. Annual Scientific Meeting and Scientific Sessions of the American-Heart-Association on Vascular Discovery - From Genes to Medicine, Boston, MA United States, 14-16 May 2019. Philadelphia, PA United States: Lippincott Williams & Wilkins.
2019
Journal Article
Risk of melanoma recurrence after diagnosis of a high-risk primary tumor
Von Schuckmann, Lena A., Hughes, Maria Celia B., Ghiasvand, Reza, Malt, Maryrose, Van Der Pols, Jolieke C., Beesley, Vanessa L., Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adele C. (2019). Risk of melanoma recurrence after diagnosis of a high-risk primary tumor. JAMA Dermatology, 155 (6), 688-693. doi: 10.1001/jamadermatol.2019.0440
2019
Journal Article
Management of organ transplant recipients attending a high-throughput skin cancer surgery and surveillance clinic in Queensland
Papier, K., Gordon, L. G., Khosrotehrani, K., Isbel, N., Campbell, S., Griffin, A. and Green, A. C. (2019). Management of organ transplant recipients attending a high-throughput skin cancer surgery and surveillance clinic in Queensland. British Journal of Dermatology, 180 (3), 631-636. doi: 10.1111/bjd.17001
2019
Conference Publication
Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring
Patel, J., Hamilton, H., Kahler, S., Sim, S., Wong, H. and Khosrotehrani, K. (2019). Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.628
2019
Conference Publication
Melanoma patient survival: Prognostic value of pSTAT5 as a biomarker
Chong, S., Rowe, C., Malt, M., Brown, S., Smithers, M. and Khosrotehrani, K. (2019). Melanoma patient survival: Prognostic value of pSTAT5 as a biomarker. Australasian College of Dermatologists, 52nd Annual Scientific Meeting, Melbourne, VIC Australia, 18–21 May 2019. Richmond, VIC Australia: Wiley-Blackwell.
2019
Conference Publication
Epidermal clonal expansion upon UV irradiation: consequences of the epidermal duality of proliferative behaviour on the skin carcinogenesis
Roy, E., Wong, H. and Khosrotehrani, K. (2019). Epidermal clonal expansion upon UV irradiation: consequences of the epidermal duality of proliferative behaviour on the skin carcinogenesis. 49th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.570
2019
Conference Publication
SOX18 activation in primary melanoma tumours
Chong, S., Rowe, C., Malt, M., Smithers, M., Green, A. and Khosrotehrani, K. (2019). SOX18 activation in primary melanoma tumours. Australasian College of Dermatologists, 52nd Annual Scientific Meeting, Melbourne, VIC Australia, 18–21 May 2019. Richmond, VIC Australia: Wiley-Blackwell.
2019
Conference Publication
Clinicopathological factors associated with death from thin (<= 1 mm) melanoma
Claeson, M., Baade, P., Brown, S., Soyer, P., Smithers, M., Green, A., Whiteman, D. and Khosrotehrani, K. (2019). Clinicopathological factors associated with death from thin (
2019
Conference Publication
Modulating NFkB signaling in skin wounds through pharmacological or probiotic intervention using Faecalibacterium prausnitzii extracts
Stefia, L., Lee, J., Legrand, J., Rodero, M., Patel, J., Linedale, R., Burman, S., Morrison, M. and Khosrotehrani, K. (2019). Modulating NFkB signaling in skin wounds through pharmacological or probiotic intervention using Faecalibacterium prausnitzii extracts. 49th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Bordeaux, France, 18-21 September 2019. New York, NY, United States: Elsevier. doi: 10.1016/j.jid.2019.07.663
2019
Conference Publication
Laser dermabrasion: a potential treatment for non-melanoma skin cancers
Wong, H., Roy, E., Kapadia, S., Murigneux, V., Chong, S. and Khosrotehrani, K. (2019). Laser dermabrasion: a potential treatment for non-melanoma skin cancers. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.567
2019
Conference Publication
Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell Carcinoma
Villani, R., Roy, E., Murigneux, V., Sim, S., Malapitan, C., Galbraith, J., Kapadia, S., Fink, L. and Khosrotehrani, K. (2019). Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell Carcinoma. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September 2019. New York, NY United States: Elsevier. doi: 10.1016/j.jid.2019.07.507
2019
Journal Article
Sun protection behaviour after diagnosis of high-risk primary melanoma and risk of a subsequent primary
von Schuckmann, Lena A., Wilson, Louise F., Hughes, Maria Celia B., Beesley, Vanessa L., Janda, Monika, van der Pols, Jolieke C., Smithers, B. Mark, Khosrotehrani, Kiarash and Green, Adele C. (2019). Sun protection behaviour after diagnosis of high-risk primary melanoma and risk of a subsequent primary. Journal of the American Academy of Dermatology, 80 (1), 139-148.e4. doi: 10.1016/j.jaad.2018.06.068
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Master Philosophy
Antibody-mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
Completed supervision
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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