
Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2017
Book Chapter
5.11 Engineering the haematopoietic stem cell niche in vitro
Muerza-Cascante, M.L., Khosrotehrani, K., Haylock, D., Hutmacher, D. W. and Loessner, D. (2017). 5.11 Engineering the haematopoietic stem cell niche in vitro. Comprehensive Biomaterials II. (pp. 187-199) Amsterdam: Elsevier. doi: 10.1016/b978-0-12-803581-8.10129-8
2017
Conference Publication
Genome wide association identifies MAPKinase pathway regulators as key genetic determinants of allergic contact dermatitis
Legrand, J., Baz, B., Mukhopadhyay, P., Wong, H., Ram, R., Morahan, G., Walker, G. and Khosrotehrani, K. (2017). Genome wide association identifies MAPKinase pathway regulators as key genetic determinants of allergic contact dermatitis. 47th Annual Meeting of the European Society for Dermatological Research (ESDR), Salzburg Austria, 27-30 September 2017. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2017.07.180
2016
Journal Article
Endosteal-like extracellular matrix expression on melt electrospun written scaffolds
Muerza-Cascante, Maria Lourdes, Shokoohmand, Ali, Khosrotehrani, Kiarash, Haylock, David, Dalton, Paul D., Hutmacher, Dietmar W. and Loessner, Daniela (2016). Endosteal-like extracellular matrix expression on melt electrospun written scaffolds. Acta Biomaterialia, 52, 145-158. doi: 10.1016/j.actbio.2016.12.040
2016
Journal Article
Response to Asgari
Youlden, Danny R., Baade, Peter D., Soyer, H. Peter, Youl, Phillipa H., Kimlin, Michael G., Aitken, Joanne F., Green, Adele C. and Khosrotehrani, Kiarash (2016). Response to Asgari. Journal of Investigative Dermatology, 137 (4), 965-966. doi: 10.1016/j.jid.2016.12.003
2016
Journal Article
Concise review: functional definition of endothelial progenitor cells: a molecular perspective
Patel, Jatin, Donovan, Prudence and Khosrotehrani, Kiarash (2016). Concise review: functional definition of endothelial progenitor cells: a molecular perspective. Stem Cells Translational Medicine, 5 (10), 1302-1306. doi: 10.5966/sctm.2016-0066
2016
Journal Article
STAT5 activation in the dermal papilla is important for hair follicle growth phase induction
Legrand, Julien M. D., Roy, Edwidge, Ellis, Jonathan J., Francois, Mathias, Brooks, Andrew J. and Khosrotehrani, Kiarash (2016). STAT5 activation in the dermal papilla is important for hair follicle growth phase induction. Journal of Investigative Dermatology, 136 (9), 1781-1791. doi: 10.1016/j.jid.2016.04.014
2016
Journal Article
Variations in supportive care needs of patients after diagnosis of localised cutaneous melanoma: a 2-year follow-up study
Beesley, Vanessa L., Smithers, B. Mark, O'Rourke, Peter, Janda, Monika, Khosrotehrani, Kiarash and Green, Adèle C. (2016). Variations in supportive care needs of patients after diagnosis of localised cutaneous melanoma: a 2-year follow-up study. Supportive Care in Cancer, 25 (1), 1-10. doi: 10.1007/s00520-016-3378-9
2016
Journal Article
Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma
Rowe, Casey J., Tang, Fiona, Hughes, Maria Celia B., Rodero, Mathieu P., Malt, Maryrose, Lambie, Duncan, Barbour, Andrew, Hayward, Nicholas K., Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2016). Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma. International Journal of Cancer, 139 (3), 664-672. doi: 10.1002/ijc.30085
2016
Journal Article
Self-renewal and high proliferative colony forming capacity of late-outgrowth endothelial progenitors is regulated by cyclin-dependent kinase inhibitors driven by notch signaling
Patel, Jatin, Wong, Ho Yi, Wang, Weili, Alexis, Josue, Shafiee, Abbas, Stevenson, Alexander J., Gabrielli, Brian, Fisk, Nicholas M. and Khosrotehrani, Kiarash (2016). Self-renewal and high proliferative colony forming capacity of late-outgrowth endothelial progenitors is regulated by cyclin-dependent kinase inhibitors driven by notch signaling. Stem Cells, 34 (4), 902-912. doi: 10.1002/stem.2262
2016
Journal Article
A molecular classification of human mesenchymal stromal cells
Rohart, Florian, Mason, Elizabeth A., Matigian, Nicholas, Mosbergen, Rowland, Korn, Othmar, Chen, Tyrone, Butcher, Suzanne, Patel, Jatin, Atkinson, Kerry, Khosrotehrani, Kiarash, Fisk, Nicholas M., Cao, Kim-Anh Le and Wells, Christine A. (2016). A molecular classification of human mesenchymal stromal cells. PeerJ, 2016 (3) 1845, e1845. doi: 10.7717/peerj.1845
2016
Journal Article
Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study
Youlden, Danny R., Baade, Peter D., Soyer, H. Peter, Youl, Philippa H., Kimlin, Michael G., Aitken, Joanne F., Green, Adele C. and Khosrotehrani, Kiarash (2016). Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study. Journal of Investigative Dermatology, 136 (11), 1-8. doi: 10.1016/j.jid.2016.03.014
2016
Journal Article
Diagnosis of an additional in situ melanoma does not influence survival for patients with a single invasive melanoma: a registry-based follow-up study
Youlden, Danny R., Khosrotehrani, Kiarash, Green, Adele C., Soyer, H. Peter, Kimlin, Michael G., Youl, Philippa H., Aitken, Joanne F. and Baade, Peter D. (2016). Diagnosis of an additional in situ melanoma does not influence survival for patients with a single invasive melanoma: a registry-based follow-up study. Australasian Journal of Dermatology, 57 (1), 57-60. doi: 10.1111/ajd.12429
2016
Conference Publication
Resident progenitors of endothelial origin contribute to neo-vessel formation through the expression of Sox18 during skin wound healing
Patel, J., Francois, M. and Khosrotehrani, K. (2016). Resident progenitors of endothelial origin contribute to neo-vessel formation through the expression of Sox18 during skin wound healing. Annual Meeting of the European Society for Dermatological Research (ESDR), Munich, Germany, 7-10 September 2016. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2016.06.596
2016
Conference Publication
Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma
Rowe, C., Tang, F., Hughes, M. C., Rodero, M., Malt, M., Lambie, D., Barbour, A., Hayward, N., Smithers, B. M., Green, A. and Khosrotehrani, K. (2016). Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma. Australasian College of Dermatologists 49th Annual Scientific Meeting, Perth, Australia, 14–17 May, 2016. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12480
2016
Conference Publication
Survival in patients with multiple primary melanomas vs. single primary melanoma
Rowe, C., Law, M., Palmer, J., MacGregor, S., Hayward, N. and Khosrotehrani, K. (2016). Survival in patients with multiple primary melanomas vs. single primary melanoma. Australasian College of Dermatologists 49th Annual Scientific Meeting, Perth, WA, Australia, 14–17 May 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12480
2016
Conference Publication
Genetic associations of skin wound healing in the collaborative cross
Baz, B., Patel, J., Ram, R., Morahan, G., Walker, G. and Khosrotehrani, K. (2016). Genetic associations of skin wound healing in the collaborative cross. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD, Australia, 25–28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
2016
Book Chapter
Perinatal tissue-derived endothelial progenitor cells
Shafiee, Abbas and Khosrotehrani, Kiarash (2016). Perinatal tissue-derived endothelial progenitor cells. Perinatal tissue-derived stem cells: alternative sources of fetal stem cells. (pp. 65-80) edited by Babak Arjmand. Cham, Switzerland: Humana Press. doi: 10.1007/978-3-319-46410-7_4
2016
Conference Publication
GWAS in the collaborative cross identifies aldose reductases as regulators of skin wound healing speed
Baz, Betoul, Patel, Jatin, Morahan, Grant, Walker, Graeme and Khosrotehrani, Kiarash (2016). GWAS in the collaborative cross identifies aldose reductases as regulators of skin wound healing speed. Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular & Experimental Pathology Society of Australasia (MEPSA), Melbourne Convention and Exhibition Centre, Melbourne, Australia, 7-9 November 2016. Hoboken, NJ, United States: Wiley-Blackwell.
2016
Conference Publication
Basal cell carcinoma development is promoted by ablation of the dermal papilla mesenchymal niche
Villani, R., Sim, S. L., Greaney, J., Wainwright, B. and Khosrotehrani, K. (2016). Basal cell carcinoma development is promoted by ablation of the dermal papilla mesenchymal niche. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD, Australia, 25–28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
2016
Conference Publication
Dual proliferation behaviour of epidermal progenitors
Roy, E., Neufeld, Z., Cerone, L., Wong, H. Y., Hodgson, S., Livet, J. and Khosrotehrani, K. (2016). Dual proliferation behaviour of epidermal progenitors. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Antibody-mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
Completed supervision
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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