
Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2025
Journal Article
Textbook outcomes for retroperitoneal sarcoma resection: a multi-centre review
Murphy, Skyle, Allan, Christopher, Barbour, Andrew, Donoghue, Victoria and Smithers, B. Mark (2025). Textbook outcomes for retroperitoneal sarcoma resection: a multi-centre review. Current Oncology, 32 (6) 364, 1-17. doi: 10.3390/curroncol32060364
2025
Journal Article
3890 Intercontinental Perspectives on Oligometastasis in Esophageal and Gastric Cancer: A Comparative Study with European Findings
Bronzwaer, Sebastiaan F.C., Kroese, Tiuri E., Smithers, B. Mark, Kang, Chang Hyun, Yang, Han Kwang, Hyung, Woo Jin, Daiko, Hiroyuki, Terashima, Masanori, Kinoshita, Takahiro, Hofstetter, Wayne, Mansfield, Paul, Badgewell, Brian, Strong, Vivian E., Sarkaria, Inderpal, Ferri, Lorenzo, Sallum, Rubens A.A., Nieponice, Alejandro, Navarette, Andres, Ruurda, Jelle P., van Laarhoven, Hanneke W.M., van Rossum, Peter S.N. and van Hillegersberg, Richard (2025). 3890 Intercontinental Perspectives on Oligometastasis in Esophageal and Gastric Cancer: A Comparative Study with European Findings. Radiotherapy and Oncology, 206, S1846-S1848. doi: 10.1016/s0167-8140(25)02032-8
2025
Journal Article
Pathological response guides adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy in surgically resected gastro-oesophageal cancer (SPACE-FLOT): international cohort study
SPACE-FLOT Investigators and Smithers, Mark (SPACE-FLOT Investigator) (2025). Pathological response guides adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy in surgically resected gastro-oesophageal cancer (SPACE-FLOT): international cohort study. British Journal of Surgery, 112 (4) znaf056. doi: 10.1093/bjs/znaf056
2025
Journal Article
Disease-free survival as surrogate for overall survival in esophageal cancer: An individual patient data meta-analysis of neoadjuvant chemotherapy and chemoradiotherapy
Cabrit, Nicolas, Cheugoua-Zanetsie, Maurice, Tierney, Jayne, Thirion, Pierre, Nankivell, Matthew, Winter, Kathryn, Yang, Hong, Wijnhoven, Bas, Vernerey, Dewi, Smithers, B.Mark, Piessen, Guillaume, Nilsson, Magnus, Boonstra, Jurjen, Ychou, Marc, Law, Simon, Cunningham, David, Vathaire, Florent de, Stahl, Michael, Urba, Susan, Valmasoni, Michele, Williaume, Danièle, Thomas, Janine, Lordick, Florian, Tepper, Joel, Gebski, Val, Burmeister, Bryan, Paoletti, Xavier, Sandick, Johanna van, Fu, Jianhua ... Michiels, Stefan (2025). Disease-free survival as surrogate for overall survival in esophageal cancer: An individual patient data meta-analysis of neoadjuvant chemotherapy and chemoradiotherapy. European Journal of Cancer, 218 115292, 115292. doi: 10.1016/j.ejca.2025.115292
2025
Journal Article
Prognostic markers could extend adjuvant immunotherapy to high-risk Stage IB/IIA melanoma: a modelling study
Tan, Samuel X., Muller, Nicholas, Zhou, Chenhao, Walpole, Euan, Smithers, B. Mark, Whiteman, David C. and Khosrotehrani, Kiarash (2025). Prognostic markers could extend adjuvant immunotherapy to high-risk Stage IB/IIA melanoma: a modelling study. JAAD International, 18, 86-87. doi: 10.1016/j.jdin.2024.09.010
2024
Journal Article
Preoperative chemoradiotherapy for resectable gastric cancer
Leong, Trevor, Smithers, B. Mark, Michael, Michael, Haustermans, Karin, Wong, Rebecca, Gebski, Val, O’Connell, Rachel L., Zalcberg, John, Boussioutas, Alex, Findlay, Michael, Willis, David, Moore, Alisha, Murray, William K., Lordick, Florian, O’Callaghan, Chris, Swallow, Carol, Darling, Gail, Miller, Danielle, Strickland, Andrew, Liberman, Moishe, Mineur, Laurent and Simes, John (2024). Preoperative chemoradiotherapy for resectable gastric cancer. The New England Journal of Medicine, 391 (19), 1810-1821. doi: 10.1056/nejmoa2405195
2024
Conference Publication
A Randomised, Placebo-Controlled, Phase II Trial of Adjuvant Avelumab in Patients with Stage I-III Merkel Cell Carcinoma
Xu, Wen, Poulsen, Michael, Atkinson, Victoria, Fogarty, Gerald, Veness, Michael, Smithers, Bernard, Gyorki, David, Mar, Victoria and Guminski, Alexander (2024). A Randomised, Placebo-Controlled, Phase II Trial of Adjuvant Avelumab in Patients with Stage I-III Merkel Cell Carcinoma. Medical Oncology Group of Australia Incorporated Annual Scientific Meeting, Sydney, NSW Australia, 14-16 August 2024. Chichester, West Sussex United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.14111
2024
Journal Article
Quality performance indicators for oesophageal and gastric cancer: ANZ expert Delphi consensus
Kulasegaran, Suheelan, Woodhouse, Braden, Wang, Yijiao, Siddaiah‐Subramanya, Manjunath, Merrett, Neil, Smithers, Bernard Mark, Watson, David, MacCormick, Andrew, Srinivasa, Sanket and Koea, Jonathan (2024). Quality performance indicators for oesophageal and gastric cancer: ANZ expert Delphi consensus. ANZ Journal of Surgery, 94 (10), 1732-1737. doi: 10.1111/ans.19173
2024
Conference Publication
A randomized phase III trial of perioperative chemotherapy (periop CT) with or without preoperative chemoradiotherapy (preop CRT) for resectable gastric cancer (AGITG TOPGEAR): Final results from an intergroup trial of AGITG, TROG, EORTC and CCTG
Leong, T., Smithers, B.M., Michael, M., Haustermans, K.M., Wong, R., Gebski, V., O'Connell, R., Zalcberg, J.R., Boussioutas, A., Findlay, M., Willis, D., Moore, A., Lordick, F., O'Callaghan, C., Swallow, C., Darling, G.E., Strickland, A., Liberman, M., Mineur, L. and Simes, J. (2024). A randomized phase III trial of perioperative chemotherapy (periop CT) with or without preoperative chemoradiotherapy (preop CRT) for resectable gastric cancer (AGITG TOPGEAR): Final results from an intergroup trial of AGITG, TROG, EORTC and CCTG. ESMO Congress 2024, Barcelona, Spain, 13-17 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2024.08.2300
2024
Conference Publication
Alterations In Local Oesophageal Microbiota And Outcomes After Oesophagectomy For Oesophago-gastric Cancer: A Pilot Study
Stokes, Matthew, (Frank) Yu, Zirong, Schlebusch, Sanmarie, Jennison, Amy, Graham, Rikki, Cooper, Caroline, Smithers, B. Mark, Barbour, Andrew, Thomson, Iain and Frankel, Adam (2024). Alterations In Local Oesophageal Microbiota And Outcomes After Oesophagectomy For Oesophago-gastric Cancer: A Pilot Study. 20th ISDE World Congress for Esophageal Diseases, Edinburgh, United Kingdom, 22 - 24 September 2024. Cary, NC United States: Oxford University Press. doi: 10.1093/dote/doae057.006
2024
Journal Article
Achieving a textbook outcome in patients undergoing gastric resections in a low incidence, high volume Australian Upper GI unit
Bouffler, Clare, King, Sarah, Frankel, Adam, Barbour, Andrew, Scott, Justin, Thomas, Janine, Smithers, B. Mark and Thomson, Iain (2024). Achieving a textbook outcome in patients undergoing gastric resections in a low incidence, high volume Australian Upper GI unit. Journal of Gastrointestinal Surgery, 28 (9), 1436-1442. doi: 10.1016/j.gassur.2024.06.005
2024
Journal Article
Complications and adverse events in lymphadenectomy of the inguinal area: worldwide expert consensus
Sotelo, René, Sayegh, Aref S., Medina, Luis G., Perez, Laura C., La Riva, Anibal, Eppler, Michael B., Gaona, José, Tobias-Machado, Marcos, Spiess, Philippe E., Pettaway, Curtis A., Lima Pompeo, Antonio Carlos, Lima Mattos, Pablo Aloisio, Wilson, Timothy G., Villoldo, Gustavo M., Chung, Eric, Samaniego, Aldo, Ornellas, Antonio Augusto, Pinheiro, Vladimir, Brazão, Eder S., Subira-Rios, David, Koifman, Leandro, Zequi, Stênio de Cassio, Pontillo Z, Humberto M., Rodrigues Calixto, José de Ribamar, Campos Silva, Rafael, Smithers, B. Mark, Garzon, Simone, Haase, Oliver, Sommariva, Antonio ... Cacciamani, Giovanni E. (2024). Complications and adverse events in lymphadenectomy of the inguinal area: worldwide expert consensus. BJS Open, 8 (4) zrae056, 1-8. doi: 10.1093/bjsopen/zrae056
2024
Journal Article
Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma
Tan, Samuel X., Chong, Sharene, Rowe, Casey, Galbraith, Jack, Dight, James, Zhou, Chenhao, Malt, Maryrose, Smithers, Bernard Mark and Khosrotehrani, Kiarash (2024). Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma. Experimental Dermatology, 33 (3) e15041, 1-7. doi: 10.1111/exd.15041
2024
Journal Article
iCare – a self-directed, interactive online program to improve health and wellbeing for people living with upper gastrointestinal or hepato-pancreato-biliary cancers, and their informal carers: the study protocol for a Phase II randomised controlled trial
Livingston, Patricia M., Winter, Natalie, Ugalde, Anna, Orellana, Liliana, Mikocka-Walus, Antonina, Jefford, Michael, Zalcberg, John, Orford, Neil, Hutchinson, Alison M., Barbour, Andrew, Kiss, Nicole, Smithers, Bernard Mark, Watson, David I., McCaffrey, Nikki and White, Victoria (2024). iCare – a self-directed, interactive online program to improve health and wellbeing for people living with upper gastrointestinal or hepato-pancreato-biliary cancers, and their informal carers: the study protocol for a Phase II randomised controlled trial. BMC Cancer, 24 (1) 144. doi: 10.1186/s12885-024-11861-2
2024
Journal Article
Novel Textbook Outcomes following emergency laparotomy: Delphi exercise
Naumann, David N., Bhangu, Aneel, Brooks, Adam, Martin, Matthew, Cotton, Bryan A., Khan, Mansoor, Midwinter, Mark J., Pearce, Lyndsay, Bowley, Douglas M., Holcomb, John B., Griffiths, Ewen A., Smithers, Mark (BEACON Collaborative group member) and BEACON Collaborative (2024). Novel Textbook Outcomes following emergency laparotomy: Delphi exercise. BJS Open, 8 (1) zrad145. doi: 10.1093/bjsopen/zrad145
2024
Journal Article
Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study
Tan, Samuel X., Aung, Thazin N., Claeson, Magdalena, Acs, Balazs, Zhou, Chenhao, Brown, Susan, Lambie, Duncan, Baade, Peter D., Pandeya, Nirmala, Soyer, H. Peter, Smithers, B. Mark, Whiteman, David C., Rimm, David L. and Khosrotehrani, Kiarash (2024). Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study. Journal of the American Academy of Dermatology, 90 (1), 179-182. doi: 10.1016/j.jaad.2023.09.026
2023
Journal Article
pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma
Tan, Samuel X., Chong, Sharene, Rowe, Casey, Claeson, Magdalena, Dight, James, Zhou, Chenhao, Rodero, Mathieu P., Malt, Maryrose, Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2023). pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma. Melanoma Research, 33 (6), 506-513. doi: 10.1097/cmr.0000000000000915
2023
Journal Article
PHYSIO+++: protocol for a pilot randomised controlled trial assessing the feasibility of physiotherapist-led non-invasive ventilation for patients with hypoxaemia following abdominal surgery
Hackett, Claire, Denehy, Linda, Kruger, Peter, Ripley, Nina, Reid, Natasha, Smithers, B. Mark, Walker, Rachel M., Hope, Louise and Boden, Ianthe (2023). PHYSIO+++: protocol for a pilot randomised controlled trial assessing the feasibility of physiotherapist-led non-invasive ventilation for patients with hypoxaemia following abdominal surgery. BMJ Open, 13 (12) e078175, 1-10. doi: 10.1136/bmjopen-2023-078175
2023
Journal Article
Prognosis of naevoid melanomas
Cook, Martin G., Grant, Megan, Sylvestre, Yvonne, Akhras, Victoria, Khosrotehrani, Kiarash, Hughes, Maria Celia B, Malt, Maryrose, Smithers, B. Mark, Massi, Daniela, De Giorgi, Vincenzo, Marais, Richard and Green, Adele C. (2023). Prognosis of naevoid melanomas. Pathology - Research and Practice, 251 154881, 154881. doi: 10.1016/j.prp.2023.154881
2023
Journal Article
ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients
Aoude, Lauren G., Brosda, Sandra, Ng, Jessica, Lonie, James M., Belle, Clemence J., Patel, Kalpana, Koufariotis, Lambros T., Wood, Scott, Atkinson, Victoria, Smithers, B. Mark, Pearson, John V., Waddell, Nicola, Barbour, Andrew P. and Bonazzi, Vanessa F. (2023). ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients. Journal of Molecular Diagnostics, 25 (10), 771-781. doi: 10.1016/j.jmoldx.2023.06.014
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
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Master Philosophy
Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.
Principal Advisor
Other advisors: Professor Andrew Barbour
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Master Philosophy
Trends in the regional nodal management of cutaneous melanoma.
Principal Advisor
Other advisors: Professor Peter Soyer
-
Doctor Philosophy
Utilising the Multi-Disciplinary Resources at Tertiary Centres to Improve Outcomes from Pancreatic Cancer
Associate Advisor
Other advisors: Dr David Cavallucci
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
Completed supervision
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2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
-
2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer, Associate Professor Helmut Schaider
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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