Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
Featured
2020
Journal Article
Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors
Roy, Edwige, Wong, Ho Yi, Villani, Rehan, Rouille, Thomas, Salik, Basit, Sim, Seen Ling, Murigneux, Valentine, Stark, Mitchell S., Fink, J. Lynn, Soyer, H. Peter, Walker, Graeme, Lyons, J. Guy, Saunders, Nicholas and Khosrotehrani, Kiarash (2020). Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors. Cell Reports, 31 (9) 107702, 107702. doi: 10.1016/j.celrep.2020.107702
2019
Journal Article
Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells
Lukowski, Samuel W., Patel, Jatin, Andersen, Stacey B., Sim, Seen-Ling, Wong, Ho Yi, Tay, Joshua, Winkler, Ingrid, Powell, Joseph E. and Khosrotehrani, Kiarash (2019). Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells. Cell Reports, 27 (9), 2748-2758. doi: 10.1016/j.celrep.2019.04.102
Featured
2019
Journal Article
Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis
Donovan, Prudence, Patel, Jatin, Dight, James, Wong, Ho Yi, Sim, Seen-Ling, Murigneux, Valentine, Francois, Mathias and Khosrotehrani, Kiarash (2019). Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis. Nature Communications, 10 (1) 18, 18. doi: 10.1038/s41467-018-07961-w
Featured
2018
Journal Article
Genetic variation in the MAPK/ERK pathway affects contact hypersensitivity responses
Legrand, Julien M. D., Roy, Edwige, Baz, Batoul, Mukhopadhyay, Pamela, Wong, Ho Yi, Ram, Ramesh, Morahan, Grant, Walker, Graeme and Khosrotehrani, Kiarash (2018). Genetic variation in the MAPK/ERK pathway affects contact hypersensitivity responses. Journal of Allergy and Clinical Immunology, 142 (3), 981-984.e7. doi: 10.1016/j.jaci.2018.04.028
Featured
2016
Journal Article
Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling
Roy, Edwige, Neufeld, Zoltan, Cerone, Luca, Wong, Ho Yi, Hodgson, Samantha, Livet, Jean and Khosrotehrani, Kiarash (2016). Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling. EMBO Journal, 35 (24), 2658-2670. doi: 10.15252/embj.201693806
Featured
2013
Journal Article
Reduced Il17a expression distinguishes a Ly6c lo MHCIIhi macrophage population promoting wound healing
Rodero, Mathieu P., Hodgson, Samantha S., Hollier, Brett, Combadiere, Christophe and Khosrotehrani, Kiarash (2013). Reduced Il17a expression distinguishes a Ly6c lo MHCIIhi macrophage population promoting wound healing. Journal of Investigative Dermatology, 133 (3), 783-792. doi: 10.1038/jid.2012.368
Featured
2011
Journal Article
Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease
Peyrin-Biroulet, Laurent, Khosrotehrani, Kiarash, Carrat, Fabrice, Bouvier, Anne-Marie, Chevaux, Jean-Baptiste, Simon, Tabassome, Carbonnel, Frank, Colombel, Jean-Frederic, Dupas, Jean-Louis, Godeberge, Philippe, Hugot, Jean-Pierre, Lemann, Marc, Nahon, Stephane, Sabate, Jean-Marc, Tucat, Gilbert, Beaugerie, Laurent and For the Cesame Study Group (2011). Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology, 141 (5), 1621-1628.e5. doi: 10.1053/j.gastro.2011.06.050
2024
Journal Article
Diversifying dermatology: Improving skin of colour representation
Susanto, Alyssa, Nathan, Vaishnavi, Janda, Monika, Khosrotehrani, Kiarash, McMeniman, Erin, Soyer, H. Peter and Betz‐Stablein, Brigid (2024). Diversifying dermatology: Improving skin of colour representation. Australasian Journal of Dermatology. doi: 10.1111/ajd.14356
2024
Journal Article
Management of Skin Toxicities in Cancer Treatment: An Australian/New Zealand Perspective
Ladwa, Rahul, Fogarty, Gerald, Chen, Peggy, Grewal, Gurpreet, McCormack, Chris, Mar, Victoria, Kerob, Delphine and Khosrotehrani, Kiarash (2024). Management of Skin Toxicities in Cancer Treatment: An Australian/New Zealand Perspective. Cancers, 16 (14) ARTN 2526, 2526. doi: 10.3390/cancers16142526
2024
Journal Article
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Zhao, Jilai, Sormani, Laura, Jacquelin, Sebastien, Li, Haiming, Styke, Cassandra, Zhou, Chenhao, Beesley, Jonathan, Oon, Linus, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Dight, James, Hashemi, Ghazaleh, Shafiee, Abbas, Roy, Edwige, Patel, Jatin and Khosrotehrani, Kiarash (2024). Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium. Angiogenesis, 27 (3), 1-16. doi: 10.1007/s10456-024-09927-7
2024
Journal Article
An optimized protocol for generating appendage-bearing skin organoids from human-induced pluripotent stem cells
Ahmed, Imaan, Sun, Jane, Brown, Jason, Khosrotehrani, Kiarash and Shafiee, Abbas (2024). An optimized protocol for generating appendage-bearing skin organoids from human-induced pluripotent stem cells. Biology Methods and Protocols, 9 (1) bpae019, bpae019. doi: 10.1093/biomethods/bpae019
2024
Journal Article
Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma
Tan, Samuel X., Chong, Sharene, Rowe, Casey, Galbraith, Jack, Dight, James, Zhou, Chenhao, Malt, Maryrose, Smithers, Bernard Mark and Khosrotehrani, Kiarash (2024). Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma. Experimental Dermatology, 33 (3) e15041, 1-7. doi: 10.1111/exd.15041
2024
Journal Article
Treatment of lichen planopilaris with Janus kinase inhibitors
Gonzalez Matheus, Gabriela A. and Khosrotehrani, Kiarash (2024). Treatment of lichen planopilaris with Janus kinase inhibitors. Australasian Journal of Dermatology, 65 (4), 381-383. doi: 10.1111/ajd.14240
2024
Journal Article
Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study
Tan, Samuel X., Aung, Thazin N., Claeson, Magdalena, Acs, Balazs, Zhou, Chenhao, Brown, Susan, Lambie, Duncan, Baade, Peter D., Pandeya, Nirmala, Soyer, H. Peter, Smithers, B. Mark, Whiteman, David C., Rimm, David L. and Khosrotehrani, Kiarash (2024). Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study. Journal of the American Academy of Dermatology, 90 (1), 179-182. doi: 10.1016/j.jaad.2023.09.026
2023
Journal Article
Development of physiologically relevant skin organoids from human induced pluripotent stem cells
Shafiee, Abbas, Sun, Jane, Ahmed, Imaan A., Phua, Felicia, Rossi, Gustavo R., Lin, Cheng‐Yu, Souza‐Fonseca‐Guimaraes, Fernando, Wolvetang, Ernst J., Brown, Jason and Khosrotehrani, Kiarash (2023). Development of physiologically relevant skin organoids from human induced pluripotent stem cells. Small, 20 (16) e2304879, 1-14. doi: 10.1002/smll.202304879
2023
Journal Article
The role of dermocosmetics in the management of cancer-related skin toxicities: international expert consensus
Dreno, Brigitte, Khosrotehrani, Kiarash, De Barros Silva, Giselle, Wolf, Julie Ryan, Kerob, Delphine, Trombetta, Mark, Atenguena, Etienne, Dielenseger, Pascale, Pan, Meng, Scotte, Florian, Krakowski, Ivan and Lacouture, Mario (2023). The role of dermocosmetics in the management of cancer-related skin toxicities: international expert consensus. Supportive Care in Cancer, 31 (12) 672, 672. doi: 10.1007/s00520-023-08116-4
2023
Journal Article
pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma
Tan, Samuel X., Chong, Sharene, Rowe, Casey, Claeson, Magdalena, Dight, James, Zhou, Chenhao, Rodero, Mathieu P., Malt, Maryrose, Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2023). pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma. Melanoma Research, 33 (6), 506-513. doi: 10.1097/cmr.0000000000000915
2023
Journal Article
Prognosis of naevoid melanomas
Cook, Martin G., Grant, Megan, Sylvestre, Yvonne, Akhras, Victoria, Khosrotehrani, Kiarash, Hughes, Maria Celia B, Malt, Maryrose, Smithers, B. Mark, Massi, Daniela, De Giorgi, Vincenzo, Marais, Richard and Green, Adele C. (2023). Prognosis of naevoid melanomas. Pathology - Research and Practice, 251 154881, 154881. doi: 10.1016/j.prp.2023.154881
2023
Conference Publication
Dermocosmetics in management of cancer-related skin toxicities: International expert consensus highlighting the key role of oncology nurses
Dielenseger, P., Lacouture, M., Khosrotehrani, K., De Barros Silva, G., Wolf, J. Ryan, Kerob, D., Trombetta, M., Atenguena, E.O., Pan, M., Scotte, F., Krakowski, I. and Dreno, B. (2023). Dermocosmetics in management of cancer-related skin toxicities: International expert consensus highlighting the key role of oncology nurses. ESMO Congress 2023, Madrid, Spain, 20-24 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2023.09.873
2023
Journal Article
Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns
Chand, Kirat, Patel, Jatin, Matthews, Kate, Nano, Rachel, Musco, Hannah, Khosrotehrani, Kiarash, Colditz, Paul and Wixey, Julie (2023). Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns. IBRO Neuroscience Reports, 15, S171-S171. doi: 10.1016/j.ibneur.2023.08.249
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Doctor Philosophy
predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
-
Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Dr Brigid Betz-Stablein, Ms Laura Sormani Le Bourhis
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
-
Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Elucidate the role of interferon signalling pathways in skin diseases
Associate Advisor
Other advisors: Associate Professor Fiona Simpson, Dr Snehlata Kumari
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Dr Timothy Wells
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Associate Advisor
Other advisors: Professor Annette Dobson, Dr Lena Von Schuckmann
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Dr Mitchell Stark
Completed supervision
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
Other advisors: Associate Professor Andrew Brooks
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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