
Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2013
Journal Article
Patients undergoing lymphadenectomy for Stage III melanomas of known or unknown primary site do not differ in outcome
Hughes, Maria Celia, Wright, Annaliesa, Barbour, Andrew, Thomas, Janine, Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2013). Patients undergoing lymphadenectomy for Stage III melanomas of known or unknown primary site do not differ in outcome. International Journal of Cancer, 133 (12), 3000-3007. doi: 10.1002/ijc.28318
2013
Journal Article
Selective organ specific inflammation in offspring harbouring microchimerism from strongly alloreactive mothers
Leveque, Lucie, Hodgson, Samantha, Peyton, Stephen, Koyama, Motoko, Macdonald, Kelli P. A. and Khosrotehrani, Kiarash (2013). Selective organ specific inflammation in offspring harbouring microchimerism from strongly alloreactive mothers. Journal of Autoimmunity, 50, 51-58. doi: 10.1016/j.jaut.2013.10.005
2013
Journal Article
Prospective surface marker-based isolation and expansion of fetal endothelial colony-forming cells from human term placenta
Patel, Jatin, Seppanen, Elke, Chong, Mark S. K., Yeo, Julie S. L., Teo, Erin Y. L., Chan, Jerry K. Y., Fisk, Nicholas M. and Khosrotehrani, Kiarash (2013). Prospective surface marker-based isolation and expansion of fetal endothelial colony-forming cells from human term placenta. Stem Cells Translational Medicine, 2 (11), 839-847. doi: 10.5966/sctm.2013-0092
2013
Journal Article
UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages
Handoko, Herlina Y., Rodero, Mathieu P., Boyle, Glen M., Ferguson, Blake, Engwerda, Christian, Hill, Geoff, Muller, H. Konrad, Khosrotehrani, Kiarash and Walker, Graeme J. (2013). UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages. Journal of Investigative Dermatology, 133 (7), 1803-1812. doi: 10.1038/jid.2013.9
2013
Journal Article
Mesenchymal stem cell therapy in skin: why and what for?
Khosrotehrani, Kiarash (2013). Mesenchymal stem cell therapy in skin: why and what for?. Experimental Dermatology, 22 (5), 307-310. doi: 10.1111/exd.12141
2013
Journal Article
Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model
Seppanen, Elke, Roy, Edwige, Ellis, Rebecca, Bou-Gharios, George, Fisk, Nicholas M. and Khosrotehrani, Kiarash (2013). Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model. PloS One, 8 (5) e62662, e62662. doi: 10.1371/journal.pone.0062662
2013
Journal Article
Pregnancy-acquired fetal progenitor cells
Seppanen, E., Fisk, N. M. and Khosrotehrani, K. (2013). Pregnancy-acquired fetal progenitor cells. Journal of Reproductive Immunology, 97 (1), 27-35. doi: 10.1016/j.jri.2012.08.004
2013
Journal Article
Wound-associated macrophages control collagen 1alpha2 transcription during the early stages of skin wound healing.
Rodero, Mathieu P., Legrand, Julien M. D., Bou-Garios, George and Khosrotehrani, Kiarash (2013). Wound-associated macrophages control collagen 1alpha2 transcription during the early stages of skin wound healing.. Experimental Dermatology, 22 (2), 143-145. doi: 10.1111/exd.12068
2013
Conference Publication
Survival and recurrence outcome in patients with melanomas of unknown primary invading lymph nodes
Wright, A., Hughes, M., Siskind, V., Smithers, M., Thomas, J., Green, A. and Khosrotehrani, K. (2013). Survival and recurrence outcome in patients with melanomas of unknown primary invading lymph nodes. The Australasian College of Dermatologists 46th Annual Scientific Meeting, Sydney, NSW Australia, 19 – 22 May 2013. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/ajd.12051
2013
Conference Publication
The interfollicular epidermis is maintained by a hierarchy defined by stem cells within the non-cycling portion of hair follicles and committed progenitors
Roy, E., Neufeld, Z., Cerone, L., Wong, A., Hodgson, S., Tabansky, I., Eggan, K., Livet, J. and Khosrotehrani, K. (2013). The interfollicular epidermis is maintained by a hierarchy defined by stem cells within the non-cycling portion of hair follicles and committed progenitors. International Investigative Dermatology Meeting, Edinburgh, Scotland, 8-11 May 2013. London, United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2013.106
2013
Book Chapter
Pregnancy-acquired fetal progenitors as natural cell therapy
Seppanen, Elke, Fisk, Nicholas M and Khosrotehrani, Kiarash (2013). Pregnancy-acquired fetal progenitors as natural cell therapy. Perinatal stem cells. (pp. 221-234) edited by Kyle J Cetrulo, Curtis L Cetrulo and Rouzbeh R Taghizadeh. Hoboken, NJ, United States: John Wiley & Sons, Inc.. doi: 10.1002/9781118497883.ch15
2013
Conference Publication
The influence of pregnancy on prognosis of melanoma
Byrom, L., Siskind, V., Green, A. and Khosrotehrani, K. (2013). The influence of pregnancy on prognosis of melanoma. The Australasian College of Dermatologists 46th Annual Scientific Meeting, Sydney, NSW Australia, 19 – 22 May 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12051
2013
Journal Article
Increase lymphangiogenesis in melanoma during pregnancy: correlation with the prolactin signalling pathway
Rodero, M. P., Prignon, A., Avril, M. F., Aractingi, S. and Khosrotehrani, K. (2013). Increase lymphangiogenesis in melanoma during pregnancy: correlation with the prolactin signalling pathway. Journal of the European Academy of Dermatology and Venereology : JEADV, 127-128 (1), e144-e145. doi: 10.1111/j.1468-3083.2012.04550.x
2013
Conference Publication
A mouse model for in vivo quantitative monitoring of Wnt/B-Catenin signalling in skin reveals macroscopic hair cycle dynamics in health and disease
Hodgson, S., Neufeld, Z. and Khosrotehrani, K. (2013). A mouse model for in vivo quantitative monitoring of Wnt/B-Catenin signalling in skin reveals macroscopic hair cycle dynamics in health and disease. International Investigative Dermatology Meeting, Edinburgh, Scotland, 8-11 May 2013. London, United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2013.97
2013
Conference Publication
Pilot multi-marker analysis to evaluate prognosis in stage Ib and II melanomas
Rowe, C. J., Rodero, M., Malt, M., Smithers, M., Green, A. and Khosrotehrani, K. (2013). Pilot multi-marker analysis to evaluate prognosis in stage Ib and II melanomas. The Australasian College of Dermatologists 46th Annual Scientific Meeting, Sydney, NSW Australia, 19 – 22 May 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12051
2012
Journal Article
Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females
Seppanen, Elke Jane, Hodgson, Samantha Susan, Khosrotehrani, Kiarash, Bou-Gharios, George and Fisk, Nicholas M. (2012). Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females. Stem Cells and Development, 21 (15), 2809-2816. doi: 10.1089/scd.2012.0047
2012
Journal Article
Calpain activity is essential in skin wound healing and contributes to scar formation
Nassar, Dany, Letavernier, Emmanuel, Baud, Laurent, Aractingi, Selim and Khosrotehrani, Kiarash (2012). Calpain activity is essential in skin wound healing and contributes to scar formation. PLoS One, 7 (5) e37084, e37084.1-e37084.10. doi: 10.1371/journal.pone.0037084
2012
Journal Article
Fetal microchimerism in skin wound healing
Nassar, Dany, Khosrotehrani, Kiarash and Aractingi, Selim (2012). Fetal microchimerism in skin wound healing. Chimerism, 2 (3), 45-47. doi: 10.4161/chim.20739
2012
Conference Publication
Increased lymphatic angiogenesis in melanomas occurring during gestation and correlation to prolactin signaling
Rodero, M. P., Byrom, L., Prignon, A., Avril, M. F., Boitier, F., Aractingi, S. and Khosrotehrani, K. (2012). Increased lymphatic angiogenesis in melanomas occurring during gestation and correlation to prolactin signaling. The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane, Australia, 20-23 May 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-0960.2012.00892.x
2012
Journal Article
Fetal progenitor cells naturally transferred through pregnancy participate in inflammation and angiogenesis during wound healing
Nassar, Dany, Droitcourt, Catherine, Mathieu-d'Argent, Emmanuelle, Kim, Min Ji, Khosrotehrani, Kiarash and Aractingi, Selim (2012). Fetal progenitor cells naturally transferred through pregnancy participate in inflammation and angiogenesis during wound healing. The FASEB Journal, 26 (1), 149-157. doi: 10.1096/fj.11-180695
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Master Philosophy
Antibody-mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
Completed supervision
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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