
Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2012
Conference Publication
Does fetal microchimerism confer a protective role against melanoma in women?
Leveque, L., Rodero, M., Fisk, N. and Khosrotehrani, K. (2012). Does fetal microchimerism confer a protective role against melanoma in women?. Conjoint 3rd Australasian Wound & Tissue Repair Society and 9th Australasian Society for Dermatology Research Conference, Sydney, NSW, Australia, 22-24 May 2012. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1524-475X.2012.00835.x
2012
Conference Publication
Predictive value of skin histology in chronic graft versus host disease
Andani, R., Robertson, I., MacDonald, K., Hill, G. and Khosrotehrani, K. (2012). Predictive value of skin histology in chronic graft versus host disease. The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane, Australia, 20-23 May 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-0960.2012.00892.x
2012
Conference Publication
A mouse model for in vivo quantitative monitoring of Wnt/b-catenin signaling in skin reveals hair cycle dynamics in sox18 mutant mice
Hodgson, S. S., Francois, M. and Khosrotehrani, K. (2012). A mouse model for in vivo quantitative monitoring of Wnt/b-catenin signaling in skin reveals hair cycle dynamics in sox18 mutant mice. 22nd Annual Meeting of the European Tissue Repair Society, Athens, Greece, October 4–5 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1524-475X.2012.00835.x
2012
Conference Publication
Fetal microchimerism of pregnancy associated progenitor cells: A new model to study stem cell response to tissue injury
Khosrotehrani, K. (2012). Fetal microchimerism of pregnancy associated progenitor cells: A new model to study stem cell response to tissue injury. Joint International Congress of the American-Society-for-Reproductive-Immunology (ASRI) and the European-Society-for-Reproductive-Immunology (ESRI), Hamburg, Germany, 30 May - 2 June 2012. Shannon, Co. Clare, Ireland: Elsevier. doi: 10.1016/j.jri.2012.03.274
2012
Conference Publication
A multicolour unbiased model to determine the Epidermal cell fate: localization and study of the epidermal stem cell niche
Roy, E., Neufeld, Z., Livet, J. and Khosrotehrani, K. (2012). A multicolour unbiased model to determine the Epidermal cell fate: localization and study of the epidermal stem cell niche. 42nd Annual Meeting of the European Society for Dermatological Research (ESDR), Venice, Italy, 7-10 September 2012. Oxford, United Kingdom: Elsevier. doi: 10.1038/jid.2012.301
2012
Conference Publication
Activation of stat5 is an indicator of good prognosis in stage Ib and II melanomas
Rodero, M., Wright, A., Malt, M., Smithers, M., Green, A. and Khosrotehrani, K. (2012). Activation of stat5 is an indicator of good prognosis in stage Ib and II melanomas. The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane, QLD, Australia, 20-23 May 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-0960.2012.00892.x
2012
Conference Publication
Revisiting endothelial progenitors in skin tissue injury paradigms
Khosrotehrani, K. (2012). Revisiting endothelial progenitors in skin tissue injury paradigms. Conjoint 3rd Australasian Wound & Tissue Repair Society and 9th Australasian Society for Dermatology Research Conference, Sydney, NSW, Australia, 22-24 May 2012. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1524-475X.2012.00835.x
2012
Conference Publication
Human placental endothelial progenitor cells accelerate skin wound angiogenesis and have synergistic action with mesenchymal stem cells
Patel, J., Seppanen, E., Fisk, N. and Khosrotehrani, K. (2012). Human placental endothelial progenitor cells accelerate skin wound angiogenesis and have synergistic action with mesenchymal stem cells. 22nd Annual Meeting of the European Tissue Repair Society, Athens, Greece, October 4–5 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1524-475X.2012.00835.x
2012
Conference Publication
Increased lymphatic angiogenesis in melanomas occurring during gestation and correlation to prolactin signaling
Rodero, M. P., Byrom, L., Prignon, A., Avril, M. F., Boitier, F., Aractingi, S. and Khosrotehrani, K. (2012). Increased lymphatic angiogenesis in melanomas occurring during gestation and correlation to prolactin signaling. The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane, Australia, 20-23 May 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-0960.2012.00892.x
2011
Journal Article
Can maternal microchimeric cells influence the fetal response toward self antigens?
Leveque, Lucie and Khosrotehrani, Kiarash (2011). Can maternal microchimeric cells influence the fetal response toward self antigens?. Chimerism, 2 (3), 71-77. doi: 10.4161/chim.2.3.17589
2011
Journal Article
Superficial Spreading-Like Melanoma in Arf−/−::Tyr-NrasQ61K::K14-Kitl Mice: Keratinocyte Kit Ligand Expression Sufficient to “Translocate” Melanomas from Dermis to Epidermis
Walker, Graeme J., Soyer, H. Peter, Handoko, Herlina Y., Ferguson, Blake, Kunisada, Takahiro, Khosrotehrani, Kiarash, Box, Neil F. and Muller, H. Konrad (2011). Superficial Spreading-Like Melanoma in Arf−/−::Tyr-NrasQ61K::K14-Kitl Mice: Keratinocyte Kit Ligand Expression Sufficient to “Translocate” Melanomas from Dermis to Epidermis. Journal of Investigative Dermatology, 131 (6), 1384-1387. doi: 10.1038/jid.2011.21
2011
Journal Article
Specific maternal microchimeric T cells targeting fetal antigens in β cells predispose to auto-immune diabetes in the child
Roy, Edwige, Leduc, Michele, Guegan, Sarah, Rachdi, Latif, Kluger, Nicolas, Scharfmann, Raphael, Aractingi, Selim and Khosrotehrani, Kiarash (2011). Specific maternal microchimeric T cells targeting fetal antigens in β cells predispose to auto-immune diabetes in the child. Journal of Autoimmunity, 36 (3-4), 253-262. doi: 10.1016/j.jaut.2011.02.003
2011
Journal Article
Pregnancy promotes melanoma metastasis through enhanced lymphangiogenesis
Khosrotehrani, Kiarash, Nguyen Huu, Sau, Prignon, Aurelie, Avril, Marie-Francoise, Boitier, Francoise, Oster, Michele, Mortier, Laurent, Richard, Marie-Aleth, Maubec, Eve, Kerob, Delphine, Mansard, Sandrine, Merheb, Charbel, Moguelet, Philippe, Nassar, Dany, Guegan, Sarah and Aractingi, Selim (2011). Pregnancy promotes melanoma metastasis through enhanced lymphangiogenesis. American Journal of Pathology, 178 (4), 1870-1880. doi: 10.1016/j.ajpath.2010.12.044
2011
Conference Publication
Does fetal microchimerism confer a protective role against melanoma in women?
Leveque, Lucie, Rodero, Mathieu, Fisk, Nicholas and Khosrotehrani, Kiarash (2011). Does fetal microchimerism confer a protective role against melanoma in women?. 41st Annual Meeting of the European Society for Dermatological Research, Barcelona, Spain, 7-10 September 2011. London, United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2011.214
2011
Conference Publication
In vivo Quantitative Monitoring of Hair Cycle Dynamics in Mice During Pregnancy and Lactation
Hodgson, Samantha and Khosrotehrani, Kiarash (2011). In vivo Quantitative Monitoring of Hair Cycle Dynamics in Mice During Pregnancy and Lactation. 41st Annual Meeting of the European Society for Dermatological Research, Barcelona, Spain, 7-10 September 2011.
2011
Conference Publication
Mouse models to investigate stem cells in skin homeostasis and wounds
Khosrotehrani, K. (2011). Mouse models to investigate stem cells in skin homeostasis and wounds. 38th Annual Meeting of the Society for Cutaneous Ultrastructure Research, Brisbane, Australia, 30-31 May 2011. Oxford, England, U. K.: Wiley-Blackwell Publishing. doi: 10.1111/j.1600-0625.2011.01352.x
2011
Conference Publication
Macrophages influence melanocyte proliferation after ultraviolet radiation exposure
Rodero, Mathieu, Handoko, Herlina, Walker, Graeme and Khosrotehrani, Kiarash (2011). Macrophages influence melanocyte proliferation after ultraviolet radiation exposure. Annual Meeting of the European Society for Dermatological Research (41st, ESDR, 2011), Barcelona, Spain, 7-10 September 2011. London, Hamps, U.K.: Nature Publishing Group. doi: 10.1038/jid.2011.214
2011
Conference Publication
Novel hierarchy of resident endothelial progenitors integral to skin wound angiogenesis
Seppanen, Elke, Rodero, Mathieu, Fisk, Nicholas and Khosrotehrani, Kiarash (2011). Novel hierarchy of resident endothelial progenitors integral to skin wound angiogenesis. 41st Annual Meeting of the European Society for Dermatological Research, Barcelona, Spain, 7-10 September 2011. London, England, U.K.: Nature Publishing Group. doi: 10.1038/jid.2011.214
2011
Conference Publication
The immune response influences melanocyte proliferation after ultraviolet radiation exposure
Handoko, H. Y., Rodero, M., Walker, G. and Khosrotehrani, Ki (2011). The immune response influences melanocyte proliferation after ultraviolet radiation exposure. International Pigment Cell Conference (XXIst , IPCC, 2011), Bordeaux, France, 21-24 September 2011. Malden, MA, U.S.A.: Wiley-Blackwell Publishing. doi: 10.1111/j.1755-148X.2011.00885.x
2011
Conference Publication
Characterisation and control of macrophage recruitment during skin wound healing by systemic CX3CR1 antagonism (F1)
Rodero, Mathieu, Dorgham, Karim, Hodgson, Samatha, Combadiere, Christophe and Khosrotehrani, Kiarash (2011). Characterisation and control of macrophage recruitment during skin wound healing by systemic CX3CR1 antagonism (F1). 41st Annual Meeting of the European Society for Dermatological Research, Barcelona, Spain, 7-10 September 2011.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Master Philosophy
Antibody-mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Completed supervision
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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