
Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2016
Conference Publication
Skin wound inflammation modulated by IL-17 producing macrophages is dependent on IL-23
Lee, J. S., Rodero, M. P., Moi, D., Patel, J., Mazzieri, R. and Khosrotehrani, K. (2016). Skin wound inflammation modulated by IL-17 producing macrophages is dependent on IL-23. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD, Australia, 25–28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
2016
Conference Publication
Systems analysis of skin biology and cancer using the Collaborative Cross
Walker, Graeme, Baz, Betoul, Ferguson, Blake, Legrand, Julien, Mukhopadhyay, Pamela, Handoko, Herlina and Khosrotehrani, Kiarash (2016). Systems analysis of skin biology and cancer using the Collaborative Cross. Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular & Experimental Pathology Society of Australasia (MEPSA), Melbourne Convention and Exhibition Centre, Melbourne, Australia, 7-9 November 2016. Hoboken, NJ, United States: Wiley-Blackwell.
2016
Conference Publication
Resident progenitors of endothelial origin contribute to neo-vessel formation through the expression of Sox18 during skin wound healing
Patel, J., Francois, M. and Khosrotehrani, K. (2016). Resident progenitors of endothelial origin contribute to neo-vessel formation through the expression of Sox18 during skin wound healing. Annual Meeting of the European Society for Dermatological Research (ESDR), Munich, Germany, 7-10 September 2016. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2016.06.596
2016
Conference Publication
Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma
Rowe, C., Tang, F., Hughes, M. C., Rodero, M., Malt, M., Lambie, D., Barbour, A., Hayward, N., Smithers, B. M., Green, A. and Khosrotehrani, K. (2016). Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma. Australasian College of Dermatologists 49th Annual Scientific Meeting, Perth, Australia, 14–17 May, 2016. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12480
2016
Conference Publication
Survival in patients with multiple primary melanomas vs. single primary melanoma
Rowe, C., Law, M., Palmer, J., MacGregor, S., Hayward, N. and Khosrotehrani, K. (2016). Survival in patients with multiple primary melanomas vs. single primary melanoma. Australasian College of Dermatologists 49th Annual Scientific Meeting, Perth, WA, Australia, 14–17 May 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12480
2015
Journal Article
Intrauterine bone marrow transplantation in osteogenesis imperfecta mice yields donor osteoclasts and osteomacs but not osteoblasts
Millard, Susan M., Pettit, Allison R., Ellis, Rebecca, Chan, Jerry K. Y., Raggatt, Liza J., Khosrotehrani, Kiarash and Fisk, Nicholas M. (2015). Intrauterine bone marrow transplantation in osteogenesis imperfecta mice yields donor osteoclasts and osteomacs but not osteoblasts. Stem Cell Reports, 5 (5), 682-689. doi: 10.1016/j.stemcr.2015.09.017
2015
Journal Article
Survival outcomes in patients with multiple primary melanomas
Rowe, C. J., Law, M. H., Palmer, J. M., MacGregor, S., Hayward, N. K. and Khosrotehrani, K. (2015). Survival outcomes in patients with multiple primary melanomas. Journal of the European Academy of Dermatology and Venereology, 29 (11), 2120-2127. doi: 10.1111/jdv.13144
2015
Journal Article
Lack of evidence from a transgenic mouse model that the activation and migration of melanocytes to the epidermis after neonatal UVR enhances melanoma development
Handoko, Herlina Y., Rodero, Mathieu P., Muller, H. Konrad, Khosrotehrani, Kiarash and Walker, Graeme J. (2015). Lack of evidence from a transgenic mouse model that the activation and migration of melanocytes to the epidermis after neonatal UVR enhances melanoma development. Journal of Investigative Dermatology, 135 (11), 2897-2900. doi: 10.1038/jid.2015.203
2015
Journal Article
Reply to meta-analysis concerning mortality for pregnancy-associated melanoma
Byrom, L., Olsen, C. M., Khosrotehrani, K. and Green, A. C. (2015). Reply to meta-analysis concerning mortality for pregnancy-associated melanoma. Journal of the European Academy of Dermatology and Venereology, 30 (10), e106-e107. doi: 10.1111/jdv.13347
2015
Journal Article
Prospective study of patterns of surgical management in adults with primary cutaneous melanoma at high risk of spread, in Queensland, Australia
Smithers, B.Mark, Hughes, Maria Celia B., Beesley, Vanessa L., Barbour, Andrew P., Malt, Maryrose K., Weedon, David, Zonta, Mark J., Wood, Dominic J., Triscott, Joseph A., Bayley, Gerard J., Brown, Lee J., Allan, Christopher P., D'Arcy, Justin, Williamson, Richard, Khosrotehrani, Kiarash and Green, Adele C. (2015). Prospective study of patterns of surgical management in adults with primary cutaneous melanoma at high risk of spread, in Queensland, Australia. Journal of Surgical Oncology, 112 (4), 359-365. doi: 10.1002/jso.24013
2015
Journal Article
Increased mortality for pregnancy-associated melanoma: systematic review and meta-analysis
Byrom, L., Olsen, C., Knight, L., Khosrotehrani, K. and Green, A. C. (2015). Increased mortality for pregnancy-associated melanoma: systematic review and meta-analysis. Journal of the European Academy of Dermatology and Venereology, 29 (8), 1457-1466. doi: 10.1111/jdv.12972
2015
Journal Article
Does pregnancy after a diagnosis of melanoma affect prognosis? Systematic review and meta-analysis
Byrom, Lisa, Olsen, Catherine M., Knight, Lani, Khosrotehrani, Kiarash and Green, Adele C. (2015). Does pregnancy after a diagnosis of melanoma affect prognosis? Systematic review and meta-analysis. Dermatologic Surgery, 41 (8), 875-882. doi: 10.1097/DSS.0000000000000406
2015
Journal Article
Melanoma survival is superior in females across all tumour stages but is influenced by age
Khosrotehrani, Kiarash, Dasgupta, Paramita, Byrom, Lisa, Youlden, Danny R., Baade, Peter D. and Green, Adele C. (2015). Melanoma survival is superior in females across all tumour stages but is influenced by age. Archives of Dermatological Research, 307 (8), 731-740. doi: 10.1007/s00403-015-1585-8
2015
Journal Article
PARP1 polymorphisms play opposing roles in melanoma occurrence and survival
Law, Matthew H., Rowe, Casey J., Montgomery, Grant W., Hayward, Nicholas K., MacGregor, Stuart and Khosrotehrani, Kiarash (2015). PARP1 polymorphisms play opposing roles in melanoma occurrence and survival. International Journal of Cancer, 136 (10), 2488-2489. doi: 10.1002/ijc.29280
2015
Journal Article
Fetal endothelial and mesenchymal progenitors from the human term placenta: potency and clinical potential
Shafiee, Abbas, Fisk, Nicholas M., Hutmacher, Dietmar W., Khosrotehrani, Kiarash and Patel, Jatin (2015). Fetal endothelial and mesenchymal progenitors from the human term placenta: potency and clinical potential. Stem Cells Translational Medicine, 4 (5), 419-423. doi: 10.5966/sctm.2014-0224
2015
Conference Publication
Deciphering a Novel in Vivo Hierarchy of Vessel Resident Endothelial Progenitors using the Human Term Placenta
Shafiee, A., Patel, J., Fisk, N. and Khosrotehrani, K. (2015). Deciphering a Novel in Vivo Hierarchy of Vessel Resident Endothelial Progenitors using the Human Term Placenta. 4th TERMIS World Congress, Boston, MA, United States, 8-11 September, 2015. New Rochelle, NY, United States: Mary Ann Liebert. doi: 10.1089/ten.tea.2015.5000.abstracts
2015
Journal Article
ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis
Lee, James S., Seppanen, Elke, Patel, Jatin, Rodero, Mathieu P. and Khosrotehrani, Kiarash (2015). ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis. Experimental Dermatology, 25 (1), 71-74. doi: 10.1111/exd.12833
2015
Journal Article
Clinical and biological determinants of melanoma progression: Should all be considered for clinical management?
Rowe, Casey J and Khosrotehrani, Kiarash (2015). Clinical and biological determinants of melanoma progression: Should all be considered for clinical management?. Australasian Journal of Dermatology, 57 (3), 175-181. doi: 10.1111/ajd.12348
2015
Conference Publication
Mesenchymal stem cells co-transplantation enhanced the vessel formation capacity of placental derived endothelial colony forming cells in the wild type and immunodeficient mice
Shafiee, Abbas, Patel, Jatin, Fisk, Nicholas and Khosrotehrani, Kiarash (2015). Mesenchymal stem cells co-transplantation enhanced the vessel formation capacity of placental derived endothelial colony forming cells in the wild type and immunodeficient mice. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2015.07.272
2015
Conference Publication
Dominant negative mutation of Sox18 inhibits normal dermal papilla development during embryogenesis and regeneration
Villani, R. M., Hodgson, S., Legrand, J., Greaney, J., Wong, H., Pichol-Thievend, C., Adolphe, C., Wainwright, B., Francois, M. and Khosrotehrani, K. (2015). Dominant negative mutation of Sox18 inhibits normal dermal papilla development during embryogenesis and regeneration. 45th Annual Meeting of the European Society for Dermatological Research, Rotterdam, Netherlands, 9-12 September 2015. London, United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2015.272
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
Antibody-mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
Completed supervision
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
-
2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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