
Overview
Background
Professor Khosrotehrani is a clinical scientist, dermatologist, interested in skin biology, regenerative medicine and skin cancer. He leads the Experimental Dermatology Group at the University of Queensland Diamantina Institute within the Translational Research Institute in Brisbane, Australia. He is also the deputy director of the Australian Skin and Skin Cancer Research Centre in Brisbane. Dr Khosrotehrani obtained his MD from the Cochin-Port Royal School of Medicine at René Descartes University, Paris, France, where he specialized in Dermatology. He is a former graduate of the Ecole Normale Supérieure and the Institut Pasteur of Paris (Université Paris VI, Pierre et Marie Curie) where he obtained a PhD in Physiology and Physiopathology. He is a fellow of the Australian College of Dermatologists and a practising dermatologist at the Princess Alexandra Hospital, Prince Charles Hospital and the Skin and Cancer Foundation’s Queensland Institute of Dermatology.
During his post-doctoral training at Tufts-New England Medical Center, Boston, USA, Dr. Khosrotehrani helped establish the contribution of fetal stem cells to tissue repair by demonstrating their multipotent capacity with a specific potency towards the endothelial lineage. The originality of this work was acknowledged by the NHMRC through an achievement award (2011) and an NHMRC excellence award (2016). He is currently a fellow of the NHMRC of Australia. The main focus of his laboratory is on regenerative medicine and stem cell biology in particular in injury response in skin wounds and skin cancer and how these responses contribute to cancer initiation and progression. Translating his laboratory findings, Dr Khosrotehrani is leading innovative clinical trials in wound healing, keratinocyte cancers and melanoma.
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Paris
Research interests
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Tissue regeneration
Endogenous response to injury. Vascular and Epithelial repair in response to ischemia or wounding. Hair follicle biology, cycling and regeneration.
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Skin cancer
Factors determining melanoma survival. Basal Cell carcinoma formation and progression Squamous cell carcinoma formation and UV irradiation
Works
Search Professor Kiarash Khosrotehrani’s works on UQ eSpace
2021
Journal Article
Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
Chand, Kirat K., Patel, Jatin, Bjorkman, S. T., Sim, Seen-Ling, Miller, Stephanie M., Teo, Elliot, Jones, Lara, Sun, Jane, Colditz, Paul B., Khosrotehrani, Kiarash and Wixey, Julie A. (2021). Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn. npj Regenerative Medicine, 6 (1) 75, 75. doi: 10.1038/s41536-021-00185-5
2021
Journal Article
Comparative performance of predictors of death from thin (≤1.0 mm) melanoma
Claeson, M., Baade, P., Marchetti, M., Brown, S., Soyer, H.P., Smithers, B.M., Green, A.C., Whiteman, D.C. and Khosrotehrani, K. (2021). Comparative performance of predictors of death from thin (≤1.0 mm) melanoma. British Journal of Dermatology, 185 (4) bjd.20480, 849-851. doi: 10.1111/bjd.20480
2021
Journal Article
Subtype specific analyses reveal infiltrative basal cell carcinoma are highly interactive with their environment
Villani, Rehan, Murigneux, Valentine, Alexis, Josue, Sim, Seen-Ling, Wagels, Michael, Saunders, Nicholas, Soyer, H. Peter, Parmentier, Laurent, Nikolaev, Sergey, Fink, J. Lynn, Roy, Edwige and Khosrotehrani, Kiarash (2021). Subtype specific analyses reveal infiltrative basal cell carcinoma are highly interactive with their environment. The Journal of Investigative Dermatology, 141 (10), 2380-2390. doi: 10.1016/j.jid.2021.02.760
2021
Journal Article
Resident vascular endothelial progenitor definition and function: the age of reckoning
Dight, James, Zhao, Jilai, Styke, Cassandra, Khosrotehrani, Kiarash and Patel, Jatin (2021). Resident vascular endothelial progenitor definition and function: the age of reckoning. Angiogenesis, 25 (1), 15-33. doi: 10.1007/s10456-021-09817-2
2021
Journal Article
Evolution of skin cancer numbers in solid organ transplant recipients: a pilot study
Lee, Ruby Chia‐Lin, Stevenson, Paul, Yeung, Chester, Lai, Alexander, Liyanage, Upekha, Gordon, Louisa, Green, Adele C, Isbel, Nicole, Campbell, Scott, Griffin, Anthony and Khosrotehrani, Kiarash (2021). Evolution of skin cancer numbers in solid organ transplant recipients: a pilot study. Australasian Journal of Dermatology, 63 (1), e83-e86. doi: 10.1111/ajd.13685
2021
Journal Article
Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
Zhao, Jilai, Patel, Jatin, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Styke, Cassandra, Hogan, Isabella, Kahler, Sam, Hamilton, Hamish, Wadlow, Racheal, Dight, James, Hashemi, Ghazaleh, Sormani, Laura, Roy, Edwige, Yoder, Mervin C., Francois, Mathias and Khosrotehrani, Kiarash (2021). Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors. Nature Communications, 12 (1) 2564, 1-17. doi: 10.1038/s41467-021-22717-9
2021
Journal Article
Whole-mount staining coupled to a UV-inducible basal cell carcinoma murine model
Wong, Ho Yi, Khosrotehrani, Kiarash and Roy, Edwige (2021). Whole-mount staining coupled to a UV-inducible basal cell carcinoma murine model. STAR protocols, 2 (1) 100329, 100329. doi: 10.1016/j.xpro.2021.100329
2021
Journal Article
Patient age and risk of recurrence of primary melanoma at high risk of spread
Ghiasvand, R., Khosrotehrani, K., Hughes, M.C.B., von Schuckmann, L. A., Beesley, V. L., Malt, M., Smithers, B. M. and Green, A. C. (2021). Patient age and risk of recurrence of primary melanoma at high risk of spread. British Journal of Dermatology, 184 (3) bjd.19601, 566-568. doi: 10.1111/bjd.19601
2021
Journal Article
Forever connected: The lifelong biological consequences of fetomaternal and maternofetal microchimerism
Bianchi, Diana W., Khosrotehrani, Kiarash, Way, Sing Sing, MacKenzie, Tippi C., Bajema, Ingeborg and O'Donoghue, Keelin (2021). Forever connected: The lifelong biological consequences of fetomaternal and maternofetal microchimerism. Clinical Chemistry, 67 (2), 351-362. doi: 10.1093/clinchem/hvaa304
2021
Journal Article
Increased melanoma recurrence in patients with multiple primary invasive melanomas
Green, Adele C., Hughes, Maria Celia B., Williams, Gail M., Malt, Maryrose, Beesley, Vanessa L., Khosrotehrani, Kiarash and Smithers, B. Mark (2021). Increased melanoma recurrence in patients with multiple primary invasive melanomas. Journal of the American Academy of Dermatology, 86 (6), 1366-1369. doi: 10.1016/j.jaad.2021.05.025
2020
Journal Article
Clinical utility of skin cancer and melanoma risk scores for population screening: TRoPICS study
Shetty, A., Janda, M., Fry, K., Brown, S., Yau, B., Schuckmann, L. Von, Thomas, S., Rayner, J.E., Spelman, L., Wagner, G., Jenkins, H., Lun, K., Parbery, J., Soyer, H.P., Neale, R.E., Green, A.C., Whiteman, D.C., Olsen, C.M. and Khosrotehrani, K. (2020). Clinical utility of skin cancer and melanoma risk scores for population screening: TRoPICS study. Journal of the European Academy of Dermatology and Venereology, 35 (5) jdv.17062, 1094-1098. doi: 10.1111/jdv.17062
2020
Journal Article
Survival in patients with multiple primary melanomas: systematic review and meta-analysis
Peek, Genevieve, Olsen, Catherine M., Baade, Peter, Youlden, Danny R., Aitken, Joanne F., Green, Adele C. and Khosrotehrani, Kiarash (2020). Survival in patients with multiple primary melanomas: systematic review and meta-analysis. Journal of the American Academy of Dermatology, 83 (5), 1406-1414. doi: 10.1016/j.jaad.2020.03.076
2020
Journal Article
Germline variants are associated with increased primary melanoma tumor thickness at diagnosis
Mangantig, Ernest, MacGregor, Stuart, Iles, Mark M., Scolyer, Richard A., Cust, Anne E., Hayward, Nicholas K., Montgomery, Grant W., Duffy, David L., Thompson, John F., Henders, Anjali, Bowdler, Lisa, Rowe, Casey, Cadby, Gemma, Mann, Graham J., Whiteman, David C., Long, Georgina V., Ward, Sarah V., Khosrotehrani, Kiarash, Barrett, Jennifer H. and Law, Matthew H. (2020). Germline variants are associated with increased primary melanoma tumor thickness at diagnosis. Human Molecular Genetics, 29 (21), 3578-3587. doi: 10.1093/hmg/ddaa222
2020
Journal Article
Multiplex melanoma families are enriched for polygenic risk
Law, Matthew H., Aoude, Lauren G., Duffy, David L., Long, Georgina V., Johansson, Peter A., Pritchard, Antonia L., Khosrotehrani, Kiarash, Mann, Graham J., Montgomery, Grant W., Iles, Mark M., Cust, Anne E., Palmer, Jane M., Melanoma GWAS Consortium, Shannon, Kerwin F., Spillane, Andrew J., Stretch, Jonathan R., Thompson, John F., Saw, Robyn P. M., Scolyer, Richard A., Martin, Nicholas G., Hayward, Nicholas K. and MacGregor, Stuart (2020). Multiplex melanoma families are enriched for polygenic risk. Human Molecular Genetics, 29 (17), 2976-2985. doi: 10.1093/hmg/ddaa156
2020
Journal Article
Anxiety and depression after diagnosis of high-risk primary cutaneous melanoma: a 4-year longitudinal study
Beesley, Vanessa L., Hughes, Maria Celia B., Smithers, B. Mark, Khosrotehrani, Kiarash, Malt, Maryrose K., von Schuckmann, Lena A. and Green, Adèle C. (2020). Anxiety and depression after diagnosis of high-risk primary cutaneous melanoma: a 4-year longitudinal study. Journal of Cancer Survivorship, 14 (5), 712-719. doi: 10.1007/s11764-020-00885-9
2020
Journal Article
Prognostic implications of biopsy with tumor transection for patients with high-risk primary melanoma
von Schuckmann, Lena A., Khosrotehrani, Kiarash, Hughes, Maria Celia B., van der Pols, Jolieke C., Malt, Maryrose, Smithers, B. Mark and Green, Adele C. (2020). Prognostic implications of biopsy with tumor transection for patients with high-risk primary melanoma. Journal of the American Academy of Dermatology, 82 (6), 1521-1524. doi: 10.1016/j.jaad.2020.01.067
2020
Journal Article
Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis
Mahamat-Saleh, Yahya, Hughes, Maria Celia B., Miura, Kyoko, Malt, Maryrose K., von Schuckmann, Lena, Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adèle C. (2020). Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis. Cancer Epidemiology Biomarkers & Prevention, 29 (8), 1647-1653. doi: 10.1158/1055-9965.epi-20-0319
2020
Journal Article
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
Landi, Maria Teresa, GenoMEL Consortium, Bishop, D. Timothy, MacGregor, Stuart, Machiela, Mitchell J., Stratigos, Alexander J., Ghiorzo, Paola, Brossard, Myriam, Calista, Donato, Choi, Jiyeon, Fargnoli, Maria Concetta, Zhang, Tongwu, Rodolfo, Monica, Trower, Adam J., Menin, Chiara, Martinez, Jacobo, Hadjisavvas, Andreas, Song, Lei, Stefanaki, Irene, Scolyer, Richard, Yang, Rose, Goldstein, Alisa M., Potrony, Miriam, Kypreou, Katerina P., Pastorino, Lorenza, Queirolo, Paola, Pellegrini, Cristina, Cattaneo, Laura, Zawistowski, Matthew ... MelaNostrum Consortium (2020). Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. Nature Genetics, 52 (5), 494-504. doi: 10.1038/s41588-020-0611-8
2020
Journal Article
Early detection of melanoma: a consensus report from the Australian Skin and Skin Cancer Research Centre Melanoma Screening Summit
Janda, Monika, Cust, Anne E., Neale, Rachel E., Aitken, Joanne F., Baade, Peter D., Green, Adele C., Khosrotehrani, Kiarash, Mar, Victoria, Soyer, H. Peter and Whiteman, David C. (2020). Early detection of melanoma: a consensus report from the Australian Skin and Skin Cancer Research Centre Melanoma Screening Summit. Australian and New Zealand Journal of Public Health, 44 (2), 111-115. doi: 10.1111/1753-6405.12972
2020
Journal Article
Murine dorsal hair type is genetically determined by polymorphisms in candidate genes that influence BMP and WNT signalling
Villani, Rehan M., Johnson, Ayaka, Galbraith, Jack A., Baz, Betoul, Handoko, Herlina Y., Walker, Graeme J. and Khosrotehrani, Kiarash (2020). Murine dorsal hair type is genetically determined by polymorphisms in candidate genes that influence BMP and WNT signalling. Experimental Dermatology, 29 (5) exd.14090, 450-461. doi: 10.1111/exd.14090
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiarash Khosrotehrani is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Understanding the mechanisms for increased mortality risk for pregnancy-associated melanoma.
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Master Philosophy
A Pilot Observational Study of Changes in Naevi during Pregnancy using Total-Body Photography
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Understanding and targeting determinants of mortality from melanoma
Principal Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
Spatial omics to characterize the clinicopathologic subsets of melanoma
Principal Advisor
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Doctor Philosophy
Predicting melanoma survival using advanced digital imaging technologies
Principal Advisor
Other advisors: Dr Quan Nguyen
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Master Philosophy
Evaluating the impact of social determinants of health on melanoma outcomes
Principal Advisor
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Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
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Doctor Philosophy
Evaluating the impact of social determinants of health on skin cancer outcomes
Principal Advisor
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Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Fiona Simpson, Dr Snehlata Kumari
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Master Philosophy
Antibody-mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Master Philosophy
Evaluating the effects of chronic diseases and lifestyle on the risk of melanoma recurrence
Associate Advisor
Other advisors: Dr Lena Von Schuckmann
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Master Philosophy
Antibody mediated exacerbation of Pseudomonas aeruginosa infected chronic wounds
Associate Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Associate Advisor
Other advisors: Professor Gabrielle Belz, Dr Snehlata Kumari
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Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Associate Advisor
Other advisors: Associate Professor Mitchell Stark
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Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Nikolas Haass, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Understanding Melanoma Vascularisation to prevent metastasis
Associate Advisor
Other advisors: Ms Laura Sormani Le Bourhis
Completed supervision
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2024
Doctor Philosophy
Mechanisms of Vascular Remodelling in Melanoma
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
-
2024
Master Philosophy
Anatomical Distribution and Immunoprevention of Keratinocyte Carcinoma
Principal Advisor
-
2024
Doctor Philosophy
Identifying genetic and epigenetic regulators of skin and hair follicle physiology and disease in mice: A systems-based approach using The Collaborative Cross
Principal Advisor
Other advisors: Dr Sally Mortlock
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2024
Doctor Philosophy
Potency and activity of meso-endothelial bipotent progenitors in vivo in homeostasis and injury
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Principal Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Antje Blumenthal
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2023
Doctor Philosophy
Investigating the contribution of vascular Sox9 to fibrosis in homeostasis and systemic sclerosis
Principal Advisor
Other advisors: Dr Simranpreet Kaur
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2023
Master Philosophy
Mutation burden as a biomarker of keratinocyte cancer risk prediction and field treatment efficacy
Principal Advisor
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2022
Doctor Philosophy
Defining endovascular progenitors in homeostasis and disease
Principal Advisor
Other advisors: Ms Laura Sormani Le Bourhis
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2022
Doctor Philosophy
Uncovering the Role of Endovascular Progenitors in Melanoma Development and Metastatic Progression
Principal Advisor
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2020
Master Philosophy
Predicting melanoma outcome using clinical and biological indicators
Principal Advisor
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2019
Master Philosophy
Dissecting Molecular Events in Pregnancy-Associated Melanoma
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Master Philosophy
Understanding the differences between basal cell carcinoma subtypes at the genomic and transcriptomic level.
Principal Advisor
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2018
Doctor Philosophy
The Role of Skin Macrophages Under Conditions of Stress and Injury: Ultraviolet Irradiation and Wound Healing
Principal Advisor
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2017
Doctor Philosophy
Prognostic factors in early stage invasive cutaneous melanoma
Principal Advisor
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2017
Doctor Philosophy
A Genome-wide Approach to Identify Genetic Determinants of Skin Wound Healing and Scar Formation.
Principal Advisor
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2015
Master Philosophy
The influence of pregnancy, parity, and sex on melanoma prognosis
Principal Advisor
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2015
Doctor Philosophy
Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration
Principal Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
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2018
Doctor Philosophy
The role of SOX7 transcription factor in early blood vessel development
Associate Advisor
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2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2013
Doctor Philosophy
Endogenous stem cell behaviour in tissue repair: lessons from fetal microchimerism
Associate Advisor
Media
Enquiries
Contact Professor Kiarash Khosrotehrani directly for media enquiries about:
- basal cell carcinoma
- Dermatology
- Fetal stem cells
- Melanoma
- Skin cancer
- Skin wound healing
- squamous cell carcinoma
- Stem cells - fetal
- Stem cells - skin wound healing
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