Overview
Background
- Director, Herston Imaging Research Facility
- Professorial Research Fellow and Senior Group Leader, AIBN
- Nuclear Medicine Specialist, Dept Nuclear Medicine & PET Services, Royal Brisbane & Women’s Hospital
Ros Francis is an academic Nuclear Medicine specialist who has established an innovative and highly collaborative research career focused on clinical trials, novel radiopharmaceuticals for imaging and therapy, and innovative approaches for quantitative imaging. Her expertise spans diverse fields including oncology, cardiology, neurology and inflammatory diseases, with a focus on research translation. Ros is passionate about nuclear medicine clinical trials and has been integral in the establishment of Australasian Radiopharmaceutical Trials Network (ARTnet), for which she has been Scientific Chair since 2014.
Ros relocated to Brisbane in 2024 from Western Australia and is enjoying new opportunities in Queensland’s vibrant and innovative biodiscovery ecosystem. As Director of Herston Imaging Research Facility and Senior Group Leader AIBN, Ros aims to lead translational research to improve outcomes for patients
Availability
- Professor Roslyn Francis is:
- Available for supervision
Research impacts
Ros is an academic Nuclear Medicine Specialist and combines clinical practice with an active and impactful research career. After graduating from University of Western Australia in 1994 she held a Cancer Research UK Clinical Research Fellowship for 4 years, undertaking a PhD at the Royal Free Hospital London on antibody therapies. Following relocation back to Australia in 2003, Ros completed Australian requirements for physician training and specialisation in Nuclear Medicine. Ros has held positions in Western Australia as Nuclear Medicine Specialist at Sir Charles Gairdner Hospital from 2007 (Head of Department 2013-2023) and an academic appointment at UWA from 2010 as A/Prof Molecular Imaging, UWA Medical School. In 2024, Ros commenced in Brisbane as Nuclear Medicine Specialist at the Royal Brisbane and Women’s Hospital, Professor and Group Leader UQ-AIBN and Director Herston Imaging Research Facility.
Ros has a research portfolio encompassing discovery research to clinical trials with radiopharmaceuticals for imaging or therapy (theranostics). Her research has spanned preclinical and human imaging, with a strong focus on image quality and quantitation. Ros is chief investigator on competitive research grants > $36million in the last 10 years, including NHMRC CRE, MRFF clinical trials and ACRF infrastructure grants. In Queensland, Ros is leading an $1.8 million MRFF grant investigating a new radio-imaging agent to guide targeted therapy for epithelial ovarian cancer. Ros has 95 publications, 52 the last 5 years, including in leading journals Lancet x2, Lancet Oncol x4 and J Nucl Med x 5 (h index 31, >5000 citations).
Ros has been inaugural Scientific Chair of Australasian Radiopharmaceutical Trials network (ARTnet) since 2014. ARTnet has facilitated internationally impactful multicentre clinical trials in Australia, leading to high citation publications (Lancet 2020; Lancet 2021), social media and public interest, government/policy impact (Medicare recommendations) and incorporation into international practice guidelines. The ProPSMA trial, the first co-badged ARTnet/ANZUP study, was awarded the Australian Clinical Trials Alliance Trial of the Year in 2021. ARTnet has also established quality programs including PET camera accreditation, and radiopharmaceutical production standards which are critical for imaging validity in multicentre trials.
Ros has made a significant professional contribution to Nuclear Medicine in Australia. She is past President of Australian and New Zealand Society of Nuclear Medicine (ANZSNM), and is actively engaged with National Imaging Facility, including leading activity streams in the human molecular imaging translational network. She has participated in government/advisory roles including WA Radiological Council, MSAC radiopharmaceuticals working group committee, MSAC review subcommittee (Oncology) and ANSTO clinical advisory committee. Her strong international standing in clinical trials with radiopharmaceuticals is highlighted by invited presentations to EORTC imaging group, and participation in international working groups to enhance research facilitation. She has been an invited speaker at multiple national and international scientific meetings, including plenary sessions. She is a previous co-convenor of ANZSNM annual scientific meeting.
Ros values mentorship and supervision. She has supervised 4 PhD students to completion and is currently supervising 4 PhD students. She has provided clinical mentorship for Nuclear Medicine advanced trainees for over 15 years and provides mentorship for early career researchers. She has undertaken career engagement activities including clinician academic career events (Academy of Health and Medical Sciences) and as invited speaker for International Women’s Day.
Works
Search Professor Roslyn Francis’s works on UQ eSpace
2023
Journal Article
Considerations for imaging of malignant pleural mesothelioma: a consensus statement from the International Mesothelioma Interest Group
Katz, Sharyn I., Straus, Christopher M., Roshkovan, Leonid, Blyth, Kevin G., Frauenfelder, Thomas, Gill, Ritu R., Lalezari, Ferry, Erasmus, Jeremy, Nowak, Anna K., Gerbaudo, Victor H., Francis, Roslyn J. and Armato, Samuel G. (2023). Considerations for imaging of malignant pleural mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Journal of Thoracic Oncology, 18 (3), 278-298. doi: 10.1016/j.jtho.2022.11.018
2022
Journal Article
Unravelling the role of macrophages in cardiovascular inflammation through imaging: a state-of-the-art review
Parry, Reece, Majeed, Kamran, Pixley, Fiona, Hillis, Graham Scott, Francis, Roslyn Jane and Schultz, Carl Johann (2022). Unravelling the role of macrophages in cardiovascular inflammation through imaging: a state-of-the-art review. European Heart Journal Cardiovascular Imaging, 23 (12), e504-e525. doi: 10.1093/ehjci/jeac167
2022
Journal Article
Fully automatic prognostic biomarker extraction from metastatic prostate lesion segmentations in whole-body [68Ga]Ga-PSMA-11 PET/CT images
Kendrick, Jake, Francis, Roslyn J., Hassan, Ghulam Mubashar, Rowshanfarzad, Pejman, Ong, Jeremy S. L. and Ebert, Martin A. (2022). Fully automatic prognostic biomarker extraction from metastatic prostate lesion segmentations in whole-body [68Ga]Ga-PSMA-11 PET/CT images. European Journal of Nuclear Medicine and Molecular Imaging, 50 (1), 67-79. doi: 10.1007/s00259-022-05927-1
2022
Journal Article
The effect of vitamin-K1 and colchicine on vascular calcification activity in subjects with diabetes mellitus (ViKCoVaC): a double-blind 2x2 factorial randomized controlled trial
Bellinge, Jamie W., Francis, Roslyn J., Lee, Sing Ching, Vickery, Alistair, Macdonald, William, Gan, Seng Khee, Chew, Gerard T., Phillips, Michael, Lewis, Joshua R., Watts, Gerald F. and Schultz, Carl J. (2022). The effect of vitamin-K1 and colchicine on vascular calcification activity in subjects with diabetes mellitus (ViKCoVaC): a double-blind 2x2 factorial randomized controlled trial. Journal of Nuclear Cardiology, 29 (4), 1855-1866. doi: 10.1007/s12350-021-02589-8
2022
Journal Article
Event‐free survival after radical prostatectomy according to PSMA PET and EAU Biochemical Recurrence Risk Groups
Roberts, Matthew J., Chatfield, Mark D., Hruby, George, Nandurkar, Rohan, Roach, Paul, Watts, Jo Anne, Cusick, Thomas, Kneebone, Andrew, Eade, Thomas, Ho, Bao, Nguyen, Andrew, Tang, Colin, McCarthy, Michael, Francis, Roslyn, Stricker, Phillip and Emmett, Louise (2022). Event‐free survival after radical prostatectomy according to PSMA PET and EAU Biochemical Recurrence Risk Groups. BJU International, 130 (S3), 32-39. doi: 10.1111/bju.15762
2022
Conference Publication
TheraP: <sup>177</sup>Lu-PSMA-617 (LuPSMA) versus cabazitaxel in metastatic castration-resistant prostate cancer (mCRPC) progressing after docetaxel-Overall survival after median follow-up of 3 years (ANZUP 1603)
Hofman, Michael S., Emmett, Louise, Sandhu, Shahneen, Iravani, Amir, Joshua, Anthony M., Goh, Jeffrey C., Pattison, David A., Tan, Thean Hsiang, Kirkwood, Ian D., Francis, Roslyn J., Gedye, Craig, Rutherford, Natalie K., Zhang, Alison Yan, McJannett, Margaret Mary, Stockler, Martin R., Williams, Scott, Martin, Andrew James and Davis, Ian D. (2022). TheraP: 177Lu-PSMA-617 (LuPSMA) versus cabazitaxel in metastatic castration-resistant prostate cancer (mCRPC) progressing after docetaxel-Overall survival after median follow-up of 3 years (ANZUP 1603). Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Virtual, 3-7 June 2022. Philadelphia, PA USA: Lippincott Williams & Wilkins.
2022
Journal Article
The importance of training, accreditation, and guidelines for the practice of theranostics: the Australian perspective
Lee, Sze Ting, Emmett, Louise M., Pattison, David A., Hofman, Michael S., Bailey, Dale L., Latter, Melissa J., Francis, Roslyn J. and Scott, Andrew M. (2022). The importance of training, accreditation, and guidelines for the practice of theranostics: the Australian perspective. Journal of Nuclear Medicine, 63 (6), 819-822. doi: 10.2967/jnumed.122.263996
2022
Journal Article
Subcutaneous sarcoidosis (Darier–Roussy sarcoidosis) with extensive disease on positron emission tomography: a case report and review of the literature
Youn, Paul, Francis, Roslyn J., Preston, Henry and Lake, Fiona (2022). Subcutaneous sarcoidosis (Darier–Roussy sarcoidosis) with extensive disease on positron emission tomography: a case report and review of the literature. Respirology Case Reports, 10 (5) e0949. doi: 10.1002/rcr2.949
2022
Conference Publication
A prospective, multi-centre trial of FET-PET In Glioblastoma patients - the TROG 18.06 FIG Study: results of the Nuclear Medicine and Radiation Oncology credentialing program
Koh, E. S., Moore, A., Francis, R. J., Ebert, M. A., Gan, H. K., Lee, S. T., Lau, E., Rossi, A., Grose, A., Ng, S. P., Barnes, E. H., Moffat, B. A., Scott, F. E., Adda, L., Foroudi, F., Nowak, A. K., Bailey, D. L., Back, M., Lourenco, R. De Abreu and Scott, A. M. (2022). A prospective, multi-centre trial of FET-PET In Glioblastoma patients - the TROG 18.06 FIG Study: results of the Nuclear Medicine and Radiation Oncology credentialing program. HOBOKEN: WILEY.
2022
Journal Article
Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study)
Lam, Virginie, Clarnette, Roger, Francis, Roslyn, Bynevelt, Michael, Watts, Gerald, Flicker, Leon, Orr, Carolyn F, Loh, Poh, Lautenschlager, Nicola, Reid, Christopher M., Foster, Jonathan K., Dhaliwal, Satvinder S., Robinson, Suzanne, Corti, Emily, Vaccarezza, Mauro, Horgan, Ben, Takechi, Ryusuke and Mamo, John (2022). Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study). BMJ Open, 12 (2) e058826, e058826. doi: 10.1136/bmjopen-2021-058826
2022
Conference Publication
ENZA-p: A randomized phase II trial using PSMA as a therapeutic agent and prognostic indicator in men with metastatic castration-resistant prostate cancer treated with enzalutamide (ANZUP 1901)
Emmett, Louise, Subramaniam, Shalini, Martin, Andrew James, Zhang, Alison Yan, Yip, Sonia, Crumbaker, Megan, Rana, Nisha, Francis, Roslyn J., Hofman, Michael S., Joshua, Anthony M., Sandhu, Shahneen Kaur, Azad, Arun, Gedye, Craig, Weickhardt, Andrew James, Goh, Jeffrey C., Ng, Siobhan, Voskoboynik, Mark, McJannett, Margaret Mary, Stockler, Martin R. and Davis, Ian D. (2022). ENZA-p: A randomized phase II trial using PSMA as a therapeutic agent and prognostic indicator in men with metastatic castration-resistant prostate cancer treated with enzalutamide (ANZUP 1901). ASCO Genitourinary Cancers Symposium, Electr Network, Feb 17-19, 2022. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1200/JCO.2022.40.6_suppl.TPS205
2022
Conference Publication
PSMA PET and FDG PET as predictors of response and prognosis in a randomized phase 2 trial of <SUP>177</SUP>Lu-PSMA-617 (LuPSMA) versus cabazitaxel in metastatic, castration-resistant prostate cancer (mCRPC) progressing after docetaxel (TheraP ANZUP 1603)
Buteau, James Patrick, Martin, Andrew James, Emmett, Louise, Iravani, Amir, Sandhu, Shahneen Kaur, Joshua, Anthony M., Zhang, Alison Yan, Francis, Roslyn J., Scott, Andrew Mark, Azad, Arun, McJannett, Margaret Mary, Stockler, Martin R., Williams, Scott, Davis, Ian D. and Hofman, Michael S. (2022). PSMA PET and FDG PET as predictors of response and prognosis in a randomized phase 2 trial of 177Lu-PSMA-617 (LuPSMA) versus cabazitaxel in metastatic, castration-resistant prostate cancer (mCRPC) progressing after docetaxel (TheraP ANZUP 1603). ASCO Genitourinary Cancers Symposium, Electr Network, Feb 17-19, 2022. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1200/JCO.2022.40.6_suppl.010
2022
Journal Article
Imaging in pleural mesothelioma: a review of the 15th International Conference of the International Mesothelioma Interest Group
Armato, Samuel G., Nowak, Anna K., Francis, Roslyn J., Katz, Sharyn I., Kholmatov, Manizha, Blyth, Kevin G., Gudmundsson, Eyjolfur, Kidd, Andrew C. and Gill, Ritu R. (2022). Imaging in pleural mesothelioma: a review of the 15th International Conference of the International Mesothelioma Interest Group. Lung Cancer, 164, 76-83. doi: 10.1016/j.lungcan.2021.12.008
2022
Journal Article
The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial
Bellinge, Jamie W., Francis, Roslyn J., Lee, Sing C., Bondonno, Nicola P., Sim, Marc, Lewis, Joshua R., Watts, Gerald F. and Schultz, Carl J. (2022). The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial. The American Journal of Clinical Nutrition, 115 (1), 45-52. doi: 10.1093/ajcn/nqab306
2021
Journal Article
18F-sodium fluoride positron emission tomography activity predicts the development of new coronary artery calcifications
Bellinge, Jamie W., Francis, Roslyn J., Lee, Sing Ching, Phillips, Michael, Rajwani, Adil, Lewis, Joshua R., Watts, Gerald F. and Schultz, Carl J. (2021). 18F-sodium fluoride positron emission tomography activity predicts the development of new coronary artery calcifications. Arteriosclerosis, Thrombosis, and Vascular Biology, 41 (1), 534-541. doi: 10.1161/ATVBAHA.120.315364
2021
Journal Article
ENZA-p trial protocol: a randomized phase II trial using prostate-specific membrane antigen as a therapeutic target and prognostic indicator in men with metastatic castration-resistant prostate cancer treated with enzalutamide (ANZUP 1901)
Emmett, Louise, Subramaniam, Shalini, Joshua, Anthony M., Crumbaker, Megan, Martin, Andrew, Zhang, Alison Y., Rana, Nisha, Langford, Ailsa, Mitchell, Jenna, Yip, Sonia, Francis, Roslyn, Hofman, Michael S., Sandhu, Shahneen, Azad, Arun, Gedye, Craig, McJannett, Margaret, Stockler, Martin R. and Davis, Ian D. (2021). ENZA-p trial protocol: a randomized phase II trial using prostate-specific membrane antigen as a therapeutic target and prognostic indicator in men with metastatic castration-resistant prostate cancer treated with enzalutamide (ANZUP 1901). BJU International, 128 (5), 642-651. doi: 10.1111/bju.15491
2021
Journal Article
Radiomics for identification and prediction in metastatic prostate cancer: a review of studies
Kendrick, Jake, Francis, Roslyn, Hassan, Ghulam Mubashar, Rowshanfarzad, Pejman, Jeraj, Robert, Kasisi, Collin, Rusanov, Branimir and Ebert, Martin (2021). Radiomics for identification and prediction in metastatic prostate cancer: a review of studies. Frontiers in Oncology, 11 (771787) 771787, 1-22. doi: 10.3389/fonc.2021.771787
2021
Journal Article
Imaging inflammation in patients and animals: focus on PET imaging the vulnerable plaque
Bartlett, Benjamin, Ludewick, Herbert P., Lee, Silvia, Verma, Shipra, Francis, Roslyn J. and Dwivedi, Girish (2021). Imaging inflammation in patients and animals: focus on PET imaging the vulnerable plaque. Cells, 10 (10) 2573, 2573. doi: 10.3390/cells10102573
2021
Journal Article
Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype
Lam, Virginie, Takechi, Ryusuke, Hackett, Mark J., Francis, Roslyn, Bynevelt, Michael, Celliers, Liesl M., Nesbit, Michael, Mamsa, Somayra, Arfuso, Frank, Das, Sukanya, Koentgen, Frank, Hagan, Maree, Codd, Lincoln, Richardson, Kirsty, O’Mara, Brenton, Scharli, Rainer K., Morandeau, Laurence, Gauntlett, Jonathan, Leatherday, Christopher, Boucek, Jan and Mamo, John C.L. (2021). Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype. PLoS Biology, 19 (9) e3001358, 1-26. doi: 10.1371/journal.pbio.3001358
2021
Journal Article
Impact of COVID-19 pandemic on cardiovascular testing in Asia: the IAEA INCAPS-COVID Study
Kudo, Takashi, Lahey, Ryan, Hirschfeld, Cole B., Williams, Michelle C., Lu, Bin, Alasnag, Mirvat, Bhatia, Mona, Henry Bom, Hee-Seung, Dautov, Tairkhan, Fazel, Reza, Karthikeyan, Ganesan, Keng, Felix Y.J., Rubinshtein, Ronen, Better, Nathan, Cerci, Rodrigo Julio, Dorbala, Sharmila, Raggi, Paolo, Shaw, Leslee J., Villines, Todd C., Vitola, João V., Choi, Andrew D., Malkovskiy, Eli, Goebel, Benjamin, Cohen, Yosef A., Randazzo, Michael, Pascual, Thomas N.B., Pynda, Yaroslav, Dondi, Maurizio, Paez, Diana ... Nguyen, Xuan Canh (2021). Impact of COVID-19 pandemic on cardiovascular testing in Asia: the IAEA INCAPS-COVID Study. JACC: Asia, 1 (2), 187-199. doi: 10.1016/j.jacasi.2021.06.002
Funding
Current funding
Supervision
Availability
- Professor Roslyn Francis is:
- Available for supervision
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