
Overview
Background
- Director, Herston Imaging Research Facility
- Professorial Research Fellow and Senior Group Leader, AIBN
- Nuclear Medicine Specialist, Dept Nuclear Medicine & PET Services, Royal Brisbane & Women’s Hospital
Ros Francis is an academic Nuclear Medicine specialist who has established an innovative and highly collaborative research career focused on clinical trials, novel radiopharmaceuticals for imaging and therapy, and innovative approaches for quantitative imaging. Her expertise spans diverse fields including oncology, cardiology, neurology and inflammatory diseases, with a focus on research translation. Ros is passionate about nuclear medicine clinical trials and has been integral in the establishment of Australasian Radiopharmaceutical Trials Network (ARTnet), for which she has been Scientific Chair since 2014.
Ros relocated to Brisbane in 2024 from Western Australia and is enjoying new opportunities in Queensland’s vibrant and innovative biodiscovery ecosystem. As Director of Herston Imaging Research Facility and Senior Group Leader AIBN, Ros aims to lead translational research to improve outcomes for patients
Availability
- Professor Roslyn Francis is:
- Available for supervision
Research impacts
Ros is an academic Nuclear Medicine Specialist and combines clinical practice with an active and impactful research career. After graduating from University of Western Australia in 1994 she held a Cancer Research UK Clinical Research Fellowship for 4 years, undertaking a PhD at the Royal Free Hospital London on antibody therapies. Following relocation back to Australia in 2003, Ros completed Australian requirements for physician training and specialisation in Nuclear Medicine. Ros has held positions in Western Australia as Nuclear Medicine Specialist at Sir Charles Gairdner Hospital from 2007 (Head of Department 2013-2023) and an academic appointment at UWA from 2010 as A/Prof Molecular Imaging, UWA Medical School. In 2024, Ros commenced in Brisbane as Nuclear Medicine Specialist at the Royal Brisbane and Women’s Hospital, Professor and Group Leader UQ-AIBN and Director Herston Imaging Research Facility.
Ros has a research portfolio encompassing discovery research to clinical trials with radiopharmaceuticals for imaging or therapy (theranostics). Her research has spanned preclinical and human imaging, with a strong focus on image quality and quantitation. Ros is chief investigator on competitive research grants > $36million in the last 10 years, including NHMRC CRE, MRFF clinical trials and ACRF infrastructure grants. In Queensland, Ros is leading an $1.8 million MRFF grant investigating a new radio-imaging agent to guide targeted therapy for epithelial ovarian cancer. Ros has 95 publications, 52 the last 5 years, including in leading journals Lancet x2, Lancet Oncol x4 and J Nucl Med x 5 (h index 31, >5000 citations).
Ros has been inaugural Scientific Chair of Australasian Radiopharmaceutical Trials network (ARTnet) since 2014. ARTnet has facilitated internationally impactful multicentre clinical trials in Australia, leading to high citation publications (Lancet 2020; Lancet 2021), social media and public interest, government/policy impact (Medicare recommendations) and incorporation into international practice guidelines. The ProPSMA trial, the first co-badged ARTnet/ANZUP study, was awarded the Australian Clinical Trials Alliance Trial of the Year in 2021. ARTnet has also established quality programs including PET camera accreditation, and radiopharmaceutical production standards which are critical for imaging validity in multicentre trials.
Ros has made a significant professional contribution to Nuclear Medicine in Australia. She is past President of Australian and New Zealand Society of Nuclear Medicine (ANZSNM), and is actively engaged with National Imaging Facility, including leading activity streams in the human molecular imaging translational network. She has participated in government/advisory roles including WA Radiological Council, MSAC radiopharmaceuticals working group committee, MSAC review subcommittee (Oncology) and ANSTO clinical advisory committee. Her strong international standing in clinical trials with radiopharmaceuticals is highlighted by invited presentations to EORTC imaging group, and participation in international working groups to enhance research facilitation. She has been an invited speaker at multiple national and international scientific meetings, including plenary sessions. She is a previous co-convenor of ANZSNM annual scientific meeting.
Ros values mentorship and supervision. She has supervised 4 PhD students to completion and is currently supervising 4 PhD students. She has provided clinical mentorship for Nuclear Medicine advanced trainees for over 15 years and provides mentorship for early career researchers. She has undertaken career engagement activities including clinician academic career events (Academy of Health and Medical Sciences) and as invited speaker for International Women’s Day.
Works
Search Professor Roslyn Francis’s works on UQ eSpace
2024
Journal Article
An automated radiosynthesis of [68Ga]Ga-FAPI-46 for routine clinical use
Morandeau, Laurence, Ioppolo, Joseph A., Alvarez de Eulate, Eva, Mohamed, Shifaza, Cullen, Danica, Asad, Ali H., Francis, Roslyn J. and Atkinson, Janette (2024). An automated radiosynthesis of [68Ga]Ga-FAPI-46 for routine clinical use. Journal of Visualized Experiments, 2024 (207) e66708. doi: 10.3791/66708
2024
Conference Publication
The feasibility of peri-coronary fat attenuation analysis on non-contrast cardiac CT and association with microcalcification activity
Bellinge, Brynn, Smith, B., Bellinge, J., Francis, R. and Schultz, C. (2024). The feasibility of peri-coronary fat attenuation analysis on non-contrast cardiac CT and association with microcalcification activity. RACP Congress 2024, Shaping Healthcare, Sydney, NSW, Australia, 16-17 May 2024. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/imj.16_16398
2024
Journal Article
[177Lu]Lu-PSMA-617 plus enzalutamide in patients with metastatic castration-resistant prostate cancer (ENZA-p): an open-label, multicentre, randomised, phase 2 trial
Emmett, Louise, Subramaniam, Shalini, Crumbaker, Megan, Nguyen, Andrew, Joshua, Anthony M., Weickhardt, Andrew, Lee, Sze-Ting, Ng, Siobhan, Francis, Roslyn J., Goh, Jeffrey C., Pattison, David A., Tan, Thean Hsiang, Kirkwood, Ian D., Gedye, Craig, Rutherford, Natalie K., Sandhu, Shahneen, Kumar, Aravind Ravi, Pook, David, Ramdave, Shakher, Nadebaum, David P., Voskoboynik, Mark, Redfern, Andrew D., Macdonald, William, Krieger, Laurence, Schembri, Geoff, Chua, Wei, Lin, Peter, Horvath, Lisa, Bastick, Patricia ... Davis, Ian D. (2024). [177Lu]Lu-PSMA-617 plus enzalutamide in patients with metastatic castration-resistant prostate cancer (ENZA-p): an open-label, multicentre, randomised, phase 2 trial. The Lancet Oncology, 25 (5), 563-571. doi: 10.1016/s1470-2045(24)00135-9
2024
Journal Article
Plasma lipoprotein(a) is associated with calcification activity of the thoracic aorta and aortic valve in statin naïve individuals with diabetes mellitus
Bellinge, Jamie W., Chan, Dick C., Pang, Jing, Francis, Roslyn J., Page, Michael M., Watts, Gerald F. and Schultz, Carl J. (2024). Plasma lipoprotein(a) is associated with calcification activity of the thoracic aorta and aortic valve in statin naïve individuals with diabetes mellitus. European Journal of Clinical Investigation, 54 (5) e14167. doi: 10.1111/eci.14167
2024
Journal Article
Evaluating the impact of FET PET on radiotherapy target volume delineation: Results of the radiation oncology credentialing program from the prospective, multi-centre trial evaluating FET PET in glioblastoma (FIG) study – TROG 18.06
Barry, Nathaniel, Koh, Eng-Siew, Ebert, Martin A., Moore, Alisha, Francis, Roslyn J., Rowshanfarzad, Pejman, Mubashar Hassan, Ghulam, Ng, Sweet P., Back, Michael, Chua, Benjamin, Pinkham, Mark B, Pullar, Andrew, Phillips, Claire, Sia, Joseph, Gorayski, Peter, Le, Hien, Gill, Suki, Croker, Jeremy, Bucknell, Nicholas, Bettington, Catherine, Syed, Farhan, Jung, Kylie, Chang, Joe, Bece, Andrej, Clark, Catherine, Wada, Mori, Cook, Olivia, Whitehead, Angela, Rossi, Alana ... Scott, Andrew M. (2024). Evaluating the impact of FET PET on radiotherapy target volume delineation: Results of the radiation oncology credentialing program from the prospective, multi-centre trial evaluating FET PET in glioblastoma (FIG) study – TROG 18.06. Physics and Imaging in Radiation Oncology, 30 100568, 1-8. doi: 10.1016/j.phro.2024.100568
2024
Journal Article
The prognostic value of F18 Fluorothymidine positron emission tomography for assessing the response of malignant pleural mesothelioma to chemotherapy – a prospective cohort study
May, Isaac J., Nowak, Anna K., Francis, Roslyn J., Ebert, Martin A. and Dhaliwal, Satvinder S. (2024). The prognostic value of F18 Fluorothymidine positron emission tomography for assessing the response of malignant pleural mesothelioma to chemotherapy – a prospective cohort study. Journal of Medical Imaging and Radiation Oncology, 68 (1), 57-66. doi: 10.1111/1754-9485.13592
2024
Journal Article
The Australian traumatic brain injury initiative: systematic review and consensus process to determine the predictive value of demographic, injury event, and social characteristics on outcomes for people with moderate-severe traumatic brain injury
Gabbe, Belinda J., Keeves, Jemma, Mckimmie, Ancelin, Gadowski, Adelle M., Holland, Andrew J., Semple, Bridgette D., Young, Jesse T., Crowe, Louise, Ownsworth, Tamara, Bagg, Matthew K., Antonic-Baker, Ana, Hicks, Amelia J., Hill, Regina, Curtis, Kate, Romero, Lorena, Ponsford, Jennie L., Lannin, Natasha A., O'brien, Terence J., Cameron, Peter A., Cooper, Jamie, Rushworth, Nick, Fitzgerald, Melinda, Alexander, Tara, Anderson, Vicki, Armstrong, Elizabeth, Babl, Franz E., Balogh, Zsolt J., Barlow, Karen M. (AUS-TBI Initiative Investigators member), Bellapart, Judith ... Honeybul, Stephen (2024). The Australian traumatic brain injury initiative: systematic review and consensus process to determine the predictive value of demographic, injury event, and social characteristics on outcomes for people with moderate-severe traumatic brain injury. Journal of Neurotrauma. doi: 10.1089/neu.2023.0461
2024
Journal Article
The Australian traumatic brain injury initiative: systematic review and consensus process to determine the predictive value of pre-existing health conditions for people with moderate-severe traumatic brain injury
Antonic-Baker, Ana, Auvrez, Clarissa, Tao, Gerard, Bagg, Matthew K., Gadowski, Adelle, McKimmie, Ancelin, Hicks, Amelia J., Hill, Regina, Romero, Lorena, Ponsford, Jennie L., Lannin, Natasha A., Gabbe, Belinda J., Cameron, Peter A., Cooper, D. Jamie, Rushworth, Nick, Fitzgerald, Melinda, O'Brien, Terence J., Alexander, Tara, Anderson, Vicki, Armstrong, Elizabeth, Babl, Franz E., Balogh, Zsolt J., Barlow, Karen M. (AUS-TBI Initiative Investigators group member), Bellapart, Judith, Bidargaddi, Niranjan, Bosio, Erika, Bragge, Peter, Bynevelt, Michael, Caeyenberghs, Karen ... Zeeman, Heidi (2024). The Australian traumatic brain injury initiative: systematic review and consensus process to determine the predictive value of pre-existing health conditions for people with moderate-severe traumatic brain injury. Journal of Neurotrauma. doi: 10.1089/neu.2023.0462
2024
Journal Article
The impact of fluorine-18-fluoroethyltyrosine positron emission tomography scan timing on radiotherapy planning in newly diagnosed patients with glioblastoma
Ryan, John, Hardcastle, Nicholas, Francis, Roslyn, Ferjančič, Peter, Ng, Sweet Ping, Koh, Eng-Siew, Geso, Moshi, Kelly, Jennifer and Ebert, Martin A. (2024). The impact of fluorine-18-fluoroethyltyrosine positron emission tomography scan timing on radiotherapy planning in newly diagnosed patients with glioblastoma. Physics and Imaging in Radiation Oncology, 29 100536, 100536. doi: 10.1016/j.phro.2024.100536
2024
Journal Article
Overall survival with [177Lu]Lu-PSMA-617 versus cabazitaxel in metastatic castration-resistant prostate cancer (TheraP): secondary outcomes of a randomised, open-label, phase 2 trial
Hofman, Michael S., Emmett, Louise, Sandhu, Shahneen, Iravani, Amir, Buteau, James P., Joshua, Anthony M., Goh, Jeffrey C., Pattison, David A., Tan, Thean Hsiang, Kirkwood, Ian D., Ng, Siobhan, Francis, Roslyn J., Gedye, Craig, Rutherford, Natalie K., Weickhardt, Andrew, Scott, Andrew M., Lee, Sze-Ting, Kwan, Edmond M., Azad, Arun A., Ramdave, Shakher, Redfern, Andrew D., Macdonald, William, Guminski, Alex, Hsiao, Edward, Chua, Wei, Lin, Peter, Zhang, Alison Yan, Stockler, Martin R., Williams, Scott G. ... Yip, Sonia (2024). Overall survival with [177Lu]Lu-PSMA-617 versus cabazitaxel in metastatic castration-resistant prostate cancer (TheraP): secondary outcomes of a randomised, open-label, phase 2 trial. The Lancet Oncology, 25 (1), 99-107. doi: 10.1016/s1470-2045(23)00529-6
2023
Journal Article
Quantitative [68Ga]Ga-PSMA-11 PET biomarkers for the analysis of lesion-level progression in biochemically recurrent prostate cancer: a multicentre study
Kendrick, Jake, Francis, Roslyn J., Hassan, Ghulam Mubashar, Rowshanfarzad, Pejman, Ong, Jeremy S. L., Barry, Nathaniel, Rusanov, Branimir and Ebert, Martin A. (2023). Quantitative [68Ga]Ga-PSMA-11 PET biomarkers for the analysis of lesion-level progression in biochemically recurrent prostate cancer: a multicentre study. Scientific Reports, 13 (1) 17673, 17673. doi: 10.1038/s41598-023-45106-2
2023
Journal Article
Prospective inter-and intra-tracer repeatability analysis of radiomics features in [68Ga]Ga-PSMA-11 and [18F]F-PSMA-1007 PET scans in metastatic prostate cancer
Kendrick, Jake, Francis, Roslyn J., Hassan, Ghulam Mubashar, Rowshanfarzad, Pejman, Ong, Jeremy S.L., Jeraj, Robert, Barry, Nathaniel, Hagan, Tammy and Ebert, Martin A. (2023). Prospective inter-and intra-tracer repeatability analysis of radiomics features in [68Ga]Ga-PSMA-11 and [18F]F-PSMA-1007 PET scans in metastatic prostate cancer. British Journal of Radiology, 96 (1152) 20221178, 1-11. doi: 10.1259/bjr.20221178
2023
Journal Article
Prognostic utility of RECIP 1.0 with manual and AI-based segmentations in biochemically recurrent prostate cancer from [68Ga]Ga-PSMA-11 PET images
Kendrick, Jake, Francis, Roslyn J., Hassan, Ghulam Mubashar, Rowshanfarzad, Pejman, Ong, Jeremy S. L., McCarthy, Michael, Alexander, Sweeka and Ebert, Martin A. (2023). Prognostic utility of RECIP 1.0 with manual and AI-based segmentations in biochemically recurrent prostate cancer from [68Ga]Ga-PSMA-11 PET images. European Journal of Nuclear Medicine and Molecular Imaging, 50 (13), 4077-4086. doi: 10.1007/s00259-023-06382-2
2023
Journal Article
Improved arterial inflammation with high dose omega-3 fatty acids in patients with elevated lipoprotein(a): selective effect of eicosapentaenoic acid?
Ward, Natalie C., Ying, Qidi, Chan, Dick C., Pang, Jing, Mori, Trevor A., Schultz, Carl J., Dwivedi, Girish, Francis, Roslyn J. and Watts, Gerald F. (2023). Improved arterial inflammation with high dose omega-3 fatty acids in patients with elevated lipoprotein(a): selective effect of eicosapentaenoic acid?. Journal of Clinical Lipidology, 17 (5), 694-699. doi: 10.1016/j.jacl.2023.08.004
2023
Journal Article
Delineation and agreement of FET PET biological volumes in glioblastoma: results of the nuclear medicine credentialing program from the prospective, multi-centre trial evaluating FET PET In Glioblastoma (FIG) study—TROG 18.06
Barry, Nathaniel, Francis, Roslyn J., Ebert, Martin A., Koh, Eng-Siew, Rowshanfarzad, Pejman, Hassan, Ghulam Mubashar, Kendrick, Jake, Gan, Hui K., Lee, Sze T., Lau, Eddie, Moffat, Bradford A., Fitt, Greg, Moore, Alisha, Thomas, Paul, Pattison, David A., Akhurst, Tim, Alipour, Ramin, Thomas, Elizabeth L., Hsiao, Edward, Schembri, Geoffrey P., Lin, Peter, Ly, Tam, Yap, June, Kirkwood, Ian, Vallat, Wilson, Khan, Shahroz, Krishna, Dayanethee, Ngai, Stanley, Yu, Chris ... Scott, Andrew M. (2023). Delineation and agreement of FET PET biological volumes in glioblastoma: results of the nuclear medicine credentialing program from the prospective, multi-centre trial evaluating FET PET In Glioblastoma (FIG) study—TROG 18.06. European Journal of Nuclear Medicine and Molecular Imaging, 50 (13), 3970-3981. doi: 10.1007/s00259-023-06371-5
2023
Journal Article
[18F]-fluoroethyl-L-tyrosine (FET) in glioblastoma (FIG) TROG 18.06 study: protocol for a prospective, multicentre PET/CT trial
Koh, Eng-Siew, Gan, Hui K., Senko, Clare, Francis, Roslyn J., Ebert, Martin, Lee, Sze Ting, Lau, Eddie, Khasraw, Mustafa, Nowak, Anna K., Bailey, Dale L., Moffat, Bradford A., Fitt, Greg, Hicks, Rodney J., Coffey, Robert, Verhaak, Roel, Walsh, Kyle M., Barnes, Elizabeth H., De Abreu Lourenco, Richard, Rosenthal, Mark, Adda, Lucas, Foroudi, Farshad, Lasocki, Arian, Moore, Alisha, Thomas, Paul A., Roach, Paul, Back, Michael, Leonard, Robyn and Scott, Andrew M. (2023). [18F]-fluoroethyl-L-tyrosine (FET) in glioblastoma (FIG) TROG 18.06 study: protocol for a prospective, multicentre PET/CT trial. BMJ Open, 13 (8) e071327. doi: 10.1136/bmjopen-2022-071327
2023
Journal Article
Targeted alveo-pleural fistula endobronchial valve treatment using ventilation scintigraphy
Sidhu, Calvin, Ratnagobal, Shoba, Thomas, Rajesh, Lee, Gary Y. C., Drudy, Enya and Francis, Roslyn J. (2023). Targeted alveo-pleural fistula endobronchial valve treatment using ventilation scintigraphy. Respirology Case Reports, 11 (5) e01146. doi: 10.1002/rcr2.1146
2023
Journal Article
Considerations for imaging of malignant pleural mesothelioma: a consensus statement from the International Mesothelioma Interest Group
Katz, Sharyn I., Straus, Christopher M., Roshkovan, Leonid, Blyth, Kevin G., Frauenfelder, Thomas, Gill, Ritu R., Lalezari, Ferry, Erasmus, Jeremy, Nowak, Anna K., Gerbaudo, Victor H., Francis, Roslyn J. and Armato, Samuel G. (2023). Considerations for imaging of malignant pleural mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Journal of Thoracic Oncology, 18 (3), 278-298. doi: 10.1016/j.jtho.2022.11.018
2022
Journal Article
Unravelling the role of macrophages in cardiovascular inflammation through imaging: a state-of-the-art review
Parry, Reece, Majeed, Kamran, Pixley, Fiona, Hillis, Graham Scott, Francis, Roslyn Jane and Schultz, Carl Johann (2022). Unravelling the role of macrophages in cardiovascular inflammation through imaging: a state-of-the-art review. European Heart Journal Cardiovascular Imaging, 23 (12), e504-e525. doi: 10.1093/ehjci/jeac167
2022
Journal Article
Fully automatic prognostic biomarker extraction from metastatic prostate lesion segmentations in whole-body [68Ga]Ga-PSMA-11 PET/CT images
Kendrick, Jake, Francis, Roslyn J., Hassan, Ghulam Mubashar, Rowshanfarzad, Pejman, Ong, Jeremy S. L. and Ebert, Martin A. (2022). Fully automatic prognostic biomarker extraction from metastatic prostate lesion segmentations in whole-body [68Ga]Ga-PSMA-11 PET/CT images. European Journal of Nuclear Medicine and Molecular Imaging, 50 (1), 67-79. doi: 10.1007/s00259-022-05927-1
Funding
Current funding
Supervision
Availability
- Professor Roslyn Francis is:
- Available for supervision
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