
Overview
Background
- Director, Herston Imaging Research Facility
- Professorial Research Fellow and Senior Group Leader, AIBN
- Nuclear Medicine Specialist, Dept Nuclear Medicine & PET Services, Royal Brisbane & Women’s Hospital
Ros Francis is an academic Nuclear Medicine specialist who has established an innovative and highly collaborative research career focused on clinical trials, novel radiopharmaceuticals for imaging and therapy, and innovative approaches for quantitative imaging. Her expertise spans diverse fields including oncology, cardiology, neurology and inflammatory diseases, with a focus on research translation. Ros is passionate about nuclear medicine clinical trials and has been integral in the establishment of Australasian Radiopharmaceutical Trials Network (ARTnet), for which she has been Scientific Chair since 2014.
Ros relocated to Brisbane in 2024 from Western Australia and is enjoying new opportunities in Queensland’s vibrant and innovative biodiscovery ecosystem. As Director of Herston Imaging Research Facility and Senior Group Leader AIBN, Ros aims to lead translational research to improve outcomes for patients
Availability
- Professor Roslyn Francis is:
- Available for supervision
Research impacts
Ros is an academic Nuclear Medicine Specialist and combines clinical practice with an active and impactful research career. After graduating from University of Western Australia in 1994 she held a Cancer Research UK Clinical Research Fellowship for 4 years, undertaking a PhD at the Royal Free Hospital London on antibody therapies. Following relocation back to Australia in 2003, Ros completed Australian requirements for physician training and specialisation in Nuclear Medicine. Ros has held positions in Western Australia as Nuclear Medicine Specialist at Sir Charles Gairdner Hospital from 2007 (Head of Department 2013-2023) and an academic appointment at UWA from 2010 as A/Prof Molecular Imaging, UWA Medical School. In 2024, Ros commenced in Brisbane as Nuclear Medicine Specialist at the Royal Brisbane and Women’s Hospital, Professor and Group Leader UQ-AIBN and Director Herston Imaging Research Facility.
Ros has a research portfolio encompassing discovery research to clinical trials with radiopharmaceuticals for imaging or therapy (theranostics). Her research has spanned preclinical and human imaging, with a strong focus on image quality and quantitation. Ros is chief investigator on competitive research grants > $36million in the last 10 years, including NHMRC CRE, MRFF clinical trials and ACRF infrastructure grants. In Queensland, Ros is leading an $1.8 million MRFF grant investigating a new radio-imaging agent to guide targeted therapy for epithelial ovarian cancer. Ros has 95 publications, 52 the last 5 years, including in leading journals Lancet x2, Lancet Oncol x4 and J Nucl Med x 5 (h index 31, >5000 citations).
Ros has been inaugural Scientific Chair of Australasian Radiopharmaceutical Trials network (ARTnet) since 2014. ARTnet has facilitated internationally impactful multicentre clinical trials in Australia, leading to high citation publications (Lancet 2020; Lancet 2021), social media and public interest, government/policy impact (Medicare recommendations) and incorporation into international practice guidelines. The ProPSMA trial, the first co-badged ARTnet/ANZUP study, was awarded the Australian Clinical Trials Alliance Trial of the Year in 2021. ARTnet has also established quality programs including PET camera accreditation, and radiopharmaceutical production standards which are critical for imaging validity in multicentre trials.
Ros has made a significant professional contribution to Nuclear Medicine in Australia. She is past President of Australian and New Zealand Society of Nuclear Medicine (ANZSNM), and is actively engaged with National Imaging Facility, including leading activity streams in the human molecular imaging translational network. She has participated in government/advisory roles including WA Radiological Council, MSAC radiopharmaceuticals working group committee, MSAC review subcommittee (Oncology) and ANSTO clinical advisory committee. Her strong international standing in clinical trials with radiopharmaceuticals is highlighted by invited presentations to EORTC imaging group, and participation in international working groups to enhance research facilitation. She has been an invited speaker at multiple national and international scientific meetings, including plenary sessions. She is a previous co-convenor of ANZSNM annual scientific meeting.
Ros values mentorship and supervision. She has supervised 4 PhD students to completion and is currently supervising 4 PhD students. She has provided clinical mentorship for Nuclear Medicine advanced trainees for over 15 years and provides mentorship for early career researchers. She has undertaken career engagement activities including clinician academic career events (Academy of Health and Medical Sciences) and as invited speaker for International Women’s Day.
Works
Search Professor Roslyn Francis’s works on UQ eSpace
2021
Journal Article
UpFrontPSMA: a randomized phase 2 study of sequential 177Lu-PSMA-617 and docetaxel vs docetaxel in metastatic hormone-naive prostate cancer (clinical trial protocol)
Dhiantravan, Nattakorn, Emmett, Louise, Joshua, Anthony M., Pattison, David A., Francis, Roslyn J., Williams, Scott, Sandhu, Shahneen, Davis, Ian D., Vela, Ian, Neha, Nitika, Bressel, Mathias, Murphy, Declan G., Hofman, Michael S. and Azad, Arun A. (2021). UpFrontPSMA: a randomized phase 2 study of sequential 177Lu-PSMA-617 and docetaxel vs docetaxel in metastatic hormone-naive prostate cancer (clinical trial protocol). BJU International, 128 (3) bju.15384, 331-342. doi: 10.1111/bju.15384
2021
Journal Article
Is Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Imaging Cost-effective in Prostate Cancer: An Analysis Informed by the proPSMA Trial
de Feria Cardet, Rafael E., Hofman, Michael S., Segard, Tatiana, Yim, Jackie, Williams, Scott, Francis, Roslyn J., Frydenberg, Mark, Lawrentschuk, Nathan, Murphy, Declan G. and De Abreu Lourenco, Richard (2021). Is Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Imaging Cost-effective in Prostate Cancer: An Analysis Informed by the proPSMA Trial. European Urology, 79 (3), 413-418. doi: 10.1016/j.eururo.2020.11.043
2021
Journal Article
Coronary 18F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome
Majeed, Kamran, Bellinge, Jamie W., Butcher, Steele C., Alcock, Richard, Spiro, Jon, Playford, David, Hillis, Graham S., Newby, David E., Mori, Trevor A., Francis, Roslyn and Schultz, Carl J. (2021). Coronary 18F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome. Atherosclerosis, 319, 142-148. doi: 10.1016/j.atherosclerosis.2020.12.010
2020
Journal Article
Re: Prostate-Specific Membrane Antigen PET-CT in Patients with High-Risk Prostate Cancer before Curative-Intent Surgery or Radiotherapy (proPSMA): A Prospective, Randomised, Multicentre Study
Hofman, M. S., Lawrentschuk, N., Francis, R. J., Tang, C., Vela, I., Thomas, P., Rutherford, N., Martin, J. M., Frydenberg, M., Shakher, R., Wong, L. M., Taubman, K., Lee, S. T., Hsiao, E., Roach, P., Nottage, M., Kirkwood, I., Hayne, D., Link, E., Marusic, P., Matera, A., Herschtal, A., Iravani, A., Hicks, R. J., Williams, S., Murphy, D. G. and Taneja, Samir S. (2020). Re: Prostate-Specific Membrane Antigen PET-CT in Patients with High-Risk Prostate Cancer before Curative-Intent Surgery or Radiotherapy (proPSMA): A Prospective, Randomised, Multicentre Study. Journal of Urology, 204 (4), 878-879. doi: 10.1097/JU.0000000000001220.01
2020
Journal Article
Coronary artery 18F-NaF PET analysis with the use of an elastic motion correction software
Bellinge, Jamie W., Majeed, Kamran, Carr, Stuart S., Jones, Judson, Hong, Inki, Francis, Roslyn J. and Schultz, Carl J. (2020). Coronary artery 18F-NaF PET analysis with the use of an elastic motion correction software. Journal of Nuclear Cardiology, 27 (3), 952-961. doi: 10.1007/s12350-018-01587-7
2020
Journal Article
3-year freedom from progression following 68GaPSMA PET CT triaged management in men with biochemical recurrence post radical prostatectomy: results of a prospective multi-center trial
Emmett, Louise, Tang, Reuben, Nandurkar, Rohan H., Hruby, George, Roach, Paul J., Watts, Jo Anne, Cusick, Thomas, Kneebone, Andrew, Ho, Bao, Chan, Lyn, van Leeuwen, Pim, Scheltema, Matthijs, Nguyen, Andrew, Yin, Charlotte, Scott, Andrew, Tang, Colin, McCarthy, Michael, Fullard, Karen, Roberts, Matthew, Francis, Roslyn and Stricker, Phillip (2020). 3-year freedom from progression following 68GaPSMA PET CT triaged management in men with biochemical recurrence post radical prostatectomy: results of a prospective multi-center trial. The Journal of Nuclear Medicine, 61 (6), 866-872. doi: 10.2967/jnumed.119.235028
2020
Journal Article
Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study
Hofman, Michael S., Lawrentschuk, Nathan, Francis, Roslyn J., Tang, Colin, Vela, Ian, Thomas, Paul, Rutherford, Natalie, Martin, Jarad M., Frydenberg, Mark, Shakher, Ramdave, Wong, Lih-Ming, Taubman, Kim, Ting Lee, Sze, Hsiao, Edward, Roach, Paul, Nottage, Michelle, Kirkwood, Ian, Hayne, Dickon, Link, Emma, Marusic, Petra, Matera, Anetta, Herschtal, Alan, Iravani, Amir, Hicks, Rodney J., Williams, Scott and Murphy, Declan G. (2020). Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study. The Lancet, 395 (10231), 1208-1216. doi: 10.1016/S0140-6736(20)30314-7
2020
Journal Article
Baseline and post-treatment 18F-fluorocholine PET/CT predicts outcomes in hepatocellular carcinoma following locoregional therapy
Wallace, Michael C., Sek, Kenny, Francis, Roslyn J., Samuelson, Shaun, Ferguson, John, Tibballs, Jonathan, Asad, Ali, Preen, David B., MacQuillan, Gerry, Garas, George, Adams, Leon A. and Jeffrey, Gary P. (2020). Baseline and post-treatment 18F-fluorocholine PET/CT predicts outcomes in hepatocellular carcinoma following locoregional therapy. Digestive Diseases and Sciences, 65 (2), 647-657. doi: 10.1007/s10620-019-05781-6
2019
Journal Article
TheraP: a randomized phase 2 trial of 177Lu-PSMA-617 theranostic treatment vs cabazitaxel in progressive metastatic castration-resistant prostate cancer (Clinical Trial Protocol ANZUP 1603)
Hofman, Michael S., Emmett, Louise, Violet, John, Y. Zhang, Alison, Lawrence, Nicola J., Stockler, Martin, Francis, Roslyn J., Iravani, Amir, Williams, Scott, Azad, Arun, Martin, Andrew, McJannett, Margaret and Davis, Ian D. (2019). TheraP: a randomized phase 2 trial of 177Lu-PSMA-617 theranostic treatment vs cabazitaxel in progressive metastatic castration-resistant prostate cancer (Clinical Trial Protocol ANZUP 1603). BJU International, 124 (S1), 5-13. doi: 10.1111/bju.14876
2019
Conference Publication
Radiologic considerations and standardization of malignant pleural mesothelioma imaging within clinical trials: consensus statement from the NCI Thoracic Malignancy Steering Committee – International Association for the Study of Lung Cancer – Mesothelioma Applied Research Foundation Clinical Trials Planning Meeting
Gill, Ritu R., Tsao, Anne S., Kindler, Hedy L., Richards, William G, Armato, Samuel G., Francis, Roslyn J., Gomez, Daniel R., Dahlberg, Suzanne, Rimner, Andreas, Simone, Charles B., de Perrot, Marc, Blumenthal, Gideon, Adjei, Alex A., Bueno, Raphael, Harpole, David H., Hesdorffer, Mary, Hirsch, Fred R., Pass, Harvey I., Yorke, Ellen, Rosenzweig, Kenneth, Burt, Bryan, Fennell, Dean A., Lindwasser, Wolf, Malik, Shakun, Peikert, Tobias, Mansfield, Aaron S., Salgia, Ravi, Yang, Haining, Rusch, Valerie W. and Nowak, Anna K. (2019). Radiologic considerations and standardization of malignant pleural mesothelioma imaging within clinical trials: consensus statement from the NCI Thoracic Malignancy Steering Committee – International Association for the Study of Lung Cancer – Mesothelioma Applied Research Foundation Clinical Trials Planning Meeting. Unknown, Unknown, Unknown. New York, NY USA: Elsevier. doi: 10.1016/j.jtho.2019.08.012
2019
Journal Article
Comparison between gallium-68 citrate positron emission tomography-computed tomography and gallium-67 citrate scintigraphy for infection imaging
Segard, Tatiana, Morandeau, Laurence M. J. A., Dunne, Marina L., Robinson, James O., Murray, Ronan J., Geelhoed, Elizabeth A. and Francis, Roslyn J. (2019). Comparison between gallium-68 citrate positron emission tomography-computed tomography and gallium-67 citrate scintigraphy for infection imaging. Internal Medicine Journal, 49 (8), 1016-1022. doi: 10.1111/imj.14231
2019
Conference Publication
Test-Retest Repeatability of 18F-FET PET in Small Volumes
Ferjancic, P., Ebert, M. A., Nowak, A. K., Francis, R. J. and Jeraj, R. (2019). Test-Retest Repeatability of 18F-FET PET in Small Volumes. Annual Meeting of the American-Association-of-Physicists-in-Medicine (AAPM), San Antonio Tx, Jul 14-18, 2019. HOBOKEN: WILEY.
2019
Journal Article
Imaging in pleural mesothelioma: a review of the 14th International Conference of the International Mesothelioma Interest Group
Armato, Samuel G., Francis, Roslyn J., Katz, Sharyn I., Ak, Guntulu, Opitz, Isabelle, Gudmundsson, Eyjolfur, Blyth, Kevin G. and Gupta, Ashish (2019). Imaging in pleural mesothelioma: a review of the 14th International Conference of the International Mesothelioma Interest Group. Lung Cancer, 130, 108-114. doi: 10.1016/j.lungcan.2018.11.033
2018
Journal Article
In search of the vulnerable patient or the vulnerable plaque: 18F-sodium fluoride positron emission tomography for cardiovascular risk stratification
Bellinge, Jamie W., Francis, Roslyn J., Majeed, Kamran, Watts, Gerald F. and Schultz, Carl J. (2018). In search of the vulnerable patient or the vulnerable plaque: 18F-sodium fluoride positron emission tomography for cardiovascular risk stratification. Journal of Nuclear Cardiology, 25 (5), 1774-1783. doi: 10.1007/s12350-018-1360-2
2018
Journal Article
68Ga-somatostatin analogue PET-CT: Analysis of costs and benefits in a public hospital setting
Segard, Tatiana, Morandeau, Laurence M. J. A., Geelhoed, Elizabeth A and Francis, Roslyn J (2018). 68Ga-somatostatin analogue PET-CT: Analysis of costs and benefits in a public hospital setting. Journal of Medical Imaging and Radiation Oncology, 62 (1), 57-63. doi: 10.1111/1754-9485.12638
2018
Journal Article
The impact of 68 Ga-PSMA PET/CT on management intent in prostate cancer: Results of an australian prospective multicenter study
Roach, Paul J., Francis, Roslyn, Emmett, Louise, Hsiao, Edward, Kneebone, Andrew, Hruby, George, Eade, Thomas, Nguyen, Quoc A., Thompson, Benjamin D., Cusick, Thomas, McCarthy, Michael, Tang, Colin, Ho, Bao, Stricker, Philip D. and Scott, Andrew M. (2018). The impact of 68 Ga-PSMA PET/CT on management intent in prostate cancer: Results of an australian prospective multicenter study . Journal of Nuclear Medicine, 59 (1), 82-88. doi: 10.2967/jnumed.117.197160
2017
Conference Publication
Clinical management intent of Ga68 PSMA PET/CT imaging in prostate cancer: an Australian multicentre study
Roach, Paul, Francis, Roslyn, Emmett, Louise, McCarthy, Michael and Scott, Andrew (2017). Clinical management intent of Ga68 PSMA PET/CT imaging in prostate cancer: an Australian multicentre study. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), Denver, CO United States, 10-14 June 2017. Reston, VA United States: Society of Nuclear Medicine.
2017
Conference Publication
ATYPICAL FOR PROSTATE METASTASIS
Culleton, S. and Francis, R. (2017). ATYPICAL FOR PROSTATE METASTASIS. HOBOKEN: WILEY.
2017
Conference Publication
A RARE CASE OF MERKEL CELL CARCINOMA CARDIAC METASTASIS CAUSING CARDIAC TAMPONADE: REVIEW OF THE ROLE OF FDG PET IN MERKEL CELL CARCINOMA
Di Loreto, M., Millward, M. and Francis, R. (2017). A RARE CASE OF MERKEL CELL CARCINOMA CARDIAC METASTASIS CAUSING CARDIAC TAMPONADE: REVIEW OF THE ROLE OF FDG PET IN MERKEL CELL CARCINOMA. HOBOKEN: WILEY.
2017
Journal Article
Is FCH PET able to identify foci of infection superiorly to FDG PET?
Hardy, Liesel Elisabeth, Hessamodini, Hannah, Wallace, Michael and Francis, Roslyn (2017). Is FCH PET able to identify foci of infection superiorly to FDG PET?. BMJ Case Reports, 2017 bcr-2017-219944, 1-1. doi: 10.1136/bcr-2017-219944
Funding
Current funding
Supervision
Availability
- Professor Roslyn Francis is:
- Available for supervision
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