
Overview
Background
- Director, Herston Imaging Research Facility
- Professorial Research Fellow and Senior Group Leader, AIBN
- Nuclear Medicine Specialist, Dept Nuclear Medicine & PET Services, Royal Brisbane & Women’s Hospital
Ros Francis is an academic Nuclear Medicine specialist who has established an innovative and highly collaborative research career focused on clinical trials, novel radiopharmaceuticals for imaging and therapy, and innovative approaches for quantitative imaging. Her expertise spans diverse fields including oncology, cardiology, neurology and inflammatory diseases, with a focus on research translation. Ros is passionate about nuclear medicine clinical trials and has been integral in the establishment of Australasian Radiopharmaceutical Trials Network (ARTnet), for which she has been Scientific Chair since 2014.
Ros relocated to Brisbane in 2024 from Western Australia and is enjoying new opportunities in Queensland’s vibrant and innovative biodiscovery ecosystem. As Director of Herston Imaging Research Facility and Senior Group Leader AIBN, Ros aims to lead translational research to improve outcomes for patients
Availability
- Professor Roslyn Francis is:
- Available for supervision
Research impacts
Ros is an academic Nuclear Medicine Specialist and combines clinical practice with an active and impactful research career. After graduating from University of Western Australia in 1994 she held a Cancer Research UK Clinical Research Fellowship for 4 years, undertaking a PhD at the Royal Free Hospital London on antibody therapies. Following relocation back to Australia in 2003, Ros completed Australian requirements for physician training and specialisation in Nuclear Medicine. Ros has held positions in Western Australia as Nuclear Medicine Specialist at Sir Charles Gairdner Hospital from 2007 (Head of Department 2013-2023) and an academic appointment at UWA from 2010 as A/Prof Molecular Imaging, UWA Medical School. In 2024, Ros commenced in Brisbane as Nuclear Medicine Specialist at the Royal Brisbane and Women’s Hospital, Professor and Group Leader UQ-AIBN and Director Herston Imaging Research Facility.
Ros has a research portfolio encompassing discovery research to clinical trials with radiopharmaceuticals for imaging or therapy (theranostics). Her research has spanned preclinical and human imaging, with a strong focus on image quality and quantitation. Ros is chief investigator on competitive research grants > $36million in the last 10 years, including NHMRC CRE, MRFF clinical trials and ACRF infrastructure grants. In Queensland, Ros is leading an $1.8 million MRFF grant investigating a new radio-imaging agent to guide targeted therapy for epithelial ovarian cancer. Ros has 95 publications, 52 the last 5 years, including in leading journals Lancet x2, Lancet Oncol x4 and J Nucl Med x 5 (h index 31, >5000 citations).
Ros has been inaugural Scientific Chair of Australasian Radiopharmaceutical Trials network (ARTnet) since 2014. ARTnet has facilitated internationally impactful multicentre clinical trials in Australia, leading to high citation publications (Lancet 2020; Lancet 2021), social media and public interest, government/policy impact (Medicare recommendations) and incorporation into international practice guidelines. The ProPSMA trial, the first co-badged ARTnet/ANZUP study, was awarded the Australian Clinical Trials Alliance Trial of the Year in 2021. ARTnet has also established quality programs including PET camera accreditation, and radiopharmaceutical production standards which are critical for imaging validity in multicentre trials.
Ros has made a significant professional contribution to Nuclear Medicine in Australia. She is past President of Australian and New Zealand Society of Nuclear Medicine (ANZSNM), and is actively engaged with National Imaging Facility, including leading activity streams in the human molecular imaging translational network. She has participated in government/advisory roles including WA Radiological Council, MSAC radiopharmaceuticals working group committee, MSAC review subcommittee (Oncology) and ANSTO clinical advisory committee. Her strong international standing in clinical trials with radiopharmaceuticals is highlighted by invited presentations to EORTC imaging group, and participation in international working groups to enhance research facilitation. She has been an invited speaker at multiple national and international scientific meetings, including plenary sessions. She is a previous co-convenor of ANZSNM annual scientific meeting.
Ros values mentorship and supervision. She has supervised 4 PhD students to completion and is currently supervising 4 PhD students. She has provided clinical mentorship for Nuclear Medicine advanced trainees for over 15 years and provides mentorship for early career researchers. She has undertaken career engagement activities including clinician academic career events (Academy of Health and Medical Sciences) and as invited speaker for International Women’s Day.
Works
Search Professor Roslyn Francis’s works on UQ eSpace
2009
Journal Article
A phase I clinical trial of CHT-25 a 131I-labeled chimeric anti-CD25 antibody showing efficacy in patients with refractory lymphoma
Dancey, Gairin, Violet, John, Malaroda, Alessandra, Green, Alan J., Sharma, Surinder K., Francis, Roslyn, Othman, Shokri, Parker, Sweta, Buscombe, John, Griffin, Natalie, Chan, Pei-San, Malhotra, Anmol, Woodward, Nicholas, Ramsay, Alan, Ross, Philip, Lister, T. Andrew, Amlot, Peter, Begent, Richard and McNamara, Christopher (2009). A phase I clinical trial of CHT-25 a 131I-labeled chimeric anti-CD25 antibody showing efficacy in patients with refractory lymphoma. Clinical Cancer Research, 15 (24), 7701-7710. doi: 10.1158/1078-0432.CCR-09-1421
2008
Journal Article
Assessment of tumour response with 18F-fluorodeoxyglucose positron emission tomography using three-dimensional measures compared to SUVmax - A phantom study
Boucek, J. A., Francis, R. J., Jones, C. G., Khan, N., Turlach, B. A. and Green, A. J. (2008). Assessment of tumour response with 18F-fluorodeoxyglucose positron emission tomography using three-dimensional measures compared to SUVmax - A phantom study. Physics in Medicine and Biology, 53 (16), 4213-4230. doi: 10.1088/0031-9155/53/16/001
2008
Journal Article
Semiautomatic volume of interest drawing for 18F-FDG image analysis - Method and preliminary results
Green, A. J., Francis, R. J., Baig, S. and Begent, R. H.J. (2008). Semiautomatic volume of interest drawing for 18F-FDG image analysis - Method and preliminary results. European Journal of Nuclear Medicine and Molecular Imaging, 35 (2), 393-406. doi: 10.1007/s00259-007-0602-3
2007
Journal Article
Early prediction of response to chemotherapy and survival in malignant pleural mesothelioma using a novel semiautomated 3-dimensional volume-based analysis of serial 18F-FDG PET scans
Francis, Roslyn J., Byrne, Michael J., Van Der Schaaf, Agatha A., Boucek, Jan A., Nowak, Anna K., Phillips, Michael, Price, Richard, Patrikeos, Andrew P., Musk, A. William and Millward, Michael J. (2007). Early prediction of response to chemotherapy and survival in malignant pleural mesothelioma using a novel semiautomated 3-dimensional volume-based analysis of serial 18F-FDG PET scans. Journal of Nuclear Medicine, 48 (9), 1449-1458. doi: 10.2967/jnumed.107.042333
2006
Journal Article
A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug
Mayer, Astrid, Francis, Roslyn J., Sharma, Surinder K., Tolner, Berend, Springer, Caroline J., Martin, Jan, Boxer, Geoff M., Bell, James, Green, Alan J., Hartley, John A., Cruickshank, Clare, Wren, Julie, Chester, Kerry A. and Begent, Richard H. J. (2006). A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug. Clinical Cancer Research, 12 (21), 6509-6516. doi: 10.1158/1078-0432.CCR-06-0769
Funding
Current funding
Supervision
Availability
- Professor Roslyn Francis is:
- Available for supervision
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