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2024 Journal Article Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endotheliumZhao, Jilai, Sormani, Laura, Jacquelin, Sebastien, Li, Haiming, Styke, Cassandra, Zhou, Chenhao, Beesley, Jonathan, Oon, Linus, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Dight, James, Hashemi, Ghazaleh, Shafiee, Abbas, Roy, Edwige, Patel, Jatin and Khosrotehrani, Kiarash (2024). Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium. Angiogenesis, 27 (3), 1-16. doi: 10.1007/s10456-024-09927-7 |
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2023 Journal Article Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapyWong, Ho Yi, Lee, Ruby C., Chong, Sharene, Kapadia, Stuti, Freeman, Michael, Murigneux, Valentine, Brown, Susan, Soyer, H. Peter, Roy, Edwige and Khosrotehrani, Kiarash (2023). Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy. Science Advances, 9 (19) eadf2384, 1-13. doi: 10.1126/sciadv.adf2384 |
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2022 Journal Article Chemoprevention of cutaneous squamous cell carcinoma and its precursors in solid organ transplant recipients using topical sirolimus: a randomized, double-blind, placebo-controlled pilot trialChong, Sharene, Wong, Ho Yi, Althabteh, Ahmad, Cox, Charlotte, Stevenson, Paul H., Brown, Susan, Griffin, Anthony, Isbel, Nicole, Siller, Gregory, Soyer, H. Peter, Schaider, Helmut, Roy, Edwige, Campbell, Scott, Green, Adele C. and Khosrotehrani, Kiarash (2022). Chemoprevention of cutaneous squamous cell carcinoma and its precursors in solid organ transplant recipients using topical sirolimus: a randomized, double-blind, placebo-controlled pilot trial. Journal of the American Academy of Dermatology, 87 (5), 1163-1166. doi: 10.1016/j.jaad.2022.02.039 |
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2021 Journal Article Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitorsZhao, Jilai, Patel, Jatin, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Styke, Cassandra, Hogan, Isabella, Kahler, Sam, Hamilton, Hamish, Wadlow, Racheal, Dight, James, Hashemi, Ghazaleh, Sormani, Laura, Roy, Edwige, Yoder, Mervin C., Francois, Mathias and Khosrotehrani, Kiarash (2021). Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors. Nature Communications, 12 (1) 2564, 1-17. doi: 10.1038/s41467-021-22717-9 |
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2021 Journal Article Whole-mount staining coupled to a UV-inducible basal cell carcinoma murine modelWong, Ho Yi, Khosrotehrani, Kiarash and Roy, Edwige (2021). Whole-mount staining coupled to a UV-inducible basal cell carcinoma murine model. STAR protocols, 2 (1) 100329, 100329. doi: 10.1016/j.xpro.2021.100329 |
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2020 Journal Article Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal ProgenitorsRoy, Edwige, Wong, Ho Yi, Villani, Rehan, Rouille, Thomas, Salik, Basit, Sim, Seen Ling, Murigneux, Valentine, Stark, Mitchell S., Fink, J. Lynn, Soyer, H. Peter, Walker, Graeme, Lyons, J. Guy, Saunders, Nicholas and Khosrotehrani, Kiarash (2020). Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors. Cell Reports, 31 (9) 107702, 107702. doi: 10.1016/j.celrep.2020.107702 |
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2019 Journal Article Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cellsLukowski, Samuel W., Patel, Jatin, Andersen, Stacey B., Sim, Seen-Ling, Wong, Ho Yi, Tay, Joshua, Winkler, Ingrid, Powell, Joseph E. and Khosrotehrani, Kiarash (2019). Single-cell transcriptional profiling of aortic endothelium identifies a hierarchy from endovascular progenitors to differentiated cells. Cell Reports, 27 (9), 2748-2758. doi: 10.1016/j.celrep.2019.04.102 |
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Featured 2019 Journal Article Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasisDonovan, Prudence, Patel, Jatin, Dight, James, Wong, Ho Yi, Sim, Seen-Ling, Murigneux, Valentine, Francois, Mathias and Khosrotehrani, Kiarash (2019). Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis. Nature Communications, 10 (1) 18, 18. doi: 10.1038/s41467-018-07961-w |
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2018 Journal Article Genetic variation in the MAPK/ERK pathway affects contact hypersensitivity responsesLegrand, Julien M. D., Roy, Edwige, Baz, Batoul, Mukhopadhyay, Pamela, Wong, Ho Yi, Ram, Ramesh, Morahan, Grant, Walker, Graeme and Khosrotehrani, Kiarash (2018). Genetic variation in the MAPK/ERK pathway affects contact hypersensitivity responses. Journal of Allergy and Clinical Immunology, 142 (3), 981-984.e7. doi: 10.1016/j.jaci.2018.04.028 |
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2018 Journal Article A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradationChhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. and Waters, M. J. (2018). A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation. Oncogene, 37 (4), 489-501. doi: 10.1038/onc.2017.352 |
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2017 Journal Article Accelerated Endothelial to Mesenchymal Transition increased fibrosis via deleting Notch signalling in wound vasculaturePatel, Jatin, Baz, Betoul, Wong, Ho Yi, Lee, James S. and Khosrotehrani, Kiarash (2017). Accelerated Endothelial to Mesenchymal Transition increased fibrosis via deleting Notch signalling in wound vasculature. The Journal of Investigative Dermatology, 138 (5), 1166-1175. doi: 10.1016/j.jid.2017.12.004 |
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2017 Journal Article Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair typesVillani, Rehan, Hodgson, Samantha, Legrand, Julien, Greaney, Jessica, Wong, Ho Yi, Pichol-Thievend, Cathy, Adolphe, Christelle, Wainwight, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2017). Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development, 144 (10), 1887-1895. doi: 10.1242/dev.143917 |
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2017 Journal Article Functional definition of progenitors versus mature endothelial cells reveals key SoxF-dependent differentiation processPatel, Jatin, Seppanen, Elke J., Rodero, Mathieu, Wong, Ho Yi, Donovan, Prudence, Neufeld, Zoltan, Fisk, Nicholas, Francois, Mathias and Khosrotehrani, Kiarash (2017). Functional definition of progenitors versus mature endothelial cells reveals key SoxF-dependent differentiation process. Circulation, 135 (8), 786-805. doi: 10.1161/CIRCULATIONAHA.116.024754 |
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2017 Journal Article Priming of endothelial colony-forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signalingShafiee, Abbas, Patel, Jatin, Wong, Ho Yi, Donovan, Prudence, Hutmacher, Dietmar W., Fisk, Nicholas M. and Khosrotehrani, Kiarash (2017). Priming of endothelial colony-forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling. The FASEB Journal, 31 (2), 610-624. doi: 10.1096/fj.201600937 |
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2016 Journal Article Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cyclingRoy, Edwige, Neufeld, Zoltan, Cerone, Luca, Wong, Ho Yi, Hodgson, Samantha, Livet, Jean and Khosrotehrani, Kiarash (2016). Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling. EMBO Journal, 35 (24), 2658-2670. doi: 10.15252/embj.201693806 |
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2016 Journal Article Self-renewal and high proliferative colony forming capacity of late-outgrowth endothelial progenitors is regulated by cyclin-dependent kinase inhibitors driven by notch signalingPatel, Jatin, Wong, Ho Yi, Wang, Weili, Alexis, Josue, Shafiee, Abbas, Stevenson, Alexander J., Gabrielli, Brian, Fisk, Nicholas M. and Khosrotehrani, Kiarash (2016). Self-renewal and high proliferative colony forming capacity of late-outgrowth endothelial progenitors is regulated by cyclin-dependent kinase inhibitors driven by notch signaling. Stem Cells, 34 (4), 902-912. doi: 10.1002/stem.2262 |
