Dr Alain Wuethrich
Dr

Alain Wuethrich

Email: 

Background

Dr Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland (UQ). Dr Wuethrich obtained his PhD from the University of Tasmania in 2016 after completing a Master’s degree in Switzerland. His research expertise lies in liquid biopsy, electrohydrodynamics, surface-enhanced Raman spectroscopy, nanotechnology and diagnostics. He held positions in international pharmaceutical companies and became lead inventor on a European patent. He has actively engaged with national and international companies to translate diagnostic nanotechnologies. Since 2017 he has provided continuous research mentoring to the group and has supervised >30 postgraduate and graduate students in nanotechnological strategies to detect cancer and other diseases.

Availability

Dr Alain Wuethrich is:
Available for supervision

Qualifications

  • Postgraduate Diploma, University of Tasmania
  • Doctor of Philosophy, University of Tasmania

Research interests

  • Liquid biopsy

  • Nanotechnology

  • Diagnostics

  • Electrohydrodynamics

  • Biosensing

Search Professor Alain Wuethrich’s works on UQ eSpace

81 works between 2013 and 2024
All (81) Journal Article (73) Book Chapter (6) Conference Publication (2)

1 - 20 of 81 works

2024

Journal Article

A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue

Shanmugasundaram, Karthik B., Ahmed, Emtiaz, Miao, Xinzhe, Kulasinghe, Arutha, Fletcher, James A., Monkman, James, Mainwaring, Paul, Masud, Mostafa Kamal, Park, Hyeongyu, Hossain, Md Shahriar A., Yamauchi, Yusuke, Sina, Abu A. I., O’Byrne, Kenneth, Wuethrich, Alain and Trau, Matt (2024). A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue. ACS Sensors, 9 (6), 3009-3016. doi: 10.1021/acssensors.4c00192

A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue

2024

Journal Article

Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles

Niu, Xueming, Zhang, Zhen, Zhou, Quan, Wuethrich, Alain, Lobb, Richard and Trau, Matt (2024). Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles. Proteomics, 24 (11) 2300094, e2300094. doi: 10.1002/pmic.202300094

Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles

2024

Journal Article

Molecular Stratification and Treatment Monitoring of Lung Cancer Using a Small Extracellular Vesicle-Activated Nanocavity Architecture

Li, Junrong, Li, Meiqin, Wuethrich, Alain, Guan, Rui, Zhao, Lihui, Hu, Cong, Trau, Matt and Sun, Yao (2024). Molecular Stratification and Treatment Monitoring of Lung Cancer Using a Small Extracellular Vesicle-Activated Nanocavity Architecture. Analytical Chemistry, 96 (19), 7651-7660. doi: 10.1021/acs.analchem.4c00558

Molecular Stratification and Treatment Monitoring of Lung Cancer Using a Small Extracellular Vesicle-Activated Nanocavity Architecture

2024

Journal Article

High Accuracy of Clinical Verification of Electrohydrodynamic-Driven Nanobox-on-Mirror Platform for Molecular Identification of Respiratory Viruses

Li, Junrong, Guan, Rui, Wuethrich, Alain, Yan, Mingzhe, Cheng, Jing, Liu, Guorong, Zhan, Jianbo, Trau, Matt and Sun, Yao (2024). High Accuracy of Clinical Verification of Electrohydrodynamic-Driven Nanobox-on-Mirror Platform for Molecular Identification of Respiratory Viruses. Analytical Chemistry, 96 (11), 4495-4504. doi: 10.1021/acs.analchem.3c05120

High Accuracy of Clinical Verification of Electrohydrodynamic-Driven Nanobox-on-Mirror Platform for Molecular Identification of Respiratory Viruses

2024

Journal Article

Special issue Methods: Nano-/bio-interface and biomedical applications

Li, Li and Wuethrich, Alain (2024). Special issue Methods: Nano-/bio-interface and biomedical applications. Methods, 223, 146-147. doi: 10.1016/j.ymeth.2024.02.001

Special issue Methods: Nano-/bio-interface and biomedical applications

2024

Journal Article

Digital platforms enabling single-molecule analysis for cancer detection

Li, Junrong, Zhang, Zhen, Trau, Matt and Wuethrich, Alain (2024). Digital platforms enabling single-molecule analysis for cancer detection. TrAC Trends in Analytical Chemistry, 171 117502, 117502. doi: 10.1016/j.trac.2023.117502

Digital platforms enabling single-molecule analysis for cancer detection

2024

Journal Article

Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes

Zhou, Quan, Wang, Jing, Zhang, Zhen, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes. Biosensors and Bioelectronics, 244 115819, 1-10. doi: 10.1016/j.bios.2023.115819

Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes

2024

Journal Article

Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer

Zhou, Quan, Niu, Xueming, Zhang, Zhen, O'Byrne, Kenneth, Kulasinghe, Arutha, Fielding, David, Möller, Andreas, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer. Advanced Science, 11 (33) 2401818, e2401818. doi: 10.1002/advs.202401818

Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer

2024

Journal Article

A perspective about the potential use of nanotechnology to monitor immune correlates of the clinical course of major mood disorders

Wuethrich, Alain, Crouse, Jacob J., Vedelago, Courtney, Zhang, Yiwen, Farokhinejad, Fahimeh, Hickie, Ian B. and Trau, Matt (2024). A perspective about the potential use of nanotechnology to monitor immune correlates of the clinical course of major mood disorders. Research Directions: Depression, 1 e20. doi: 10.1017/dep.2024.3

A perspective about the potential use of nanotechnology to monitor immune correlates of the clinical course of major mood disorders

2023

Conference Publication

Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC

O'Byrne, K., Shanmugasundaram, K.B., Ahmed, E., Kulasinghe, A., Monkman, J., Fletcher, J.A., Mainwaring, P.N., Masud, M.K., Park, H., Hossain, M.S.A., Yamauchi, Y., Sina, A.A.I., Wuethrich, A. and Trau, M. (2023). Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.432

Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC

2023

Journal Article

Multiplex SERS-lectin-immunoassay for esophageal adenocarcinoma screening

Khamis, Ramlah, Shanmugasundaram, Karthik B., Zhou, Quan, Lu, Jennifer, Zhang, Zhen, Hill, Michelle M., Sina, Abu Ali Ibn, Trau, Matt and Wuethrich, Alain (2023). Multiplex SERS-lectin-immunoassay for esophageal adenocarcinoma screening. ACS Applied Nano Materials, 6 (21), 20190-20197. doi: 10.1021/acsanm.3c03987

Multiplex SERS-lectin-immunoassay for esophageal adenocarcinoma screening

2023

Journal Article

Erratum: Correction: Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung diseases (Nanoscale horizons (2023) 8 6 (746-758))

Yuan, Liwen, Chen, Yanpin, Ke, Longfeng, Zhou, Quan, Chen, Jiayou, Fan, Min, Wuethrich, Alain, Trau, Matt and Wang, Jing (2023). Erratum: Correction: Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung diseases (Nanoscale horizons (2023) 8 6 (746-758)). Nanoscale horizons, 8 (9), 1288-1289. doi: 10.1039/d3nh90028b

Erratum: Correction: Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung diseases (Nanoscale horizons (2023) 8 6 (746-758))

2023

Journal Article

A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell

Ahmed, Emtiaz, Shanmugasundaram, Karthik Balaji, Li, Junrong, Behren, Andreas, Lobb, Richard, Möller, Andreas, Wuethrich, Alain, Dey, Shuvashis, Sina, Abu Ali Ibn and Trau, Matt (2023). A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell. Advanced Sensor Research, 2 (12) ARTN 2300059. doi: 10.1002/adsr.202300059

A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell

2023

Book Chapter

A microfluidic SERS assay to characterize the phenotypic heterogeneity in cancer-derived small extracellular vesicles

Wang, Jing, Trau, Matt and Wuethrich, Alain (2023). A microfluidic SERS assay to characterize the phenotypic heterogeneity in cancer-derived small extracellular vesicles. Microfluidic systems for cancer diagnosis. (pp. 241-253) edited by Jose L. Garcia-Cordero and Alexander Revzin. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-3271-0_17

A microfluidic SERS assay to characterize the phenotypic heterogeneity in cancer-derived small extracellular vesicles

2023

Journal Article

A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments

Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1

A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments

2023

Journal Article

Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung disease

Yuan, Liwen, Chen, Yanping, Ke, Longfeng, Zhou, Quan, Chen, Jiayou, Fan, Min, Wuethrich, Alain, Trau, Matt and Wang, Jing (2023). Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung disease. Nanoscale Horizons, 8 (6), 746-758. doi: 10.1039/d2nh00570k

Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung disease

2023

Journal Article

Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring

Ahmed, Mostak, Wuethrich, Alain, Constantin, Nicolas, Shanmugasundaram, Karthik Balaji, Mainwaring, Paul, Kulasinghe, Arutha, O’Leary, Connor, O’Byrne, Ken, Sina, Abu Ali Ibn, Carrascosa, Laura G. and Trau, Matt (2023). Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring. Analytical Chemistry, 95 (22), 8522-8532. doi: 10.1021/acs.analchem.3c00519

Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring

2023

Journal Article

A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern

Vedelago, Courtney, Li, Junrong, Lowry, Kym, Howard, Christopher, Wuethrich, Alain and Trau, Matt (2023). A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern. ACS Sensors, 8 (4), 1648-1657. doi: 10.1021/acssensors.2c02782

A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern

2023

Journal Article

Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer

Liao, Caizhi, Wu, Zhihao, Lin, Chan, Chen, Xiaofeng, Zou, Yaqun, Zhao, Wan, Li, Xin, Huang, Guangqi, Xu, Baisheng, Briganti, Giovanni E., Qi, Yan, Wang, Xianshu, Zeng, Tao, Wuethrich, Alain and Zou, Hongzhi (2023). Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer. Smart Medicine, 2 (1), 1-30. doi: 10.1002/smmd.20220020

Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer

2023

Journal Article

Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions

Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207

Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions

Current funding

  • 2025 - 2029
    Immune Dashboard Chip (IDC): Single-molecule digital nanotechnology for profiling trace immune dysregulations in Long COVID-19 and improving mRNA vaccines
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    ALL IN - AI and Laboratory Led IdentificatioN of PASC
    NHMRC MRFF Post-Acute Sequalae of COVID-19
    Open grant
  • 2024 - 2025
    A blood-based nanotechnology to decipher the extracellular vesicle code in ALS
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2027
    Rhythms and blues: Personalising care for body clock dysfunction in mood disorders (NHMRC Synergy grant administered by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2025
    nanoIMPAC: Monitoring immune toxicities and tumour immune evasion in lung cancer
    Cancer Australia
    Open grant
  • 2020 - 2024
    A protein phosphorylation mapping tool for monitoring tyrosine kinase inhibition therapy in cancer patients
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2023
    Single molecule sensing on nanopillars: Reading complex molecular circuits
    ARC Discovery Projects
    Open grant
  • 2020
    Harnessing nanotechnology to unravel extracellular vesicle heterogeneity
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2019
    Towards personalized nanomedicine: Exploring interfacial nanomixing as a tool to monitor aberrant protein phosphorylation pathways in cancer
    UQ Early Career Researcher
    Open grant
  • 2018 - 2019
    Enhanced electrochemical biosensing through electrohydrodynamic nanofluidics for cancer diagnostics
    UQ Development Fellowships
    Open grant

Availability

Dr Alain Wuethrich is:
Available for supervision

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Available projects

Supervision history

Current supervision

  • Doctor Philosophy

    Harnessing nanotechnology to unravel the phenotypic heterogeneity of extracellular vesicles

    Principal Advisor

    Other advisors: Professor Matt Trau, Dr Abu Sina, Dr Mitchell Stark

  • Doctor Philosophy

    Advanced Micro and Nano Engineered Sensors for Post Translational Modification based Liquid Biopsy Analysis of Cancer

    Principal Advisor

    Other advisors: Professor Matt Trau, Dr Abu Sina

  • Doctor Philosophy

    Digital nanotechnologies to unravel immune dysregulation in long COVID

    Principal Advisor

    Other advisors: Professor Matt Trau

  • Doctor Philosophy

    A nano-map of cytokines in skin: Personalising treatment of skin inflammation by a digital nanotechnology

    Principal Advisor

    Other advisors: Professor Matt Trau, Dr Mitchell Stark

  • Doctor Philosophy

    A nano-engineered chip to help manage acute and long-haul COVID-19 patients

    Associate Advisor

    Other advisors: Professor Matt Trau

  • Doctor Philosophy

    Digital Nanotechnologies to track molecular aberrations in cancer

    Associate Advisor

    Other advisors: Dr Richard Lobb, Professor Matt Trau

  • Doctor Philosophy

    The investigation of microglial activation in brain cancer and brain metastasis by an integrated nano-sensor

    Associate Advisor

    Other advisors: Professor Matt Trau, Dr Richard Lobb

  • Doctor Philosophy

    Utilising extracellular vesicles for the diagnosis of lung cancer.

    Associate Advisor

    Other advisors: Professor Matt Trau, Dr Richard Lobb

  • Doctor Philosophy

    Single molecule sensing on nanopillars: Reading complex molecular circuits

    Associate Advisor

    Other advisors: Dr Abu Sina, Dr Selvakumar Edwardraja, Professor Matt Trau

Completed supervision

Enquiries

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