Overview
Background
Dr Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland (UQ). Dr Wuethrich obtained his PhD from the University of Tasmania in 2016 after completing a Master’s degree in Switzerland. His research expertise lies in liquid biopsy, electrohydrodynamics, surface-enhanced Raman spectroscopy, nanotechnology and diagnostics. He held positions in international pharmaceutical companies and became lead inventor on a European patent. He has actively engaged with national and international companies to translate diagnostic nanotechnologies. Since 2017 he has provided continuous research mentoring to the group and has supervised >30 postgraduate and graduate students in nanotechnological strategies to detect cancer and other diseases.
Availability
- Dr Alain Wuethrich is:
- Available for supervision
Qualifications
- Postgraduate Diploma, University of Tasmania
- Doctor of Philosophy, University of Tasmania
Research interests
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Liquid biopsy
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Nanotechnology
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Diagnostics
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Electrohydrodynamics
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Biosensing
Works
Search Professor Alain Wuethrich’s works on UQ eSpace
2023
Journal Article
Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions
Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207
2023
Journal Article
Status quo of extracellular vesicle isolation and detection methods for clinical utility
Visan, Kekoolani S., Wu, Li-Ying, Voss, Sarah, Wuethrich, Alain and Möller, Andreas (2023). Status quo of extracellular vesicle isolation and detection methods for clinical utility. Seminars in Cancer Biology, 88, 157-171. doi: 10.1016/j.semcancer.2022.12.008
2022
Journal Article
SERS multiplex profiling of melanoma circulating tumor cells for predicting the response to immune checkpoint blockade therapy
Li, Junrong, Wuethrich, Alain, Zhang, Zhen, Wang, Jing, Lin, Lynlee L., Behren, Andreas, Wang, Yuling and Trau, Matt (2022). SERS multiplex profiling of melanoma circulating tumor cells for predicting the response to immune checkpoint blockade therapy. Analytical Chemistry, 94 (42), 14573-14582. doi: 10.1021/acs.analchem.2c02398
2022
Journal Article
Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes
Farokhinejad, Fahimeh, Li, Junrong, Hugo, Leon E., Howard, Christopher B., Wuethrich, Alain and Trau, Matt (2022). Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes. Analytical Chemistry, 94 (41), 14177-14184. doi: 10.1021/acs.analchem.2c02012
2022
Journal Article
A T‐junction dual nanopore for single nanoparticle analysis
Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain and Trau, Matt (2022). A T‐junction dual nanopore for single nanoparticle analysis. Advanced Engineering Materials, 24 (4) 2101015, 2101015. doi: 10.1002/adem.202101015
2022
Journal Article
C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett’s esophagus and esophageal adenocarcinoma
Kolka, Cathryn M., Webster, Julie, Lepletier, Ailin, Winterford, Clay, Brown, Ian, Richards, Renee S., Zelek, Wioleta M., Cao, Yilang, Khamis, Ramlah, Shanmugasundaram, Karthik B., Wuethrich, Alain, Trau, Matt, Brosda, Sandra, Barbour, Andrew, Shah, Alok K., Eslick, Guy D., Clemons, Nicholas J., Morgan, B. Paul and Hill, Michelle M. (2022). C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett’s esophagus and esophageal adenocarcinoma. Frontiers in Immunology, 13 842023. doi: 10.3389/fimmu.2022.842023
2022
Journal Article
An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers
Dey, Shuvashis, Ahmed, Emtiaz, Somvanshi, Pranjal Satishchandra, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2022). An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers. Chemosensors, 10 (3) 93, 93. doi: 10.3390/chemosensors10030093
2022
Journal Article
Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy
Shanmugasundaram, Karthik Balaji, Li, Junrong, Sina, Abu Ibn, Wuethrich, Alain and Trau, Matt (2022). Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy. Materials Advances, 3 (3), 1459-1471. doi: 10.1039/d1ma00848j
2021
Journal Article
Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis
Zhang, Zhen, Wuethrich, Alain, Wang, Jing, Korbie, Darren, Lin, Lynlee L. and Trau, Matt (2021). Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis. Analytical Chemistry, 93 (50) acs.analchem.1c03167, 16787-16795. doi: 10.1021/acs.analchem.1c03167
2021
Journal Article
Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection
Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001
2021
Journal Article
A stationary pseudophase semi-permanent coating for open-tubular capillary liquid chromatography and electrochromatography
Ahmed, Mohamed Adel, Felisilda, Bren Mark, Wuethrich, Alain and Quirino, Joselito P. (2021). A stationary pseudophase semi-permanent coating for open-tubular capillary liquid chromatography and electrochromatography. Journal of Chromatography A, 1657 462553, 462553. doi: 10.1016/j.chroma.2021.462553
2021
Journal Article
An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas
Wang, Jing, Kao, Yung‐Ching, Zhou, Quan, Wuethrich, Alain, Stark, Mitchell S., Schaider, Helmut, Soyer, H. Peter, Lin, Lynlee L. and Trau, Matt (2021). An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas. Advanced Functional Materials, 32 (3) 2010296, 1-9. doi: 10.1002/adfm.202010296
2021
Journal Article
Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay
Li, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657
2021
Journal Article
Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip
Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358
2021
Journal Article
In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment
Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Wang, Jing, Behren, Andreas, Antaw, Fiach, Wang, Yuling, Sina, Abu Ali Ibn and Trau, Matt (2021). In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment. ACS Nano, 15 (7) acsnano.0c10008, 11231-11243. doi: 10.1021/acsnano.0c10008
2021
Journal Article
Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma
Webster, Julie A., Wuethrich, Alain, Shanmugasundaram, Karthik B., Richards, Renee S., Zelek, Wioleta M., Shah, Alok K., Gordon, Louisa G., Kendall, Bradley J., Hartel, Gunter, Morgan, B. Paul, Trau, Matt and Hill, Michelle M. (2021). Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma. Cancers, 13 (12) 2865, 2865. doi: 10.3390/cancers13122865
2021
Journal Article
On the behavior of nanoparticles beyond the nanopore interface
Antaw, Fiach, Anderson, Will, Wuethrich, Alain and Trau, Matt (2021). On the behavior of nanoparticles beyond the nanopore interface. Langmuir, 37 (16), 4772-4782. doi: 10.1021/acs.langmuir.0c03083
2021
Book Chapter
Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor
Wuethrich, Alain, Dey, Shuvashis, Koo, Kevin M, Sina, Abu A. I. and Trau, Matt (2021). Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor. Melanoma. (pp. 265-276) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1205-7_20
2021
Journal Article
A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
Li, Junrong, Wuethrich, Alain, Sina, Abu A. I., Cheng, Han-Hao, Wang, Yuling, Behren, Andreas, Mainwaring, Paul N. and Trau, Matt (2021). A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy. Nature Communications, 12 (1) 1087, 1-12. doi: 10.1038/s41467-021-21431-w
2021
Book Chapter
Derivatization of carbohydrates for analysis by liquid chromatography and capillary electrophoresis
Yu, Raymond B., Dalman, Neil A. V., Wuethrich, Alain and Quirino, Joselito P. (2021). Derivatization of carbohydrates for analysis by liquid chromatography and capillary electrophoresis. Carbohydrate Analysis by Modern Liquid Phase Separation Techniques. (pp. 1-33) edited by Ziad El Rassi. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-821447-3.00019-6
Funding
Current funding
Past funding
Supervision
Availability
- Dr Alain Wuethrich is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Digital nanotechnologies for profiling trace of immune dysregulations and tissue damage in emerging diseases
This PhD project aims to develop breakthrough biomedical technologies to investigate the origins and temporal development of immune dysregulations in cancer therapy, COVID-19, and tissue damage.
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Digital nanotechnologies for profiling trace immune dysregulations and tissue damage in emerging diseases
This PhD project aims to develop breakthrough biomedical technologies to investigate the origins and temporal development of immune dysregulations in cancer therapy, COVID-19, and tissue damage.
Supervision history
Current supervision
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Doctor Philosophy
Harnessing nanotechnology to unravel the phenotypic heterogeneity of extracellular vesicles
Principal Advisor
Other advisors: Professor Matt Trau, Dr Abu Sina, Dr Mitchell Stark
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Doctor Philosophy
Advanced Micro and Nano Engineered Sensors for Post Translational Modification based Liquid Biopsy Analysis of Cancer
Principal Advisor
Other advisors: Professor Matt Trau, Dr Abu Sina
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Doctor Philosophy
A nano-map of cytokines in skin: Personalising treatment of skin inflammation by a digital nanotechnology
Principal Advisor
Other advisors: Professor Matt Trau, Dr Mitchell Stark
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Doctor Philosophy
Digital nanotechnologies to unravel immune dysregulation in long COVID
Principal Advisor
Other advisors: Professor Matt Trau
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Doctor Philosophy
A nano-map of cytokines in skin: Personalising treatment of skin inflammation by a digital nanotechnology
Principal Advisor
Other advisors: Professor Matt Trau, Dr Mitchell Stark
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Doctor Philosophy
A nano-engineered chip to help manage acute and long-haul COVID-19 patients
Associate Advisor
Other advisors: Professor Matt Trau
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Doctor Philosophy
Digital Nanotechnologies to track molecular aberrations in cancer
Associate Advisor
Other advisors: Dr Richard Lobb, Professor Matt Trau
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Doctor Philosophy
The investigation of microglial activation in brain cancer and brain metastasis by an integrated nano-sensor
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
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Doctor Philosophy
Utilising extracellular vesicles for the diagnosis of lung cancer.
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
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Doctor Philosophy
Single molecule sensing on nanopillars: Reading complex molecular circuits
Associate Advisor
Other advisors: Professor Matt Trau, Dr Selvakumar Edwardraja, Dr Abu Sina
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Doctor Philosophy
Single Molecule Readout of Immune Disfunction
Associate Advisor
Other advisors: Dr Richard Lobb, Professor Matt Trau
Completed supervision
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2024
Doctor Philosophy
Advanced Micro and Nano Engineered Sensors for Post Translational Modification based Liquid Biopsy Analysis of Cancer
Principal Advisor
Other advisors: Professor Matt Trau, Dr Abu Sina
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2024
Doctor Philosophy
Clinical Epigenetics: Technology Development for Biomarkers of Human Health and Diseases
Associate Advisor
Other advisors: Dr Darren Korbie, Dr Abu Sina, Professor Matt Trau
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2023
Doctor Philosophy
Bioengineering yeast nanofragment affinity probes for dengue diagnostics
Associate Advisor
Other advisors: Dr Christopher Howard, Professor Matt Trau
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2023
Doctor Philosophy
Precision Nano-Diagnostics for Dynamically Profiling Glioblastoma Multiforme and the Epithelial-Mesenchymal Transition in Cancer
Associate Advisor
Other advisors: Professor Matt Trau
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2021
Doctor Philosophy
Two Photon Laser Techniques for 3D Miniaturized Structures: Resistive-pulse Sensing and Potential Bio-uses
Associate Advisor
Other advisors: Professor Matt Trau
Media
Enquiries
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