Dr Alain Wuethrich
Dr

Alain Wuethrich

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Background

Dr Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland (UQ). Dr Wuethrich obtained his PhD from the University of Tasmania in 2016 after completing a Master’s degree in Switzerland. His research expertise lies in liquid biopsy, electrohydrodynamics, surface-enhanced Raman spectroscopy, nanotechnology and diagnostics. He held positions in international pharmaceutical companies and became lead inventor on a European patent. He has actively engaged with national and international companies to translate diagnostic nanotechnologies. Since 2017 he has provided continuous research mentoring to the group and has supervised >30 postgraduate and graduate students in nanotechnological strategies to detect cancer and other diseases.

Availability

Dr Alain Wuethrich is:
Available for supervision

Qualifications

  • Postgraduate Diploma, University of Tasmania
  • Doctor of Philosophy, University of Tasmania

Research interests

  • Liquid biopsy

  • Nanotechnology

  • Diagnostics

  • Electrohydrodynamics

  • Biosensing

Search Professor Alain Wuethrich’s works on UQ eSpace

83 works between 2013 and 2025
All (83) Journal Article (75) Book Chapter (6) Conference Publication (2)

21 - 40 of 83 works

2023

Journal Article

Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer

Liao, Caizhi, Wu, Zhihao, Lin, Chan, Chen, Xiaofeng, Zou, Yaqun, Zhao, Wan, Li, Xin, Huang, Guangqi, Xu, Baisheng, Briganti, Giovanni E., Qi, Yan, Wang, Xianshu, Zeng, Tao, Wuethrich, Alain and Zou, Hongzhi (2023). Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer. Smart Medicine, 2 (1), 1-30. doi: 10.1002/smmd.20220020

Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer

2023

Journal Article

Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions

Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207

Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions

2023

Journal Article

Status quo of extracellular vesicle isolation and detection methods for clinical utility

Visan, Kekoolani S., Wu, Li-Ying, Voss, Sarah, Wuethrich, Alain and Möller, Andreas (2023). Status quo of extracellular vesicle isolation and detection methods for clinical utility. Seminars in Cancer Biology, 88, 157-171. doi: 10.1016/j.semcancer.2022.12.008

Status quo of extracellular vesicle isolation and detection methods for clinical utility

2022

Journal Article

SERS multiplex profiling of melanoma circulating tumor cells for predicting the response to immune checkpoint blockade therapy

Li, Junrong, Wuethrich, Alain, Zhang, Zhen, Wang, Jing, Lin, Lynlee L., Behren, Andreas, Wang, Yuling and Trau, Matt (2022). SERS multiplex profiling of melanoma circulating tumor cells for predicting the response to immune checkpoint blockade therapy. Analytical Chemistry, 94 (42), 14573-14582. doi: 10.1021/acs.analchem.2c02398

SERS multiplex profiling of melanoma circulating tumor cells for predicting the response to immune checkpoint blockade therapy

2022

Journal Article

Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes

Farokhinejad, Fahimeh, Li, Junrong, Hugo, Leon E., Howard, Christopher B., Wuethrich, Alain and Trau, Matt (2022). Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes. Analytical Chemistry, 94 (41), 14177-14184. doi: 10.1021/acs.analchem.2c02012

Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes

2022

Journal Article

A T‐junction dual nanopore for single nanoparticle analysis

Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain and Trau, Matt (2022). A T‐junction dual nanopore for single nanoparticle analysis. Advanced Engineering Materials, 24 (4) 2101015, 2101015. doi: 10.1002/adem.202101015

A T‐junction dual nanopore for single nanoparticle analysis

2022

Journal Article

C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett’s esophagus and esophageal adenocarcinoma

Kolka, Cathryn M., Webster, Julie, Lepletier, Ailin, Winterford, Clay, Brown, Ian, Richards, Renee S., Zelek, Wioleta M., Cao, Yilang, Khamis, Ramlah, Shanmugasundaram, Karthik B., Wuethrich, Alain, Trau, Matt, Brosda, Sandra, Barbour, Andrew, Shah, Alok K., Eslick, Guy D., Clemons, Nicholas J., Morgan, B. Paul and Hill, Michelle M. (2022). C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett’s esophagus and esophageal adenocarcinoma. Frontiers in Immunology, 13 842023. doi: 10.3389/fimmu.2022.842023

C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett’s esophagus and esophageal adenocarcinoma

2022

Journal Article

An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers

Dey, Shuvashis, Ahmed, Emtiaz, Somvanshi, Pranjal Satishchandra, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2022). An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers. Chemosensors, 10 (3) 93, 93. doi: 10.3390/chemosensors10030093

An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers

2022

Journal Article

Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy

Shanmugasundaram, Karthik Balaji, Li, Junrong, Sina, Abu Ibn, Wuethrich, Alain and Trau, Matt (2022). Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy. Materials Advances, 3 (3), 1459-1471. doi: 10.1039/d1ma00848j

Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy

2021

Journal Article

Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis

Zhang, Zhen, Wuethrich, Alain, Wang, Jing, Korbie, Darren, Lin, Lynlee L. and Trau, Matt (2021). Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis. Analytical Chemistry, 93 (50) acs.analchem.1c03167, 16787-16795. doi: 10.1021/acs.analchem.1c03167

Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis

2021

Journal Article

Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection

Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001

Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection

2021

Journal Article

A stationary pseudophase semi-permanent coating for open-tubular capillary liquid chromatography and electrochromatography

Ahmed, Mohamed Adel, Felisilda, Bren Mark, Wuethrich, Alain and Quirino, Joselito P. (2021). A stationary pseudophase semi-permanent coating for open-tubular capillary liquid chromatography and electrochromatography. Journal of Chromatography A, 1657 462553, 462553. doi: 10.1016/j.chroma.2021.462553

A stationary pseudophase semi-permanent coating for open-tubular capillary liquid chromatography and electrochromatography

2021

Journal Article

An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas

Wang, Jing, Kao, Yung‐Ching, Zhou, Quan, Wuethrich, Alain, Stark, Mitchell S., Schaider, Helmut, Soyer, H. Peter, Lin, Lynlee L. and Trau, Matt (2021). An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas. Advanced Functional Materials, 32 (3) 2010296, 1-9. doi: 10.1002/adfm.202010296

An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas

2021

Journal Article

Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay

Li, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657

Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay

2021

Journal Article

Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip

Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358

Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip

2021

Journal Article

In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment

Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Wang, Jing, Behren, Andreas, Antaw, Fiach, Wang, Yuling, Sina, Abu Ali Ibn and Trau, Matt (2021). In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment. ACS Nano, 15 (7) acsnano.0c10008, 11231-11243. doi: 10.1021/acsnano.0c10008

In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment

2021

Journal Article

Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma

Webster, Julie A., Wuethrich, Alain, Shanmugasundaram, Karthik B., Richards, Renee S., Zelek, Wioleta M., Shah, Alok K., Gordon, Louisa G., Kendall, Bradley J., Hartel, Gunter, Morgan, B. Paul, Trau, Matt and Hill, Michelle M. (2021). Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma. Cancers, 13 (12) 2865, 2865. doi: 10.3390/cancers13122865

Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma

2021

Journal Article

On the behavior of nanoparticles beyond the nanopore interface

Antaw, Fiach, Anderson, Will, Wuethrich, Alain and Trau, Matt (2021). On the behavior of nanoparticles beyond the nanopore interface. Langmuir, 37 (16), 4772-4782. doi: 10.1021/acs.langmuir.0c03083

On the behavior of nanoparticles beyond the nanopore interface

2021

Book Chapter

Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor

Wuethrich, Alain, Dey, Shuvashis, Koo, Kevin M, Sina, Abu A. I. and Trau, Matt (2021). Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor. Melanoma. (pp. 265-276) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1205-7_20

Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor

2021

Journal Article

A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

Li, Junrong, Wuethrich, Alain, Sina, Abu A. I., Cheng, Han-Hao, Wang, Yuling, Behren, Andreas, Mainwaring, Paul N. and Trau, Matt (2021). A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy. Nature Communications, 12 (1) 1087, 1-12. doi: 10.1038/s41467-021-21431-w

A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

Current funding

  • 2025 - 2029
    Immune Dashboard Chip (IDC): Single-molecule digital nanotechnology for profiling trace immune dysregulations in Long COVID-19 and improving mRNA vaccines
    NHMRC Investigator Grants
    Open grant
  • 2025
    Nanoscale profiling of immune overreactions in cancer therapy, infectious and autoimmune diseases
    UQ Foundation Research Excellence Awards
    Open grant
  • 2024 - 2026
    ALL IN - AI and Laboratory Led IdentificatioN of PASC
    NHMRC MRFF Post-Acute Sequelae of COVID-19
    Open grant
  • 2024 - 2025
    A blood-based nanotechnology to decipher the extracellular vesicle code in ALS
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2027
    Rhythms and blues: Personalising care for body clock dysfunction in mood disorders (NHMRC Synergy grant administered by University of Sydney)
    University of Sydney
    Open grant

Past funding

  • 2022 - 2025
    nanoIMPAC: Monitoring immune toxicities and tumour immune evasion in lung cancer
    Cancer Australia
    Open grant
  • 2021 - 2023
    Single molecule sensing on nanopillars: Reading complex molecular circuits
    ARC Discovery Projects
    Open grant
  • 2020 - 2024
    A protein phosphorylation mapping tool for monitoring tyrosine kinase inhibition therapy in cancer patients
    NHMRC Investigator Grants
    Open grant
  • 2020
    Harnessing nanotechnology to unravel extracellular vesicle heterogeneity
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2019
    Towards personalized nanomedicine: Exploring interfacial nanomixing as a tool to monitor aberrant protein phosphorylation pathways in cancer
    UQ Early Career Researcher
    Open grant
  • 2018 - 2019
    Enhanced electrochemical biosensing through electrohydrodynamic nanofluidics for cancer diagnostics
    UQ Development Fellowships
    Open grant

Availability

Dr Alain Wuethrich is:
Available for supervision

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Available projects

Supervision history

Current supervision

Completed supervision

Enquiries

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