Dr Alain Wuethrich
Dr

Alain Wuethrich

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Background

Dr Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland (UQ). Dr Wuethrich obtained his PhD from the University of Tasmania in 2016 after completing a Master’s degree in Switzerland. His research expertise lies in liquid biopsy, electrohydrodynamics, surface-enhanced Raman spectroscopy, nanotechnology and diagnostics. He held positions in international pharmaceutical companies and became lead inventor on a European patent. He has actively engaged with national and international companies to translate diagnostic nanotechnologies. Since 2017 he has provided continuous research mentoring to the group and has supervised >30 postgraduate and graduate students in nanotechnological strategies to detect cancer and other diseases.

Availability

Dr Alain Wuethrich is:
Available for supervision

Qualifications

  • Postgraduate Diploma, University of Tasmania
  • Doctor of Philosophy, University of Tasmania

Research interests

  • Liquid biopsy

  • Nanotechnology

  • Diagnostics

  • Electrohydrodynamics

  • Biosensing

Search Professor Alain Wuethrich’s works on UQ eSpace

83 works between 2013 and 2025
All (83) Journal Article (75) Book Chapter (6) Conference Publication (2)

41 - 60 of 83 works

2021

Book Chapter

Derivatization of carbohydrates for analysis by liquid chromatography and capillary electrophoresis

Yu, Raymond B., Dalman, Neil A. V., Wuethrich, Alain and Quirino, Joselito P. (2021). Derivatization of carbohydrates for analysis by liquid chromatography and capillary electrophoresis. Carbohydrate Analysis by Modern Liquid Phase Separation Techniques. (pp. 1-33) edited by Ziad El Rassi. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-821447-3.00019-6

Derivatization of carbohydrates for analysis by liquid chromatography and capillary electrophoresis

2020

Journal Article

Stacked dual‐pore architecture for deciphering and manipulating dynamics of individual nanoparticles

Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain and Trau, Matt (2020). Stacked dual‐pore architecture for deciphering and manipulating dynamics of individual nanoparticles. Advanced Materials Technologies, 5 (11) 2000701, 2000701. doi: 10.1002/admt.202000701

Stacked dual‐pore architecture for deciphering and manipulating dynamics of individual nanoparticles

2020

Journal Article

Configurable miniaturized 3D pores for robust single‐nanoparticle analysis

Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain, Anderson, Will and Trau, Matt (2020). Configurable miniaturized 3D pores for robust single‐nanoparticle analysis. Small Structures, 1 (2) 2000011. doi: 10.1002/sstr.202000011

Configurable miniaturized 3D pores for robust single‐nanoparticle analysis

2020

Journal Article

Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020)

Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020). Advanced Functional Materials, 30 (37) 2070248. doi: 10.1002/adfm.202070248

Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020)

2020

Journal Article

Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA

Sina, Abu Ali Ibn, Lin, Ting-Yun, Vaidyanathan, Ramanathan, Wang, Zhaoran, Dey, Shuvashis, Wang, Jing, Behren, Andreas, Wuethrich, Alain, Carrascosa, Laura G. and Trau, Matt (2020). Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA. Nanoscale Horizons, 5 (9), 1317-1323. doi: 10.1039/d0nh00258e

Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA

2020

Journal Article

A material odyssey for 3D nano/microstructures: two photon polymerization based nanolithography in bioapplications

Liao, Caizhi, Wuethrich, Alain and Trau, Matt (2020). A material odyssey for 3D nano/microstructures: two photon polymerization based nanolithography in bioapplications. Applied Materials Today, 19 100635, 100635. doi: 10.1016/j.apmt.2020.100635

A material odyssey for 3D nano/microstructures: two photon polymerization based nanolithography in bioapplications

2020

Journal Article

Tracking drug-induced epithelial–mesenchymal transition in breast cancer by a microfluidic surface-enhanced raman spectroscopy immunoassay

Zhang, Zhen, Wang, Jing, Shanmugasundaram, Karthik Balaji, Yeo, Belinda, Möller, Andreas, Wuethrich, Alain, Lin, Lynlee L. and Trau, Matt (2020). Tracking drug-induced epithelial–mesenchymal transition in breast cancer by a microfluidic surface-enhanced raman spectroscopy immunoassay. Small, 16 (13) 1905614, e1905614. doi: 10.1002/smll.201905614

Tracking drug-induced epithelial–mesenchymal transition in breast cancer by a microfluidic surface-enhanced raman spectroscopy immunoassay

2020

Journal Article

Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma

Wang, Jing, Wuethrich, Alain, Sina, Abu Ali Ibn, Lane, Rebecca E., Lin, Lynlee L., Wang, Yuling, Cebon, Jonathan, Behren, Andreas and Trau, Matt (2020). Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma. Science Advances, 6 (9) eaax3223, eaax3223. doi: 10.1126/sciadv.aax3223

Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma

2020

Journal Article

Ultrasensitive melanoma biomarker detection using a microchip SERS immunoassay with anisotropic Au–Ag alloy nanoboxes

Kumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Li, Junrong, Zhang, Zhen, Ibn Sina, Abu Ali, Wuethrich, Alain and Trau, Matt (2020). Ultrasensitive melanoma biomarker detection using a microchip SERS immunoassay with anisotropic Au–Ag alloy nanoboxes. RSC Advances, 10 (48), 28778-28785. doi: 10.1039/d0ra05032f

Ultrasensitive melanoma biomarker detection using a microchip SERS immunoassay with anisotropic Au–Ag alloy nanoboxes

2020

Journal Article

The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies

Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies. Advanced Functional Materials, 30 (37) 1909306, 1909306. doi: 10.1002/adfm.201909306

The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies

2019

Journal Article

Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor

Wuethrich, Alain, Rajkumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Reza, Kamil K., Dey, Shuvashis, Howard, Christopher B., Sina, Abu Ali Ibn and Trau, Matt (2019). Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor. The Analyst, 144 (23), 6914-6921. doi: 10.1039/c9an01450k

Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor

2019

Journal Article

Toward personalized cancer treatment: from diagnostics to therapy monitoring in miniaturized electrohydrodynamic systems

Khondakar, Kamil Reza, Dey, Shuvashis, Wuethrich, Alain, Sina, Abu Ali Ibn and Trau, Matt (2019). Toward personalized cancer treatment: from diagnostics to therapy monitoring in miniaturized electrohydrodynamic systems. Accounts of Chemical Research, 52 (8) acs.accounts.9b00192, 2113-2123. doi: 10.1021/acs.accounts.9b00192

Toward personalized cancer treatment: from diagnostics to therapy monitoring in miniaturized electrohydrodynamic systems

2019

Journal Article

Tracking antigen specific T-cells: technological advancement and limitations

Dey, Shuvashis, Kamil Reza, K., Wuethrich, Alain, Korbie, Darren, Ibn Sina, Abu Ali and Trau, Matt (2019). Tracking antigen specific T-cells: technological advancement and limitations. Biotechnology Advances, 37 (1), 145-153. doi: 10.1016/j.biotechadv.2018.11.010

Tracking antigen specific T-cells: technological advancement and limitations

2019

Journal Article

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2016–2018)

Breadmore, Michael C., Grochocki, Wojciech, Kalsoom, Umme, Alves, Mónica N., Phung, Sui Ching, Rokh, Masoomeh Tehrani, Cabot, Joan M., Ghiasvand, Alireza, Li, Feng, Shallan, Aliaa I., Keyon, Aemi S. Abdul, Alhusban, Ala A., See, Hong Heng, Wuethrich, Alain, Dawod, Mohamed and Quirino, Joselito P. (2019). Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2016–2018). Electrophoresis, 40 (1), 17-39. doi: 10.1002/elps.201800384

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2016–2018)

2019

Journal Article

Label-free detection of exosomes using surface plasmon resonance biosensor

Sina, A.A.I., Vaidyanathan, R., Wuethrich, A., Carrascosa, L. G. and Trau, M. (2019). Label-free detection of exosomes using surface plasmon resonance biosensor. Analytical and Bioanalytical Chemistry, 411 (7), 1311-1318. doi: 10.1007/s00216-019-01608-5

Label-free detection of exosomes using surface plasmon resonance biosensor

2018

Journal Article

An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells

Dey, Shuvashis, Koo, Kevin, Wang, Zhaoran, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2018). An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells. Lab on a Chip, 19 (5), 738-748. doi: 10.1039/c8lc00991k

An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells

2018

Journal Article

A SERS microfluidic platform for targeting multiple soluble immune checkpoints

Reza, K. Kamil, Sina, Abu Ali Ibn, Wuethrich, Alain, Grewal, Yadveer S., Howard, Christopher B., Korbie, Darren and Trau, Matt (2018). A SERS microfluidic platform for targeting multiple soluble immune checkpoints. Biosensors and Bioelectronics, 126, 178-186. doi: 10.1016/j.bios.2018.10.044

A SERS microfluidic platform for targeting multiple soluble immune checkpoints

2018

Journal Article

Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay

Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Sina, Abu Ali Ibn, Korbie, Darren, Wang, Yuling and Trau, Matt (2018). Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay. Nanoscale, 10 (39), 18482-18491. doi: 10.1039/c8nr02886a

Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay

2018

Journal Article

A decade of microchip electrophoresis for clinical diagnostics – a review of 2008-2017

Wuethrich, Alain and Quirino, Joselito P. (2018). A decade of microchip electrophoresis for clinical diagnostics – a review of 2008-2017. Analytica Chimica Acta, 1045, 42-66. doi: 10.1016/j.aca.2018.08.009

A decade of microchip electrophoresis for clinical diagnostics – a review of 2008-2017

2018

Journal Article

An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells

Ahmed, Mostak, Carrascosa, Laura G, Wuethrich, Alain, Mainwaring, Paul and Trau, Matt (2018). An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells. Biomaterials Science, 6 (9), 2336-2341. doi: 10.1039/c8bm00629f

An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells

Current funding

  • 2025 - 2029
    Immune Dashboard Chip (IDC): Single-molecule digital nanotechnology for profiling trace immune dysregulations in Long COVID-19 and improving mRNA vaccines
    NHMRC Investigator Grants
    Open grant
  • 2025
    Nanoscale profiling of immune overreactions in cancer therapy, infectious and autoimmune diseases
    UQ Foundation Research Excellence Awards
    Open grant
  • 2024 - 2026
    ALL IN - AI and Laboratory Led IdentificatioN of PASC
    NHMRC MRFF Post-Acute Sequelae of COVID-19
    Open grant
  • 2024 - 2025
    A blood-based nanotechnology to decipher the extracellular vesicle code in ALS
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2027
    Rhythms and blues: Personalising care for body clock dysfunction in mood disorders (NHMRC Synergy grant administered by University of Sydney)
    University of Sydney
    Open grant

Past funding

  • 2022 - 2025
    nanoIMPAC: Monitoring immune toxicities and tumour immune evasion in lung cancer
    Cancer Australia
    Open grant
  • 2021 - 2023
    Single molecule sensing on nanopillars: Reading complex molecular circuits
    ARC Discovery Projects
    Open grant
  • 2020 - 2024
    A protein phosphorylation mapping tool for monitoring tyrosine kinase inhibition therapy in cancer patients
    NHMRC Investigator Grants
    Open grant
  • 2020
    Harnessing nanotechnology to unravel extracellular vesicle heterogeneity
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2019
    Towards personalized nanomedicine: Exploring interfacial nanomixing as a tool to monitor aberrant protein phosphorylation pathways in cancer
    UQ Early Career Researcher
    Open grant
  • 2018 - 2019
    Enhanced electrochemical biosensing through electrohydrodynamic nanofluidics for cancer diagnostics
    UQ Development Fellowships
    Open grant

Availability

Dr Alain Wuethrich is:
Available for supervision

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Available projects

Supervision history

Current supervision

Completed supervision

Enquiries

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