Overview
Background
Dr Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland (UQ). Dr Wuethrich obtained his PhD from the University of Tasmania in 2016 after completing a Master’s degree in Switzerland. His research expertise lies in liquid biopsy, electrohydrodynamics, surface-enhanced Raman spectroscopy, nanotechnology and diagnostics. He held positions in international pharmaceutical companies and became lead inventor on a European patent. He has actively engaged with national and international companies to translate diagnostic nanotechnologies. Since 2017 he has provided continuous research mentoring to the group and has supervised >30 postgraduate and graduate students in nanotechnological strategies to detect cancer and other diseases.
Availability
- Dr Alain Wuethrich is:
- Available for supervision
Qualifications
- Postgraduate Diploma, University of Tasmania
- Doctor of Philosophy, University of Tasmania
Research interests
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Liquid biopsy
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Nanotechnology
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Diagnostics
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Electrohydrodynamics
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Biosensing
Works
Search Professor Alain Wuethrich’s works on UQ eSpace
2020
Journal Article
Configurable miniaturized 3D pores for robust single‐nanoparticle analysis
Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain, Anderson, Will and Trau, Matt (2020). Configurable miniaturized 3D pores for robust single‐nanoparticle analysis. Small Structures, 1 (2) 2000011. doi: 10.1002/sstr.202000011
2020
Journal Article
Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020)
Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020). Advanced Functional Materials, 30 (37) 2070248. doi: 10.1002/adfm.202070248
2020
Journal Article
Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA
Sina, Abu Ali Ibn, Lin, Ting-Yun, Vaidyanathan, Ramanathan, Wang, Zhaoran, Dey, Shuvashis, Wang, Jing, Behren, Andreas, Wuethrich, Alain, Carrascosa, Laura G. and Trau, Matt (2020). Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA. Nanoscale Horizons, 5 (9), 1317-1323. doi: 10.1039/d0nh00258e
2020
Journal Article
A material odyssey for 3D nano/microstructures: two photon polymerization based nanolithography in bioapplications
Liao, Caizhi, Wuethrich, Alain and Trau, Matt (2020). A material odyssey for 3D nano/microstructures: two photon polymerization based nanolithography in bioapplications. Applied Materials Today, 19 100635, 100635. doi: 10.1016/j.apmt.2020.100635
2020
Journal Article
Tracking drug-induced epithelial–mesenchymal transition in breast cancer by a microfluidic surface-enhanced raman spectroscopy immunoassay
Zhang, Zhen, Wang, Jing, Shanmugasundaram, Karthik Balaji, Yeo, Belinda, Möller, Andreas, Wuethrich, Alain, Lin, Lynlee L. and Trau, Matt (2020). Tracking drug-induced epithelial–mesenchymal transition in breast cancer by a microfluidic surface-enhanced raman spectroscopy immunoassay. Small, 16 (13) 1905614, e1905614. doi: 10.1002/smll.201905614
2020
Journal Article
Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma
Wang, Jing, Wuethrich, Alain, Sina, Abu Ali Ibn, Lane, Rebecca E., Lin, Lynlee L., Wang, Yuling, Cebon, Jonathan, Behren, Andreas and Trau, Matt (2020). Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma. Science Advances, 6 (9) eaax3223, eaax3223. doi: 10.1126/sciadv.aax3223
2020
Journal Article
Ultrasensitive melanoma biomarker detection using a microchip SERS immunoassay with anisotropic Au–Ag alloy nanoboxes
Kumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Li, Junrong, Zhang, Zhen, Ibn Sina, Abu Ali, Wuethrich, Alain and Trau, Matt (2020). Ultrasensitive melanoma biomarker detection using a microchip SERS immunoassay with anisotropic Au–Ag alloy nanoboxes. RSC Advances, 10 (48), 28778-28785. doi: 10.1039/d0ra05032f
2020
Journal Article
The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies
Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies. Advanced Functional Materials, 30 (37) 1909306, 1909306. doi: 10.1002/adfm.201909306
2019
Journal Article
Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor
Wuethrich, Alain, Rajkumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Reza, Kamil K., Dey, Shuvashis, Howard, Christopher B., Sina, Abu Ali Ibn and Trau, Matt (2019). Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor. The Analyst, 144 (23), 6914-6921. doi: 10.1039/c9an01450k
2019
Journal Article
Toward personalized cancer treatment: from diagnostics to therapy monitoring in miniaturized electrohydrodynamic systems
Khondakar, Kamil Reza, Dey, Shuvashis, Wuethrich, Alain, Sina, Abu Ali Ibn and Trau, Matt (2019). Toward personalized cancer treatment: from diagnostics to therapy monitoring in miniaturized electrohydrodynamic systems. Accounts of Chemical Research, 52 (8) acs.accounts.9b00192, 2113-2123. doi: 10.1021/acs.accounts.9b00192
2019
Journal Article
Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2016–2018)
Breadmore, Michael C., Grochocki, Wojciech, Kalsoom, Umme, Alves, Mónica N., Phung, Sui Ching, Rokh, Masoomeh Tehrani, Cabot, Joan M., Ghiasvand, Alireza, Li, Feng, Shallan, Aliaa I., Keyon, Aemi S. Abdul, Alhusban, Ala A., See, Hong Heng, Wuethrich, Alain, Dawod, Mohamed and Quirino, Joselito P. (2019). Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2016–2018). Electrophoresis, 40 (1), 17-39. doi: 10.1002/elps.201800384
2019
Journal Article
Label-free detection of exosomes using surface plasmon resonance biosensor
Sina, A.A.I., Vaidyanathan, R., Wuethrich, A., Carrascosa, L. G. and Trau, M. (2019). Label-free detection of exosomes using surface plasmon resonance biosensor. Analytical and Bioanalytical Chemistry, 411 (7), 1311-1318. doi: 10.1007/s00216-019-01608-5
2019
Journal Article
Tracking antigen specific T-cells: technological advancement and limitations
Dey, Shuvashis, Kamil Reza, K., Wuethrich, Alain, Korbie, Darren, Ibn Sina, Abu Ali and Trau, Matt (2019). Tracking antigen specific T-cells: technological advancement and limitations. Biotechnology Advances, 37 (1), 145-153. doi: 10.1016/j.biotechadv.2018.11.010
2018
Journal Article
An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells
Dey, Shuvashis, Koo, Kevin, Wang, Zhaoran, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2018). An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells. Lab on a Chip, 19 (5), 738-748. doi: 10.1039/c8lc00991k
2018
Journal Article
A SERS microfluidic platform for targeting multiple soluble immune checkpoints
Reza, K. Kamil, Sina, Abu Ali Ibn, Wuethrich, Alain, Grewal, Yadveer S., Howard, Christopher B., Korbie, Darren and Trau, Matt (2018). A SERS microfluidic platform for targeting multiple soluble immune checkpoints. Biosensors and Bioelectronics, 126, 178-186. doi: 10.1016/j.bios.2018.10.044
2018
Journal Article
Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay
Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Sina, Abu Ali Ibn, Korbie, Darren, Wang, Yuling and Trau, Matt (2018). Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay. Nanoscale, 10 (39), 18482-18491. doi: 10.1039/c8nr02886a
2018
Journal Article
A decade of microchip electrophoresis for clinical diagnostics – a review of 2008-2017
Wuethrich, Alain and Quirino, Joselito P. (2018). A decade of microchip electrophoresis for clinical diagnostics – a review of 2008-2017. Analytica Chimica Acta, 1045, 42-66. doi: 10.1016/j.aca.2018.08.009
2018
Journal Article
An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells
Ahmed, Mostak, Carrascosa, Laura G, Wuethrich, Alain, Mainwaring, Paul and Trau, Matt (2018). An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells. Biomaterials Science, 6 (9), 2336-2341. doi: 10.1039/c8bm00629f
2018
Journal Article
Interfacial nano-mixing in a miniaturised platform enables signal enhancement and in situ detection of cancer biomarkers
Wuethrich, Alain, Sina, Abu Ali Ibn, Ahmed, Mostak, Lin, Ting-Yun, Carrascosa, Laura G. and Trau, Matt (2018). Interfacial nano-mixing in a miniaturised platform enables signal enhancement and in situ detection of cancer biomarkers. Nanoscale, 10 (23), 10884-10890. doi: 10.1039/C7NR09496E
2018
Book Chapter
Stacking or On-line Sample Concentration in CE-MS for Metabolomics
Wuethrich, Alain and Quirino, Joselito P. (2018). Stacking or On-line Sample Concentration in CE-MS for Metabolomics. Capillary electrophoresis–mass spectrometry for metabolomics. (pp. 83-112) Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781788012737-00083
Funding
Current funding
Past funding
Supervision
Availability
- Dr Alain Wuethrich is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Digital nanotechnologies for profiling trace of immune dysregulations and tissue damage in emerging diseases
This PhD project aims to develop breakthrough biomedical technologies to investigate the origins and temporal development of immune dysregulations in cancer therapy, COVID-19, and tissue damage.
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Digital nanotechnologies for profiling trace immune dysregulations and tissue damage in emerging diseases
This PhD project aims to develop breakthrough biomedical technologies to investigate the origins and temporal development of immune dysregulations in cancer therapy, COVID-19, and tissue damage.
Supervision history
Current supervision
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Doctor Philosophy
Harnessing nanotechnology to unravel the phenotypic heterogeneity of extracellular vesicles
Principal Advisor
Other advisors: Professor Matt Trau, Dr Abu Sina, Dr Mitchell Stark
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Doctor Philosophy
Advanced Micro and Nano Engineered Sensors for Post Translational Modification based Liquid Biopsy Analysis of Cancer
Principal Advisor
Other advisors: Professor Matt Trau, Dr Abu Sina
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Doctor Philosophy
Digital nanotechnologies to unravel immune dysregulation in long COVID
Principal Advisor
Other advisors: Professor Matt Trau
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Doctor Philosophy
A nano-map of cytokines in skin: Personalising treatment of skin inflammation by a digital nanotechnology
Principal Advisor
Other advisors: Professor Matt Trau, Dr Mitchell Stark
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Doctor Philosophy
A nano-engineered chip to help manage acute and long-haul COVID-19 patients
Associate Advisor
Other advisors: Professor Matt Trau
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Doctor Philosophy
Digital Nanotechnologies to track molecular aberrations in cancer
Associate Advisor
Other advisors: Dr Richard Lobb, Professor Matt Trau
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Doctor Philosophy
The investigation of microglial activation in brain cancer and brain metastasis by an integrated nano-sensor
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
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Doctor Philosophy
Utilising extracellular vesicles for the diagnosis of lung cancer.
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
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Doctor Philosophy
Single molecule sensing on nanopillars: Reading complex molecular circuits
Associate Advisor
Other advisors: Dr Abu Sina, Dr Selvakumar Edwardraja, Professor Matt Trau
Completed supervision
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2024
Doctor Philosophy
Clinical Epigenetics: Technology Development for Biomarkers of Human Health and Diseases
Associate Advisor
Other advisors: Dr Darren Korbie, Dr Abu Sina, Professor Matt Trau
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2023
Doctor Philosophy
Bioengineering yeast nanofragment affinity probes for dengue diagnostics
Associate Advisor
Other advisors: Dr Christopher Howard, Professor Matt Trau
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2023
Doctor Philosophy
Precision Nano-Diagnostics for Dynamically Profiling Glioblastoma Multiforme and the Epithelial-Mesenchymal Transition in Cancer
Associate Advisor
Other advisors: Professor Matt Trau
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2021
Doctor Philosophy
Two Photon Laser Techniques for 3D Miniaturized Structures: Resistive-pulse Sensing and Potential Bio-uses
Associate Advisor
Other advisors: Professor Matt Trau
Media
Enquiries
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