
Overview
Background
Professor Ian Frazer is a clinician scientist, trained as a clinical immunologist in Scotland. As a professor at the University of Queensland, he leads a research group working at TRI in Brisbane, Australia on the immunobiology of epithelial cancers. He is recognised as co-inventor of the technology enabling the HPV vaccines, currently used worldwide to help prevent cervical cancer. He heads a biotechnology company, Jingang Medicine (Aus) Pty Ltd, working on new vaccine technologies, and is a board member of several companies and not for profit organisations. He was the inaugural president of the Australian Academy of Health and Medical Sciences, and a member of the Australian National Science and Technology Council. He chairs the Australian Medical Research Advisory Board of the Medical Research Future Fund.
He was recognised as Australian of the Year in 2006. He was recipient of the Prime Ministers Prize for Science, and of the Balzan Prize, in 2008, and was elected Fellow of the Royal Society of London in 2012. He was appointed Companion of the Order of Australia in the Queen’s Birthday Honours list in 2013.
Availability
- Professor Ian Frazer is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Edinburgh
- Bachelor of Medicine Surgery, University of Edinburgh
- Doctoral Diploma of Medicine, University of Melbourne
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
- Royal College of Physicians of Edinburgh, Royal College of Physicians of Edinburgh
Works
Search Professor Ian Frazer’s works on UQ eSpace
2015
Journal Article
Consensus nomenclature for CD8(+) T cell phenotypes in cancer
Apetoh, Lionel, Smyth, Mark J., Drake, Charles G., Abastado, Jean-Pierre, Apte, Ron N., Ayyoub, Maha, Blay, Jean-Yves, Bonneville, Marc, Butterfield, Lisa H., Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Esteban, Chen, Lieping, Colombo, Mario P., Comin-Anduix, Begona, Coukos, Georges, Dhodapkar, Madhav V., Dranoff, Glenn, Frazer, Ian H., Fridman, Wolf-Herve, Gabrilovich, Dmitry I., Gilboa, Eli, Gnjatic, Sacha, Jaeger, Dirk, Kalinski, Pawel, Kaufman, Howard L., Kiessling, Rolf, Kirkwood, John ... Anderson, Ana C. (2015). Consensus nomenclature for CD8(+) T cell phenotypes in cancer. Oncoimmunology, 4 (4) e998538, e998538-1-e998538-10. doi: 10.1080/2162402X.2014.998538
2015
Journal Article
Human papillomavirus 18 genetic variation and cervical cancer risk worldwide
Chen, Alyce A., Gheit, Tarik, Franceschi, Silvia, Tommasino, Massimo, Clifford, Gary M., the IARC HPV Variant Study Group, Herrero, R., Bosch, X., Hammouda, D., Loria, D., Matos, E., Tshomo, U., Rios-Dalenz, J. L., Eluf-Neto, J., Ghadirian, P., Ferreccio, C., Ojeda, J. M., Dai, M., Li, L. K., Wu, R. F., Torroella, M., Pearce, N., Alibegashvili, T., Kordzaia, D., Keita, N., Koulibaly, M., Rajkumar, T., Rajkumar, R., Sarjadi, ... Frazer, I. H. (2015). Human papillomavirus 18 genetic variation and cervical cancer risk worldwide. Journal of Virology, 89 (20), 10680-10687. doi: 10.1128/JVI.01747-15
2015
Conference Publication
The future of HPV vaccination
Frazer, I. H. (2015). The future of HPV vaccination. RCOG World Congress 2015, Brisbane, Queensland, Australia, 12-15 April. HOBOKEN: WILEY-BLACKWELL.
2015
Journal Article
The actinic keratosis virome: can we prevent squamous cell carcinoma with a vaccine?
Frazer, I. H. (2015). The actinic keratosis virome: can we prevent squamous cell carcinoma with a vaccine?. Current Problems in Dermatology (Switzerland), 46, 28-35. doi: 10.1159/000366532
2014
Journal Article
Microprojection arrays to immunise at mucosal surfaces
McNeilly, Celia L., Crichton, Michael L., Primiero, Clare A., Frazer, Ian H., Roberts, Michael S. and Kendall, Mark A. F. (2014). Microprojection arrays to immunise at mucosal surfaces. Journal of Controlled Release, 196, 252-260. doi: 10.1016/j.jconrel.2014.09.028
2014
Journal Article
Human papillomavirus 16/18 seroprevalence in unvaccinated women over 30 years with normal cytology and with high grade cervical abnormalities in Australia: results from an observational study
Velentzis, Louiza S., Sitas, Freddy, O'Connell, Dianne L., Darlington-Brown, Jessica, Egger, Sam, Sinha, Rohit, Banks, Emily, Frazer, Ian H. and Canfell, Karen (2014). Human papillomavirus 16/18 seroprevalence in unvaccinated women over 30 years with normal cytology and with high grade cervical abnormalities in Australia: results from an observational study. BMC Infectious Diseases, 14 (3861) 3861, 1-10. doi: 10.1186/s12879-014-0676-z
2014
Journal Article
Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage
Freeman, Andrew, Bridge, Jennifer A., Maruthayanar, Pirashanthini, Overgaard, Nana H., Jung, Ji-Won, Simpson, Fiona, Prow, Tarl W., Soyer, H. Peter, Frazer, Ian H., Freeman, Michael and Wells, James W. (2014). Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage. PLoS One, 9 (10) e110928, e110928.1-e110928.9. doi: 10.1371/journal.pone.0110928
2014
Journal Article
HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells
Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014). HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 (10) e1004466, 1-11. doi: 10.1371/journal.ppat.1004466
2014
Journal Article
Colocalization of cell death with antigen deposition in skin enhances vaccine immunogenicity
Depelsenaire, Alexandra C. I., Meliga, Stefano C., McNeilly, Celia, Pearson, Frances E., Coffey, Jacob, Haigh, Oscar L., Flaim, Christopher J., Frazer, Ian H. and Kendall, Mark A. F. (2014). Colocalization of cell death with antigen deposition in skin enhances vaccine immunogenicity. The Journal of Investigative Dermatology, 134 (9), 2361-2370. doi: 10.1038/jid.2014.174
2014
Journal Article
IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia
Gosmann, Christina, Mattarollo, Stephen R., Bridge, Jennifer A., Frazer, Ian H. and Blumenthal, Antje (2014). IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. Journal of Immunology, 193 (5), 2248-2257. doi: 10.4049/jimmunol.1400216
2014
Journal Article
CXCL1 gene silencing in skin using liposome-encapsulated siRNA delivered by microprojection array
Haigh, Oscar, Depelsenaire, Alexandra C. I., Meliga, Stefano C., Yukiko, Sally R., McMillan, Nigel A. J., Frazer, Ian H. and Kendall, Mark A. F. (2014). CXCL1 gene silencing in skin using liposome-encapsulated siRNA delivered by microprojection array. Journal of Controlled Release, 194, 148-156. doi: 10.1016/j.jconrel.2014.08.021
2014
Journal Article
Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells
Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (6) e101381, e101381. doi: 10.1371/journal.pone.0101381
2014
Journal Article
IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin
Gosmann, Christina, Frazer, Ian H., Mattarollo, Stephen R. and Blumenthal, Antje (2014). IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin. Journal of Investigative Dermatology, 134 (10), 2562-2569. doi: 10.1038/jid.2014.201
2014
Journal Article
The kinematics of cytotoxic lymphocytes influence their ability to kill target cells
Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). The kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (5) e95248, e95248.1-e95248.11. doi: 10.1371/journal.pone.0095248
2014
Journal Article
Development and implementation of papillomavirus prophylactic vaccines
Frazer, Ian H. (2014). Development and implementation of papillomavirus prophylactic vaccines. Journal of Immunology, 192 (9), 4007-4011. doi: 10.4049/jimmunol.1490012
2014
Journal Article
The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals
Wikstrom, Matthew E., Khong, Andrea, Fleming, Peter, Kuns, Rachel, Hertzog, Paul J., Frazer, Ian H., Andoniou, Christopher E., Hill, Geoffrey R. and Degli-Esposti, Mariapia A. (2014). The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals. European Journal of Immunology, 44 (2), 409-419. doi: 10.1002/eji.201243109
2014
Conference Publication
Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo
Gatica-Andrades, M. D., Nguyen, T. T. K., Schultz, T. E., Wyer, O. J. K., Melo-Bolivar, J., Walker, M. J., Frazer, I. H., Barnett, T. C. and Blumenthal, A. (2014). Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo. British Society for Immunology Annual Congress 2014, Brighton, United Kingdom, 1-4 December 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/imm.12406
2014
Journal Article
Human papillomavirus E7 oncoprotein transgenic skin develops an enhanced inflammatory response to 2,4-dinitrochlorobenzene by an arginase-1-dependent mechanism
Tran, Le Son, Bergot, Anne-Sophie, Mattarollo, Stephen R., Mittal, Deepak and Frazer, Ian H. (2014). Human papillomavirus E7 oncoprotein transgenic skin develops an enhanced inflammatory response to 2,4-dinitrochlorobenzene by an arginase-1-dependent mechanism. Journal of Investigative Dermatology, 134 (9), 2438-2446. doi: 10.1038/jid.2014.186
2014
Journal Article
Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4
Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014). Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 (5), 1480-1490. doi: 10.1002/eji.201343959
2013
Journal Article
A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice
Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Marshak, Joshua O., Xu, Yan, Huang, Meei-Li, Dong, Lichun, Frazer, Ian H. and Koelle, David M. (2013). A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice. PloS One, 8 (10) e76407, e76407.1-e76407.9. doi: 10.1371/journal.pone.0076407
Funding
Current funding
Past funding
Supervision
Availability
- Professor Ian Frazer is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
Assessment of predictors of response to checkpoint blockades in cancer patients.
Associate Advisor
Other advisors: Dr Ahmed Mehdi, Dr Janin Chandra, Dr Bree Tillett
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
Completed supervision
-
2024
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of the skin microbiota in cutaneous squamous cell carcinoma
Principal Advisor
Other advisors: Professor Mark Morrison
-
2020
Doctor Philosophy
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Dr Janin Chandra
-
2018
Doctor Philosophy
Association of Local Immune Suppression in Skin with HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2017
Master Philosophy
Aetiology of Oral Cavity Squamous Cell Carcinoma - An Exploration utilising Next Generation Sequencing
Principal Advisor
-
2015
Doctor Philosophy
Mechanisms of 2,4-Dinitrochlorobenzene-induced acute inflammation in Human Papillomavirus type 16 E7 oncoprotein expressing skin
Principal Advisor
-
2014
Doctor Philosophy
Mechanisms of immunoregulation in human papillomavirus-associated epithelial hyperplasia: of mice and (wo)men
Principal Advisor
Other advisors: Professor Antje Blumenthal
-
2013
Doctor Philosophy
LANGERHANS CELLS IN SKIN EXPRESSING HUMAN PAPILLOMAVIRUS TYPE 16 E7
Principal Advisor
-
2010
Doctor Philosophy
CD4+ T cells provide help to CD8+ T cells in immune recall responses in skin
Principal Advisor
-
2010
Doctor Philosophy
Augmenting CD8+ T cell-mediated cutaneous immunotherapy in a murine model system
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2010
Doctor Philosophy
Role of dendritic epidermal T cells in skin graft rejection
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2009
Doctor Philosophy
Human Papillomavirus 16 E7 Inhibits the ability of IFN-γ in Enhancement of MHC Class I Antigen Presentation and CTL Lysis by Affecting IRF-1 Expression in Keratinocytes
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Principal Advisor
Other advisors: Honorary Professor Geoffrey Hill
-
2003
Doctor Philosophy
IMMUNE RESPONSE TO PAPILLOMAVIRUS INFECTION
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2002
Doctor Philosophy
DETERMINING CTL CHARACTERISTICS WHICH CORRELATE WITH TUMOUR REGRESSION IN VIVO
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2023
Doctor Philosophy
Local Delivery Of Immunotherapeutic Antibodies To Skin Cancers
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor Graham Leggatt
-
2022
Doctor Philosophy
Understanding CD4+ T cell responses to HPV16 E7 antigen in a mouse model of precancerous skin
Associate Advisor
Other advisors: Dr Kelvin Tuong, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of CD8+ T cells in the regression of squamous cell carcinoma
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
-
2017
Doctor Philosophy
Uncovering novel regulators of CD8+ T-cell function in the skin
Associate Advisor
Other advisors: Associate Professor James Wells
-
2016
Doctor Philosophy
Evaluating CD8+ T-cell function in skin and squamous cell carcinoma following systemic suppression with rapamycin and tacrolimus.
Associate Advisor
Other advisors: Professor Fiona Simpson, Associate Professor James Wells
-
2015
Doctor Philosophy
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2015
Doctor Philosophy
Contributions of Wnt signalling to immune responses during acute bacterial infection
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2011
Doctor Philosophy
The effects of the balance of Type I and Type II NKT cells on CD8 T cells and Tumour Therapy
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
-
2008
Doctor Philosophy
Interactions among Control Beliefs, Illness Severity, Biological Factors and a Psychological Preparation for Heart Surgery: Predictors of Health Outcomes
Associate Advisor
Other advisors: Emeritus Professor Kenneth Pakenham
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2007
Doctor Philosophy
Treatment of Cervical Cancer using RNA-Interference Against Human Papillomavirus Oncogenes
Associate Advisor
-
2005
Doctor Philosophy
Regulation of squamous differentiation by the E2F family transcription factors
Associate Advisor
-
2003
Doctor Philosophy
DENDRITIC CELL IMMUNOTHERAPY BASED ON HUMAN PAPILLOMAVIRUS
Associate Advisor
Other advisors: Professor Ranjeny Thomas
-
2003
Doctor Philosophy
THE ROLE OF AP2 IN SQUAMOUS DIFFERENTIATION
Associate Advisor
-
2003
Doctor Philosophy
IDENTIFICATION AND CLONING OF GENES ASSOCIATED WITH SQUAMOUS CELL CARCINOMA IN HUMAN SKIN TUMOURS
Associate Advisor
-
Doctor Philosophy
Peripheral Mechanisms of CD8+ T Cell Tolerance in H-2b K14E7 Transgenic Mice
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
Media
Enquiries
Contact Professor Ian Frazer directly for media enquiries about:
- Allergy
- Autoimmune disease
- Cancer - immunity
- Cancer - vaccines to prevent
- Cervical cancer vaccine
- Education - medical
- Genital wart virus disease
- Host-virus interactions
- Immunity
- Immunodeficiency
- Immunology
- Medical education
- Papillomavirus vaccines
- Pathology
- Transplantation immunology
- Tumour immunology
- Tumour vaccines
- Vaccines
- Viral infection
- Viral vaccines
- Viruses
- Warts - genital
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