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2024 Journal Article A phase Ib study to assess the safety of the human papillomavirus DNA vaccine (AMV002) in combination with durvalumab for HPV-associated oropharyngeal squamous cell carcinomaLadwa, Rahul, Chandra, Janin, Woo, Wai-Ping, Finlayson, Neil, Liu, Howard, McGrath, Margaret, See, Adrienne, Hughes, Brett G., Cooper, Caroline L., Jackson, Jim E., Dzienis, Marcin, Xu, Yan, Panizza, Benedict, Frazer, Ian and Porceddu, Sandro V. (2024). A phase Ib study to assess the safety of the human papillomavirus DNA vaccine (AMV002) in combination with durvalumab for HPV-associated oropharyngeal squamous cell carcinoma. Frontiers in Oncology, 14 1419258. doi: 10.3389/fonc.2024.1419258 |
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2024 Conference Publication A phase 2 study of de-escalation in resectable, locally advanced cutaneous squamous cell carcinoma (cSCC) with the use of neoadjuvant pembrolizumab: De-SquamateLadwa, Rahul, Lee, Jenny H.J., Porceddu, Sandro V., McGrath, Margaret Louise, Cooper, Caroline, Liu, Howard, Gupta, Ruta, Cuscaden, Claire, Nottage, Michelle K., Clark, Jonathan, Le, Dieu, Pauley, Marketa, Gonzalez-Cruz, Jazmina, Frazer, Ian, Hughes, Brett Gordon Maxwell and Panizza, Benedict J. (2024). A phase 2 study of de-escalation in resectable, locally advanced cutaneous squamous cell carcinoma (cSCC) with the use of neoadjuvant pembrolizumab: De-Squamate. 2024 ASCO Annual Meeting, Chicago, IL United States, 31 May - 4 June 2024. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2024.42.16_suppl.9514 |
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2024 Journal Article Characterization of the skin microbiome in normal and cutaneous squamous cell carcinoma affected cats and dogsBromfield, Jacoba I., Zaugg, Julian, Straw, Rodney C., Cathie, Julia, Krueger, Annika, Sinha, Debottam, Chandra, Janin, Hugenholtz, Philip and Frazer, Ian H. (2024). Characterization of the skin microbiome in normal and cutaneous squamous cell carcinoma affected cats and dogs. mSphere, 9 (4), e0055523. doi: 10.1128/msphere.00555-23 |
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2024 Journal Article Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicityWright, Quentin G, Sinha, Debottam, Wells, James W, Frazer, Ian H, Gonzalez Cruz, Jazmina L and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960, e007960. doi: 10.1136/jitc-2023-007960 |
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2023 Journal Article Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failureCauser, Andrew, Tan, Xiao, Lu, Xuehan, Moseley, Philip, Teoh, Siok M., Molotkov, Natalie, McGrath, Margaret, Kim, Taehyun, Simpson, Peter T, Perry, Christopher, Frazer, Ian H., Panizza, Benedict, Ladwa, Rahul, Nguyen, Quan and Gonzalez-Cruz, Jazmina L. (2023). Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failure. n p j Precision Oncology, 7 (1) 89, 89. doi: 10.1038/s41698-023-00444-2 |
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2023 Journal Article Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hostsVeitch, Margaret, Beaumont, Kimberly, Pouwer, Rebecca, Chew, Hui Yi, Frazer, Ian H., Soyer, H. Peter, Campbell, Scott, Dymock, Brian W., Harvey, Andrew, Cock, Terrie-Anne and Wells, James W. (2023). Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts. Journal for ImmunoTherapy of Cancer, 11 (9) e006783, 1-15. doi: 10.1136/jitc-2023-006783 |
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2023 Journal Article Skin-grafting and dendritic cell “boosted” humanized mouse models allow the pre-clinical evaluation of therapeutic cancer vaccinesZeng, Bijun, Moi, Davide, Molotkov, Natalie, Tolley, Lynn, Frazer, Ian Hector, Perry, Christopher, Dolcetti, Riccardo, Mazzieri, Roberta and Cruz, Jazmina L. G. (2023). Skin-grafting and dendritic cell “boosted” humanized mouse models allow the pre-clinical evaluation of therapeutic cancer vaccines. Cells, 12 (16) 2094, 1-21. doi: 10.3390/cells12162094 |
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2023 Journal Article Salivary micro RNAs as biomarkers for oropharyngeal cancerEkanayake Weeramange, Chameera, Tang, Kai Dun, Barrero, Roberto A., Hartel, Gunter, Liu, Zhen, Ladwa, Rahul, Langton-Lockton, Julian, Frazer, Ian, Kenny, Lizbeth, Vasani, Sarju and Punyadeera, Chamindie (2023). Salivary micro RNAs as biomarkers for oropharyngeal cancer. Cancer Medicine, 12 (14), 15128-15140. doi: 10.1002/cam4.6185 |
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2023 Journal Article Targeting Staphylococcus aureus dominated skin dysbiosis in actinic keratosis to prevent the onset of cutaneous squamous cell carcinoma: Outlook for future therapies?Bromfield, Jacoba Isobella, Hugenholtz, Philip, Frazer, Ian Hector, Khosrotehrani, Kiarash and Chandra, Janin (2023). Targeting Staphylococcus aureus dominated skin dysbiosis in actinic keratosis to prevent the onset of cutaneous squamous cell carcinoma: Outlook for future therapies?. Frontiers in Oncology, 13 1091379, 1091379. doi: 10.3389/fonc.2023.1091379 |
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2022 Journal Article HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancerMehdi, Ahmed M., Zhou, Chenhao, Turrell, Gavin, Walpole, Euan, Porceddu, Sandro, Frazer, Ian H. and Chandra, Janin (2022). HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancer. Cancer Gene Therapy, 30 (4), 1-12. doi: 10.1038/s41417-022-00577-9 |
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2022 Journal Article Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockadeSinha, Debottam, Moseley, Philip, Lu, Xuehan, Wright, Quentin, Gabrielli, Brian, Frazer, Ian H. and Cruz, Jazmina L. G. (2022). Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockade. Cancers, 14 (24) 6150, 1-26. doi: 10.3390/cancers14246150 |
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2022 Journal Article Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene–environment associationsMuralidharan, Sachin, Ali, Sarah, Yang, Lilin, Badshah, Joshua, Zahir, Syeda Farah, Ali, Rubbiya A., Chandra, Janin, Frazer, Ian H., Thomas, Ranjeny and Mehdi, Ahmed M. (2022). Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene–environment associations. Scientific Reports, 12 (1) 18710, 1-19. doi: 10.1038/s41598-022-21988-6 |
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2022 Conference Publication Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivoWright, Q., Sinha, D., Gonzalez-Cruz, J., Frazer, I. and Leggatt, G. (2022). Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo. ESMO Immuno-Oncology Congress 2022, Geneva, Switzerland, 7-9 December 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.iotech.2022.100289 |
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2022 Conference Publication Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunityDang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert. |
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2022 Journal Article Caerin 1.1/1.9 enhances antitumour immunity by activating the IFN-α response signalling pathway of tumour macrophagesYang, Xiaodan, Liu, Xiaosong, Li, Junjie, Zhang, Pingping, Li, Hejie, Chen, Guoqiang, Zhang, Wei, Wang, Tianfang, Frazer, Ian and Ni, Guoying (2022). Caerin 1.1/1.9 enhances antitumour immunity by activating the IFN-α response signalling pathway of tumour macrophages. Cancers, 14 (23) 5785, 1-22. doi: 10.3390/cancers14235785 |
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2022 Journal Article A robust experimental and computational analysis framework at multiple resolutions, modalities and coveragesTran, M., Yoon, S., Teoh, M., Andersen, S., Lam, PY., Purdue, B. W., Raghubar, A., Hanson, S.J., Devitt, K., Jones, K., Walters, S., Monkman, J., Kulasinghe, A., Tuong, Z.K., Soyer, H.P., Frazer, I. H. and Nguyen, Q. (2022). A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages. Frontiers in Immunology, 13 911873, 911873. doi: 10.3389/fimmu.2022.911873 |
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2022 Journal Article Cancer vaccinesSchiller, John T., Lowy, Douglas R., Frazer, Ian H., Finn, Olivera J., Vilar, Eduardo, Lyerly, H. Kim, Gnjatic, Sacha, Zaidi, Neeha, Ott, Patrick A., Balachandran, Vinod P., Dietrich, Pierre-Yves, Migliorini, Denis, Vonderheide, Robert H. and Domchek, Susan M. (2022). Cancer vaccines. Cancer Cell, 40 (6), 559-564. doi: 10.1016/j.ccell.2022.05.015 |
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2022 Journal Article Skin cancer-associated S. aureus strains can induce DNA damage in human keratinocytes by downregulating DNA repair and promoting oxidative stressKrueger, Annika, Mohamed, Ahmed, Kolka, Cathryn M., Stoll, Thomas, Zaugg, Julian, Linedale, Richard, Morrison, Mark, Soyer, H. Peter, Hugenholtz, Philip, Frazer, Ian H. and Hill, Michelle M. (2022). Skin cancer-associated S. aureus strains can induce DNA damage in human keratinocytes by downregulating DNA repair and promoting oxidative stress. Cancers, 14 (9) 2143, 2143. doi: 10.3390/cancers14092143 |
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2022 Journal Article Analysis of human leukocyte antigen associations in human papillomavirus–positive and –negative head and neck cancer: Comparison with cervical cancerEkanayake Weeramange, Chameera, Shu, Danhua, Tang, Kai Dun, Batra, Jyotsna, Ladwa, Rahul, Kenny, Lizbeth, Vasani, Sarju, Frazer, Ian H., Dolcetti, Riccardo, Ellis, Jonathan J., Sturm, Richard A., Leo, Paul and Punyadeera, Chamindie (2022). Analysis of human leukocyte antigen associations in human papillomavirus–positive and –negative head and neck cancer: Comparison with cervical cancer. Cancer, 128 (10), 1937-1947. doi: 10.1002/cncr.34148 |
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2022 Journal Article Changes in the skin microbiome associated with squamous cell carcinoma in transplant recipientsKrueger, Annika, Zaugg, Julian, Lachner, Nancy, Bialasiewicz, Seweryn, Lin, Lynlee L., Gabizon, Sharon, Sobarun, Priyamvada, Morrison, Mark, Soyer, H. Peter, Hugenholtz, Philip and Frazer, Ian H. (2022). Changes in the skin microbiome associated with squamous cell carcinoma in transplant recipients. ISME Communications, 2 (1) 13, 13. doi: 10.1038/s43705-022-00095-7 |
