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Non-viral vectors for targeted delivery of RNAi nucleotides to cervical cancers (2007-2009)

Abstract

RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using RNA interference we can turn off the expression of these two genes which results in the death of the cancer cell. We are also able to cure mice of tumours derived from human cervical cancer. The major issue with gene silencing is how to deliver it effectively to patients. Here we are investigating novel nanoparticulate systems to deliver this new gene-inhibiting drugs preferentially to the tumour site.

Experts

Dr Harendra Parekh

Senior Lecturer
School of Pharmacy
Faculty of Health and Behavioural Sciences
Harendra Parekh
Harendra Parekh

Professor Ian Frazer

Emeritus Professor
Faculty of Medicine
Ian Frazer
Ian Frazer