Professor Trent Woodruff
Professor

Trent Woodruff

Email: 
Phone: 
+61 7 336 52924

Background

Dr Woodruff is a Professor of Pharmacology who leads a research team aiming to find new therapeutic treatments for neurodegenerative disorders. Current therapies for these diseases are vastly inadequate, and so new research is needed to identify novel targets to slow or halt their progression. Prof Woodruff’s specific research revolves around the innate immune system in the brain, and the role of neuroinflammation in propagating disease. A key focus of his current work is testing new drugs developed at the University of Queensland in models of motor neuron disease (amyotrophic lateral sclerosis), Huntington’s disease, and Parkinson's disease, as well as maintaining an active interest in acute inflammatory disorders including sepsis and ischemia-reperfusion injuries. Using a series of potent and orally active complement C5a and NLRP3 inflammasome inhibitors developed at UQ, Prof Woodruff's team has demonstrated the therapeutic potential of targeting innate immune-mediated neuroinflammation to reduce neuronal cell death in animal models of these neurodegenerative diseases. His team has recently shown that in addition to their roles in neurodegeneration, innate immune factors also play essential roles in stem and neuronal cell development during embryogenesis, revealing the widespread physiological and pathological roles of this evolutionarily ancient immune system.

Availability

Professor Trent Woodruff is:
Available for supervision
Media expert

Fields of research

Immunology Neurosciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Neurodegenerative disease

    Studying new treatments to halt disease progression

  • Parkinson's disease

    Studying new treatments to halt disease progression

  • Motor neuron disease

    Studying new treatments to halt disease progression

Search Professor Trent Woodruff’s works on UQ eSpace

309 works between 2000 and 2024
All (309) Journal Article (234) Book Chapter (10) Conference Publication (64) Other Outputs (1)

21 - 40 of 309 works

Featured

2020

Journal Article

Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis

McGill, Raquel B., Steyn, Frederik J., Ngo, Shyuan T., Thorpe, Kathryn A., Heggie, Susan, Ruitenberg, Marc J., Henderson, Robert D., McCombe, Pamela A. and Woodruff, Trent M. (2020). Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. Brain Communications, 2 (1) fcaa013, fcaa013. doi: 10.1093/braincomms/fcaa013

Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis

Featured

2020

Journal Article

The complement C5a-C5aR1 GPCR axis in COVID-19 therapeutics

Woodruff, Trent M. and Shukla, Arun K. (2020). The complement C5a-C5aR1 GPCR axis in COVID-19 therapeutics. Trends in Immunology, 41 (11), 965-967. doi: 10.1016/j.it.2020.09.008

The complement C5a-C5aR1 GPCR axis in COVID-19 therapeutics

Featured

2018

Journal Article

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Featured

2018

Journal Article

Complement: the emerging architect of the developing brain

Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). Complement: the emerging architect of the developing brain. Trends in Neurosciences, 41 (6), 373-384. doi: 10.1016/j.tins.2018.03.009

Complement: the emerging architect of the developing brain

Featured

2017

Journal Article

Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ

Coulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017). Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 (22), 5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017

Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ

Featured

2017

Journal Article

Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Lee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730

Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Featured

2016

Journal Article

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

Featured

2014

Journal Article

Role for terminal complement activation in amyotrophic lateral sclerosis disease progression

Woodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111

Role for terminal complement activation in amyotrophic lateral sclerosis disease progression

Featured

2013

Journal Article

The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization

Wu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110

The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization

2024

Journal Article

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

Stables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743, 106743. doi: 10.1016/j.nbd.2024.106743

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

2024

Journal Article

Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment

Snelson, Matthew, Deliyanti, Devy, Tan, Sih Min, Drake, Anna M., de Pasquale, Cassandra, Kumar, Vinod, Woodruff, Trent M., Wilkinson-Berka, Jennifer L. and Coughlan, Melinda T. (2024). Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment. Nutrition and Diabetes, 14 (1) 46, 1-9. doi: 10.1038/s41387-024-00305-2

Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment

2024

Journal Article

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A. ... Olcina, Monica M. (2024). Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 134 (16). doi: 10.1172/jci185067

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

2024

Journal Article

Sex differences in Huntington's disease from a neuroinflammation perspective

Risby-Jones, Grace, Lee, John D., Woodruff, Trent M. and Fung, Jenny N. (2024). Sex differences in Huntington's disease from a neuroinflammation perspective. Frontiers in Neurology, 15 1384480, 1-7. doi: 10.3389/fneur.2024.1384480

Sex differences in Huntington's disease from a neuroinflammation perspective

2024

Conference Publication

C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environment

Ahmari, Niousha, Perrino, Melissa, Pundavela, Jay, Szabo, Sara, Woodruff, Trent, Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environment. American Society for Pharmacology and Experimental Therapeutics. doi: 10.1124/jpet.249.988670

C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environment

2024

Journal Article

Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure

Chen, Hsiao-Jou Cortina, Spiers, Jereme G., Lerskiatiphanich, Titaya, Parker, Sandra E., Lavidis, Nickolas A., Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2024). Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure. Biological Psychiatry: Global Open Science, 4 (3) 100306, 100306. doi: 10.1016/j.bpsgos.2024.100306

Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure

2024

Conference Publication

Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironments

Beach, Callum, MacLean, David, Majorova, Dominika, Valbuena, Gabriel N., Damavandi, Mahnaz Darvish, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Moon, Eui Jung, Guglietta, Silvia, Krieg, Carsten, Woodruff, Trent M., Maughan, Tim, Buczacki, Simon J.A., Leedham, Simon J., Giaccia, Amato J., Clark, Heather and Olcina, Monica M. (2024). Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironments. ESTRO meets Asia 2024, Kuala Lumpur, Malaysia, 23-25 August 2024. Shannon, Ireland: Elsevier. doi: 10.1016/s0167-8140(24)01225-8

Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironments

2024

Journal Article

C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis

Perrino, Melissa R., Ahmari, Niousha, Hall, Ashley, Jackson, Mark, Na, Youjin, Pundavela, Jay, Szabo, Sara, Woodruff, Trent M., Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis. Life Science Alliance, 7 (5) e202302229, 1-16. doi: 10.26508/lsa.202302229

C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis

2024

Journal Article

A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosis

Vassileff, Natasha, Spiers, Jereme G., Lee, John D., Woodruff, Trent M., Ebrahimie, Esmaeil, Mohammadi Dehcheshmeh, Manijeh, Hill, Andrew F. and Cheng, Lesley (2024). A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosis. Molecular Neurobiology, 61 (8), 5901-5915. doi: 10.1007/s12035-023-03857-z

A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosis

2024

Book Chapter

The role of the complement system in cancer etiology and management

Sonderegger, Stefan E., Manzanero, Silvia, Woodruff, Trent M., Farouqa, Jad, Nabizadeh, Jamileh, Panagides, Nadya and Rolfe, Barbara E. (2024). The role of the complement system in cancer etiology and management. Clinical immuno-oncology. (pp. 41-60.e10) edited by John E. Niederhuber. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-323-87763-3.00012-5

The role of the complement system in cancer etiology and management

2023

Journal Article

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Alexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al-hosaini, Khaled, Back, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean-Martin, Beck-Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne ... Ye, Richard D. (2023). The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180, S23-S144. doi: 10.1111/bph.16177

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Current funding

  • 2024 - 2027
    Preclinical development of complement C5a receptor 2 modulators for motor neuron disease
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2024 - 2025
    Examining the efficacy of monepantel in the 6-OHDA model of Parkinson's disease
    PharmAust Limited
    Open grant
  • 2024 - 2025
    Investigating the pharmacological activity of monepantel on autophagy in the NSC-34 motor neuron cell line
    PharmAust Limited
    Open grant
  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2023 - 2024
    Inhibiting complement C5a receptors to improve heart function in type 2 diabetes (DARP Grant administered by Monash University
    Monash University
    Open grant
  • 2022 - 2025
    Therapeutic Inhibition of Neutrophil Activity as a Disease-Modifying Treatment for Amyotrophic Lateral Sclerosis
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant
  • 2022 - 2025
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2026
    Developing new therapies targeting innate immune mediated inflammation in neurodegenerative disease
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2023 - 2024
    Therapeutic potential of targeting one of the core players of inflammation (Inflammasome) in MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2024
    C9orf72 dipeptide-mediated activation of microglia as a therapeutic target for MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2022 - 2024
    Profiling monocytes in MND to assess disease progression and heterogeneity
    Cure for MND Foundation - Impact Grants
    Open grant
  • 2022 - 2023
    An integrated analytical network for protein characterisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2022 - 2024
    Developing FXIIa inhibitors as next-generation anticoagulants
    NHMRC Development Grant
    Open grant
  • 2021
    Transcriptomic and Functional Evaluation of Immune-Activated Monocytes in MND
    Motor Neurone Disease Research Institute of Australia Inc Linda Rynalski Bridge Funding Grant
    Open grant
  • 2021 - 2023
    Complement C5aR1: A novel therapeutic target for brain cancer
    Brain Cancer Innovation Project Grants
    Open grant
  • 2021 - 2023
    Targeting complement C5a receptor 2 as a disease-modifying treatment for motor neuron disease
    NHMRC Development Grant
    Open grant
  • 2020 - 2021
    Inflammatory biomarkers in 6-OHDA mouse model of Parkinson's disease
    UniQuest Pty Ltd
    Open grant
  • 2020 - 2024
    Preclinical development of centrally active complement C3a receptor modulators as disease-modifying drugs for motor neuron disease
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2020 - 2022
    Investigating the PROfile of complement activation in relation to Vasospasm, delayed cerebral Ischaemia and aneurysmal Subarachnoid haemorrhage Outcomes (ProcVISO Study) (administered by RBWH)
    Metro North Hospital and Health Service
    Open grant
  • 2020 - 2021
    Transcriptomic and Functional Evaluation of Immune-Activated Monocytes in MND.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2020 - 2021
    Investigating the therapeutic inhibition of CXCR2 as a disease modifying treatment for motor neurone disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2020 - 2022
    Eph receptor blockade to prevent and repair endothelial damage in systemic inflammation
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2020
    Investigating the beneficial effects of complement C3aR on immune cell glucose metabolism in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2019 - 2020
    Manipulation of free fatty acid receptors to tame the immune response in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2023
    Harnessing the Innate Immune System to Target Cancer: A Novel Immunotherapeutic Strategy for Solid Tumours
    NHMRC Development Grant
    Open grant
  • 2019 - 2020
    Role of NLRP3 inflammasome activation in the prognosis of secondary progressive multiple sclerosis
    Metro North Hospital and Health Service
    Open grant
  • 2019 - 2022
    Understanding the mechanism of action for intravenous immunoglobulin (IVIG) therapy in spinal cord injury
    NHMRC Project Grant
    Open grant
  • 2018 - 2019
    Targeting peripheral inflammatory pathology in Parkinson's disease using repurposed drugs
    Wesley Medical Research Ltd
    Open grant
  • 2018 - 2019
    Therapeutic inhibition of the terminal complement pathway as a disease-modifying treatment for motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2018 - 2019
    Therapeutic testing of the clinical candidate drug PMX205 in a TDP43-based model of MND and its mechanism
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2018 - 2020
    Therapeutic potential of inhibiting Eph/ephrin signalling to repair the vascular endothelium in septic shock
    NHMRC Project Grant
    Open grant
  • 2018 - 2022
    Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    A potential role for C5a antagonism in the medical management of feline hypertrophic cardiornyopathy
    Peter & Mary Ellen Stone Memorial Fund
    Open grant
  • 2017 - 2019
    Defining inflammatory biomarkers in motor neuron disease patients to assist in clinical trial efficiency of the C5aR antagonist PMX205
    Wesley Medical Research Ltd
    Open grant
  • 2017 - 2020
    New Treatments for Brain Disease
    Queensland Government Advance Queensland Innovation Partnerships
    Open grant
  • 2017 - 2023
    The Queensland Drug Repurposing Initiative
    Queensland Government Advance Queensland Innovation Partnerships
    Open grant
  • 2017 - 2019
    Is there a potential therapeutic role for Eph/ephrin signalling blockade in children with severe sepsis?
    Financial Markets Foundation for Children
    Open grant
  • 2017 - 2018
    Therapeutic inhibition of HMGB1 to slow disease progression in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2021
    Preclinical Development of Complement C5aR Antagonists for the Treatment of Motor Neuron Disease
    NHMRC Development Grant
    Open grant
  • 2016 - 2018
    Pharmacological Targeting of Proinflammatory Kinase Signalling in Parkinson's disease
    The Michael J Fox Foundation for Parkinsons Research
    Open grant
  • 2016 - 2020
    Blocking inflammasome-induced neuroinflammation in PD with a potent, orally available small molecule
    The Michael J Fox Foundation Therapeutic Pipeline Program
    Open grant
  • 2016 - 2018
    Is there a potential therapeutic role for Eph/ephrin signalling blockade in patients with septic shock?
    Bayer Pharma AG
    Open grant
  • 2016 - 2017
    Development of complement C5aR1 antagonists for the treatment of motor neuron disease
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2016 - 2017
    Exploiting the opposing actions of complement receptors C3aR and C5aR1 in the treatment of MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016 - 2020
    Therapeutic targeting of neuroinflammation to slow the progression of neurodegenerative disease
    NHMRC Career Development Fellowship
    Open grant
  • 2016
    Exosome and Bio/Nanoparticle Characterisation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2018
    Targeting the Complement Cascade: A Novel Therapeutic Strategy for Metastatic Melanoma
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Pharmacological targeting of the NLRP3 inflammasome in pre-clinical models of Parkinson's disease using a potent orally active inhibitor
    The Michael J Fox Foundation for Parkinsons Research
    Open grant
  • 2015 - 2017
    Complement activation as a therapeutic target and clinical biomarker for Parkinson's disease
    NHMRC Project Grant
    Open grant
  • 2015 - 2020
    Determining the contribution of peripheral immune complement signalling in the progression of motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Inhibitors of NLRP3 activation for treatment of inflammatory CNS diseases
    NHMRC Project Grant
    Open grant
  • 2015
    Therapeutic targeting of inflammation in Parkinson's disease
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2015 - 2016
    Therapeutic targeting of the NLRP3 inflammasome using a potent and orally active inhibitor in experimental MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2014 - 2015
    Development of a rapid ex vivo screening assay for immunotoxicity of nanoparticles
    UQ Collaboration and Industry Engagement Fund - Seed Research Grant
    Open grant
  • 2014
    Innate immune complement signalling in peripheral immune cells during the progression of motor neurone disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2016
    Investigating the Role of the Innate Immune Complement System in the Abnormal Development of the Central Nervous System
    ARC Future Fellowships
    Open grant
  • 2012 - 2014
    Contribution of Complement C5a to Neuronal Cell Death during Ischemic Stroke
    NHMRC Project Grant
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Microdialysis to monitor fluid shifts and predict organ failure in the systemic inflammatory response syndrome
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Molecular Stereology Facility Upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Real time regional tissue analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    The role of the innate immune system during the progression of motor neuron disease; the search for new therapeutic targets
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2011 - 2013
    Therapeutic Targeting of Complement C5a Receptors in Huntington's Disease
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    Therapeutic modulation of the innate immune complement system as a new and adjunct therapy to treat a wide variety of cancers
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2010 - 2013
    Development of chaperonin 10-based second generation biopharmaceuticals for treatment of inflammatory diseases
    ARC Linkage Projects
    Open grant
  • 2010 - 2012
    Complement activation in experimental epilepsy: role of C5a receptors
    NHMRC Project Grant
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2010 - 2011
    Notch-1 contributes to neuronal cell death and glial inflammation by modulating NFkappaB activity in ischaemic stroke
    National Heart Foundation of Australia
    Open grant
  • 2009 - 2011
    Characterizing novel therapeutic interventions in a new model of focal retinopathy
    NHMRC Project Grant
    Open grant
  • 2009 - 2013
    Complement C5a Receptors , Placental Inflammation and Reproductive Impairment.
    NHMRC Project Grant
    Open grant
  • 2009
    Liquid Scintillation Spectroscopy Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Role of Complements Anaphylatoxin Receptors in Experimental Stroke
    UQ Early Career Researcher
    Open grant
  • 2008 - 2010
    Characterisation of the effect of C5a receptor antagonists against the C5a-like receptor 2 (C5L2)
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2008 - 2010
    Establishment of therapeutically relevant animal models and markers for Crohn's Disease
    ARC Linkage Projects
    Open grant
  • 2008 - 2012
    NHMRC Career Development Award (Biomedical - Level 1): The role of the complement system in neurodegeneration and the therapeutic potential of complement inhibition
    NHMRC Career Development Award
    Open grant
  • 2008
    Role of the complement system in the healthy and diseased central nervous system
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    Scientific Visit - Protective actions of novel anti-inflammatory agents in neurotoxin-damaged neuronal cultures mimicking Parkinson's disease
    Australian Academy of Science
    Open grant
  • 2005
    The effectiveness of C5a receptor antagonists in the treatment of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant

Availability

Professor Trent Woodruff is:
Available for supervision

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Available projects

  • Role of immune and inflammatory pathways in the progression of neurodegenerative disease

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Professor Trent Woodruff directly for media enquiries about:

  • Drug Development
  • Huntington's disease
  • motor neuron disese
  • Neurodegenerative disease
  • Parkinson's disease

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