Overview
Background
Dr Jenny Fung is a senior postdoctoral research fellow and lecturer of pharmacology course at the School of Biomedical Sciences (SBMS), UQ. She is an emerging researcher in the reproductive disease field with experience in molecular biology techniques, genetics, functional genomics, statistical and high-throughput computational skills, ex-vivo and in-vivo models of diseases, as well as industry engagement. In 2013, she was awarded a PhD at UQ and continued post-doctoral research in Professor Grant Montgomery's laboratory at QIMRB and IMB, in the field of genetics and genomics with a focus on functional genomics studies in complex diseases and a special interest in endometriosis. Her research has led to the seminal publication identifying the genetics of gene expression in endometrium and the role of gene regulation underlying endometriosis-related pathogenesis. In 2019, she joined Professor Trent Woodruff’s laboratory at SBMS, UQ to work on immunotherapy development for cancer through funding from Pfizer, where she performed immune cell functional assays and genomics analyses. Dr Fung is in a unique position to perform both the wet and dry lab components of multi-disciplinary research. She is currently co-leading multiple projects, where she is contributing her expertise on genetics and functional genomics on immunology to discover target genes and putative pathways underlying disease progression, with an ultimate goal to develop potential effective drugs for reproductive and brain disorders.
Availability
- Dr Jenny Fung is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Jenny Fung’s works on UQ eSpace
2024
Journal Article
Sex differences in Huntington's disease from a neuroinflammation perspective
Risby-Jones, Grace, Lee, John D., Woodruff, Trent M. and Fung, Jenny N. (2024). Sex differences in Huntington's disease from a neuroinflammation perspective. Frontiers in Neurology, 15 1384480, 1-7. doi: 10.3389/fneur.2024.1384480
2024
Journal Article
Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure
Chen, Hsiao-Jou Cortina, Spiers, Jereme G., Lerskiatiphanich, Titaya, Parker, Sandra E., Lavidis, Nickolas A., Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2024). Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure. Biological Psychiatry: Global Open Science, 4 (3) 100306, 100306. doi: 10.1016/j.bpsgos.2024.100306
2024
Journal Article
Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing
Li, Xaria X., Fung, Jenny N., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2024). Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. Proceedings of the National Academy of Sciences, 121 (5) e2314627121, 1-10. doi: 10.1073/pnas.2314627121
2023
Journal Article
A molecular staging model for accurately dating the endometrial biopsy
Teh, W. T., Chung, J., Holdsworth-Carson, S. J., Donoghue, J. F., Healey, M., Rees, H. C., Bittinger, S., Obers, V., Sloggett, C., Kendarsari, R., Fung, J. N., Mortlock, S., Montgomery, G. W., Girling, J. E. and Rogers, P. A. W. (2023). A molecular staging model for accurately dating the endometrial biopsy. Nature Communications, 14 (1) 6222, 6222. doi: 10.1038/s41467-023-41979-z
2023
Journal Article
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Rahmioglu, Nilufer, Mortlock, Sally, Ghiasi, Marzieh, Møller, Peter L., Stefansdottir, Lilja, Galarneau, Geneviève, Turman, Constance, Danning, Rebecca, Law, Matthew H., Sapkota, Yadav, Christofidou, Paraskevi, Skarp, Sini, Giri, Ayush, Banasik, Karina, Krassowski, Michal, Lepamets, Maarja, Marciniak, Błażej, Nõukas, Margit, Perro, Danielle, Sliz, Eeva, Sobalska-Kwapis, Marta, Thorleifsson, Gudmar, Topbas-Selcuki, Nura F., Vitonis, Allison, Westergaard, David, Arnadottir, Ragnheidur, Burgdorf, Kristoffer S., Campbell, Archie, Cheuk, Cecilia S. K. ... The 23andMe Research Team (2023). The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nature Genetics, 55 (3), 423-436. doi: 10.1038/s41588-023-01323-z
2023
Journal Article
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0
2022
Book Chapter
Neuroinflammation in Huntington’s
Lee, John D., Lo, Martin W., Fung, Jenny N. T. and Woodruff, Trent M. (2022). Neuroinflammation in Huntington’s. Neurodegenerative Diseases Biomarkers. (pp. 215-233) edited by Philip V. Peplow, Bridget Martinez and Thomas A. Gennarelli. New York, NY, United States: Springer US. doi: 10.1007/978-1-0716-1712-0_9
2021
Journal Article
Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity
Gorman, Declan M., Li, Xaria X., Lee, John D., Fung, Jenny N., Cui, Cedric S., Lee, Han Siean, Rolfe, Barbara E., Woodruff, Trent M. and Clark, Richard J. (2021). Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. Journal of Medicinal Chemistry, 64 (22) acs.jmedchem.1c01174, 16598-16608. doi: 10.1021/acs.jmedchem.1c01174
2021
Journal Article
Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism
McDonald, Tanya S., Kumar, Vinod, Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2021). Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism. The FASEB Journal, 35 (7) e21707, e21707. doi: 10.1096/fj.202002450r
2021
Journal Article
Elucidating the role of long intergenic non-coding RNA 339 in human endometrium and endometriosis
Holdsworth-Carson, Sarah J., Churchill, Molly, Donoghue, Jacqueline F., Mortlock, Sally, Fung, Jenny N., Sloggett, Clare, Chung, Jessica, Cann, Leonie, Teh, Wan Tinn, Campbell, Katie-Rose, Luwor, Rodney, Healey, Martin, Montgomery, Grant, Girling, Jane E. and Rogers, Peter A. W. (2021). Elucidating the role of long intergenic non-coding RNA 339 in human endometrium and endometriosis. Molecular Human Reproduction, 27 (3) gaab010. doi: 10.1093/molehr/gaab010
2021
Journal Article
An immunoregulatory role for complement receptors in murine models of breast cancer
Akhir, Fazrena Nadia Md, Noor, Mohd Hezmee Mohd, Leong, Keith Weng Kit, Nabizadeh, Jamileh A., Manthey, Helga D., Sonderegger, Stefan E., Fung, Jenny Nga Ting, McGirr, Crystal E., Shiels, Ian A., Mills, Paul C., Woodruff, Trent M. and Rolfe, Barbara E. (2021). An immunoregulatory role for complement receptors in murine models of breast cancer. Antibodies, 10 (1) 2, 1-12. doi: 10.3390/antib10010002
2021
Journal Article
Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium
Marla, S., Mortlock, S., Houshdaran, S., Fung, J., McKinnon, B., Holdsworth-Carson, S. J., Girling, J. E., Rogers, P. A. W., Giudice, L. C. and Montgomery, G. W. (2021). Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium. Molecular Human Reproduction, 27 (1) gaaa082. doi: 10.1093/molehr/gaaa082
2020
Journal Article
Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis
Lee, John D., McDonald, Tanya S., Fung, Jenny N. T. and Woodruff, Trent M. (2020). Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis. Molecular Neurobiology, 57 (10), 4143-4155. doi: 10.1007/s12035-020-02019-9
2020
Journal Article
Tissue specific regulation of transcription in endometrium and association with disease
Mortlock, Sally, Kendarsari, Raden I., Fung, Jenny N., Gibson, Greg, Yang, Fei, Restuadi, Restuadi, Girling, Jane E., Holdsworth-Carson, Sarah J., Teh, Wan Tinn, Lukowski, Samuel W., Healey, Martin, Qi, Ting, Rogers, Peter A. W., Yang, Jian, McKinnon, Brett and Montgomery, Grant W. (2020). Tissue specific regulation of transcription in endometrium and association with disease. Human Reproduction, 35 (2), 377-393. doi: 10.1093/humrep/dez279
2020
Journal Article
Obesity does not alter endometrial gene expression in women with endometriosis
Holdsworth-Carson, Sarah J, Chung, Jessica, Sloggett, Clare, Mortlock, Sally, Fung, Jenny N., Montgomery, Grant W., Dior, Uri P., Healey, Martin, Rogers, Peter A.W. and Girling, Jane E. (2020). Obesity does not alter endometrial gene expression in women with endometriosis. Reproductive BioMedicine Online, 41 (1), 113-118. doi: 10.1016/j.rbmo.2020.03.015
2019
Journal Article
Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases
Mortlock, Sally, Restuadi, Restuadi, Levien, Rupert, Girling, Jane E., Holdsworth-Carson, Sarah J., Healey, Martin, Zhu, Zhihong, Qi, Ting, Wu, Yang, Lukowski, Samuel W., Rogers, Peter A. W., Yang, Jian, McRae, Allan F., Fung, Jenny N. and Montgomery, Grant W. (2019). Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Clinical Epigenetics, 11 (1) 49, 49. doi: 10.1186/s13148-019-0648-7
2019
Journal Article
Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes
Holdsworth-Carson, S. J., Colgrave, E. M., Donoghue, J. F., Fung, J. N., Churchill, M. L., Mortlock, S., Paiva, P., Healey, M., Montgomery, G. W., Girling, J. E. and Rogers, P. A. W. (2019). Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes. MHR: Basic science of reproductive medicine, 25 (4), 194-205. doi: 10.1093/molehr/gaz006
2019
Conference Publication
Identifying Target Genes for Endometriosis through Integration of Genetic Effects on Transcription and Methylation in Human Endometrium
Mortlock, Sally, Fung, Jenny N., Girling, Jane E., Holdsworth-Carson, Sarah J., Healey, Martin, Lukowski, Samuel W., McKinnon, Brett D., Yang, Jian, McRae, Allan, Rogers, Peter A. W. and Montgomery, Grant W. (2019). Identifying Target Genes for Endometriosis through Integration of Genetic Effects on Transcription and Methylation in Human Endometrium. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage.
2019
Conference Publication
Obesity Does Not Impact on Endometrial Gene Expression in Women with Endometriosis
Holdsworth-Carson, Sarah J., Chung, Jessica, Healey, Martin, Fung, Jenny N., Montgomery, Grant, Rogers, Peter and Girling, Jane (2019). Obesity Does Not Impact on Endometrial Gene Expression in Women with Endometriosis. 66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Paris, France, 12-16 March 2019 . Thousand Oaks, CA, United States: Sage.
2019
Conference Publication
Generation of Immortalized Human Endometrial Stromal Cell Lines with Different Endometriosis Risk Genotypes
Holdsworth-Carson, Sarah J., Donoghue, Jacqueline, Colgrave, Eliza, Fung, Jenny N., Churchill, Molly, Healey, Martin, Montgomery, Grant, Girling, Jane and Rogers, Peter (2019). Generation of Immortalized Human Endometrial Stromal Cell Lines with Different Endometriosis Risk Genotypes. 66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage.
Funding
Past funding
Supervision
Availability
- Dr Jenny Fung is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The potential role of CXCR2 activation in motor neuron disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Professor Pamela McCombe, Dr John Lee
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Doctor Philosophy
Unravelling the Role of Astrocytes in Motor Neuron Disease to discover new therapeutic targets
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr John Lee
-
Doctor Philosophy
The potential role of CXCR2 activation in motor neuron disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Professor Pamela McCombe, Dr John Lee
-
Doctor Philosophy
The role of terminal complement pathway in neurodevelopment
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr John Lee
-
Doctor Philosophy
The role of neuronal complement activation in Motor Neuron Disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr John Lee
-
Doctor Philosophy
The Role of Neutrophils in Motor Neuron Disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Professor Pamela McCombe, Dr John Lee, Dr Cedric Cui
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Doctor Philosophy
The role of terminal complement pathway in neurodevelopment
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr John Lee
Media
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