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2025 Journal Article IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microgliaRisby-Jones, Grace, Marallag, Jianina, Jagaraj, Cyril Jones, Atkin, Julie D., Walker, Adam K., Woodruff, Trent M., Lee, John D. and Fung, Jenny N. (2025). IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microglia. Brain, Behavior, and Immunity, 129, 296-304. doi: 10.1016/j.bbi.2025.06.021 |
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2025 Journal Article Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trialFung, Jenny, Lee, John and Woodruff, Trent (2025). Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trial. Immunobiology, 230 (4) 153003, 35-35. doi: 10.1016/j.imbio.2025.153003 |
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2025 Journal Article Genetic variants in complement-related genes: potential implications for cancer risk and progressionFung, Jenny N. and Pio, Ruben (2025). Genetic variants in complement-related genes: potential implications for cancer risk and progression. Immunobiology, 230 (4) 153100, 153100-4. doi: 10.1016/j.imbio.2025.153100 |
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2025 Journal Article Investigating the role of neuronally-expressed C5aR1 in motor neuron diseaseRisby-Jones, Grace, Woodruff, Trent M., Fung, Jenny N. and Lee, John D. (2025). Investigating the role of neuronally-expressed C5aR1 in motor neuron disease. Immunobiology, 230 (4) 153079, 68-68. doi: 10.1016/j.imbio.2025.153079 |
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2025 Journal Article Complement C3a receptor signalling mitigates motor neuron degeneration by modulating neurotoxic astrocytesJulianisya, Alana R., Fung, Jenny N.T., Lerskiatiphanich, Titaya, Woodruff, Trent M. and Lee, John D. (2025). Complement C3a receptor signalling mitigates motor neuron degeneration by modulating neurotoxic astrocytes. Immunobiology, 230 (4) 153081, 69-69. doi: 10.1016/j.imbio.2025.153081 |
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2025 Conference Publication A detrimental role for complement C5aR1 activation in Huntington’s diseaseMarallag, Jianina, Fung, Jenny, Lee, John and Woodruff, Trent (2025). A detrimental role for complement C5aR1 activation in Huntington’s disease. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153080 |
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2025 Journal Article Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesisRead, Austin, Lee, John, Fung, Jenny and Woodruff, Trent (2025). Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesis. Immunobiology, 230 (4) 153063, 61-61. doi: 10.1016/j.imbio.2025.153063 |
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2025 Journal Article Investigating complement receptor C3aR1 signalling in metabolic dysfunction in the R6/1 mouse model of Huntington’s diseaseLerskiatiphanich, Titaya, McDonald, Tanya, Cui, Cedric, Fung, Jenny, Woodruff, Trent and Lee, John (2025). Investigating complement receptor C3aR1 signalling in metabolic dysfunction in the R6/1 mouse model of Huntington’s disease. Immunobiology, 230 (4) 153064, 61-62. doi: 10.1016/j.imbio.2025.153064 |
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2025 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Dent, Joshua, Gorman, Declan, Li, Xaria, Wu, Xiaosa, Cui, Cedric, Fung, Jenny, Lee, John, Rosengren, Johan and Woodruff, Trent (2025). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153001 |
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2025 Conference Publication Concurrent spatial transcriptomics and metabolomics map differential effects of drug across brain cancer tissuesVo, Tuan, Cui, Cedric, Causer, Andrew, Tan, Xiao, Kim, Eunju, Xiong, Zherui, Vu, Hani, Hodson, Mark, Lu, Tianyao, Freytag, Saskia, Fung, Jenny, Lee, John and Nguyen, Quan (2025). Concurrent spatial transcriptomics and metabolomics map differential effects of drug across brain cancer tissues. AACR Annual Meeting 2025, 25-30 April 2025, Chicago, IL USA. Washington, DC USA: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-5067 |
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2025 Journal Article Peripheral and central elevation of IL-8 in patients with Huntington’s diseaseFung, Jenny N., Lee, John D., Adam, Robert, O’Sullivan, John D. and Woodruff, Trent M. (2025). Peripheral and central elevation of IL-8 in patients with Huntington’s disease. Molecular Immunology, 179, 84-93. doi: 10.1016/j.molimm.2025.02.003 |
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2024 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Gorman, Declan, Li, Xaria, Dent, Joshua, Cui, Cedric, Lee, Han Siean, Fung, Jenny, Lee, John, Rosengren, K. Johan and Woodruff, Trent (2024). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
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2024 Journal Article Sex differences in Huntington's disease from a neuroinflammation perspectiveRisby-Jones, Grace, Lee, John D., Woodruff, Trent M. and Fung, Jenny N. (2024). Sex differences in Huntington's disease from a neuroinflammation perspective. Frontiers in Neurology, 15 1384480, 1-7. doi: 10.3389/fneur.2024.1384480 |
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2024 Journal Article Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposureChen, Hsiao-Jou Cortina, Spiers, Jereme G., Lerskiatiphanich, Titaya, Parker, Sandra E., Lavidis, Nickolas A., Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2024). Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure. Biological Psychiatry: Global Open Science, 4 (3) 100306, 100306. doi: 10.1016/j.bpsgos.2024.100306 |
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2024 Journal Article Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killingLi, Xaria X., Fung, Jenny N., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2024). Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. Proceedings of the National Academy of Sciences, 121 (5) e2314627121, 1-10. doi: 10.1073/pnas.2314627121 |
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2023 Journal Article A molecular staging model for accurately dating the endometrial biopsyTeh, W. T., Chung, J., Holdsworth-Carson, S. J., Donoghue, J. F., Healey, M., Rees, H. C., Bittinger, S., Obers, V., Sloggett, C., Kendarsari, R., Fung, J. N., Mortlock, S., Montgomery, G. W., Girling, J. E. and Rogers, P. A. W. (2023). A molecular staging model for accurately dating the endometrial biopsy. Nature Communications, 14 (1) 6222, 6222. doi: 10.1038/s41467-023-41979-z |
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2023 Journal Article The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditionsRahmioglu, Nilufer, Mortlock, Sally, Ghiasi, Marzieh, Møller, Peter L., Stefansdottir, Lilja, Galarneau, Geneviève, Turman, Constance, Danning, Rebecca, Law, Matthew H., Sapkota, Yadav, Christofidou, Paraskevi, Skarp, Sini, Giri, Ayush, Banasik, Karina, Krassowski, Michal, Lepamets, Maarja, Marciniak, Błażej, Nõukas, Margit, Perro, Danielle, Sliz, Eeva, Sobalska-Kwapis, Marta, Thorleifsson, Gudmar, Topbas-Selcuki, Nura F., Vitonis, Allison, Westergaard, David, Arnadottir, Ragnheidur, Burgdorf, Kristoffer S., Campbell, Archie, Cheuk, Cecilia S. K. ... The 23andMe Research Team (2023). The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nature Genetics, 55 (3), 423-436. doi: 10.1038/s41588-023-01323-z |
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2023 Journal Article SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike proteinAlbornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0 |
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2022 Book Chapter Neuroinflammation in Huntington’sLee, John D., Lo, Martin W., Fung, Jenny N. T. and Woodruff, Trent M. (2022). Neuroinflammation in Huntington’s. Neurodegenerative Diseases Biomarkers. (pp. 215-233) edited by Philip V. Peplow, Bridget Martinez and Thomas A. Gennarelli. New York, NY, United States: Springer US. doi: 10.1007/978-1-0716-1712-0_9 |
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2021 Journal Article Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo ActivityGorman, Declan M., Li, Xaria X., Lee, John D., Fung, Jenny N., Cui, Cedric S., Lee, Han Siean, Rolfe, Barbara E., Woodruff, Trent M. and Clark, Richard J. (2021). Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. Journal of Medicinal Chemistry, 64 (22) acs.jmedchem.1c01174, 16598-16608. doi: 10.1021/acs.jmedchem.1c01174 |
