Associate Professor Fiona Simpson
Associate Professor

Fiona Simpson

Email: 
Phone: 
+61 7 344 36930

Background

PLEASE NOTE THAT ANY AUTHORSHIP ALTERATIONS LISTING ME AS SIMPSON-FRASER BELOW ARE INCORRECT. ALL PUBLICATIONS ARE FIONA SIMPSON. MY PROFESSIONAL NAME IS FIONA SIMPSON.

https://www.abc.net.au/radionational/programs/ockhamsrazor/the-tricky-business-of-cancer-research/9498246

Our laboratory is involved in cross-discipline research studying endocytosis, cancer, pharmacology and immunology to improve therapies used in cancer treatment.

Availability

Associate Professor Fiona Simpson is:
Available for supervision
Media expert

Fields of research

Biological Sciences Clinical sciences Genetics

Qualifications

  • Doctor of Philosophy, University of Cambridge
  • Bachelor (Honours) of Biochemistry, University of Edinburgh

Research interests

  • Changing the timing of anti-tumour therapy

    We are interested in slowing down or speeding up the delivery of drugs into tumour cells to maximise their anti-tumour activity and improve outcomes for cancer patients while reducing side-effects.

Search Professor Fiona Simpson’s works on UQ eSpace

84 works between 1993 and 2024
All (84) Journal Article (65) Book Chapter (2) Conference Publication (17)

41 - 60 of 84 works

2015

Journal Article

A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinoma

Hazar-Rethinam, Mehlika, Merida De Long, Lilia, Gannon, Orla M., Topkas, Eleni, Boros, Samuel, Vargas, Ana Cristina, Dzienis, Marcin, Mukhopadhyay, Pamela, Simpson, Fiona, Endo-Munoz, Liliana and Saunders, Nicholas A. (2015). A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinoma. Clinical Cancer Research, 21 (2), 417-427. doi: 10.1158/1078-0432.CCR-14-1962

A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinoma

2015

Book Chapter

Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma

Joseph, Shannon R., Endo-Munoz, Liliana, Gaffney, Daniel C., Saunders, Nicholas A. and Simpson, Fiona (2015). Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma. Actinic keratosis. (pp. 20-27) edited by H. Peter Soyer, Tarl W. Prow and Gregor B.E. Jemec. Basel, Switzerland: S Karger AG. doi: 10.1159/000367959

Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma

2015

Conference Publication

Calcium signalling and the acquisition of trastuzumab resistance in HER2 positive breast cancer cells

Kaemmerer, Elke, Pere, Elena, Peters, Amelia A., Yapa, Kunsala T. D. S., Simpson, Fiona, O'Donnell, Jake, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2015). Calcium signalling and the acquisition of trastuzumab resistance in HER2 positive breast cancer cells. APSA ASCEPT Joint Scientific Meeting 2015, Hobart, TAS Australia, 29 November - 2 December 2015.

Calcium signalling and the acquisition of trastuzumab resistance in HER2 positive breast cancer cells

2014

Journal Article

Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage

Freeman, Andrew, Bridge, Jennifer A., Maruthayanar, Pirashanthini, Overgaard, Nana H., Jung, Ji-Won, Simpson, Fiona, Prow, Tarl W., Soyer, H. Peter, Frazer, Ian H., Freeman, Michael and Wells, James W. (2014). Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage. PLoS One, 9 (10) e110928, e110928.1-e110928.9. doi: 10.1371/journal.pone.0110928

Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage

2014

Journal Article

The epidermal growth factor receptor in squamous cell carcinoma: an emerging drug target

Gaffney, Daniel C., Soyer, H. Peter and Simpson, Fiona (2014). The epidermal growth factor receptor in squamous cell carcinoma: an emerging drug target. Australasian Journal of Dermatology, 55 (1), 24-34. doi: 10.1111/ajd.12025

The epidermal growth factor receptor in squamous cell carcinoma: an emerging drug target

2014

Conference Publication

Single Agent Panitumumab in Patients With Incurable Cutaneous Squamous Cell Carcinoma: A Single-Center Phase 2 Study

Porceddu, S., Foote, M., McGrath, M., Guminski, A., Hughes, B., Meakin, J., Thomson, D., Thomson, D. and Simpson, F. (2014). Single Agent Panitumumab in Patients With Incurable Cutaneous Squamous Cell Carcinoma: A Single-Center Phase 2 Study. ELSEVIER SCIENCE INC. doi: 10.1016/j.ijrobp.2013.11.179

Single Agent Panitumumab in Patients With Incurable Cutaneous Squamous Cell Carcinoma: A Single-Center Phase 2 Study

2013

Conference Publication

Single agent panitumumab in patients with incurable cutaneous squamous cell carcinoma: A single centre phase II study

Foote, M., McGrath, M., Guminski, A., Hughes, B., Meakin, J., Thomson, D., Simpson, F. and Porceddu, S. (2013). Single agent panitumumab in patients with incurable cutaneous squamous cell carcinoma: A single centre phase II study. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam Netherlands, Sep 27-Oct 01, 2013. Oxford United Kingdom: Pergamon Press. doi: 10.1016/S0959-8049(13)70065-0

Single agent panitumumab in patients with incurable cutaneous squamous cell carcinoma: A single centre phase II study

2013

Conference Publication

E2F7 regulates sensitivity to the cytotoxic actions of anthracyclins in squamous cell carcinoma

Rethinam, Mehlika Hazar, Saunders, Nicholas and Simpson, Fiona (2013). E2F7 regulates sensitivity to the cytotoxic actions of anthracyclins in squamous cell carcinoma. 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington Dc, 6 - 10 April 2013. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1156/1538-7445.Alv2013-4359

E2F7 regulates sensitivity to the cytotoxic actions of anthracyclins in squamous cell carcinoma

2012

Journal Article

Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1

Hill, Michelle M., Daud, Noor Huda, Aung, Cho Sanda, Loo, Dorothy, Martin, Sally, Murphy, Samantha, Black, Debra M., Barry, Rachael, Simpson, Fiona, Liu, Libin, Pilch, Paul F, Hancock, John F., Marie-Odile Parat and Parton, Robert G. (2012). Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1. PLoS One, 7 (8) e43041, e43041.1-e43041.9. doi: 10.1371/journal.pone.0043041

Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1

2012

Journal Article

Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives

Saunders, Nicholas A., Simpson, Fiona, Thompson, Erik W., Hill, Michelle M., Endo-Munoz, Liliana, Leggatt, Graham, Minchin, Rodney F. and Guminski, Alexander (2012). Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives. EMBO Molecular Medicine, 4 (8), 675-684. doi: 10.1002/emmm.201101131

Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives

2011

Journal Article

KIAA0101 (KIAA0101)

Joseph, Shannon, Hu, Lingbo and Simpson, Fiona (2011). KIAA0101 (KIAA0101). Atlas of Genetics and Cytogenetics in Oncology and Haematology

KIAA0101 (KIAA0101)

2011

Conference Publication

Estimation of EGF receptor expression and trafficking dysregulation in live tissue samples of cutaneous SCC and precursor lesions

Gaffney, D. C., Barry, R., Lambie, D., Porceddu, S. V., Foote, M., Strutton, G., Saunders, N. A., Soyer, H. P. and Simpson, F. (2011). Estimation of EGF receptor expression and trafficking dysregulation in live tissue samples of cutaneous SCC and precursor lesions. Australasian College of Dermatologists Biennial Spring Conference 2011, Hobart, Australia, 13-16 October 2011. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-0960.2011.00810.x

Estimation of EGF receptor expression and trafficking dysregulation in live tissue samples of cutaneous SCC and precursor lesions

2010

Journal Article

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

Howes, Mark T., Kirkham, Matthew, Riches, James, Cortese, Katia, Walser, Piers J., Simpson, Fiona, Hill, Michelle M., Jones, Alun, Lundmark, Richard, Lindsay, Margaret R., Hernandez-Deviez, Delia J., Hadzic, Gordana, McCluskey, Adam, Bashir, Rumasia, Liu, Libin, Pilch, Paul, McMahon, Harvey, Robinson, Phillip J., Hancock, John F., Mayor, Satyajit and Parton, Robert G. (2010). Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. Journal of Cell Biology, 190 (4), 675-691. doi: 10.1083/jcb.201002119

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

2010

Journal Article

Adiponectin-It's all about the modifications

Simpson, Fiona and Whitehead, Jonathan P. (2010). Adiponectin-It's all about the modifications. International Journal of Biochemistry & Cell Biology, 42 (6), 785-788. doi: 10.1016/j.biocel.2009.12.021

Adiponectin-It's all about the modifications

2010

Journal Article

ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling

Charlton, HK, Webster, J, Kruger, S, Simpson, F, Richards, AA and Whitehead, JP (2010). ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling. Biochemical and Biophysical Research Communications, 392 (2), 234-239. doi: 10.1016/j.bbrc.2010.01.029

ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling

2009

Journal Article

Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation

Richards, AA, Colgrave, ML, Zhang, JL, Webster, J, Simpson, F, Preston, E, Wilks, D, Hoehn, KL, Stephenson, M, Macdonald, GA, Prins, JB, Cooney, GJ, Xu, AM and Whitehead, JP (2009). Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation. MOLECULAR ENDOCRINOLOGY, 24 (1), 229-239. doi: 10.1210/me.2009-0133

Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation

2009

Journal Article

Trafficking, development and hedgehog

Simpson, Fiona, Kerr, Markus C. and Wicking, Carol (2009). Trafficking, development and hedgehog. Mechanisms of Development, 126 (5 - 6), 279-288. doi: 10.1016/j.mod.2009.01.007

Trafficking, development and hedgehog

2009

Journal Article

ATF3 and p15(PAF) are novel gatekeepers of genomic integrity upon UV stress

Turchi, L., Fareh, M., Aberdam, E., Kitajima, S., Simpson, F, Wicking, C., Aberdam, D. and Virolle, T. (2009). ATF3 and p15(PAF) are novel gatekeepers of genomic integrity upon UV stress. Cell Death and Differentiation, 16 (5), 728-737. doi: 10.1038/cdd.2009.2

ATF3 and p15(PAF) are novel gatekeepers of genomic integrity upon UV stress

2008

Conference Publication

ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress

Turchi, L., Fareh, M., Aberdam, E., Kitajima, S., Simpson, F., Wicking, C., Aberdam, D. and Virolle, T. (2008). ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress. 20th Meeting of the European Association for Cancer Research, Lyon, France, 5-8 July 2008. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/S1359-6349(08)71531-3

ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress

2007

Journal Article

The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13

Bennetts, Jennifer S., Rendtorff, Nanna D., Simpson, Fiona, Tranebjaerg, Lisbeth and Wicking, Carol (2007). The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13. Developmental Dynamics, 236 (3), 843-852. doi: 10.1002/dvdy.21064

The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13

Current funding

  • 2024 - 2029
    Building mRNA Cancer Vaccines for Australia.
    MRFF - National Critical Infrastructure Initiative
    Open grant
  • 2024 - 2028
    Traffic calming: Clinically applicable ways of altering endocytosis (cell uptake) to improve drug pharmacology and efficacy.
    NHMRC Investigator Grants
    Open grant
  • 2023 - 2026
    Personalising Innate-immunotherapy for Superior Treatment Outcomes with Large anticancer applicability (PISTOL)
    NHMRC MRFF EMCR - Early to Mid-Career Researchers
    Open grant
  • 2023 - 2024
    Cold atmospheric Plasma in the treatment and sensitisation of Radiation Therapy in extensive skin field cancerisation - PlasmaRT study
    Metro South Health Research Support Scheme Early Career Researcher Grant
    Open grant
  • 2021 - 2024
    The Ins and Outs of Endocytosis inhibition: Providing diverse opportunities for treatment of incurable cancers
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2025
    Improving immune memory responses to monoclonal antibody therapies.
    Merchant Charitable Foundation
    Open grant
  • 2019 - 2024
    Donation to support the research of Fiona Simpson
    PA Research Foundation
    Open grant

Past funding

  • 2022 - 2023
    Laser capture microdissection to empower cancer discoveries, improve diagnosis, treatment and outcomes in amyloidosis patients
    IPF Healthy - Medical Research
    Open grant
  • 2020
    Increasing the number of breast cancer therapeutic antibody possibilities, patient choices and success rates.
    PA Research Foundation
    Open grant
  • 2019 - 2021
    Towards effective treatment of cutaneous SCC of the head and neck with perineural invasion.
    PA Research Foundation
    Open grant
  • 2019 - 2022
    Dynamin modulators for reversing immunotherapy resistance in head and neck cancer (NHMRC Project Grants led by The University of Newcastle)
    University of Newcastle
    Open grant
  • 2018 - 2019
    Pre-clinical testing for combination therapy
    PA Research Foundation
    Open grant
  • 2018 - 2020
    Increasing the number of breast cancer therapeutic antibody possibilities, patient choices and success
    PA Research Foundation
    Open grant
  • 2017 - 2018
    Adjuvant therapy for checkpoint inhibitor efficacy in murine oncology models
    UniQuest Pty Ltd
    Open grant
  • 2017 - 2022
    CESTEM-1 research support
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2016 - 2017
    Cell biological mechanism of reversing resistance to cancer therapeutic antibodies
    Research Donation Generic
    Open grant
  • 2016
    Molecular mechanisms of perineural invasion in cutaneous squamous cell carcinoma of the head and neck
    PA Research Foundation
    Open grant
  • 2015 - 2016
    Making Herceptin-resistant tumours Herceptin responsive: adapting new therapeutic potential from Head and Neck Cancer research to improve breast cancer outcomes
    National Breast Cancer Foundation
    Open grant
  • 2015
    Next-generation cell analysis: Automated high-throughput 3D microscope and multimode microplate reader
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2015
    The role of epidermal growth factor receptor trafficking in tumor progression and patient therapy resistance
    Cancer Council Queensland
    Open grant
  • 2011 - 2013
    ResTeach 2011 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010 - 2011
    Growth factor signalling in health and squamous cell carcinoma.
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2007 - 2012
    NHMRC Career Development Award: Endosomal tubule formation in health and disease
    NHMRC Career Development Award
    Open grant
  • 2005 - 2007
    The making of a sea shell: function and evolution of genes encoding calcareous architectures of phenomenal strength purity and beauty
    ARC Discovery Projects
    Open grant
  • 2003
    Building Bridges at the Nexus of Cell and Developmental Biology
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2001 - 2002
    Development of an in vitro assay for GLUT4 trafficking to the cell surface
    Pfizer Pty Ltd
    Open grant
  • 2000 - 2002
    Postdoctoral Research Fellowship: the molecular mechanism of GLUT4 translocation in response to insulin receptor activation
    Juvenile Diabetes Research Foundation - International
    Open grant

Availability

Associate Professor Fiona Simpson is:
Available for supervision

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Available projects

Supervision history

Current supervision

Completed supervision

Enquiries

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