
Overview
Background
PLEASE NOTE THAT ANY AUTHORSHIP ALTERATIONS LISTING ME AS SIMPSON-FRASER BELOW ARE INCORRECT. ALL PUBLICATIONS ARE FIONA SIMPSON. MY PROFESSIONAL NAME IS FIONA SIMPSON.
Our laboratory is involved in cross-discipline research studying endocytosis, cancer, pharmacology and immunology to improve therapies used in cancer treatment.
Availability
- Professor Fiona Simpson is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Cambridge
- Bachelor (Honours) of Biochemistry, University of Edinburgh
Research interests
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Changing the timing of anti-tumour therapy
We are interested in slowing down or speeding up the delivery of drugs into tumour cells to maximise their anti-tumour activity and improve outcomes for cancer patients while reducing side-effects.
Works
Search Professor Fiona Simpson’s works on UQ eSpace
1998
Journal Article
Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation
Jost, M, Simpson, F, Kavran, JM, Lemmon, MA and Schmid, SL (1998). Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Current Biology, 8 (25), 1399-1402. doi: 10.1016/S0960-9822(98)00022-0
1997
Journal Article
Characterization of the adaptor-related protein complex, AP-3
Simpson, F., Peden, A. A., Christopoulou, L. and Robinson, M. S. (1997). Characterization of the adaptor-related protein complex, AP-3. Journal of Cell Biology, 137 (4), 835-845. doi: 10.1083/jcb.137.4.835
1996
Journal Article
A novel adaptor-related protein complex
Simpson, F., Bright, N. A., West, M. A., Newman, L. S., Darnell, R. B. and Robinson, M. S. (1996). A novel adaptor-related protein complex. Journal of Cell Biology, 133 (4), 749-760. doi: 10.1083/jcb.133.4.749
1993
Conference Publication
Tissue distribution and synthesis of TRAMP (tyrosine rich acidic matrix protein) on fibroblast culture
Forbes, E. G., Cronshaw, A. D., Macbeath, J. R.E., Kerr, I. E., Coutts, S. R.J., Genschel, U. H., Simpson, F. and Hulmes, D. J.S. (1993). Tissue distribution and synthesis of TRAMP (tyrosine rich acidic matrix protein) on fibroblast culture.
Funding
Current funding
Supervision
Availability
- Professor Fiona Simpson is:
- Available for supervision
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Available projects
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Altering the delivery of antibody-drug conjugates to increase efficacy.
Altering the endocytosis of cancer cell receptors to improve delivery and efficacy of antibodies, antibody-drug conjugates and radio-ligand conjugates.
Supervision history
Current supervision
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Master Philosophy
Biomarkers in Cancer: Novel histopathology scoring and new biomarkers in rare cancers.
Principal Advisor
-
Doctor Philosophy
Novel Biomarkers and Therapy Approaches in Breast Cancer
Principal Advisor
Other advisors: Dr Shannon Joseph, Professor Chris Pyke
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Master Philosophy
ULTRASOUND DIRECTED VACUUM ASSISTED EXCISION OF SMALL BREAST CANCERS: TRIAL OF PROOF OF CONCEPT
Principal Advisor
Other advisors: Dr Shannon Joseph
-
Doctor Philosophy
The Ins and Outs of Endocytosis inhibition: Providing diverse opportunities for treatment of incurable cancers
Principal Advisor
Other advisors: Professor Gabrielle Belz, Dr Shannon Joseph
-
Doctor Philosophy
Regulating immune system activity in oncology and auto-immune diseases.
Principal Advisor
Other advisors: Dr Shannon Joseph
-
Doctor Philosophy
Drug target stability and drug metabolism by tumour cells in vivo
Principal Advisor
Other advisors: Dr Shannon Joseph, Dr Janin Chandra
-
Doctor Philosophy
Novel Biomarkers and Therapy Approaches in Breast Cancer
Principal Advisor
Other advisors: Dr Shannon Joseph, Professor Chris Pyke
-
Doctor Philosophy
Strategies to improve immunotherapy for patients with glioblastoma or breast cancer brain metastases
Associate Advisor
Other advisors: Dr Jodi Saunus, Professor Nikolas Haass
-
Doctor Philosophy
Harnessing the power of iPSC-NK cells for cancer immunotherapy
Associate Advisor
Other advisors: Dr Mathew Jones, Associate Professor Fernando Guimaraes
-
Doctor Philosophy
Enhancement of Natural Killer cell function for therapeutic targeting and elimination of solid cancers
Associate Advisor
Other advisors: Associate Professor Fernando Guimaraes
-
Doctor Philosophy
Altering the delivery of antibody-drug conjugates to increase efficacy
Associate Advisor
Other advisors: Dr Shannon Joseph
-
Doctor Philosophy
Understanding the role of HER2 in cardiac function.
Associate Advisor
Other advisors: Professor Wally Thomas, Dr Melissa Reichelt
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani, Dr Snehlata Kumari
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Doctor Philosophy
Enhancement of Natural Killer cell function for therapeutic targeting and elimination of solid cancers
Associate Advisor
Other advisors: Associate Professor Fernando Guimaraes
-
Doctor Philosophy
The Molecular Characterisation of Myeloperoxidase (MPO) and its role in autoimmunity
Associate Advisor
Other advisors: Professor Ranjeny Thomas, Dr Pie Huda, Professor David Owen
Completed supervision
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2025
Doctor Philosophy
Novel Biomarkers and Therapy Approaches in Breast Cancer
Principal Advisor
Other advisors: Dr Shannon Joseph, Professor Chris Pyke
-
2024
Master Philosophy
Biomarkers in cancer: Novel histopathology scoring and new biomarkers in perineural invasion in cutaneous squamous cell carcinoma, adenoid cystic carcinoma and metastatic ER+ breast cancer
Principal Advisor
-
2023
Doctor Philosophy
Improving monoclonal antibody therapies with temporary and reversible endocytosis inhibition
Principal Advisor
-
2021
Doctor Philosophy
Endocytosis Inhibition to Improve Responses to Antibody Dependent Cellular Cytotoxicity-Mediating Antibodies
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ben Panizza, Associate Professor James Wells
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2019
Doctor Philosophy
Dynamin inhibition increases monoclonal antibody-dependent cellular cytotoxicity and reverses signalling pathway resistance
Principal Advisor
Other advisors: Associate Professor James Wells
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2018
Doctor Philosophy
Dysregulation of EGF-trafficking in squamous cell carcinoma and cetuximab resistance
Principal Advisor
-
2016
Doctor Philosophy
Manipulation of Epidermal Growth Factor Receptor (EGFR) Trafficking to Improve anti-EGFR Monoclonal Antibody Therapies
Principal Advisor
Other advisors: Associate Professor James Wells
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2023
Doctor Philosophy
Therapeutic targets and immune therapy for head and neck adenoid cystic carcinoma
Associate Advisor
Other advisors: Professor Ben Panizza
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2020
Master Philosophy
Investigating therapeutic possibilities for treatment of perineural invasion
Associate Advisor
Other advisors: Professor Ben Panizza
-
2019
Doctor Philosophy
EGFR and Treg targeted therapies for cutaneous squamous cell carcinoma
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells, Dr Shannon Joseph
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2017
Master Philosophy
Molecular mechanisms of perineural spread of cutaneous carcinoma: a potential role for receptor tyrosine kinases and other biomarkers
Associate Advisor
Other advisors: Professor Ben Panizza
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2016
Doctor Philosophy
Evaluating CD8+ T-cell function in skin and squamous cell carcinoma following systemic suppression with rapamycin and tacrolimus.
Associate Advisor
Other advisors: Professor Ian Frazer, Associate Professor James Wells
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2015
Doctor Philosophy
The role of E2F7 and E2F8 in squamous differentiation, UV- and chemotherapy-induced responses in keratinocytes
Associate Advisor
-
2010
Doctor Philosophy
Clathrin Independent Carriers: Molecular characterisation of a novel clathrin-independent endocytic pathway
Associate Advisor
Other advisors: Professor Robert Parton
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2008
Doctor Philosophy
Analysis of molecules controlling limb and craniofacial development in the mouse
Associate Advisor
-
2006
Doctor Philosophy
THE IDENTIFICATION AND CHARACTERISATION OF NOVEL GENES IN DEVELOPMENT
Associate Advisor
Other advisors: Associate Professor Rohan Teasdale
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2006
Doctor Philosophy
REDEFINING THE RETROMER
Associate Advisor
Other advisors: Associate Professor Rohan Teasdale
Media
Enquiries
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