Overview
Availability
- Associate Professor David Muller is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor David Muller’s works on UQ eSpace
2025
Journal Article
Kinetics of NS1 and anti-NS1 IgG following dengue infection reveals likely early formation of immune complexes in secondary infected patients
Muller, David A., Choo, Jovin J. Y., McElnea, Catriona, Duyen, Huynh T. L., Wills, Bridget and Young, Paul R. (2025). Kinetics of NS1 and anti-NS1 IgG following dengue infection reveals likely early formation of immune complexes in secondary infected patients. Scientific Reports, 15 (1) 6684. doi: 10.1038/s41598-025-91099-5
2025
Journal Article
Skin patch delivery of a SARS-CoV-2 Spike DNA vaccine produces broad neutralising antibody responses
McMillan, Christopher L.D., Corner, Andrea V., Wijesundara, Danushka K., Choo, Jovin J.Y., Pittayakhajonwut, Daraporn, Poredi, Indrajeet, Parry, Rhys H., Bindra, Guneet K., Bruce, Kimberley, Khromykh, Alexander A., Fernando, Germain J.P., Dapremont, Laurent, Young, Paul R. and Muller, David A. (2025). Skin patch delivery of a SARS-CoV-2 Spike DNA vaccine produces broad neutralising antibody responses. Heliyon, 11 (4) e42533, e42533. doi: 10.1016/j.heliyon.2025.e42533
2025
Journal Article
Vaccine microarray patch self-administration: A preliminary study in adults 50 years of age and over
Davies, C., Baker, B., Berger, M.N., Knox, S.L., Mowbray, E., Stewart, B.G., Booy, R., Hacker, E., Marmol, A., Ross, C., Muller, D.A., Mortimore, A.M., Siller, G., Forster, A.H. and Skinner, S.R. (2025). Vaccine microarray patch self-administration: A preliminary study in adults 50 years of age and over. Vaccine, 48 126699, 126699-48. doi: 10.1016/j.vaccine.2024.126699
2024
Journal Article
Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein
McMillan, Christopher L. D., Wijesundara, Danushka K., Choo, Jovin J. Y., Amarilla, Alberto A., Modhiran, Naphak, Fernando, Germain J. P., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R. and Muller, David A. (2024). Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. Journal of General Virology, 105 (1) 001947, 1-6. doi: 10.1099/jgv.0.001947
2023
Journal Article
Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine
Wijesundara, Danushka K., Yeow, Arthur, McMillan, Christopher L. D., Choo, Jovin J. Y., Todorovic, Aleksandra, Mekonnen, Zelalem A., Masavuli, Makutiro G., Young, Paul R., Gowans, Eric J., Grubor-Bauk, Branka and Muller, David A. (2023). Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine. Molecular Therapy Nucleic Acids, 34 102056. doi: 10.1016/j.omtn.2023.102056
2023
Journal Article
Elevated BMI reduces the humoral response to SARS‐CoV‐2 infection
Tong, Marcus Z. W., Sng, Julian D. J., Carney, Meagan, Cooper, Lucy, Brown, Samuel, Lineburg, Katie E., Chew, Keng Yih, Collins, Neve, Ignacio, Kirsten, Airey, Megan, Burr, Lucy, Joyce, Briony A., Jayasinghe, Dhilshan, McMillan, Christopher L. D., Muller, David A., Adhikari, Anurag, Gallo, Linda A., Dorey, Emily S., Barrett, Helen L., Gras, Stephanie, Smith, Corey, Good‐Jacobson, Kim and Short, Kirsty R. (2023). Elevated BMI reduces the humoral response to SARS‐CoV‐2 infection. Clinical and Translational Immunology, 12 (12) e1476, 1-13. doi: 10.1002/cti2.1476
2023
Journal Article
Safety, tolerability, and immunogenicity of measles and rubella vaccine delivered with a high-density microarray patch: results from a randomized, partially double-blinded, placebo-controlled phase I clinical trial
Baker, Ben, Bermingham, Imogen M., Leelasena, Indika, Hickling, Julian, Young, Paul R., Muller, David A. and Forster, Angus H. (2023). Safety, tolerability, and immunogenicity of measles and rubella vaccine delivered with a high-density microarray patch: results from a randomized, partially double-blinded, placebo-controlled phase I clinical trial. Vaccines, 11 (11) 1725, 1-17. doi: 10.3390/vaccines11111725
2023
Journal Article
Microarray patches: scratching the surface of vaccine delivery
Choo, Jovin J. Y., McMillan, Christopher L. D., Young, Paul R. and Muller, David A. (2023). Microarray patches: scratching the surface of vaccine delivery. Expert Review of Vaccines, 22 (1), 937-955. doi: 10.1080/14760584.2023.2270598
2022
Journal Article
Monoclonal antibodies specific for SARS-CoV-2 spike protein suitable for multiple applications for current variants of concern
Morgan, Mahali S., Yan, Kexin, Le, Thuy T., Johnston, Ryan A., Amarilla, Alberto A., Muller, David A., McMillan, Christopher L. D., Modhiran, Naphak, Watterson, Daniel, Potter, James R., Sng, Julian D. J., Lor, Mary, Paramitha, Devina, Isaacs, Ariel, Khromykh, Alexander A., Hall, Roy A., Suhrbier, Andreas, Rawle, Daniel J. and Hobson-Peters, Jody (2022). Monoclonal antibodies specific for SARS-CoV-2 spike protein suitable for multiple applications for current variants of concern. Viruses, 15 (1) 139, 1-18. doi: 10.3390/v15010139
2022
Journal Article
Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern
McMillan, Christopher L.D., Amarilla, Alberto A., Modhiran, Naphak, Choo, Jovin J.Y., Azuar, Armira, Honeyman, Kate E., Khromykh, Alexander A., Young, Paul R., Watterson, Daniel and Muller, David A. (2022). Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern. Vaccine, 40 (34), 4929-4932. doi: 10.1016/j.vaccine.2022.07.013
2022
Journal Article
Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants
Isaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262
2022
Journal Article
Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration
Oliveira, Camille F. de, Neto, Walter F. F., Silva, Carla P. da, Ribeiro, Ana Claudia S., Martins, Lívia C., Sousa, Alana W. de, Freitas, Maria N. O., Chiang, Jannifer O., Silva, Franko A., Santos, Eder B. dos, Medeiros, Daniele B. A., Pinheiro, Gleiciane S., Brandão, Gleiciane F., Carvalho, Valéria L., Azevedo, Raimunda S. S., Vasconcelos, Pedro F. C., Costa, Igor B., Costa, Iran B., Santos, Mirleide C. dos, Soares, Luana S., Bedran, Rayssa L. S., Ferreira, James L., Amarilla, Alberto A., Modhiran, Naphak, McMillan, Christopher L. D., Freney, Morgan E., Muller, David A., Watterson, Daniel, Casseb, Lívia M. N. and Henriques, Daniele F. (2022). Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration. Vaccines, 10 (5) 690, 690. doi: 10.3390/vaccines10050690
2022
Journal Article
Local response and barrier recovery in elderly skin following the application of high-density microarray patches
Iredahl, Fredrik, Muller, David A., Togö, Totte, Jonasson, Hanna, Baker, Ben, Anderson, Chris D. and Henricson, Joakim (2022). Local response and barrier recovery in elderly skin following the application of high-density microarray patches. Vaccines, 10 (4) 583, 583. doi: 10.3390/vaccines10040583
2022
Journal Article
Dermal delivery of a SARS-CoV-2 subunit vaccine induces immunogenicity against variants of concern
McMillan, Christopher L. D., Azuar, Armira, Choo, Jovin J. Y., Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Honeyman, Kate E., Cheung, Stacey T. M., Liang, Benjamin, Wurm, Maria J., Pino, Paco, Kint, Joeri, Fernando, Germain J. P., Landsberg, Michael J., Khromykh, Alexander A., Hobson-Peters, Jody, Watterson, Daniel, Young, Paul R. and Muller, David A. (2022). Dermal delivery of a SARS-CoV-2 subunit vaccine induces immunogenicity against variants of concern. Vaccines, 10 (4) 578, 578. doi: 10.3390/vaccines10040578
2022
Journal Article
Micropuncture closure following high density microarray patch application in healthy subjects
Henricson, Joakim, Muller, David A., Baker, S. Ben, Iredahl, Fredrik, Togö, Totte and Anderson, Chris D. (2022). Micropuncture closure following high density microarray patch application in healthy subjects. Skin Research and Technology, 28 (2), 305-310. doi: 10.1111/srt.13131
2021
Journal Article
Developing a stabilizing formulation of a live chimeric dengue virus vaccine dry coated on a high-density microarray patch
Choo, Jovin J. Y., McMillan, Christopher L. D., Fernando, Germain J. P., Hall, Roy A., Young, Paul R., Hobson-Peters, Jody and Muller, David A. (2021). Developing a stabilizing formulation of a live chimeric dengue virus vaccine dry coated on a high-density microarray patch. Vaccines, 9 (11) 1301, 1301. doi: 10.3390/vaccines9111301
2021
Journal Article
Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine
McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Cheung, Stacey T. M., Liang, Benjamin, Bielefeldt-Ohmann, Helle, Azuar, Armira, Acharya, Dhruba, Kelly, Gabrielle, Fernando, Germain J. P., Landsberg, Michael J., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., McMillan, Nigel A. J. and Muller, David A. (2021). Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine. Science Advances, 7 (44) eabj8065, eabj8065. doi: 10.1126/sciadv.abj8065
2021
Journal Article
Implications of dengue virus maturation on vaccine induced humoral immunity in mice
Scott, Connor A. P., Amarilla, Alberto A., Bibby, Summa, Newton, Natalee D., Hall, Roy A., Hobson-Peters, Jody, Muller, David A., Chappell, Keith J., Young, Paul R., Modhiran, Naphak and Watterson, Daniel (2021). Implications of dengue virus maturation on vaccine induced humoral immunity in mice. Viruses, 13 (9) 1843, 1843. doi: 10.3390/v13091843
2021
Journal Article
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses
Amarilla, Alberto A., Sng, Julian D. J., Parry, Rhys, Deerain, Joshua M., Potter, James R., Setoh, Yin Xiang, Rawle, Daniel J., Le, Thuy T., Modhiran, Naphak, Wang, Xiaohui, Peng, Nias Y. G., Torres, Francisco J., Pyke, Alyssa, Harrison, Jessica J., Freney, Morgan E., Liang, Benjamin, McMillan, Christopher L. D., Cheung, Stacey T. M., Guevara, Darwin J Da Costa, Hardy, Joshua M., Bettington, Mark, Muller, David A., Coulibaly, Fasséli, Moore, Frederick, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Hobson-Peters, Jody, Suhrbier, Andreas ... Khromykh, Alexander A. (2021). A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses. Nature Communications, 12 (1) 3431, 3431. doi: 10.1038/s41467-021-23779-5
2021
Other Outputs
Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine
McMillan, Christopher L.D., Choo, Jovin J.Y., Idris, Adi, Supramaniam, Aroon, Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Cheung, Stacey T.M., Liang, Benjamin, Bielefeldt-Ohmann, Helle, Azuar, Armira, Acharya, Dhruba, Kelly, Gabrielle, Fernando, Germain J.P., Landsberg, Michael J., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., McMillan, Nigel A.J. and Muller, David A. (2021). Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine. doi: 10.1101/2021.05.30.446357
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor David Muller is:
- Available for supervision
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Available projects
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Unravelling the immune mechanisms under the surface of skin patch vaccination
Project summary: We hypothesise the colocalisation of the vaccine antigen with damage caused by MAP application leads to infiltration of key immune cells, leading to immunity of greater magnitude, diversity, and quality.
Supervision history
Current supervision
-
Doctor Philosophy
Unpicking the molecular mechanisms of vaccination using a high-density microarray patch
Principal Advisor
-
Doctor Philosophy
Developing and optimizing bioprocesses for scale-up of their Chimeric antigen for flavivirus vaccines and diagnosis.
Associate Advisor
Other advisors: Associate Professor Jody Peters
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Doctor Philosophy
Development and optimisation of bioprocesses for scale-up manufacture of chimeric antigens for flavivirus vaccines and diagnostics
Associate Advisor
Other advisors: Associate Professor Jody Peters
Completed supervision
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2022
Doctor Philosophy
Development of Next Generation Dengue Virus Vaccines
Principal Advisor
Other advisors: Associate Professor Jody Peters
Media
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