Overview
Background
I completed my Bachelor of Biotechnology with First Class Honours at the Australian National University (ANU) during 2008. During my honours, I became interested in understanding ways to best harness the immune system in combating viral infections. Consequently, I embarked on a PhD project at The John Curtin School of Medical Research, ANU during 2010 to understand ways to improve the efficacy of genetically modified and safe pox viral vaccines to target human immunodeficiency virus (HIV). I completed this project during 2014 and worked as a an Early Career Fellow (sponsored by The Hospital Research Foundation) at the University of Adelaide to develop safe and effective vaccines against HIV, hepatitis C virus (HCV) and Zika virus. I joined the The University of Queensland during May, 2019 to develop a 'Rapid Response Vaccine Pipeline' (sponsored by The Coalition for Epidemic Preparedness Innovations (CEPI)) to target emerging/re-emerging viral infections using a prioprietary 'Molecular Clamp' vaccine technology. My career objective is to develop vaccines that can be effective in protective humans against viral infections.
Availability
- Dr Danushka Wijesundara is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Australian National University
Research impacts
As an early career researcher (PhD awarded in 2014), I have published 30 peer-reviewed manuscripts, been the recipient of 16 competitive academic awards, supervised several higher degree research students and presented mainly as a speaker in 18 national/international conferences. Three of the academic awards were presented to me in consecutive Australian Centre for HIV and hepatitis virology (ACH2) conferences (2015, 2017 and 2018), which is the premier national meeting for HIV and hepatitis basic and translational research in Australia. I have also been a chief investigator in 8 awarded grants and am the recipient of an Early Career Fellowship from The Hospital Research Foundation. I received one of these grants as the Principal Investigator during 2019 from the Channel 7 Children's Research Foundation (co-sponsored by The Hospital Research Foundation). Recently, Dr. Grubor-Bauk, Prof. Gowans and I have received a provisional patent for a highly protective vaccine that target the non-structural protein 1 (NS1) of Zika virus which received the support of a Commercial Acceleration Scheme Grant (The University of Adelaide) this year.
I was invited to speak in 4 departmental seminars (2 in the USA: Wadsworth Center, New York and Louisiana State University, New Orleans), have delivered a lecture at The Albany Pharmacy College, New York, USA, and presented to the community in numerous occasions (e.g. Science in the Pub, Science Alive, radio interviews with Coast FM (Adelaide),etc.) regarding scientific endeavours and controversies. I have reviewed manuscripts for publication in 13 peer-review journals (e.g. Scientific Reports, Frontiers in Immunology, Immunology and Cell Biology, etc.) and been an external assessor for 7 NHMRC project grant applications. I have also been fortunate enough to collaborate with the industry (e.g. Imaxio and MuPharma) and many prestigious academics (e.g. Prof. Andrew Lloyd (The University of New South Wales), Prof. Dan Barouch (Harvard Medical School) and Prof. Chris Parish (The Australian National University).
I have actively contributed to research and improving the community's understanding about vaccine research. I wish to continue on this trajectory and contribute productively to science and the community as an employee at UQ.
Works
Search Professor Danushka Wijesundara’s works on UQ eSpace
2024
Journal Article
Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein
McMillan, Christopher L. D., Wijesundara, Danushka K., Choo, Jovin J. Y., Amarilla, Alberto A., Modhiran, Naphak, Fernando, Germain J. P., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R. and Muller, David A. (2024). Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. Journal of General Virology, 105 (1) 001947, 1-6. doi: 10.1099/jgv.0.001947
2023
Journal Article
Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine
Wijesundara, Danushka K., Yeow, Arthur, McMillan, Christopher L. D., Choo, Jovin J. Y., Todorovic, Aleksandra, Mekonnen, Zelalem A., Masavuli, Makutiro G., Young, Paul R., Gowans, Eric J., Grubor-Bauk, Branka and Muller, David A. (2023). Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine. Molecular Therapy Nucleic Acids, 34 102056, 102056. doi: 10.1016/j.omtn.2023.102056
2023
Journal Article
Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial
Chappell, Keith J., Mordant, Francesca L., Amarilla, Alberto A., Modhiran, Naphak, Liang, Benjamin, Li, Zheyi, Wijesundara, Danushka K., Lackenby, Julia A., Griffin, Paul, Bennet, Jillian K., Hensen, Luca, Zhang, Wuji, Nguyen, Thi H.O., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Kedzierska, Katherine, Ranasinghe, Charani, Subbarao, Kanta, Watterson, Daniel, Young, Paul R. and Munro, Trent P. (2023). Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. eBioMedicine, 97 104842, 104842. doi: 10.1016/j.ebiom.2023.104842
2023
Journal Article
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0
2022
Journal Article
LUNG group 2 innate lymphoid cells as a new adjuvant target to enhance intranasal vaccine efficacy against influenza
Williams, Clare M., Roy, Sreeja, Sun, Wei, Furuya, Andrea M., Wijesundara, Danushka K. and Furuya, Yoichi (2022). LUNG group 2 innate lymphoid cells as a new adjuvant target to enhance intranasal vaccine efficacy against influenza. Clinical and Translational Immunology, 11 (3) e1381. doi: 10.1002/cti2.1381
2021
Journal Article
Fear of influenza resurgence amid covid-19 pandemic: need for effective flu vaccine still exists
Wijesundara, Danushka K., Williams, Clare, Sun, Wei, Furuya, Andrea Marias and Furuya, Yoichi (2021). Fear of influenza resurgence amid covid-19 pandemic: need for effective flu vaccine still exists. Vaccines, 9 (10) 1198, 1198. doi: 10.3390/VACCINES9101198
2021
Journal Article
Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial
Chappell, Keith J., Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia A., Cheung, Stacey T. M., Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Griffin, Paul, Bennet, Jillian, Hensen, Luca, Zhang, Wuji, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., Chung, Amy W., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P Mark, Kedzierska, Katherine ... Munro, Trent P. (2021). Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet Infectious Diseases, 21 (10), 1383-1394. doi: 10.1016/S1473-3099(21)00200-0
2021
Journal Article
Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2
Watterson, Daniel, Wijesundara, Danushka K., Modhiran, Naphak, Mordant, Francesca L., Li, Zheyi, Avumegah, Michael S., McMillan, Christopher L. D., Lackenby, Julia, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Cheung, Stacey T. M., Bibby, Summa, Daleris, Mallory, Hoger, Kym, Gillard, Marianne, Radunz, Eve, Jones, Martina L., Hughes, Karen, Hughes, Ben, Goh, Justin, Edwards, David, Scoble, Judith, Pearce, Lesley, Kowalczyk, Lukasz, Phan, Tram, La, Mylinh, Lu, Louis, Pham, Tam ... Chappell, Keith J. (2021). Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2. Clinical & Translational Immunology, 10 (4) e1269, e1269. doi: 10.1002/cti2.1269
2021
Journal Article
Adjuvant selection for influenza and RSV prefusion subunit vaccines
Isaacs, Ariel, Li, Zheyi, Cheung, Stacey T. M., Wijesundara, Danushka K., McMillan, Christopher L. D., Modhiran, Naphak, Young, Paul R., Ranasinghe, Charani, Watterson, Daniel and Chappell, Keith J. (2021). Adjuvant selection for influenza and RSV prefusion subunit vaccines. Vaccines, 9 (2) 71, 1-14. doi: 10.3390/vaccines9020071
2020
Journal Article
Impact of pre-existing immunity to influenza on live-attenuated influenza vaccine (Laiv) immunogenicity
Roy, Sreeja, Williams, Clare M., Wijesundara, Danushka K. and Furuya, Yoichi (2020). Impact of pre-existing immunity to influenza on live-attenuated influenza vaccine (Laiv) immunogenicity. Vaccines, 8 (4) 683, 1-13. doi: 10.3390/vaccines8040683
2020
Journal Article
Rapid response subunit vaccine design in the absence of structural information
Wijesundara, Danushka K., Avumegah, Michael S., Lackenby, Julia, Modhiran, Naphak, Isaacs, Ariel, Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2020). Rapid response subunit vaccine design in the absence of structural information. Frontiers in Immunology, 11 592370, 592370. doi: 10.3389/fimmu.2020.592370
2020
Journal Article
Immunological memory in imiquimod-induced murine model of psoriasiform dermatitis
Fenix, Kevin, Wijesundara, Danushka K., Cowin, Allison J., Grubor-Bauk, Branka and Kopecki, Zlatko (2020). Immunological memory in imiquimod-induced murine model of psoriasiform dermatitis. International Journal of Molecular Sciences, 21 (19) 7228, 1-13. doi: 10.3390/ijms21197228
2020
Journal Article
Impact of pre-existing immunity on live attenuated influenza vaccine-induced cross-protective immunity
Roy, Sreeja, Williams, Clare M., Pardo, Julian, Wijesundara, Danushka K. and Furuya, Yoichi (2020). Impact of pre-existing immunity on live attenuated influenza vaccine-induced cross-protective immunity. Vaccines, 8 (3) 459, 1-6. doi: 10.3390/vaccines8030459
2020
Journal Article
Safety profile of a multi-antigenic DNA vaccine against hepatitis C virus
Gummow, Jason, Masavuli, Makutiro G., Mekonnen, Zelalem A., Li, Yanrui, Wijesundara, Danushka K., Shrestha, Ashish C., Voskoboinik, Ilia, Gowans, Eric J. and Grubor-Bauk, Branka (2020). Safety profile of a multi-antigenic DNA vaccine against hepatitis C virus. Vaccines, 8 (1) 53, 1-15. doi: 10.3390/vaccines8010053
Funding
Past funding
Supervision
Availability
- Dr Danushka Wijesundara is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Structural and functional characterization of bat antiviral antibodies
Associate Advisor
Other advisors: Professor Daniel Watterson
-
Doctor Philosophy
Unpicking the molecular mechanisms of vaccination using a high-density microarray patch
Associate Advisor
Other advisors: Associate Professor David Muller
Media
Enquiries
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